Olfaction and memory
The ability to store and retrieve associations between specific sensory stimuli and behaviorally relevant information is a vital memory function: it allows the organism to adapt its behavior based on prior experience. Olfaction is a central sensory modality in rodents as it supports an array of crucial behaviors such as predator avoidance, feeding, reproduction, maternal behavior and social interactions. Although specific odors can trigger innate responses, most odor stimuli acquire behavioral significance upon learning and experience. The goal of our team is to identify the network mechanisms underlying the formation of olfactory memory traces across distributed brain regions. More generally, we aim at understanding how sensory information is routed and processed in the brain to integrate lasting memories.
To adress these questions, we use a combination of advanced methods that allow monitoring and manipulating in real-time neuronal ensembles in freely moving animals towards a deep mechanistic understanding of brain functions. These methods include chronic multi-site high-density silicon probe recordings (units and local field potentials), 3D behavioral tracking, optogenetic tagging and closed-loop optogenetic manipulations in behaving rodents.
Mots clés
Analyses des données, Apprentissage, Assemblées neuronales, Codage et intégration du signal, Comportement, Formation et fonctionnement des circuits neuronaux, Mémoire, Mémorisation des perceptions sensorielles, Neurocomputation, Neurophysiologie, Optogénétique, Optogénétique et chemogénétique, Plasticité des réseaux, Sommeil - Troubles du sommeil, Système olfactifSelected publications
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Sharp wave ripples during learning stabilize the hippocampal spatial map.
Lisa Roux, Bo Hu, Ronny Eichler, Eran Stark, György Buzsáki.
Nat Neurosci. 2017-04-10. 20 (6) : 845-853.
DOI: 10.1038/nn.4543 -
Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations.
L. Roux, A. Madar, M. M. Lacroix, C. Yi, K. Benchenane, C. Giaume.
Journal of Neuroscience. 2015-11-18. 35 (46) : 15339-15352.
DOI: 10.1523/jneurosci.0861-15.2015 -
Local generation of multineuronal spike sequences in the hippocampal CA1 region.
Eran Stark, Lisa Roux, Ronny Eichler, György Buzsáki.
Proc Natl Acad Sci USA. 2015-08-03. 112 (33) : 10521-10526.
DOI: 10.1073/pnas.1508785112 -
Pyramidal cell-interneuron interactions underlie hippocampal ripple oscillations.
Eran Stark, Lisa Roux, Ronny Eichler, Yuta Senzai, Sebastien Royer, György Buzsáki.
Neuron. 2014-07-01. 83 (2) : 467-480.
DOI: 10.1016/j.neuron.2014.06.023 -
In vivo optogenetic identification and manipulation of GABAergic interneuron subtypes.
Lisa Roux, Eran Stark, Lucas Sjulson, György Buzsáki.
Current Opinion in Neurobiology. 2014-06-01. 26 : 88-95.
DOI: 10.1016/j.conb.2013.12.013 -
Inhibition-induced theta resonance in cortical circuits.
Eran Stark, Ronny Eichler, Lisa Roux, Shigeyoshi Fujisawa, Horacio G. Rotstein, György Buzsáki.
Neuron. 2013-12-01. 80 (5) : 1263-1276.
DOI: 10.1016/j.neuron.2013.09.033 -
Plasticity of astroglial networks in olfactory glomeruli.
L. Roux, K. Benchenane, J. D. Rothstein, G. Bonvento, C. Giaume.
Proceedings of the National Academy of Sciences. 2011-10-13. 108 (45) : 18442-18446.
DOI: 10.1073/pnas.1107386108 -
Astroglial networks: a step further in neuroglial and gliovascular interactions.
Christian Giaume, Annette Koulakoff, Lisa Roux, David Holcman, Nathalie Rouach.
Nat Rev Neurosci. 2010-02-01. 11 (2) : 87-99.
DOI: 10.1038/nrn2757
Team member(s)
Chercheurs, Praticiens hospitaliers...
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC
Adresse :
IINS - UMR 5297 - CNRS - Université de Bordeaux - Centre Broca Nouvelle-Aquitaine - 146 rue Léo-Saignat - CS 61292 CASE 130 - 33076 Bordeaux cedex - France