Jean-Christophe Delpech
About him
Domain of research: Nutrition and Neuroinflammation
Axes of research:
Axis 1: Role of nutrition in the modulation of neuroinflammation and cognitive deficits during aging.
Axis2: Role of microglia in neurodevelopmental disorders.
Expertise: Aging, neurodegenerative diseases, Neurodevelopmental disorders, Nutrition, Microglia/neuron interaction, extracellular vesicles.
Keywords: Aging, Microglia, exosomes, Polyunsaturated fatty acids.
Scientific articles
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Modified neuroimmune processes and emotional behaviour in weaned and late adolescent male and female mice born via caesarean section.
Sci Rep. 2024-11-30. 14(1)
10.1038/s41598-024-80770-y -
Aging, sex, metabolic and life experience factors: contributions to neuro-inflammaging in Alzheimer’s disease research.
Neuroscience & Biobehavioral Reviews. 2024-07-01. 162 : 105724.
10.1016/j.neubiorev.2024.105724 -
Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits
Sci. Adv.. 2022-05-06. 8(18)
10.1126/sciadv.abm2545 -
N-3 PUFA Deficiency Affects the Ultrastructural Organization and Density of White Matter Microglia in the Developing Brain of Male Mice.
Front. Cell. Neurosci.. 2022-02-10. 16
10.3389/fncel.2022.802411 -
Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice.
Sci. Transl. Med.. 2021-09-15. 13(611)
10.1126/scitranslmed.abe8455 -
Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
Mol Neurodegeneration. 2021-04-14. 16(1)
10.1186/s13024-021-00447-2 -
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
Mol Neurodegeneration. 2021-03-22. 16(1)
10.1186/s13024-021-00440-9 -
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain.
Nat Commun. 2020-11-30. 11(1)
10.1038/s41467-020-19861-z -
Amyloid plaque deposition accelerates tau propagation via activation of microglia in a humanized APP mouse model
. 2020-09-22.
10.1101/2020.09.22.308015 -
P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice.
Mol Neurodegeneration. 2020-08-18. 15(1)
10.1186/s13024-020-00396-2 -
Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities.
Mol Psychiatry. 2020-02-18.
10.1038/s41380-020-0671-2 -
Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra.
Neuroscience. 2019-12-01. 422 : 65-74.
10.1016/j.neuroscience.2019.10.001 -
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain
. 2019-09-04.
10.1101/744136 -
Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease.
Trends in Neurosciences. 2019-05-01. 42(5) : 361-372.
10.1016/j.tins.2019.02.007 -
Blood biomarkers for evaluation of perinatal encephalopathy: state of the art.
Current Opinion in Pediatrics. 2018-04-01. 30(2) : 199-203.
10.1097/mop.0000000000000591 -
Amygdala hyper-connectivity in a mouse model of unpredictable early life stress.
Transl Psychiatry. 2018-02-21. 8(1)
10.1038/s41398-018-0092-z -
Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences.
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017-10-01. 79 : 40-48.
10.1016/j.pnpbp.2016.04.013 -
Circulating bacterial lipopolysaccharide-induced inflammation reduces flow in brain-irrigating arteries independently from cerebrovascular prostaglandin production.
Neuroscience. 2017-03-01. 346 : 160-172.
10.1016/j.neuroscience.2017.01.018 -
Early life stress perturbs the maturation of microglia in the developing hippocampus.
Brain, Behavior, and Immunity. 2016-10-01. 57 : 79-93.
10.1016/j.bbi.2016.06.006