![#](https://www.bordeaux-neurocampus.fr/wp-content/uploads/2018/07/sainlos-matthieu-DSC_9453-p.jpg)
Matthieu Sainlos
Chercheur - Responsable de la plateforme Biochimie
Chercheur - PhD (CR) / CNRS/ Contact
+33 5 33 51 47 31
www.orcid.org/0000-0001-5465-5641
/ Adresse
IINS - UMR 5297 - CNRS - Université de Bordeaux - Centre Broca Nouvelle-Aquitaine - 146 rue Léo-Saignat - CS 61292 CASE 130 - 33076 Bordeaux cedex -France
![](https://www.bordeaux-neurocampus.fr/wp-content/uploads/2018/07/sainlos-matthieu-DSC_9453-p.jpg)
Publications
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Engineering paralog-specific PSD-95 recombinant binders as minimally interfering multimodal probes for advanced imaging techniques
eLife. 2024-01-03. 13
10.7554/eLife.69620 -
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
eLife. 2022-05-09. 11
10.7554/elife.75233 -
High-Resolution Fluorescence Imaging Combined With Computer Simulations to Quantitate Surface Dynamics and Nanoscale Organization of Neuroligin-1 at Synapses.
Front. Synaptic Neurosci.. 2022-04-25. 14
10.3389/fnsyn.2022.835427 -
Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration
Nat Cell Biol. 2021-11-01. 23(11) : 1148-1162.
10.1038/s41556-021-00786-8 -
Role of regulatory C‐terminal motifs in synaptic confinement of LRRTM2
Biol. Cell. 2021-09-27.
10.1111/boc.202100026 -
High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning
. 2021-09-22.
10.1101/2021.09.21.461215 -
Engineering paralog-specific PSD-95 synthetic binders as potent and minimally invasive imaging probes
. 2021-04-08.
10.1101/2021.04.07.438431 -
Advanced imaging and labelling methods to decipher brain cell organization and function
Nat Rev Neurosci. 2021-03-12.
10.1038/s41583-021-00441-z -
Correction: Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency
eLife. 2020-12-16.
10.7554/eLife.65689 -
Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
Nat Commun. 2019-10-04. 10(1)
10.1038/s41467-019-12528-4 -
Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis
Nat Commun. 2019-10-01. 10(1)
10.1038/s41467-019-12434-9 -
TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering
Cell Reports. 2019-10-01. 29(5) : 1130-1146.e8.
10.1016/j.celrep.2019.09.051 -
Biophysical mechanisms underlying the membrane trafficking of synaptic adhesion molecules.
Neuropharmacology. 2019-03-01.
10.1016/j.neuropharm.2019.02.037 -
Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models
Nat Commun. 2018-10-15. 9(1)
10.1038/s41467-018-06675-3 -
Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses
Neuron. 2018-10-01. 100(1) : 106-119.e7.
10.1016/j.neuron.2018.09.012 -
A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation
Nat Commun. 2018-09-28. 9(1)
10.1038/s41467-018-06220-2 -
Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency
eLife. 2018-07-25. 7
10.7554/eLife.31755 -
CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity
Cell Reports. 2018-06-01. 23(11) : 3137-3145.
10.1016/j.celrep.2018.05.036 -
CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity
Cell Reports. 2018-06-01. 23(11) : 3137-3145.
10.1016/j.celrep.2018.05.036 -
Optimized labeling of membrane proteins for applications to super-resolution imaging in confined cellular environments using monomeric streptavidin
Nat Protoc. 2017-03-09. 12(4) : 748-763.
10.1038/nprot.2017.010 -
Nanoscale organization of synaptic adhesion proteins revealed by single-molecule localization microscopy
Neurophoton. 2016-11-03. 3(4) : 041810.
10.1117/1.NPh.3.4.041810 -
Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin.
Nat Comms. 2016-03-16. 7 : 10773.
10.1038/ncomms10773 -
Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95.
Neuron. 2015-04-01. 86(2) : 475-489.
10.1016/j.neuron.2015.03.013 -
Inhibition of PDZ domain-mediated interactions
Drug Discovery Today: Technologies. 2013-12-01. 10(4) : e531-e540.
