Muriel Darnaudéry
University Teacher - Researcher
Professor Researcher (PU) / Université de Bordeaux/ Contact
+33 5 57 57 12 32
www.orcid.org/0000-0003-0209-3880
/ Address of work
NutriNeuro - Bâtiment UFR Pharmacie - 2e tranche – 2e étage - Case 34 - 146 rue Léo-Saignat - 33076 Bordeaux Cedex
I am working on the hypothesis of the developmental origin of adult health and diseases using an integrative approach. My research is dedicated to the exploration of the role of early-life environment (nutrition, maternal obesity, maternal diabetes, maternal stress) on brain functions and vulnerability to neuropsychiatric diseases (depression, anxiety) in offspring using preclinical models. Our work indicates that adverse early-life events (both during pre- and postnatal periods) increase the allostatic load and program the brain vulnerability to stress later in life. I also explore the causal role of gut-brain dysfunctions (gut microbiota dysbiosis and gut leakiness) in the emergence of deficits associated with early-life stress.
Scientific articles
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Strain-specific changes in nucleus accumbens transcriptome and motivation for palatable food reward in mice exposed to maternal separation.
Front. Nutr.. 2023-07-26. 10
10.3389/fnut.2023.1190392 -
A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes
Front. Immunol.. 2022-05-23. 13
10.3389/fimmu.2022.896179 -
A new experimental design to study inflammation-related versus non-inflammation-related depression in mice
J Neuroinflammation. 2021-12-01. 18(1)
10.1186/s12974-021-02330-9 -
Targeted intestinal tight junction hyperpermeability alters the microbiome, behavior, and visceromotor responses
Cellular and Molecular Gastroenterology and Hepatology. 2020-03-01.
10.1016/j.jcmgh.2020.02.008 -
Maternal separation in rodents: a journey from gut to brain and nutritional perspectives
Proceedings of the Nutrition Society. 2019-06-28.
10.1017/s0029665119000958 -
Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner
Brain Behav Immun.. 2019-03-11.
10.1016/j.bbi.2019.03.006 -
Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation
Psychopharmacology. 2019-05-01. 236(5) : 1583-1596.
10.1007/s00213-019-05252-w -
Prenatal retinoic acid exposure reveals candidate genes for craniofacial disorders
Scientific Reports. 2018-11.
10.1038/s41598-018-35681-0. -
Unlimited sucrose consumption during adolescence generates a depressive-like phenotype in adulthood
Neuropsychopharmacol. 2018-12-27. 43(13) : 2627-2635.
10.1038/s41386-018-0025-9 -
Maternal high-fat diet and early life stress differentially modulate spine density and dendritic morphology in the medial prefrontal cortex of juvenile and adult rats.
Brain Struct Funct. 2017-10-11. 223(2) : 883-895.
10.1007/s00429-017-1526-8 -
Gender specific behavioral alterations are associated with gut dysbiosis in mice exposed to multifactorial early-life adversity
European Neuropsychopharmacology. 2017-10-01. 27 : S682-S683.
10.1016/s0924-977x(17)31269-5 -
Early restoration of gut barrier function abrogates the long-term neurobehavioral effects of early-life stress in rats
Psychoneuroendocrinology. 2017-09-01. 83 : 79.
10.1016/j.psyneuen.2017.07.450 -
Maternal high-fat diet leads to hippocampal and amygdala dendritic remodeling in adult male offspring.
Psychoneuroendocrinology. 2017-09-01. 83 : 49-57.
10.1016/j.psyneuen.2017.05.003 -
Impact of perinatal exposure to high-fat diet and stress on responses to nutritional challenges, food-motivated behaviour and mesolimbic dopamine function.
Int J Obes. 2016-12-27. 41(4) : 502-509.
10.1038/ijo.2016.236 -
Maternal high-fat diet prevents developmental programming by early-life stress
Transl Psychiatry. 2016-11-01. 6(11) : e966-e966.
