Matthieu Sainlos

Scientific articles

• Engineering paralog-specific PSD-95 recombinant binders as minimally interfering multimodal probes for advanced imaging techniques
  Charlotte Rimbault, Christelle Breillat, Benjamin Compans, Estelle Toulmé, Filipe Nunes Vicente, Monica Fernandez-Monreal, Patrice Mascalchi, Camille Genuer, Virginia Puente-Muñoz, Isabel Gauthereau, Eric Hosy, Stéphane Claverol, Gregory Giannone, Ingrid Chamma, Cameron D Mackereth, Christel Poujol, Daniel Choquet, Matthieu Sainlos.
  eLife. 2024-01-03. 13
  10.7554/eLife.69620
• MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
  Andrea Toledo, Mathieu Letellier, Giorgia Bimbi, Béatrice Tessier, Sophie Daburon, Alexandre Favereaux, Ingrid Chamma, Kristel Vennekens, Jeroen Vanderlinden, Matthieu Sainlos, Joris de Wit, Daniel Choquet, Olivier Thoumine.
  eLife. 2022-05-09. 11
  10.7554/elife.75233
• High-Resolution Fluorescence Imaging Combined With Computer Simulations to Quantitate Surface Dynamics and Nanoscale Organization of Neuroligin-1 at Synapses.
  Matthieu Lagardère, Adèle Drouet, Matthieu Sainlos, Olivier Thoumine.
  Front. Synaptic Neurosci.. 2022-04-25. 14
  10.3389/fnsyn.2022.835427
• Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration
  Amine Mehidi, Frieda Kage, Zeynep Karatas, Maureen Cercy, Matthias Schaks, Anna Polesskaya, Matthieu Sainlos, Alexis M. Gautreau, Olivier Rossier, Klemens Rottner, Grégory Giannone.
  Nat Cell Biol. 2021-11-01. 23(11) : 1148-1162.
  10.1038/s41556-021-00786-8
• Role of regulatory C‐terminal motifs in synaptic confinement of LRRTM2
  Konstantina Liouta, Julia Chabbert, Sebastien Benquet, Béatrice Tessier, Vincent Studer, Matthieu Sainlos, Joris De Wit, Olivier Thoumine, Ingrid Chamma.
  Biol. Cell. 2021-09-27.
  10.1111/boc.202100026
• High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning
  Angela M. Getz, Mathieu Ducros, Christelle Breillat, Aurélie Lampin-Saint-Amaux, Sophie Daburon, Urielle François, Agata Nowacka, Mónica Fernández-Monreal, Eric Hosy, Frédéric Lanore, Hanna Zieger, Matthieu Sainlos, Yann Humeau, Daniel Choquet.
  . 2021-09-22.
  10.1101/2021.09.21.461215
• Engineering paralog-specific PSD-95 synthetic binders as potent and minimally invasive imaging probes
  Charlotte Rimbault, Christelle Breillat, Benjamin Compans, Estelle Toulmé, Filipe Nunes Vicente, Monica Fernandez-Monreal, Patrice Mascalchi, Camille Genuer, Virginia Puente-Muñoz, Isabel Gauthereau, Eric Hosy, Gregory Giannone, Ingrid Chamma, Cameron D. Mackereth, Christel Poujol, Daniel Choquet, Matthieu Sainlos.
  . 2021-04-08.
  10.1101/2021.04.07.438431
• Advanced imaging and labelling methods to decipher brain cell organization and function
  Daniel Choquet, Matthieu Sainlos, Jean-Baptiste Sibarita.
  Nat Rev Neurosci. 2021-03-12.
  10.1038/s41583-021-00441-z
• Correction: Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency
  Kalina T Haas, Benjamin Compans, Mathieu Letellier, Thomas M Bartol Jr, Dolors Grillo-Bosch, Terrence J Sejnowski, Matthieu Sainlos, Daniel Choquet, Olivier Thoumine.
  eLife. 2020-12-16.
  10.7554/eLife.65689
• Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
  Charlotte Rimbault, Kashyap Maruthi, Christelle Breillat, Camille Genuer, Sara Crespillo, Virginia Puente-Muñoz, Ingrid Chamma, Isabel Gauthereau, Ségolène Antoine, Coraline Thibaut, Fabienne Wong Jun Tai, Benjamin Dartigues, Dolors Grillo-Bosch, Stéphane Claverol, Christel Poujol, Daniel Choquet, Cameron D. Mackereth, Matthieu Sainlos.