10.1016/j.ddtec.2012.10.003 -
Neurexin-1β Binding to Neuroligin-1 Triggers the Preferential Recruitment of PSD-95 versus Gephyrin through Tyrosine Phosphorylation of Neuroligin-1
Cell Reports. 2013-06-01. 3(6) : 1996-2007.
10.1016/j.celrep.2013.05.013 -
Caged mono- and divalent ligands for light-assisted disruption of PDZ domain-mediated interactions
J. Am. Chem. Soc.. 2013-03-13. 135(12) : 4580-4583.
10.1021/ja309870q -
Regulation of AMPA receptor surface diffusion by PSD-95 slots
Current Opinion in Neurobiology. 2012-06-01. 22(3) : 453-460.
10.1016/j.conb.2011.10.010 -
Paromomycin and neomycin B derived cationic lipids: Synthesis and transfection studies
Journal of Controlled Release. 2012-03-01. 158(3) : 461-469.
10.1016/j.jconrel.2011.12.019 -
Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization.
Nat Chem Biol. 2010-12-26. 7(2) : 81-91.
10.1038/nchembio.498 -
Dynamic and specific interaction between synaptic NR2-NMDA receptor and PDZ proteins
Proceedings of the National Academy of Sciences. 2010-10-25. 107(45) : 19561-19566.
10.1073/pnas.1002690107 -
Monitoring protein interactions and dynamics with solvatochromic fluorophores
Trends in Biotechnology. 2010-02-01. 28(2) : 73-83.
10.1016/j.tibtech.2009.11.002 -
A general screening strategy for peptide-based fluorogenic ligands: Probes for dynamic studies of PDZ domain-mediated interactions
J. Am. Chem. Soc.. 2009-05-20. 131(19) : 6680-6682.
10.1021/ja900371q -
Synthesis of anhydride precursors of the environment-sensitive fluorophores 4-dmap and 6-dmn
Nat Protoc. 2007-12-01. 2(12) : 3219-3225.
10.1038/nprot.2007.444 -
Tools for investigating peptide-protein interactions: Peptide incorporation of environment-sensitive fluorophores through spps-based ‘building block’ approach
Nat Protoc. 2007-12-01. 2(12) : 3210-3218.
10.1038/nprot.2007.443 -
Tools for investigating peptide-protein interactions: Peptide incorporation of environment-sensitive fluorophores via on-resin derivatization
Nat Protoc. 2007-12-01. 2(12) : 3201-3209.
10.1038/nprot.2007.442 -
Self-assembled lamellar complexes of siRNA with lipidic aminoglycoside derivatives promote efficient siRNA delivery and interference
Proceedings of the National Academy of Sciences. 2007-10-08. 104(42) : 16534-16539.
10.1073/pnas.0707431104 -
Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells
Nat Chem Biol. 2007-03-11. 3(4) : 222-228.
10.1038/nchembio868 -
Aminoglycoside-quinacridine conjugates: Towards recognition of the P6.1 element of telomerase RNA
ChemBioChem. 2006-01-12. 7(2) : 321-329.
10.1002/cbic.200500354 -
Neomycin-capped aromatic platforms: Quadruplex DNA recognition and telomerase inhibition
Org. Biomol. Chem.. 2006-01-01. 4(6) : 1049.
10.1039/b516378a -
Kanamycin A-derived cationic lipids as vectors for gene transfection
ChemBioChem. 2005-05-10. 6(6) : 1023-1033.
10.1002/cbic.200400344 -
The design of cationic lipids for gene delivery
CPD. 2005-02-01. 11(3) : 375-394.
10.2174/1381612053382133 -
Aminoglycoside-derived cationic lipids for gene transfection: Synthesis of kanamycin A derivatives
Eur. J. Org. Chem.. 2003-08-01. 2003(15) : 2764-2774.
10.1002/ejoc.200300164 -
Progress in gene delivery by cationic lipids: Guanidinium-cholesterol based systems as an example
CDT. 2002-02-01. 3(1)
10.2174/1389450023348082