10.1038/tp.2016.235 -
The early life nutritional environment and early life stress as potential pathways towards the metabolic syndrome in mid-life? A lifecourse analysis using the 1958 British Birth cohort
BMC Public Health. 2016-08-18. 16(1)
10.1186/s12889-016-3484-0 -
Les adversités durant l’enfance et la charge allostatique à l’âge adulte : résultats de la cohorte de naissances britannique de 1958
Revue d'Épidémiologie et de Santé Publique. 2016-04-01. 64 : S99.
10.1016/j.respe.2015.07.008 -
Origins of heath inequalities: the case for Allostatic Load
LLCS. 2016-01-28. 7(1)
10.14301/llcs.v7i1.325 -
Early life stressful experiences and neuropsychiatric vulnerability: evidences from human and animal models
Med Sci (Paris). 2016-01-01. 32(1) : 93-99.
10.1051/medsci/20163201015 -
Environnement précoce et vulnérabilité neuropsychiatrique
Med Sci (Paris). 2016-01-01. 32(1) : 93-99.
10.1051/medsci/20163201015 -
Tu1877 Targeted Epithelial Barrier Disruption Reveals IBS-Like Pathophysiology and Behavioral Modifications
Gastroenterology. 2015-04-01. 148(4) : S-925.
10.1016/s0016-5085(15)33147-4 -
Juvenile obesity enhances emotional memory and amygdala plasticity through glucocorticoids.
Journal of Neuroscience. 2015-03-04. 35(9) : 4092-4103.
10.1523/jneurosci.3122-14.2015 -
Perinatal high-fat diet increases hippocampal vulnerability to the adverse effects of subsequent high-fat feeding.
Psychoneuroendocrinology. 2015-03-01. 53 : 82-93.
10.1016/j.psyneuen.2014.12.008 -
Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort
Proc Natl Acad Sci USA. 2015-02-02. 112(7) : E738-E746.
10.1073/pnas.1417325112 -
Anxiety-like behaviour and associated neurochemical and endocrinological alterations in male pups exposed to prenatal stress
Psychoneuroendocrinology. 2012-10-01. 37(10) : 1646-1658.
10.1016/j.psyneuen.2012.02.010 -
Impact of early life stress on alcohol consumption and on the short- and long-term responses to alcohol in adolescent female rats
Behavioural Brain Research. 2011-08-01. 221(1) : 43-49.
10.1016/j.bbr.2011.02.033 -
ROCK inhibition prevents tau hyperphosphorylation and p25/CDK5 increase after global cerebral ischemia.
Behavioral Neuroscience. 2011-01-01. 125(3) : 465-472.
10.1037/a0023167 -
Reduced alcohol drinking in adult rats exposed to sucrose during adolescence
Neuropharmacology. 2010-11-01. 59(6) : 388-394.
10.1016/j.neuropharm.2010.05.015 -
Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats.
PLoS ONE. 2010-02-19. 5(2) : e9296.
10.1371/journal.pone.0009296 -
Effect of prenatal stress on alcohol preference and sensitivity to chronic alcohol exposure in male rats
Psychopharmacology. 2010-01-27. 214(1) : 197-208.
10.1007/s00213-009-1765-3 -
Ethanol Attenuates Spatial Memory Deficits and Increases mGlu1a Receptor Expression in the Hippocampus of Rats Exposed to Prenatal Stress
Alcoholism: Clinical and Experimental Research. 2009-08-01. 33(8) : 1346-1354.
10.1111/j.1530-0277.2009.00964.x -
Impaired interleukin-1beta and c-Fos expression in the hippocampus is associated with a spatial memory deficit in P2X(7) receptor-deficient mice.
PLoS ONE. 2009-06-23. 4(6) : e6006.
10.1371/journal.pone.0006006 -
Prenatal stress exacerbates the impact of an aversive procedure on the corticosterone response to stress in female rats
Psychoneuroendocrinology. 2009-06-01. 34(5) : 786-790.