  Nat Commun. 2019-10-04. 10(1)
  10.1038/s41467-019-12528-4
• Functional recruitment of dynamin requires multimeric interactions for efficient endocytosis
  Morgane Rosendale, Thi Nhu Ngoc Van, Dolors Grillo-Bosch, Silvia Sposini, Léa Claverie, Isabel Gauthereau, Stéphane Claverol, Daniel Choquet, Matthieu Sainlos, David Perrais.
  Nat Commun. 2019-10-01. 10(1)
  10.1038/s41467-019-12434-9
• TSPAN5 Enriched Microdomains Provide a Platform for Dendritic Spine Maturation through Neuroligin-1 Clustering
  Edoardo Moretto, Anna Longatti, Luca Murru, Ingrid Chamma, Alessandro Sessa, Jonathan Zapata, Eric Hosy, Matthieu Sainlos, Julien Saint-Pol, Eric Rubinstein, Daniel Choquet, Vania Broccoli, Giampietro Schiavo, Olivier Thoumine, Maria Passafaro.
  Cell Reports. 2019-10-01. 29(5) : 1130-1146.e8.
  10.1016/j.celrep.2019.09.051
• Biophysical mechanisms underlying the membrane trafficking of synaptic adhesion molecules.
  Ingrid Chamma, Matthieu Sainlos, Olivier Thoumine.
  Neuropharmacology. 2019-03-01.
  10.1016/j.neuropharm.2019.02.037
• Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models
  Hongyu Zhang, Chunlei Zhang, Jean Vincent, Diana Zala, Caroline Benstaali, Matthieu Sainlos, Dolors Grillo-Bosch, Sophie Daburon, Françoise Coussen, Yoon Cho, Denis J. David, Frederic Saudou, Yann Humeau, Daniel Choquet.
  Nat Commun. 2018-10-15. 9(1)
  10.1038/s41467-018-06675-3
• Differential Nanoscale Topography and Functional Role of GluN2-NMDA Receptor Subtypes at Glutamatergic Synapses
  Blanka Kellermayer, Joana S. Ferreira, Julien Dupuis, Florian Levet, Dolors Grillo-Bosch, Lucie Bard, Jeanne Linarès-Loyez, Delphine Bouchet, Daniel Choquet, Dmitri A. Rusakov, Pierre Bon, Jean-Baptiste Sibarita, Laurent Cognet, Matthieu Sainlos, Ana Luisa Carvalho, Laurent Groc.
  Neuron. 2018-10-01. 100(1) : 106-119.e7.
  10.1016/j.neuron.2018.09.012
• A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation
  Mathieu Letellier, Zsófia Szíber, Ingrid Chamma, Camille Saphy, Ioanna Papasideri, Béatrice Tessier, Matthieu Sainlos, Katalin Czöndör, Olivier Thoumine.
  Nat Commun. 2018-09-28. 9(1)
  10.1038/s41467-018-06220-2
• Pre-post synaptic alignment through neuroligin-1 tunes synaptic transmission efficiency
  Kalina T Haas, Benjamin Compans, Mathieu Letellier, Thomas M Bartol, Dolors Grillo-Bosch, Terrence J Sejnowski, Matthieu Sainlos, Daniel Choquet, Olivier Thoumine, Eric Hosy.
  eLife. 2018-07-25. 7
  10.7554/eLife.31755
• CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity
  Patricio Opazo, Silvia Viana da Silva, Mario Carta, Christelle Breillat, Steven J. Coultrap, Dolors Grillo-Bosch, Matthieu Sainlos, Françoise Coussen, K. Ulrich Bayer, Christophe Mulle, Daniel Choquet.
  Cell Reports. 2018-06-01. 23(11) : 3137-3145.
  10.1016/j.celrep.2018.05.036
• CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity
  Patricio Opazo, Silvia Viana da Silva, Mario Carta, Christelle Breillat, Steven J. Coultrap, Dolors Grillo-Bosch, Matthieu Sainlos, Françoise Coussen, K. Ulrich Bayer, Christophe Mulle, Daniel Choquet.
  Cell Reports. 2018-06-01. 23(11) : 3137-3145.
