Jean-Christophe Delpech

Chercheur

CR / INRAe

/ Équipe

Nutrimind (Layé ; Fioramonti)
NutriNeuro

/ Contact

www.orcid.org/0000-0003-2674-1598

A propos

Domaine de recherche: Nutrition et Neuroinflammation

Axes de recherche:

– Rôle de le nutrition dans la modulation de la neuroinflammation et des deficits cognitifs au cours du vieillissement.

– Rôle des microglies dans les troubles neurodéveloppementaux.

Expertises :
Vieillissement, maladies neurodégénératives, Troubles neurodéveloppementaux, Nutrition, Microglie/neurone interaction, vésicules extra cellulaires.

Mots-clés : Vieillissement, Microglie, exosomes, Acides gras Polyinsaturés.

See the english version

Publications

Aging, sex, metabolic and life experience factors: contributions to neuro-inflammaging in Alzheimer’s disease research.
Pasindu Hansana Singhaarachchi, Peter Antal, Frédéric Calon, Carsten Culmsee, Jean-Christophe Delpech, Martin Feldotto, Jorine Geertsema, Emmy E. Hoeksema, Aniko Korosi, Sophie Layé, Jonathan McQualter, Susanne R. de Rooij, Christoph Rummel, Mary Slayo, Luba Sominsky, Sarah J. Spencer.
Neuroscience & Biobehavioral Reviews. 2024-07-01. 162 : 105724.
10.1016/j.neubiorev.2024.105724
Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits
Diankun Yu, Tao Li, Jean-Christophe Delpech, Beika Zhu, Priya Kishore, Tatsuhiro Koshi, Rong Luo, Karishma J.B. Pratt, Galina Popova, Tomasz J. Nowakowski, Saul A. Villeda, Xianhua Piao.
Sci. Adv.. 2022-05-06. 8(18)
10.1126/sciadv.abm2545
N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice.
Fanny Decoeur, Katherine Picard, Marie-Kim St-Pierre, Andrew D. Greenhalgh, Jean-Christophe Delpech, Alexandra Sere, Sophie Layé, Marie-Eve Tremblay, Agnès Nadjar.
Front. Cell. Neurosci.. 2022-02-10. 16
10.3389/fncel.2022.802411
Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice.
Jean-Christophe Delpech, Dhruba Pathak, Merina Varghese, Srinidhi Venkatesan Kalavai, Emma C. Hays, Patrick R. Hof, W. Evan Johnson, Seiko Ikezu, Maria Medalla, Jennifer I. Luebke, Tsuneya Ikezu.
Sci. Transl. Med.. 2021-09-15. 13(611)
10.1126/scitranslmed.abe8455
Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C. Saido, Seiko Ikezu, Tsuneya Ikezu.
Mol Neurodegeneration. 2021-04-14. 16(1)
10.1186/s13024-021-00447-2
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
Kevin Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Maria Ericsson, Takashi Saito, Takaomi C. Saido, Seiko Ikezu, Tsuneya Ikezu.
Mol Neurodegeneration. 2021-03-22. 16(1)
10.1186/s13024-021-00440-9
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain.
C. Madore, Q. Leyrolle, L. Morel, M. Rossitto, A. D. Greenhalgh, J. C. Delpech, M. Martinat, C. Bosch-Bouju, J. Bourel, B. Rani, C. Lacabanne, A. Thomazeau, K. E. Hopperton, S. Beccari, A. Sere, A. Aubert, V. De Smedt-Peyrusse, C. Lecours, K. Bisht, L. Fourgeaud, S. Gregoire, L. Bretillon, N. Acar, N. J. Grant, J. Badaut, P. Gressens, A. Sierra, O. Butovsky, M. E. Tremblay, R. P. Bazinet, C. Joffre, A. Nadjar, S. Layé.
Nat Commun. 2020-11-30. 11(1)
10.1038/s41467-020-19861-z
Amyloid plaque deposition accelerates tau propagation via activation of microglia in a humanized APP mouse model