10.1016/j.psyneuen.2008.12.002 -
Epigenetic programming of the stress response in male and female rats by prenatal restraint stress
Brain Research Reviews. 2008-03-01. 57(2) : 571-585.
10.1016/j.brainresrev.2007.11.004 -
Impact of an acute exposure to ethanol on the oxidative stress status in the hippocampus of prenatal restraint stress adolescent male rats
Brain Research. 2008-01-01. 1191 : 55-62.
10.1016/j.brainres.2007.11.031 -
Early motherhood in rats is associated with a modification of hippocampal function
Psychoneuroendocrinology. 2007-08-01. 32(7) : 803-812.
10.1016/j.psyneuen.2007.05.012 -
Estradiol, insulin-like growth factor-I and brain aging
Psychoneuroendocrinology. 2007-08-01. 32 : S57-S61.
10.1016/j.psyneuen.2007.03.001 -
Maternal stress alters endocrine function of the feto-placental unit in rats
American Journal of Physiology-Endocrinology and Metabolism. 2007-06-01. 292(6) : E1526-E1533.
10.1152/ajpendo.00574.2006 -
Impact of an intense stress on ethanol consumption in female rats characterized by their pre-stress preference: Modulation by prenatal stress
Brain Research. 2007-02-01. 1131 : 181-186.
10.1016/j.brainres.2006.11.005 -
Effect of hindlimb unloading on motor activity in adult rats: Impact of prenatal stress.
Behavioral Neuroscience. 2007-01-01. 121(1) : 177-185.
10.1037/0735-7044.121.1.177 -
Hypo-response of the hypothalamic-pituitary-adrenocortical axis after an ethanol challenge in prenatally stressed adolescent male rats
European Journal of Neuroscience. 2006-08-01. 24(4) : 1193-1200.
10.1111/j.1460-9568.2006.04973.x -
Prenatal stress alters Fos protein expression in hippocampus and locus coeruleus stress-related brain structures
Psychoneuroendocrinology. 2006-07-01. 31(6) : 769-780.
10.1016/j.psyneuen.2006.02.007 -
Effects of a single footshock followed by situational reminders on HPA axis and behaviour in the aversive context in male and female rats
Psychoneuroendocrinology. 2006-01-01. 31(1) : 92-99.
10.1016/j.psyneuen.2005.05.014 -
Insulin-like growth factor 1 reduces age-related disorders induced by prenatal stress in female rats
Neurobiology of Aging. 2006-01-01. 27(1) : 119-127.
10.1016/j.neurobiolaging.2005.01.008 -
Long-term behavioural alterations in female rats after a single intense footshock followed by situational reminders
Psychoneuroendocrinology. 2005-05-01. 30(4) : 316-324.
10.1016/j.psyneuen.2004.09.003 -
Prenatal stress affects behavioral reactivity to an intense stress in adult female rats
Brain Research. 2005-01-01. 1031(1) : 67-73.
10.1016/j.brainres.2004.10.025 -
Chronic treatment with imipramine reverses immobility behaviour, hippocampal corticosteroid receptors and cortical 5-HT1A receptor mRNA in prenatally stressed rats
Neuropharmacology. 2004-11-01. 47(6) : 841-847.
10.1016/j.neuropharm.2004.06.011 -
Stress during gestation induces lasting effects on emotional reactivity of the dam rat
Behavioural Brain Research. 2004-08-01. 153(1) : 211-216.
10.1016/j.bbr.2003.12.001 -
Early and later adoptions differently modify mother-pup interactions
Behavioral Neuroscience. 2004-01-01. 118(3) : 590-596.
10.1037/0735-7044.118.3.590 -
Prenatal stress in rats predicts immobility behavior in the forced swim test
Brain Research. 2003-11-01. 989(2) : 246-251.
10.1016/s0006-8993(03)03293-1 -
Individual differences in cognitive aging: implication of pregnenolone sulfate.
Progress in Neurobiology. 2003-09-01. 71(1) : 43-48.
10.1016/j.pneurobio.2003.09.006 -
Prenatal stress and long-term consequences: implications of glucocorticoid hormones
Neuroscience & Biobehavioral Reviews. 2003-01-01. 27(1-2) : 119-127.
10.1016/s0149-7634(03)00014-9 -
The Neurosteroid Pregnenolone Sulfate Increases Cortical Acetylcholine Release: A Microdialysis Study in Freely Moving Rats
Journal of Neurochemistry. 2002-11-13. 71(5) : 2018-2022.
10.1046/j.1471-4159.1998.71052018.x -
Reliability of high and low anxiety-related behaviour:
Behavioural Brain Research. 2002-10-01. 136(1) : 227-237.
10.1016/s0166-4328(02)00135-3 -
Reliability of high and low anxiety-related behaviour: influence of laboratory environment and multifactorial analysis.
Behavioural Brain Research. 2002-10-01. 136(1) : 227-237.
10.1016/s0166-4328(02)00135-3 -
The neurosteroid pregnenolone sulfate infused into the medial septum nucleus increases hippocampal acetylcholine and spatial memory in rats
Brain Research. 2002-10-01. 951(2) : 237-242.
10.1016/s0006-8993(02)03166-9 -
Study of the addictive potential of modafinil in naive and cocaine-experienced rats.
Psychopharmacology. 2002-06-01. 161(4) : 387-395.
10.1007/s00213-002-1080-8 -
The effect of restraint stress on paradoxical sleep is influenced by the circadian cycle
Brain Research. 2002-05-01. 937(1-2) : 45-50.
10.1016/s0006-8993(02)02463-0 -
Hormonal and Behavioural Abnormalities Induced by Stressin utero: an Animal Model for Depression
Stress. 2001-01-01. 4(3) : 169-181.
10.3109/10253890109035016 -
Pregnenolone sulfate increases hippocampal acetylcholine release and spatial recognition
Brain Research. 2000-01-01. 852(1) : 173-179.
10.1016/s0006-8993(99)01964-2 -
Infusion of neurosteroids into the rat nucleus basalis affects paradoxical sleep in accordance with their memory modulating properties
Neuroscience. 1999-05-01. 92(2) : 583-588.
10.1016/s0306-4522(99)00019-6 -
Prenatal stress alters circadian activity of hypothalamo-pituitary-adrenal axis and hippocampal corticosteroid receptors in adult rats of both gender
Journal of Neurobiology. 1999-09-01. 40(3) : 302-315.
10.1002/(sici)1097-4695(19990905)40:3<302::aid-neu3>3.0.co;2-7 -
The promnesic neurosteroid pregnenolone sulfate increases paradoxical sleep in rats
Brain Research. 1999-02-01. 818(2) : 492-498.
10.1016/s0006-8993(98)01338-9 -
Neurosteroids
Neurosteroids. 1999-01-01. : 317-335.
10.1007/978-1-59259-693-5_18 -
The neurosteroid pregnenolone sulfate infused into the nucleus basalis increases both acetylcholine release in the frontal cortex or amygdala and spatial memory
Neuroscience. 1998-08-01. 87(3) : 551-558.
10.1016/s0306-4522(98)00174-2 -
Neurosteroids: Deficient cognitive performance in aged rats depends on Low pregnenolone sulfate levels in the hippocampus
Proceedings of the National Academy of Sciences. 1997-12-23. 94(26) : 14865-14870.
10.1073/pnas.94.26.14865 -
Decrease in highly polysialylated neuronal cell adhesion molecules and in spatial learning during ageing are not correlated
Brain Research. 1997-01-01. 744(2) : 285-292.
10.1016/s0006-8993(96)01115-8