  10.1016/j.celrep.2018.05.036
• Optimized labeling of membrane proteins for applications to super-resolution imaging in confined cellular environments using monomeric streptavidin
  Ingrid Chamma, Olivier Rossier, Grégory Giannone, Olivier Thoumine, Matthieu Sainlos.
  Nat Protoc. 2017-03-09. 12(4) : 748-763.
  10.1038/nprot.2017.010
• Nanoscale organization of synaptic adhesion proteins revealed by single-molecule localization microscopy
  Ingrid Chamma, Florian Levet, Jean-Baptiste Sibarita, Matthieu Sainlos, Olivier Thoumine.
  Neurophoton. 2016-11-03. 3(4) : 041810.
  10.1117/1.NPh.3.4.041810
• Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin.
  Ingrid Chamma, Mathieu Letellier, Corey Butler, Béatrice Tessier, Kok-Hong Lim, Isabel Gauthereau, Daniel Choquet, Jean-Baptiste Sibarita, Sheldon Park, Matthieu Sainlos, Olivier Thoumine.
  Nat Comms. 2016-03-16. 7 : 10773.
  10.1038/ncomms10773
• Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95.
  Anne-Sophie Hafner, Andrew C. Penn, Dolors Grillo-Bosch, Natacha Retailleau, Christel Poujol, Amandine Philippat, Françoise Coussen, Matthieu Sainlos, Patricio Opazo, Daniel Choquet.
  Neuron. 2015-04-01. 86(2) : 475-489.
  10.1016/j.neuron.2015.03.013
• Inhibition of PDZ domain-mediated interactions
  Dolors Grillo-Bosch, Daniel Choquet, Matthieu Sainlos.
  Drug Discovery Today: Technologies. 2013-12-01. 10(4) : e531-e540.
  10.1016/j.ddtec.2012.10.003
• Neurexin-1β Binding to Neuroligin-1 Triggers the Preferential Recruitment of PSD-95 versus Gephyrin through Tyrosine Phosphorylation of Neuroligin-1
  Grégory Giannone, Magali Mondin, Dolors Grillo-Bosch, Béatrice Tessier, Edouard Saint-Michel, Katalin Czöndör, Matthieu Sainlos, Daniel Choquet, Olivier Thoumine.
  Cell Reports. 2013-06-01. 3(6) : 1996-2007.
  10.1016/j.celrep.2013.05.013
• Caged mono- and divalent ligands for light-assisted disruption of PDZ domain-mediated interactions
  Matthieu Sainlos, Wendy S. Iskenderian-Epps, Nelson B. Olivier, Daniel Choquet, Barbara Imperiali.
  J. Am. Chem. Soc.. 2013-03-13. 135(12) : 4580-4583.
  10.1021/ja309870q
• Regulation of AMPA receptor surface diffusion by PSD-95 slots
  Patricio Opazo, Matthieu Sainlos, Daniel Choquet.
  Current Opinion in Neurobiology. 2012-06-01. 22(3) : 453-460.
  10.1016/j.conb.2011.10.010
• Paromomycin and neomycin B derived cationic lipids: Synthesis and transfection studies
  Mathieu Mével, Matthieu Sainlos, Benoît Chatin, Noufissa Oudrhiri, Michèle Hauchecorne, Olivier Lambert, Jean-Pierre Vigneron, Pierre Lehn, Bruno Pitard, Jean-Marie Lehn.
  Journal of Controlled Release. 2012-03-01. 158(3) : 461-469.
  10.1016/j.jconrel.2011.12.019
• Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization.
  Matthieu Sainlos, Cezar Tigaret, Christel Poujol, Nelson B Olivier, Lucie Bard, Christelle Breillat, Kevin Thiolon, Daniel Choquet, Barbara Imperiali.
  Nat Chem Biol. 2010-12-26. 7(2) : 81-91.
  10.1038/nchembio.498
• Dynamic and specific interaction between synaptic NR2-NMDA receptor and PDZ proteins
  L. Bard, M. Sainlos, D. Bouchet, S. Cousins, L. Mikasova, C. Breillat, F. A. Stephenson, B. Imperiali, D. Choquet, L. Groc.
  Proceedings of the National Academy of Sciences. 2010-10-25. 107(45) : 19561-19566.
  10.1073/pnas.1002690107
• Monitoring protein interactions and dynamics with solvatochromic fluorophores
  Galen S. Loving, Matthieu Sainlos, Barbara Imperiali.
  Trends in Biotechnology. 2010-02-01. 28(2) : 73-83.