Kevin A. Clayton, Jean Christophe Delpech, Shawn Herron, Naotoshi Iwahara, Takashi Saito, Takaomi C. Saido, Seiko Ikezu, Tsuneya Ikezu.
. 2020-09-22.
10.1101/2020.09.22.308015
P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice.
Zhi Ruan, Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, Alicia A. Van Enoo, Jianqiao Hu, Seiko Ikezu, Tsuneya Ikezu.
Mol Neurodegeneration. 2020-08-18. 15(1)
10.1186/s13024-020-00396-2
Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities.
Seiko Ikezu, Hana Yeh, Jean-Christophe Delpech, Maya E. Woodbury, Alicia A. Van Enoo, Zhi Ruan, Sudhir Sivakumaran, Yang You, Carl Holland, Teresa Guillamon-Vivancos, Asuka Yoshii-Kitahara, Mina B. Botros, Charlotte Madore, Pin-Hao Chao, Ankita Desani, Solaiappan Manimaran, Srinidhi Venkatesan Kalavai, W. Evan Johnson, Oleg Butovsky, Maria Medalla, Jennifer I. Luebke, Tsuneya Ikezu.
Mol Psychiatry. 2020-02-18.
10.1038/s41380-020-0671-2
Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra.
Yang You, Mina B. Botros, Alicia A. Van Enoo, Aaron Bockmiller, Shawn Herron, Jean Christophe Delpech, Tsuneya Ikezu.
Neuroscience. 2019-12-01. 422 : 65-74.
10.1016/j.neuroscience.2019.10.001
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain
C. Madore, Q. Leyrolle, L. Morel, J.C. Delpech, A.D. Greenhalgh, C. Lacabanne, C. Bosch-Bouju, J. Bourel, A. Thomazeau, K.E. Hopperton, S. Beccari, A. Sere, A. Aubert, V. De Smedt-Peyrusse, C. Lecours, K. Bisht, L. Fourgeaud, S. Gregoire, L. Bretillon, N. J. Grant, J. Badaut, P. Gressens, A. Sierra, O. Butovsky, M.E. Tremblay, R.P. Bazinet, C. Joffre, A. Nadjar, S. Layé.
. 2019-09-04.
10.1101/744136
Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease.
Jean-Christophe Delpech, Shawn Herron, Mina B. Botros, Tsuneya Ikezu.
Trends in Neurosciences. 2019-05-01. 42(5) : 361-372.
10.1016/j.tins.2019.02.007
Blood biomarkers for evaluation of perinatal encephalopathy: state of the art.
Ernest M. Graham, Allen D. Everett, Jean-Christophe Delpech, Frances J. Northington.
Current Opinion in Pediatrics. 2018-04-01. 30(2) : 199-203.
10.1097/mop.0000000000000591
Amygdala hyper-connectivity in a mouse model of unpredictable early life stress.
Frances K. Johnson, Jean-Christophe Delpech, Garth J. Thompson, Lan Wei, Jin Hao, Peter Herman, Fahmeed Hyder, Arie Kaffman.
Transl Psychiatry. 2018-02-21. 8(1)
10.1038/s41398-018-0092-z
Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences.
Eric S. Wohleb, Jean-Christophe Delpech.
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017-10-01. 79 : 40-48.
10.1016/j.pnpbp.2016.04.013
Circulating bacterial lipopolysaccharide-induced inflammation reduces flow in brain-irrigating arteries independently from cerebrovascular prostaglandin production.
Frédéric Villéga, Jean-Christophe Delpech, Marion Griton, Caroline André, Jean-Michel Franconi, Sylvain Miraux, Jan Pieter Konsman.
Neuroscience. 2017-03-01. 346 : 160-172.
10.1016/j.neuroscience.2017.01.018
Early life stress perturbs the maturation of microglia in the developing hippocampus.
Jean-Christophe Delpech, Lan Wei, Jin Hao, Xiaoqing Yu, Charlotte Madore, Oleg Butovsky, Arie Kaffman.
Brain, Behavior, and Immunity. 2016-10-01. 57 : 79-93.
10.1016/j.bbi.2016.06.006