Laurent Groc
Team leader
Researcher - PhD (DR) / CNRS/ Contact
+33 5 33 51 47 02
www.orcid.org/0000-0003-1814-8145
/ Address of work
IINS - UMR 5297 - CNRS - Université de Bordeaux - Centre Broca Nouvelle-Aquitaine - 146 rue Léo-Saignat - CS 61292 CASE 130 - 33076 Bordeaux cedex -France
Scientific articles
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Ketamine alleviates NMDA receptor hypofunction through synaptic trapping
Neuron. 2024-10-01. 112(19) : 3311-3328.e9.
10.1016/j.neuron.2024.06.028 -
Synaptic rearrangement of NMDA receptors controls memory engram formation and malleability in the cortex
Sci. Adv.. 2024-08-30. 10(35)
10.1126/sciadv.ado1148 -
APP fragment controls both ionotropic and non-ionotropic signaling of NMDA receptors
Neuron. 2024-06-01.
10.1016/j.neuron.2024.05.027 -
NMDA receptor autoantibodies primarily impair the extrasynaptic compartment
Brain. 2024-05-17.
10.1093/BRAIN/AWAE163 -
Converging synaptic and network dysfunctions in distinct autoimmune encephalitis
EMBO Rep. 2024-01-22.
10.1038/s44319-024-00056-2 -
Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis
Nat Commun. 2024-01-02. 15(1)
10.1038/s41467-023-44301-z -
GluN3A subunit tunes NMDA receptor synaptic trafficking and content during postnatal brain development
Cell Reports. 2023-05-01. 42(5) : 112477.
10.1016/j.celrep.2023.112477 -
Nanoscale and functional heterogeneity of the hippocampal extracellular space
Cell Reports. 2023-05-01. 42(5) : 112478.
10.1016/j.celrep.2023.112478 -
Cognitive and psychiatric features of anti-NMDA receptor encephalitis
The Lancet Neurology. 2022-10-01. 21(10) : 861-862.
10.1016/S1474-4422(22)00349-0 -
Near-Infrared Carbon Nanotube Tracking Reveals the Nanoscale Extracellular Space around Synapses
Nano Lett.. 2022-08-29.
10.1021/acs.nanolett.1c04259 -
Multi-Dimensional Spectral Single Molecule Localization Microscopy
Front. Bioinform.. 2022-03-04. 2
10.3389/fbinf.2022.813494 -
CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation
Nat Neurosci. 2021-04-29.
10.1038/s41593-021-00843-3 -
A Bottom-Up Approach to Red-Emitting Molecular-Based Nanoparticles with Natural Stealth Properties and their Use for Single-Particle Tracking Deep in Brain Tissue.
Advanced Materialds. 2021-04-21.
10.1002/adma.202006644 -
Regulation of membrane NMDA receptors by dynamics and protein interactions
Journal of Cell Biology. 2020-12-18. 220(1)
10.1083/jcb.202006101 -
CaMKII activation triggers persistent formation and segregation of postsynaptic liquid phase
. 2020-11-26.
10.1101/2020.11.25.397091 -
Distance-dependent regulation of NMDAR nanoscale organization along hippocampal neuron dendrites
Proc Natl Acad Sci USA. 2020-09-14. : 201922477.
10.1073/pnas.1922477117 -
Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling
Nat Commun. 2020-07-10. 11(1)
10.1038/s41467-020-17328-9 -
Human endogenous retroviral protein triggers deficit in glutamate synapse maturation and behaviors associated with psychosis
Sci. Adv.. 2020-07-01. 6(29) : eabc0708.
10.1126/sciadv.abc0708 -
Linking glutamate receptor movements and synapse function
Science. 2020-06-11. 368(6496) : eaay4631.
10.1126/science.aay4631 -
Fluorescent sp3 Defect-Tailored Carbon Nanotubes Enable NIR-II Single Particle Imaging in Live Brain Slices at Ultra-Low Excitation Doses
Sci Rep. 2020-03-24. 10(1)
10.1038/s41598-020-62201-w -
Aquaporin-4 Surface Trafficking Regulates Astrocytic Process Motility and Synaptic Activity in Health and Autoimmune Disease.