  10.1016/j.tibtech.2009.11.002
• A general screening strategy for peptide-based fluorogenic ligands: Probes for dynamic studies of PDZ domain-mediated interactions
  Matthieu Sainlos, Wendy S. Iskenderian, Barbara Imperiali.
  J. Am. Chem. Soc.. 2009-05-20. 131(19) : 6680-6682.
  10.1021/ja900371q
• Synthesis of anhydride precursors of the environment-sensitive fluorophores 4-dmap and 6-dmn
  Matthieu Sainlos, Barbara Imperiali.
  Nat Protoc. 2007-12-01. 2(12) : 3219-3225.
  10.1038/nprot.2007.444
• Tools for investigating peptide-protein interactions: Peptide incorporation of environment-sensitive fluorophores through spps-based ‘building block’ approach
  Matthieu Sainlos, Barbara Imperiali.
  Nat Protoc. 2007-12-01. 2(12) : 3210-3218.
  10.1038/nprot.2007.443
• Tools for investigating peptide-protein interactions: Peptide incorporation of environment-sensitive fluorophores via on-resin derivatization
  Matthieu Sainlos, Barbara Imperiali.
  Nat Protoc. 2007-12-01. 2(12) : 3201-3209.
  10.1038/nprot.2007.442
• Self-assembled lamellar complexes of siRNA with lipidic aminoglycoside derivatives promote efficient siRNA delivery and interference
  L. Desigaux, M. Sainlos, O. Lambert, R. Chevre, E. Letrou-Bonneval, J.-P. Vigneron, P. Lehn, J.-M. Lehn, B. Pitard.
  Proceedings of the National Academy of Sciences. 2007-10-08. 104(42) : 16534-16539.
  10.1073/pnas.0707431104
• Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells
  Prasanna Venkatraman, Tina T Nguyen, Matthieu Sainlos, Osman Bilsel, Sriram Chitta, Barbara Imperiali, Lawrence J Stern.
  Nat Chem Biol. 2007-03-11. 3(4) : 222-228.
  10.1038/nchembio868
• Aminoglycoside-quinacridine conjugates: Towards recognition of the P6.1 element of telomerase RNA
  Markus Kaiser, Matthieu Sainlos, Jean-Marie Lehn, Sophie Bombard, Marie-Paule Teulade-Fichou.
  ChemBioChem. 2006-01-12. 7(2) : 321-329.
  10.1002/cbic.200500354
• Neomycin-capped aromatic platforms: Quadruplex DNA recognition and telomerase inhibition
  Markus Kaiser, Anne De Cian, Matthieu Sainlos, Christian Renner, Jean-Louis Mergny, Marie-Paule Teulade-Fichou.
  Org. Biomol. Chem.. 2006-01-01. 4(6) : 1049.
  10.1039/b516378a
• Kanamycin A-derived cationic lipids as vectors for gene transfection
  Matthieu Sainlos, Michelle Hauchecorne, Noufissa Oudrhiri, Samia Zertal-Zidani, Abderrahim Aissaoui, Jean-Pierre Vigneron, Jean-Marie Lehn, Pierre Lehn.
  ChemBioChem. 2005-05-10. 6(6) : 1023-1033.
  10.1002/cbic.200400344
• The design of cationic lipids for gene delivery
  B. Martin, M. Sainlos, A. Aissaoui, N. Oudrhiri, M. Hauchecorne, J.- Vigneron, J.- Lehn, P. Lehn.
  CPD. 2005-02-01. 11(3) : 375-394.
  10.2174/1381612053382133
• Aminoglycoside-derived cationic lipids for gene transfection: Synthesis of kanamycin A derivatives
  Matthieu Sainlos, Philippe Belmont, Jean-Pierre Vigneron, Pierre Lehn, Jean-Marie Lehn.
  Eur. J. Org. Chem.. 2003-08-01. 2003(15) : 2764-2774.
  10.1002/ejoc.200300164
• Progress in gene delivery by cationic lipids: Guanidinium-cholesterol based systems as an example
  Abderrahim Aissaoui, Noufissa Oudrhiri, Laure Petit, Michelle Hauchecorne, Erwan Kan, Matthieu Sainlos, Sebastien Julia, Jean Navarro, Jean-Pierre Vigneron, Jean-Marie Lehn.
  CDT. 2002-02-01. 3(1)
  10.2174/1389450023348082