Motoneurons and synaptic partners (MotoPSyn)
Our goal is to decipher the impact of the sensory-motor environment on both the global motor physiology and the possible development of motoneuronal pathologies. Using various animal models, including invertebrates, amphibians, rodents and humans that are complementary and offer specific opportunities, our research aims principally at understanding the fundamental processes of motoneuron development and motor functions physiology in a context of permanent interactions between single neurons, neuronal networks and sensory information. Specific projects focusing on various developmental and motor pathologies (ALS, ASS, vestibulopathies) are also conducted.
Mots clés
ASDs (Autism Spectrum Disorders), Assemblées neuronales, Connectivité, Développement du système nerveux, Formation et fonctionnement des circuits neuronaux, Motricité, Mouvement, Neurophysiologie, Plasticité des réseaux, Plasticité synaptique, Sclérose latérale amyotrophique, Sensory information processing, Troubles des comportements chez l’enfant et l’adolescentSelected publications
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Functional organization of vestibulospinal inputs responsible for tail postural control in larval Xenopus
Gabriel Barrios, Anne Olechowski-Bessaguet, Mathilde Pain, Julien Bacqué-Cazenave, Laura Cardoit, Marie-Jeanne Cabirol, Didier Le Ray, François M. Lambert.
Front. Neurol.. 2024-08-16. 15
DOI: 10.3389/fneur.2024.1439784 -
BiœmuS: A new tool for neurological disorders studies through real-time emulation and hybridization using biomimetic Spiking Neural Network.
Romain Beaubois, Jérémy Cheslet, Tomoya Duenki, Giuseppe De Venuto, Marta Carè, Farad Khoyratee, Michela Chiappalone, Pascal Branchereau, Yoshiho Ikeuchi, Timothée Levi.
Nat Commun. 2024-06-20. 15 (1)
DOI: 10.1038/s41467-024-48905-x -
Excitatory action of low frequency depolarizing GABA/glycine synaptic inputs is prevalent in prenatal spinal SOD1G93A motoneurons
Hongmei Zhu, Urvashi Dalvi, William Cazenave, Daniel Cattaert, Pascal Branchereau.
The Journal of Physiology. 2024-02-12.
DOI: 10.1113/JP285105 -
Acetylcholine and spinal locomotor networks: The insider
Mille T, Quilgars C, Cazalets JR, Bertrand SS..
Physiol Rep.. 2021-02. 9 (3) : e14736.
DOI: 10.14814/phy2.14736 -
From tadpole to adult frog locomotion
Keith T. Sillar, John Simmers, Denis Combes.
Current Opinion in Neurobiology. 2023-10-01. 82 : 102753.
DOI: 10.1016/j.conb.2023.102753 -
CSF1R inhibition at chronic stage after spinal cord injury modulates microglia proliferation
Jean‐Christophe Perez, Gaetan Poulen, Maida Cardoso, Hassan Boukhaddaoui, Chloé Marie Gazard, Gilles Courtand, Sandrine Sylvie Bertrand, Yannick Nicolas Gerber, Florence Evelyne Perrin.
Glia. 2023-08-04.
DOI: 10.1002/glia.24451 -
Muscarinic cholinergic modulation of cardiovascular variables in spinal cord injured rats
Théo Mille, Aurélie Bonilla, Etienne Guillaud, Sandrine Bertrand , Clément Menuet,Jean-René Cazalets.
Experimental Neurology. 2023-05-01. 363 : 114369.
DOI: 10.1016/j.expneurol.2023.114369 -
Sodium-mediated plateau potentials in an identified decisional neuron contribute to feeding-related motor pattern genesis in Aplysia
Alexis Bedecarrats, John Simmers, Romuald Nargeot.
prePrint bioRXiv. 2023-03-31.
DOI: 10.1101/2023.03.30.534938 -
Cholinergic Modulation of Locomotor Circuits in Vertebrates
Didier Le Ray, Sandrine S. Bertrand, Réjean Dubuc.
IJMS. 2022-09-14. 23 (18) : 10738.
DOI: 10.3390/ijms231810738 -
Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice
Eléonore Bertin, Audrey Martinez, Anne Fayoux, Kevin Carvalho, Sara Carracedo, Pierre-Olivier Fernagut, Friedrich Koch-Nolte, David Blum, Sandrine S. Bertrand, Eric Boué-Grabot.
Cell. Mol. Life Sci.. 2022-07-19. 79 (8)
DOI: 10.1007/s00018-022-04461-5 -
How Does the Central Nervous System for Posture and Locomotion Cope With Damage-Induced Neural Asymmetry?
Didier Le Ray, Mathias Guayasamin.
Front. Syst. Neurosci.. 2022-03-03. 16
DOI: 10.3389/fnsys.2022.828532 -
Functional organization of vestibulospinal inputs on thoracic motoneurons responsible for trunk postural control in Xenopus
Anne Olechowski‐Bessaguet, Raphaël Grandemange, Laura Cardoit, Elric Courty,François M. Lambert, Didier Le Ray.
J Physiol.. 2020-02-03. 598 (4) : 817-838.
DOI: 10.1113/JP278599 -
Impact of acute and chronic nicotine administration on midbrain dopaminergic neuron activity and related behaviours in TRPV1 knock‐out juvenile mice
Anne‐Emilie Allain, Oceane Aribo, Maria‐Carmen Medrano, Marie‐Line Fournier, Sandrine S. Bertrand, Stephanie Caille.