Cell Reports. 2019-06-01. 27(13) : 3860-3872.e4.
10.1016/j.celrep.2019.05.097 -
Self-Interference (SELFI) Microscopy for Live Super-Resolution Imaging and Single Particle Tracking in 3D
Front. Phys.. 2019-05-08. 7
10.3389/fphy.2019.00068 -
Surface trafficking of neurotransmitter receptor: comparison between single-molecule/quantum dot strategies
J Neurosci.. 2007 Nov 14. 27(46) : 12433-7.
27/46/12433 [pii]10.1523/JNEUROSCI.3349-07.2007 -
Surface trafficking of neurotransmitter receptors: From cultured neurons to intact brain preparations
Neuropharmacology. 2019-05-01. : 107642.
10.1016/j.neuropharm.2019.05.019 -
Single nanoparticle tracking of N-methyl-D-aspartate receptors in cultured and intact brain tissue
Neurophotonics. 2016-07-12. 3(4)
10.1117/1.NPh.3.4.041808] -
Nanoscale exploration of the extracellular space in the live brain by combining single carbon nanotube tracking and super-resolution imaging analysis
Methods. 2019-03-09.
10.1016/j.ymeth.2019.03.005 -
Pathogenicity of Antibodies against NMDA Receptor: Molecular Insights into Autoimmune Psychosis.
Trends in Neurosciences. 2018-08-01. 41(8) : 502-511.
10.1016/j.tins.2018.05.002 -
Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients
Nat Commun. 2017-11-27. 8(1)
10.1038/s41467-017-01700-3 -
Dynamics of surface neurotransmitter receptors and transporters in glial cells: Single molecule insights
Cell Calcium. 2017-11-01. 67 : 46-52.
10.1016/j.ceca.2017.08.009 -
Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice
Nat Commun. 2017-10-24. 8(1)
10.1038/s41467-017-01191-2 -
Single nanoparticle tracking: A method for investigating the surface dynamics of glutamate receptors
Neuromethods. 2017-09-22. : 29-50.
10.1007/978-1-4939-7228-9_2 -
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses
eLife. 2017-06-09. 6
10.7554/eLife.25492 -
Astroglial glutamate transporters in the brain: Regulating neurotransmitter homeostasis and synaptic transmission
Journal of Neuroscience Research. 2017-02-02. 95(11) : 2140-2151.
10.1002/jnr.24029 -
Single-nanotube tracking reveals the nanoscale organization of the extracellular space in the live brain
Nature Nanotech. 2016-11-21. 12(3) : 238-243.
10.1038/nnano.2016.248 -
Co-activation of VEGF and NMDA receptors promotes synaptic targeting of AMPA receptors
Mol Psychiatry. 2016-11-16. 21(12) : 1647-1647.
10.1038/mp.2016.215 -
Targeting neurotransmitter receptors with nanoparticles in vivo allows single-molecule tracking in acute brain slices
Nat Commun. 2016-03-14. 7(1)
10.1038/ncomms10947 -
Single nanoparticle tracking of surface ion channels and receptors in brain cells
Neuromethods. 2016-01-01. : 49-58.
10.1007/978-1-4939-3064-7_5 -
Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses
The EMBO Journal. 2014-03-03. 33(8) : 842-861.
10.1002/embj.201386356 -
Surface trafficking of NMDA receptors: Gathering from a partner to another
Seminars in Cell & Developmental Biology. 2014-03-01. 27 : 3-13.
10.1016/j.semcdb.2013.10.005 -
Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule
Mol Psychiatry. 2012-06-26. 18(4) : 471-484.
10.1038/mp.2012.80 -
Temporal modulation of hippocampal excitatory transmission by corticosteroids and stress
Frontiers in Neuroendocrinology. 2011-01-01. 32(1) : 25-42.
10.1016/j.yfrne.2010.07.004 -
Stress, corticosteroids and excitatory neurotransmission
Future Neurology. 2008-11-01. 3(6) : 623-626.
10.2217/14796708.3.6.623 -
Lateral diffusion of excitatory neurotransmitter receptors during synaptogenesis
Molecular Mechanisms of Synaptogenesis. . : 221-232.
10.1007/978-0-387-32562-0_16