Eur J of Neuroscience. 2022-01-13.
DOI: 10.1111/ejn.15577 -
Chloride Homeostasis in Developing Motoneurons.
Pascal Branchereau, Daniel Cattaert.
Advances in Neurobiology. 2022-01-01. : 45-61.
DOI: 10.1007/978-3-031-07167-6_2 -
Developmentally Regulated Modulation of Lumbar Motoneurons by Metabotropic Glutamate Receptors: A Cellular and Behavioral Analysis in Newborn Mice
Camille Quilgars, Jean-René Cazalets, Sandrine S. Bertrand.
Front. Cell. Neurosci.. 2021-12-09. 15
DOI: 10.3389/fncel.2021.770250 -
Visual attention and inhibitory control in children, teenagers and adults with autism without intellectual disability: results of oculomotor tasks from a 2-year longitudinal follow-up study (InFoR)
Anouck Amestoy, Etienne Guillaud, Giulia Bucchioni, Tiziana Zalla, Daniel Umbricht, Christopher Chatham, Lorraine Murtagh, Josselin Houenou, Richard Delorme, Myriam Ly-Le Moal, Marion Leboyer, Manuel Bouvard, Jean-René Cazalets.
Molecular Autism. 2021-11-13. 12 (1)
DOI: 10.1186/s13229-021-00474-2 -
Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord
Kalaimakan Hervé Arulkandarajah, Guillaume Osterstock, Agathe Lafont, Hervé Le Corronc, Nathalie Escalas, Silvia Corsini, Barbara Le Bras, Linda Chenane, Juliette Boeri, Antonny Czarnecki, Christine Mouffle, Erika Bullier, Elim Hong, Cathy Soula, Pascal Legendre, Jean-Marie Mangin.
Current Biology. 2021-09-01.
DOI: 10.1016/j.cub.2021.08.019 -
Organelle calcium-derived voltage oscillations in pacemaker neurons drive the motor program for food-seeking behavior in Aplysia
Alexis Bédécarrats, Laura Puygrenier, John Castro O'Byrne, Quentin Lade, John Simmers, Romuald Nargeot.
eLife. 2021-06-30. 10
DOI: 10.7554/eLife.68651 -
Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity.
Juliette Boeri, Claude Meunier, Hervé Le Corronc, Pascal Branchereau, Yulia Timofeeva, François-Xavier Lejeune, Christine Mouffle, Hervé Arulkandarajah, Jean Marie Mangin, Pascal Legendre, Antonny Czarnecki.
eLife. 2021-04-26. 10
DOI: 10.7554/elife.62639 -
Locomotion-induced ocular motor behavior in larval Xenopus is developmentally tuned by visuo-vestibular reflexes
Julien Bacqué-Cazenave, Gilles Courtand, Mathieu Beraneck, Hans Straka, Denis Combes, François M. Lambert.
. 2021-01-04.
DOI: 10.1101/2021.01.04.424105 -
Locomotion and dynamic posture: neuro-evolutionary basis of bipedal gait
Etienne Guillaud, Philippe Seyres, Gregory Barrière, Vincent Jecko, Sandrine S. Bertrand, Jean-René Cazalets.
Neurophysiologie Clinique. 2020-11-01.
DOI: 10.1016/j.neucli.2020.10.012 -
Gastropod Learning and Memory (Aplysia, Hermissenda, Lymnaea, and Others)
Alexis Bédécarrats, Romuald Nargeot.
Oxford Research Encyclopedia of Neuroscience. 2020-02-28.
DOI: 10.1093/acrefore/9780190264086.013.186 -
Increased surface P2X4 receptor regulates anxiety and memory in P2X4 internalization-defective knock-in mice
Eléonore Bertin, Thomas Deluc, Kjara S. Pilch, Audrey Martinez, Johan-Till Pougnet, Evelyne Doudnikoff, Anne-Emilie Allain, Philine Bergmann, Marion Russeau, Estelle Toulmé, Erwan Bezard, Friedrich Koch-Nolte, Philippe Séguéla, Sabine Lévi, Bruno Bontempi, François Georges, Sandrine S. Bertrand, Olivier Nicole, Eric Boué-Grabot.
Mol Psychiatry. 2020-01-08.
DOI: 10.1038/s41380-019-0641-8
Team leader
Team member(s)
Chercheurs, Praticiens hospitaliers...
Jean-René Cazalets
Cazalets
(Researcher)
Guy Simonnet Simonnet (Former Hospital Practitionner - Emeritus)
Romuald Nargeot Nargeot (University Teacher- Researcher)
Denis Combes Combes (University Teacher- Researcher)
Antonny Czarnecki Czarnecki (Enseignant-chercheur)
Sandrine Bertrand Bertrand (Lab director)
Guy Simonnet Simonnet (Former Hospital Practitionner - Emeritus)
Romuald Nargeot Nargeot (University Teacher- Researcher)
Denis Combes Combes (University Teacher- Researcher)
Antonny Czarnecki Czarnecki (Enseignant-chercheur)
Sandrine Bertrand Bertrand (Lab director)
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Alexandra Reichova
Reichova
Doctorant(s)
Tess Bonnard
Bonnard
Aliénor Clerfayt Clerfayt
Maëlle Ollivier Ollivier
Léandre Lavenu Lavenu
Aurélie Bonilla Aurélie
Aliénor Clerfayt Clerfayt
Maëlle Ollivier Ollivier
Léandre Lavenu Lavenu
Aurélie Bonilla Aurélie
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC