Endocannabinoids and neuroadaptation
Endocannabinoïdes et neuroadaptation

Selected publications

• Mitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition
  Urszula Skupio, Julia Welte, Roman Serrat, Abel Eraso-Pichot, Francisca Julio-Kalajzić, Doriane Gisquet, Astrid Cannich, Sebastien Delcasso, Isabelle Matias, Unai B. Fundazuri, Sandrine Pouvreau, Antonio C. Pagano Zottola, Gianluca Lavanco, Filippo Drago, Inigo Ruiz de Azua, Beat Lutz, Luigi Bellocchio, Arnau Busquets-Garcia, Francis Chaouloff, Giovanni Marsicano.
  Neuron. 2023-04-01.
  DOI: 10.1016/j.neuron.2023.04.001
• Subcellular specificity of cannabinoid effects in striatonigral circuits.
  Soria-Gomez E, Pagano Zottola AC, Mariani Y, Desprez T, Barresi M, Bonilla-Del Río I, Muguruza C, Le Bon-Jego M, Julio-Kalajzić F, Flynn R, Terral G, Fernández-Moncada I, Robin LM, Oliveira da Cruz JF, Corinti S, Amer YO, Goncalves J, Varilh M, Cannich A, Redon B, Zhao Z, Lesté-Lasserre T, Vincent P, Tolentino-Cortes T, Busquets-García A, Puente N, Bains JS, Hebert-Chatelain E, Barreda-Gómez G, Chaouloff F, Lohman AW, Callado LF, Grandes P, Baufreton J, Marsicano G, Bellocchio L..
  Neuron. 2021-03-01.
  DOI: 10.1016/j.neuron.2021.03.007
• Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination
  Cristina Blázquez, Andrea Ruiz-Calvo, Raquel Bajo-Grañeras, Jérôme M Baufreton, Eva Resel, Marjorie Varilh, Antonio C Pagano Zottola, Yamuna Mariani, Astrid Cannich, José A Rodríguez-Navarro, Giovanni Marsicano, Ismael Galve-Roperh, Luigi Bellocchio, Manuel Guzmán.
  eLife. 2020-08-10. 9
  DOI: 10.7554/eLife.56811
• Glucose metabolism links astroglial mitochondria to cannabinoid effects
  Daniel Jimenez-Blasco, Arnau Busquets-Garcia, Etienne Hebert-Chatelain, Roman Serrat, Carlos Vicente-Gutierrez, Christina Ioannidou, Paula Gómez-Sotres, Irene Lopez-Fabuel, Monica Resch-Beusher, Eva Resel, Dorian Arnouil, Dave Saraswat, Marjorie Varilh, Astrid Cannich, Francisca Julio-Kalajzic, Itziar Bonilla-Del Río, Angeles Almeida, Nagore Puente, Svein Achicallende, Maria-Luz Lopez-Rodriguez, Charlotte Jollé, Nicole Déglon, Luc Pellerin, Charlène Josephine, Gilles Bonvento, Aude Panatier, Beat Lutz, Pier-Vincenzo Piazza, Manuel Guzmán, Luigi Bellocchio, Anne-Karine Bouzier-Sore, Pedro Grandes, Juan P. Bolaños, Giovanni Marsicano.
  Nature. 2020-07-08.
  DOI: 10.1038/s41586-020-2470-y
• mTORC1 and CB1 receptor signaling regulate excitatory glutamatergic inputs onto the hypothalamic paraventricular nucleus in response to energy availability
  Wilfrid Mazier, Nicolas Saucisse, Vincent Simon, Astrid Cannich, Giovanni Marsicano, Federico Massa, Daniela Cota.
  Molecular Metabolism. 2019-10-01. 28 : 151-159.
  DOI: 10.1016/j.molmet.2019.08.005
• Top-down control of water intake by the endocannabinoid system
  Zhe Zhao, Edgar Soria-Gómez, Marjorie Varilh, Francisca Julio-Kalajzić, Astrid Cannich, Adriana Castiglione, Léonie Vanhoutte, Alexia Duveau, Philippe Zizzari, Anna Beyeler, Daniela Cota, Luigi Bellocchio, Arnau Busquets-Garcia, Giovanni Marsicano.
  Preprint bioRxiv. 2019-08-09.
  DOI: 10.1101/729970
• The motivation for exercise over palatable food is dictated by cannabinoid type-1 receptors.
  Carolina Muguruza, Bastien Redon, Giulia R. Fois, Imane Hurel, Amandine Scocard, Claire Nguyen, Christopher Stevens, Edgar Soria-Gomez, Marjorie Varilh, Astrid Cannich, Justine Daniault, Arnau Busquets-Garcia, Teresa Pelliccia, Stéphanie Caillé, François Georges, Giovanni Marsicano, Francis Chaouloff.
  JCI Insight. 2019-03-07. 4 (5)
  DOI: 10.1172/jci.insight.126190
• Hippocampal CB1 Receptors Control Incidental Associations.
  Arnau Busquets-Garcia, José F. Oliveira da Cruz, Geoffrey Terral, Antonio C. Pagano Zottola, Edgar Soria-Gómez, Andrea Contini, Hugo Martin, Bastien Redon, Marjorie Varilh, Christina Ioannidou, Filippo Drago, Federico Massa, Xavier Fioramonti, Pierre Trifilieff, Guillaume Ferreira, Giovanni Marsicano.
  Neuron. 2018-09-01. 99 (6) : 1247-1259.e7.
  DOI: 10.1016/j.neuron.2018.08.014
• Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory.
  Laurie M. Robin, José F. Oliveira da Cruz, Valentin C. Langlais, Mario Martin-Fernandez, Mathilde Metna-Laurent, Arnau Busquets-Garcia, Luigi Bellocchio, Edgar Soria-Gomez, Thomas Papouin, Marjorie Varilh, Mark W. Sherwood, Ilaria Belluomo, Georgina Balcells, Isabelle Matias, Barbara Bosier, Filippo Drago, Ann Van Eeckhaut, Ilse Smolders, Francois Georges, Alfonso Araque, Aude Panatier, Stéphane H.R. Oliet, Giovanni Marsicano.
  Neuron. 2018-06-01. 98 (5) : 935-944.e5.
  DOI: 10.1016/j.neuron.2018.04.034
• Localization of the cannabinoid type-1 receptor in subcellular astrocyte compartments of mutant mouse hippocampus.
  Ana Gutiérrez-Rodríguez, Itziar Bonilla-Del Río, Nagore Puente, Sonia M. Gómez-Urquijo, Christine J. Fontaine, Jon Egaña-Huguet, Izaskun Elezgarai, Sabine Ruehle, Beat Lutz, Laurie M. Robin, Edgar Soria-Gómez, Luigi Bellocchio, Jalindar D. Padwal, Mario van der Stelt, Juan Mendizabal-Zubiaga, Leire Reguero, Almudena Ramos, Inmaculada Gerrikagoitia, Giovanni Marsicano, Pedro Grandes.
  Glia. 2018-02-26. 66 (7) : 1417-1431.
  DOI: 10.1002/glia.23314
• Ribosomal Protein S6 Phosphorylation Is Involved in Novelty-Induced Locomotion, Synaptic Plasticity and mRNA Translation.
  Emma Puighermanal, Anne Biever, Vincent Pascoli, Su Melser, Marine Pratlong, Laura Cutando, Stephanie Rialle, Dany Severac, Jihane Boubaker-Vitre, Oded Meyuhas, Giovanni Marsicano, Christian Lüscher, Emmanuel Valjent.
  Front. Mol. Neurosci.. 2017-12-21. 10
  DOI: 10.3389/fnmol.2017.00419
• Pathway-Specific Control of Striatal Neuron Vulnerability by Corticostriatal Cannabinoid CB1 Receptors.
  Andrea Ruiz-Calvo, Irene B Maroto, Raquel Bajo-Grañeras, Anna Chiarlone, Ángel Gaudioso, José J Ferrero, Eva Resel, José Sánchez-Prieto, José A Rodríguez-Navarro, Giovanni Marsicano, Ismael Galve-Roperh, Luigi Bellocchio, Manuel Guzmán.
  Cerebral Cortex. 2017-10-31. 28 (1) : 307-322.
  DOI: 10.1093/cercor/bhx285
• Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages.
  Inigo Ruiz de Azua, Giacomo Mancini, Raj Kamal Srivastava, Alejandro Aparisi Rey, Pierre Cardinal, Laura Tedesco, Cristina Maria Zingaretti, Antonia Sassmann, Carmelo Quarta, Claudia Schwitter, Andrea Conrad, Nina Wettschureck, V. Kiran Vemuri, Alexandros Makriyannis, Jens Hartwig, Maria Mendez-Lago, Laura Bindila, Krisztina Monory, Antonio Giordano, Saverio Cinti, Giovanni Marsicano, Stefan Offermanns, Enzo Nisoli, Uberto Pagotto, Daniela Cota, Beat Lutz.
  Journal of Clinical Investigation. 2017-10-16. 127 (11) : 4148-4162.
  DOI: 10.1172/jci83626
• Synapse-specific astrocyte gating of amygdala-related behavior.
  Mario Martin-Fernandez, Stephanie Jamison, Laurie M Robin, Zhe Zhao, Eduardo D Martin, Juan Aguilar, Michael A Benneyworth, Giovanni Marsicano, Alfonso Araque.
  Nat Neurosci. 2017-09-25. 20 (11) : 1540-1548.
  DOI: 10.1038/nn.4649
• CB1 Receptor Signaling in the Brain: Extracting Specificity from Ubiquity.
  Arnau Busquets-Garcia, Jaideep Bains, Giovanni Marsicano.
  Neuropsychopharmacology. 2017-09-01. 43 (1) : 4-20.
  DOI: 10.1038/npp.2017.206
• CB1 Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal.
  Rocio Saravia, África Flores, Ainhoa Plaza-Zabala, Arnau Busquets-Garcia, Antoni Pastor, Rafael de la Torre, Vincenzo Di Marzo, Giovanni Marsicano, Andrés Ozaita, Rafael Maldonado, Fernando Berrendero.
  Biological Psychiatry. 2017-04-01. 81 (7) : 625-634.
  DOI: 10.1016/j.biopsych.2016.07.007
• The CB1 Receptor as the Cornerstone of Exostasis.
  Pier Vincenzo Piazza, Daniela Cota, Giovanni Marsicano.
  Neuron. 2017-03-01. 93 (6) : 1252-1274.
  DOI: 10.1016/j.neuron.2017.02.002
• Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice.
  A Busquets-Garcia, E Soria-Gómez, B Redon, Y Mackenbach, M Vallée, F Chaouloff, M Varilh, G Ferreira, P-V Piazza, G Marsicano.
  Mol Psychiatry. 2017-02-21. 22 (11) : 1594-1603.
  DOI: 10.1038/mp.2017.4
• Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases.
  Marc P. Baggelaar, Annelot C. M. van Esbroeck, Eva J. van Rooden, Bogdan I. Florea, Herman S. Overkleeft, Giovanni Marsicano, Francis Chaouloff, Mario van der Stelt.
  ACS Chem. Biol.. 2017-02-13. 12 (3) : 852-861.
  DOI: 10.1021/acschembio.6b01052
• Functional Analysis of Mitochondrial CB1 Cannabinoid Receptors (mtCB1) in the Brain.
  Su Melser, Antonio C. Pagano Zottola, Roman Serrat, Nagore Puente, Pedro Grandes, Giovanni Marsicano, Etienne Hebert-Chatelain.
  Methods in Enzymology. 2017-01-01. : 143-174.
  DOI: 10.1016/bs.mie.2017.06.023
• Representation-mediated Aversion as a Model to Study Psychotic-like States in Mice.
  Arnau Busquets-Garcia, Edgar Soria-Gómez, Guillaume Ferreira, Giovanni Marsicano.
  BIO-PROTOCOL. 2017-01-01. 7 (12)
  DOI: 10.21769/bioprotoc.2358
• Interacting Cannabinoid and Opioid Receptors in the Nucleus Accumbens Core Control Adolescent Social Play.
  Antonia Manduca, Olivier Lassalle, Marja Sepers, Patrizia Campolongo, Vincenzo Cuomo, Giovanni Marsicano, Brigitte Kieffer, Louk J. M. J Vanderschuren, Viviana Trezza, Olivier J. J. Manzoni.
  Front. Behav. Neurosci.. 2016-11-16. 10
  DOI: 10.3389/fnbeh.2016.00211
• A cannabinoid link between mitochondria and memory.
  Etienne Hebert-Chatelain, Tifany Desprez, Román Serrat, Luigi Bellocchio, Edgar Soria-Gomez, Arnau Busquets-Garcia, Antonio Christian Pagano Zottola, Anna Delamarre, Astrid Cannich, Peggy Vincent, Marjorie Varilh, Laurie M. Robin, Geoffrey Terral, M. Dolores García-Fernández, Michelangelo Colavita, Wilfrid Mazier, Filippo Drago, Nagore Puente, Leire Reguero, Izaskun Elezgarai, Jean-William Dupuy, Daniela Cota, Maria-Luz Lopez-Rodriguez, Gabriel Barreda-Gómez, Federico Massa, Pedro Grandes, Giovanni Bénard, Giovanni Marsicano.
  Nature. 2016-11-01. 539 (7630) : 555-559.
  DOI: 10.1038/nature20127
• Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration.
  Juan Mendizabal-Zubiaga, Su Melser, Giovanni Bénard, Almudena Ramos, Leire Reguero, Sergio Arrabal, Izaskun Elezgarai, Inmaculada Gerrikagoitia, Juan Suarez, Fernando Rodríguez De Fonseca, Nagore Puente, Giovanni Marsicano, Pedro Grandes.
  Front. Physiol.. 2016-10-25. 7
  DOI: 10.3389/fphys.2016.00476
• Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation.
  Arnau Busquets-Garcia, Maria Gomis-González, Raj Kamal Srivastava, Laura Cutando, Antonio Ortega-Alvaro, Sabine Ruehle, Floortje Remmers, Laura Bindila, Luigi Bellocchio, Giovanni Marsicano, Beat Lutz, Rafael Maldonado, Andrés Ozaita.
  Proc Natl Acad Sci USA. 2016-08-15. 113 (35) : 9904-9909.
  DOI: 10.1073/pnas.1525066113
• Anatomical characterization of the cannabinoid CB1 receptor in cell-type-specific mutant mouse rescue models.
  Ana Gutiérrez-Rodríguez, Nagore Puente, Izaskun Elezgarai, Sabine Ruehle, Beat Lutz, Leire Reguero, Inmaculada Gerrikagoitia, Giovanni Marsicano, Pedro Grandes.
  J. Comp. Neurol.. 2016-07-08. 525 (2) : 302-318.
  DOI: 10.1002/cne.24066
• Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus.
  Michelangelo Colavita, Geoffrey Terral, Clement E. Lemercier, Filippo Drago, Giovanni Marsicano, Federico Massa.
  Sci Rep. 2016-06-27. 6 (1)
  DOI: 10.1038/srep28454
• MitoBrain, Putting energy into the brain.
  Giovanni Benard, Erwan Bezard, Giovanni Marsicano, Sandrine Pouvreau.
  Neurobiology of Disease. 2016-06-01. 90 : 1-2.
  DOI: 10.1016/j.nbd.2016.03.021
• Cannabinoid receptor type-1: breaking the dogmas.
  Arnau Busquets Garcia, Edgar Soria-Gomez, Luigi Bellocchio, Giovanni Marsicano.
  F1000Res. 2016-05-24. 5 : 990.
  DOI: 10.12688/f1000research.8245.1
• Astroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse.
  J.F. Oliveira da Cruz, L.M. Robin, F. Drago, G. Marsicano, M. Metna-Laurent.
  Neuroscience. 2016-05-01. 323 : 35-42.
  DOI: 10.1016/j.neuroscience.2015.05.002
• Running per se stimulates the dendritic arbor of newborn dentate granule cells in mouse hippocampus in a duration-dependent manner.
  Sandrine Dostes, Sarah Dubreucq, Elodie Ladevèze, Giovanni Marsicano, Djoher N. Abrous, Francis Chaouloff, Muriel Koehl.
  Hippocampus. 2015-12-08. 26 (3) : 282-288.
  DOI: 10.1002/hipo.22551
• Stimulation of in vivo dopamine transmission and intravenous self-administration in rats and mice by JWH-018, a Spice cannabinoid.
  M.A. De Luca, Z. Bimpisidis, M. Melis, M. Marti, P. Caboni, V. Valentini, G. Margiani, N. Pintori, I. Polis, G. Marsicano, L.H. Parsons, G. Di Chiara.
  Neuropharmacology. 2015-12-01. 99 : 705-714.
  DOI: 10.1016/j.neuropharm.2015.08.041
• The endocannabinoid system in guarding against fear, anxiety and stress.
  Beat Lutz, Giovanni Marsicano, Rafael Maldonado, Cecilia J. Hillard.
  Nat Rev Neurosci. 2015-12-01. 16 (12) : 705-718.
  DOI: 10.1038/nrn4036
• Differential Control of Cocaine Self-Administration by GABAergic and Glutamatergic CB1 Cannabinoid Receptors.
  Elena Martín-García, Lucie Bourgoin, Adeline Cathala, Fernando Kasanetz, Miguel Mondesir, Ana Gutiérrez-Rodriguez, Leire Reguero, Jean- François Fiancette, Pedro Grandes, Umberto Spampinato, Rafael Maldonado, Pier Vincenzo Piazza, Giovanni Marsicano, Véronique Deroche-Gamonet.
  Neuropsychopharmacol. 2015-11-27. 41 (9) : 2192-2205.
  DOI: 10.1038/npp.2015.351
• The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice.
  Francisco J. Bermudez-Silva, Silvana Y. Romero-Zerbo, Magalie Haissaguerre, Inmaculada Ruz-Maldonado, Said Lhamyani, Rajaa El Bekay, Antoine Tabarin, Giovanni Marsicano, Daniela Cota.
  Dis. Model. Mech.. 2015-11-12. 9 (1) : 51-61.
  DOI: 10.1242/dmm.020750
• Habenular CB1 Receptors Control the Expression of Aversive Memories.
  Edgar Soria-Gómez, Arnau Busquets-Garcia, Fei Hu, Amine Mehidi, Astrid Cannich, Liza Roux, Ines Louit, Lucille Alonso, Theresa Wiesner, Francois Georges, Danièle Verrier, Peggy Vincent, Guillaume Ferreira, Minmin Luo, Giovanni Marsicano.
  Neuron. 2015-10-01. 88 (2) : 306-313.
  DOI: 10.1016/j.neuron.2015.08.035
• Dissecting the cannabinergic control of behavior: The where matters.
  Arnau Busquets-Garcia, Tifany Desprez, Mathilde Metna-Laurent, Luigi Bellocchio, Giovanni Marsicano, Edgar Soria-Gomez.
  BioEssays. 2015-08-11. 37 (11) : 1215-1225.
  DOI: 10.1002/bies.201500046
• Duration- and environment-dependent effects of repeated voluntary exercise on anxiety and cued fear in mice.
  Sarah Dubreucq, Giovanni Marsicano, Francis Chaouloff.
  Behavioural Brain Research. 2015-04-01. 282 : 1-5.
  DOI: 10.1016/j.bbr.2014.12.042
• Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 receptors located on glutamatergic neurons and on astrocytes.
  Ilaria Belluomo, Isabelle Matias, Camille Pernègre, Giovanni Marsicano, Francis Chaouloff.
  J. Neurochem.. 2015-02-25. 133 (1) : 26-37.
  DOI: 10.1111/jnc.13044
• Cannabinoid type 1 (CB1) receptors on Sim1-expressing neurons regulate energy expenditure in male mice.
  Pierre Cardinal, Luigi Bellocchio, Omar Guzmán-Quevedo, Caroline André, Samantha Clark, Melissa Elie, Thierry Leste-Lasserre, Delphine Gonzales, Astrid Cannich, Giovanni Marsicano, Daniela Cota.
  Endocrinology. 2015-02-01. 156 (2) : 411-418.
  DOI: 10.1210/en.2014-1437
• Rising stars: modulation of brain functions by astroglial type-1 cannabinoid receptors.
  Mathilde Metna-Laurent, Giovanni Marsicano.
  Glia. 2014-12-01. 63 (3) : 353-364.
  DOI: 10.1002/glia.22773
• New insights on food intake control by olfactory processes: the emerging role of the endocannabinoid system.
  Edgar Soria-Gomez, Luigi Bellocchio, Giovanni Marsicano.
  Molecular and Cellular Endocrinology. 2014-11-01. 397 (1-2) : 59-66.
  DOI: 10.1016/j.mce.2014.09.023
• CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin.
  Pierre Cardinal, Caroline André, Carmelo Quarta, Luigi Bellocchio, Samantha Clark, Melissa Elie, Thierry Leste-Lasserre, Marlene Maitre, Delphine Gonzales, Astrid Cannich, Uberto Pagotto, Giovanni Marsicano, Daniela Cota.
  Molecular Metabolism. 2014-10-01. 3 (7) : 705-716.
  DOI: 10.1016/j.molmet.2014.07.004
• Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats.
  M. Melis, C. Sagheddu, M. De Felice, A. Casti, C. Madeddu, S. Spiga, A. L. Muntoni, K. Mackie, G. Marsicano, G. Colombo, M. P. Castelli, M. Pistis.
  Journal of Neuroscience. 2014-09-17. 34 (38) : 12716-12724.
  DOI: 10.1523/jneurosci.1844-14.2014
• Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor.
  Etienne Hebert-Chatelain, Leire Reguero, Nagore Puente, Beat Lutz, Francis Chaouloff, Rodrigue Rossignol, Pier-Vincenzo Piazza, Giovanni Benard, Pedro Grandes, Giovanni Marsicano.
  Molecular Metabolism. 2014-07-01. 3 (4) : 495-504.
  DOI: 10.1016/j.molmet.2014.03.007
• Studying mitochondrial CB1 receptors: Yes we can.
  Etienne Hebert-Chatelain, Leire Reguero, Nagore Puente, Beat Lutz, Francis Chaouloff, Rodrigue Rossignol, Pier-Vincenzo Piazza, Giovanni Benard, Pedro Grandes, Giovanni Marsicano.
  Molecular Metabolism. 2014-07-01. 3 (4) : 339.
  DOI: 10.1016/j.molmet.2014.03.008
• Cannabinoid type-1 receptors in the paraventricular nucleus of the hypothalamus inhibit stimulated food intake.
  E. Soria-Gómez, F. Massa, L. Bellocchio, P.E. Rueda-Orozco, P. Ciofi, D. Cota, S.H.R. Oliet, O. Prospéro-García, G. Marsicano.
  Neuroscience. 2014-03-01. 263 : 46-53.
  DOI: 10.1016/j.neuroscience.2014.01.005
• The endocannabinoid system controls food intake via olfactory processes.
  Edgar Soria-Gómez, Luigi Bellocchio, Leire Reguero, Gabriel Lepousez, Claire Martin, Mounir Bendahmane, Sabine Ruehle, Floor Remmers, Tifany Desprez, Isabelle Matias, Theresa Wiesner, Astrid Cannich, Antoine Nissant, Aya Wadleigh, Hans-Christian Pape, Anna Paola Chiarlone, Carmelo Quarta, Daniéle Verrier, Peggy Vincent, Federico Massa, Beat Lutz, Manuel Guzmán, Hirac Gurden, Guillaume Ferreira, Pierre-Marie Lledo, Pedro Grandes, Giovanni Marsicano.
  Nat Neurosci. 2014-02-09. 17 (3) : 407-415.
  DOI: 10.1038/nn.3647
• Pregnenolone can protect the brain from cannabis intoxication.
  Monique Vallée, Sergio Vitiello, Luigi Bellocchio, Etienne Hébert-Chatelain, Stéphanie Monlezun, Elena Martin-Garcia, Fernando Kasanetz, Gemma L. Baillie, Francesca Panin, Adeline Cathala, Valérie Roullot-Lacarrière, Sandy Fabre, Dow P. Hurst, Diane L. Lynch, Derek M. Shore, Véronique Deroche-Gamonet, Umberto Spampinato, Jean-Michel Revest, Rafael Maldonado, Patricia H. Reggio, Ruth A. Ross, Giovanni Marsicano, Pier Vincenzo Piazza.
  Science. 2014-01-02. 343 (6166) : 94-98.
  DOI: 10.1126/science.1243985
• Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists.
  Gareth Pryce, Cristina Visintin, Sreeram V. Ramagopalan, Sarah Al-Izki, Lia E. De Faveri, Rosamond A. Nuamah, Charles A. Mein, Alexandre Montpetit, Alison J. Hardcastle, Gijs Kooij, Helga E. de Vries, Sandra Amor, Sarah A. Thomas, Catherine Ledent, Giovanni Marsicano, Beat Lutz, Alan J. Thompson, David L. Selwood, Gavin Giovannoni, David Baker.
  The FASEB Journal. 2014-01-01. 28 (1) : 117-130.
  DOI: 10.1096/fj.13-239442
• Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis.
  C. Glangetas, D. Girard, L. Groc, G. Marsicano, F. Chaouloff, F. Georges.
  Journal of Neuroscience. 2013-12-11. 33 (50) : 19657-19663.
  DOI: 10.1523/jneurosci.3175-13.2013
• Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes.
  Barbara Bosier, Luigi Bellocchio, Mathilde Metna-Laurent, Edgar Soria-Gomez, Isabelle Matias, Etienne Hebert-Chatelain, Astrid Cannich, Marlène Maitre, Thierry Leste-Lasserre, Pierre Cardinal, Juan Mendizabal-Zubiaga, Miren Josune Canduela, Leire Reguero, Emmanuel Hermans, Pedro Grandes, Daniela Cota, Giovanni Marsicano.
  Molecular Metabolism. 2013-11-01. 2 (4) : 393-404.
  DOI: 10.1016/j.molmet.2013.08.001
• Activation of STAT3 is involved in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptors in rats.
  Heng Zhou, Zhi Zhang, Haidong Wei, Feng Wang, Fan Guo, Zijun Gao, Giovanni Marsicano, Qiang Wang, Lize Xiong.
  Brain Research. 2013-09-01. 1529 : 154-164.
  DOI: 10.1016/j.brainres.2013.07.006
• Glycogen synthase kinase-3β is involved in electroacupuncture pretreatment via the cannabinoid CB1 receptor in ischemic stroke.
  Haidong Wei, Xi Yao, Lifang Yang, Shiquan Wang, Fan Guo, Heng Zhou, Giovanni Marsicano, Qiang Wang, Lize Xiong.
  Mol Neurobiol. 2013-08-14. 49 (1) : 326-336.
  DOI: 10.1007/s12035-013-8524-5
• Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions.
  S. Ruehle, F. Remmers, H. Romo-Parra, F. Massa, M. Wickert, S. Wortge, M. Haring, N. Kaiser, G. Marsicano, H.-C. Pape, B. Lutz.
  Journal of Neuroscience. 2013-06-19. 33 (25) : 10264-10277.
  DOI: 10.1523/jneurosci.4171-12.2013
• Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance.
  Sarah Dubreucq, Audrey Durand, Isabelle Matias, Giovanni Bénard, Elodie Richard, Edgar Soria-Gomez, Christelle Glangetas, Laurent Groc, Aya Wadleigh, Federico Massa, Dusan Bartsch, Giovanni Marsicano, Francois Georges, Francis Chaouloff.
  Biological Psychiatry. 2013-05-01. 73 (9) : 895-903.
  DOI: 10.1016/j.biopsych.2012.10.025
• Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB₁ receptor blockade.
  L. Bellocchio, E. Soria-Gomez, C. Quarta, M. Metna-Laurent, P. Cardinal, E. Binder, A. Cannich, A. Delamarre, M. Haring, M. Martin-Fontecha, D. Vega, T. Leste-Lasserre, D. Bartsch, K. Monory, B. Lutz, F. Chaouloff, U. Pagotto, M. Guzman, D. Cota, G. Marsicano.
  Proceedings of the National Academy of Sciences. 2013-03-04. 110 (12) : 4786-4791.
  DOI: 10.1073/pnas.1218573110
• Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus.
  Frauke Steindel, Raissa Lerner, Martin Häring, Sabine Ruehle, Giovanni Marsicano, Beat Lutz, Krisztina Monory.
  J. Neurochem.. 2013-02-13. 124 (6) : 795-807.
  DOI: 10.1111/jnc.12137
• Two-photon excitation STED microscopy in two colors in acute brain slices.
  Philipp Bethge, Ronan Chéreau, Elena Avignone, Giovanni Marsicano, U. Valentin Nägerl.
  Biophysical Journal. 2013-02-01. 104 (4) : 778-785.
  DOI: 10.1016/j.bpj.2012.12.054
• Dissociation of the pharmacological effects of THC by mTOR blockade.
  Emma Puighermanal, Arnau Busquets-Garcia, Maria Gomis-González, Giovanni Marsicano, Rafael Maldonado, Andrés Ozaita.
  Neuropsychopharmacol. 2013-01-28. 38 (7) : 1334-1343.
  DOI: 10.1038/npp.2013.31
• Striatal GABAergic and cortical glutamatergic neurons mediate contrasting effects of cannabinoids on cortical network synchrony.
  C. Sales-Carbonell, P. E. Rueda-Orozco, E. Soria-Gomez, G. Buzsaki, G. Marsicano, D. Robbe.
  Proceedings of the National Academy of Sciences. 2012-12-26. 110 (2) : 719-724.
  DOI: 10.1073/pnas.1217144110
• Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor.
  F. A. Pamplona, J. Ferreira, O. Menezes de Lima, F. S. Duarte, A. F. Bento, S. Forner, J. G. Villarinho, L. Bellocchio, C. T. Wotjak, R. Lerner, K. Monory, B. Lutz, C. Canetti, I. Matias, J. B. Calixto, G. Marsicano, M. Z. P. Guimaraes, R. N. Takahashi.
  Proceedings of the National Academy of Sciences. 2012-11-12. 109 (51) : 21134-21139.
  DOI: 10.1073/pnas.1202906109
• Hypothalamic CB1 cannabinoid receptors regulate energy balance in mice.
  Pierre Cardinal, Luigi Bellocchio, Samantha Clark, Astrid Cannich, Matthias Klugmann, Beat Lutz, Giovanni Marsicano, Daniela Cota.
  Endocrinology. 2012-09-01. 153 (9) : 4136-4143.
  DOI: 10.1210/en.2012-1405
• Endocannabinoids measurement in human saliva as potential biomarker of obesity.
  Isabelle Matias, Blandine Gatta-Cherifi, Antoine Tabarin, Samantha Clark, Thierry Leste-Lasserre, Giovanni Marsicano, Pier Vincenzo Piazza, Daniela Cota.
  PLoS ONE. 2012-07-31. 7 (7) : e42399.
  DOI: 10.1371/journal.pone.0042399
• Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo.
  Wolfgang Jacob, Rudolph Marsch, Giovanni Marsicano, Beat Lutz, Carsten T. Wotjak.
  Neurobiology of Learning and Memory. 2012-07-01. 98 (1) : 47-55.
  DOI: 10.1016/j.nlm.2012.04.008
• Bimodal control of fear-coping strategies by CB₁ cannabinoid receptors.
  M. Metna-Laurent, E. Soria-Gomez, D. Verrier, M. Conforzi, P. Jego, P. Lafenetre, G. Marsicano.
  Journal of Neuroscience. 2012-05-23. 32 (21) : 7109-7118.
  DOI: 10.1523/jneurosci.1054-12.2012
• Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice.
  Sarah Dubreucq, Isabelle Matias, Pierre Cardinal, Martin Häring, Beat Lutz, Giovanni Marsicano, Francis Chaouloff.
  Neuropsychopharmacol. 2012-03-21. 37 (8) : 1885-1900.
  DOI: 10.1038/npp.2012.36
• Mitochondrial CB₁ receptors regulate neuronal energy metabolism.
  Giovanni Bénard, Federico Massa, Nagore Puente, Joana Lourenço, Luigi Bellocchio, Edgar Soria-Gómez, Isabel Matias, Anna Delamarre, Mathilde Metna-Laurent, Astrid Cannich, Etienne Hebert-Chatelain, Christophe Mulle, Silvia Ortega-Gutiérrez, Mar Martín-Fontecha, Matthias Klugmann, Stephan Guggenhuber, Beat Lutz, Jürg Gertsch, Francis Chaouloff, María Luz López-Rodríguez, Pedro Grandes, Rodrigue Rossignol, Giovanni Marsicano.
  Nat Neurosci. 2012-03-04. 15 (4) : 558-564.
  DOI: 10.1038/nn.3053
• Cannabinoid type 1 receptors located on single-minded 1-expressing neurons control emotional behaviors.
  S. Dubreucq, S. Kambire, M. Conforzi, M. Metna-Laurent, A. Cannich, E. Soria-Gomez, E. Richard, G. Marsicano, F. Chaouloff.
  Neuroscience. 2012-03-01. 204 : 230-244.
  DOI: 10.1016/j.neuroscience.2011.08.049
• Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD.
  Jing Han, Philip Kesner, Mathilde Metna-Laurent, Tingting Duan, Lin Xu, Francois Georges, Muriel Koehl, Djoher Nora Abrous, Juan Mendizabal-Zubiaga, Pedro Grandes, Qingsong Liu, Guang Bai, Wei Wang, Lize Xiong, Wei Ren, Giovanni Marsicano, Xia Zhang.
  Cell. 2012-03-01. 148 (5) : 1039-1050.
  DOI: 10.1016/j.cell.2012.01.037
• Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses
  Maddalena D. Caiati, Sudhir Sivakumaran, Frederic Lanore, Christophe Mulle, Elodie Richard, Dany Verrier, Giovanni Marsicano, Richard Miles, Enrico Cherubini.
  Sci Rep. 2012-02-24. 2 (1)
  DOI: 10.1038/srep00285
• Moving bliss: a new anandamide transporter.
  Giovanni Marsicano, Francis Chaouloff.
  Nat Neurosci. 2012-01-01. 15 (1) : 5-6.
  DOI: 10.1038/nn.3011
• State-dependent, bidirectional modulation of neural network activity by endocannabinoids.
  R. Piet, A. Garenne, F. Farrugia, G. Le Masson, G. Marsicano, P. Chavis, O. J. Manzoni.
  Journal of Neuroscience. 2011-11-16. 31 (46) : 16591-16596.
  DOI: 10.1523/jneurosci.4297-11.2011
• GABAergic and cortical and subcortical glutamatergic axon terminals contain CB1 cannabinoid receptors in the ventromedial nucleus of the hypothalamus.
  Leire Reguero, Nagore Puente, Izaskun Elezgarai, Juan Mendizabal-Zubiaga, Miren Josune Canduela, Ianire Buceta, Almudena Ramos, Juan Suárez, Fernando Rodríguez de Fonseca, Giovanni Marsicano, Pedro Grandes.
  PLoS ONE. 2011-10-11. 6 (10) : e26167.
  DOI: 10.1371/journal.pone.0026167
• Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity.
  B Gatta-Cherifi, I Matias, M Vallée, A Tabarin, G Marsicano, P V Piazza, D Cota.
  Int J Obes Relat Metab Disord. 2011-08-16. 36 (6) : 880-885.
  DOI: 10.1038/ijo.2011.165
• New fat and new neurons: endocannabinoids control neurogenesis in obesity (Commentary on Rivera et al.).
  Daniela Cota, Giovanni Marsicano.
  European Journal of Neuroscience. 2011-05-01. 33 (9) : 1575-1576.
  DOI: 10.1111/j.1460-9568.2011.07684.x
• Endocannabinoids and motor behavior: CB1 receptors also control running activity.
  Francis Chaouloff, Sarah Dubreucq, Luigi Bellocchio, Giovanni Marsicano.
  Physiology. 2011-04-01. 26 (2) : 76-77.
  DOI: 10.1152/physiol.00050.2010
• Emotional consequences of wheel running in mice: which is the appropriate control?
  Sarah Dubreucq, Giovanni Marsicano, Francis Chaouloff.
  Hippocampus. 2011-02-24. 21 (3) : 239-242.
  DOI: 10.1002/hipo.20778
• Presynaptic CB1 receptors regulate synaptic plasticity at cerebellar parallel fiber synapses.
  Megan R. Carey, Michael H. Myoga, Kimberly R. McDaniels, Giovanni Marsicano, Beat Lutz, Ken Mackie, Wade G. Regehr.
  Journal of Neurophysiology. 2011-02-01. 105 (2) : 958-963.
  DOI: 10.1152/jn.00980.2010
• Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease.
  Cristina Blázquez, Anna Chiarlone, Onintza Sagredo, Tania Aguado, M. Ruth Pazos, Eva Resel, Javier Palazuelos, Boris Julien, María Salazar, Christine Börner, Cristina Benito, Carolina Carrasco, María Diez-Zaera, Paola Paoletti, Miguel Díaz-Hernández, Carolina Ruiz, Michael Sendtner, José J. Lucas, Justo G. de Yébenes, Giovanni Marsicano, Krisztina Monory, Beat Lutz, Julián Romero, Jordi Alberch, Silvia Ginés, Jürgen Kraus, Javier Fernández-Ruiz, Ismael Galve-Roperh, Manuel Guzmán.
  Brain. 2010-10-07. 134 (1) : 119-136.
  DOI: 10.1093/brain/awq278
• CB1 receptor deficiency decreases wheel-running activity: consequences on emotional behaviours and hippocampal neurogenesis.
  Sarah Dubreucq, Muriel Koehl, Djoher N. Abrous, Giovanni Marsicano, Francis Chaouloff.
  Experimental Neurology. 2010-07-01. 224 (1) : 106-113.
  DOI: 10.1016/j.expneurol.2010.01.017
• CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance.
  Carmelo Quarta, Luigi Bellocchio, Giacomo Mancini, Roberta Mazza, Cristina Cervino, Luzie J. Braulke, Csaba Fekete, Rocco Latorre, Cristina Nanni, Marco Bucci, Laura E. Clemens, Gerhard Heldmaier, Masahiko Watanabe, Thierry Leste-Lassere, Marlène Maitre, Laura Tedesco, Flaminia Fanelli, Stefan Reuss, Susanne Klaus, Raj Kamal Srivastava, Krisztina Monory, Alessandra Valerio, Annamaria Grandis, Roberto De Giorgio, Renato Pasquali, Enzo Nisoli, Daniela Cota, Beat Lutz, Giovanni Marsicano, Uberto Pagotto.
  Cell Metabolism. 2010-04-01. 11 (4) : 273-285.
  DOI: 10.1016/j.cmet.2010.02.015
• Bimodal control of stimulated food intake by the endocannabinoid system.
  Luigi Bellocchio, Pauline Lafenêtre, Astrid Cannich, Daniela Cota, Nagore Puente, Pedro Grandes, Francis Chaouloff, Pier Vincenzo Piazza, Giovanni Marsicano.
  Nat Neurosci. 2010-02-07. 13 (3) : 281-283.
  DOI: 10.1038/nn.2494
• Localization and function of the cannabinoid CB1 receptor in the anterolateral bed nucleus of the stria terminalis.
  Nagore Puente, Izaskun Elezgarai, Mathieu Lafourcade, Leire Reguero, Giovanni Marsicano, François Georges, Olivier J. Manzoni, Pedro Grandes.
  PLoS ONE. 2010-01-25. 5 (1) : e8869.
  DOI: 10.1371/journal.pone.0008869
• Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses.
  Joana Lourenço, Astrid Cannich, Mario Carta, Françoise Coussen, Christophe Mulle, Giovanni Marsicano.
  Nat Neurosci. 2010-01-17. 13 (2) : 197-204.
  DOI: 10.1038/nn.2481
• Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system.
  Pauline Lafenêtre, Francis Chaouloff, Giovanni Marsicano.
  Neuropharmacology. 2009-12-01. 57 (7-8) : 715-721.
  DOI: 10.1016/j.neuropharm.2009.07.014
• Self-modulation of neocortical pyramidal neurons by endocannabinoids.
  Silvia Marinelli, Simone Pacioni, Astrid Cannich, Giovanni Marsicano, Alberto Bacci.
  Nat Neurosci. 2009-11-15. 12 (12) : 1488-1490.
  DOI: 10.1038/nn.2430
• Endocannabinoids render exploratory behaviour largely independent of the test aversiveness: role of glutamatergic transmission.
  W. Jacob, A. Yassouridis, G. Marsicano, K. Monory, B. Lutz, C. T. Wotjak.
  Genes, Brain and Behavior. 2009-10-01. 8 (7) : 685-698.
  DOI: 10.1111/j.1601-183x.2009.00512.x
• Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization.
  A. J. Pernia-Andrade, A. Kato, R. Witschi, R. Nyilas, I. Katona, T. F. Freund, M. Watanabe, J. Filitz, W. Koppert, J. Schuttler, G. Ji, V. Neugebauer, G. Marsicano, B. Lutz, H. Vanegas, H. U. Zeilhofer.
  Science. 2009-08-06. 325 (5941) : 760-764.
  DOI: 10.1126/science.1171870
• Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling.
  Emma Puighermanal, Giovanni Marsicano, Arnau Busquets-Garcia, Beat Lutz, Rafael Maldonado, Andrés Ozaita.
  Nat Neurosci. 2009-08-02. 12 (9) : 1152-1158.
  DOI: 10.1038/nn.2369
• WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease.
  David A. Price, Alex A. Martinez, Alexandre Seillier, Wouter Koek, Yolanda Acosta, Elizabeth Fernandez, Randy Strong, Beat Lutz, Giovanni Marsicano, James L. Roberts, Andrea Giuffrida.
  European Journal of Neuroscience. 2009-06-01. 29 (11) : 2177-2186.
  DOI: 10.1111/j.1460-9568.2009.06764.x
• Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling.
  K. Kamprath, W. Plendl, G. Marsicano, J. M. Deussing, W. Wurst, B. Lutz, C. T. Wotjak.
  Genes, Brain and Behavior. 2009-03-01. 8 (2) : 203-211.
  DOI: 10.1111/j.1601-183x.2008.00463.x
• Roles of the endocannabinoid system in learning and memory.
  Giovanni Marsicano, Pauline Lafenêtre.
  Behavioral Neurobiology of the Endocannabinoid System. 2009-01-01. : 201-230.
  DOI: 10.1007/978-3-540-88955-7_8
• Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice.
  Douglas Osei-Hyiaman, Jie Liu, Liang Zhou, Grzegorz Godlewski, Judith Harvey-White, Won-il Jeong, Sándor Bátkai, Giovanni Marsicano, Beat Lutz, Christoph Buettner, George Kunos.
  J. Clin. Invest.. 2008-09-02. 118 (9) : 3160-3169.
  DOI: 10.1172/jci34827
• Conditional cannabinoid receptor type 1 mutants reveal neuron subpopulation-specific effects on behavioral and neuroendocrine stress responses.
  Michel A. Steiner, Giovanni Marsicano, Carsten T. Wotjak, Beat Lutz.
  Psychoneuroendocrinology. 2008-09-01. 33 (8) : 1165-1170.
  DOI: 10.1016/j.psyneuen.2008.06.004
• Cannabinoids enhance susceptibility of immature brain to ethanol neurotoxicity.
  Henrik H. Hansen, Birte Krutz, Marco Sifringer, Vanya Stefovska, Petra Bittigau, Fritz Pragst, Giovanni Marsicano, Beat Lutz, Chrysanthy Ikonomidou.
  Ann Neurol.. 2008-07-01. 64 (1) : 42-52.
  DOI: 10.1002/ana.21287
• Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning.
  J. Mulder, T. Aguado, E. Keimpema, K. Barabas, C. J. Ballester Rosado, L. Nguyen, K. Monory, G. Marsicano, V. Di Marzo, Y. L. Hurd, F. Guillemot, K. Mackie, B. Lutz, M. Guzman, H.-C. Lu, I. Galve-Roperh, T. Harkany.
  Proceedings of the National Academy of Sciences. 2008-06-18. 105 (25) : 8760-8765.
  DOI: 10.1073/pnas.0803545105
• Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes.
  L. Tedesco, A. Valerio, C. Cervino, A. Cardile, C. Pagano, R. Vettor, R. Pasquali, M. O. Carruba, G. Marsicano, B. Lutz, U. Pagotto, E. Nisoli.
  Diabetes. 2008-05-13. 57 (8) : 2028-2036.
  DOI: 10.2337/db07-1623
• Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver.
  Won-il Jeong, Douglas Osei-Hyiaman, Ogyi Park, Jie Liu, Sándor Bátkai, Partha Mukhopadhyay, Norio Horiguchi, Judith Harvey-White, Giovanni Marsicano, Beat Lutz, Bin Gao, George Kunos.
  Cell Metabolism. 2008-03-01. 7 (3) : 227-235.
  DOI: 10.1016/j.cmet.2007.12.007
• Activation of CB1 specifically located on GABAergic interneurons inhibits LTD in the lateral amygdala.
  S. C. Azad, J. Kurz, G. Marsicano, B. Lutz, W. Zieglgansberger, G. Rammes.
  Learning & Memory. 2008-02-22. 15 (3) : 143-152.
  DOI: 10.1101/lm.741908
• Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice.
  Michel A. Steiner, Giovanni Marsicano, Eric J. Nestler, Florian Holsboer, Beat Lutz, Carsten T. Wotjak.
  Psychoneuroendocrinology. 2008-01-01. 33 (1) : 54-67.
  DOI: 10.1016/j.psyneuen.2007.09.008
• The endocannabinoid system in the processing of anxiety and fear and how CB1 receptors may modulate fear extinction.
  Pauline Lafenêtre, Francis Chaouloff, Giovanni Marsicano.
  Pharmacological Research. 2007-11-01. 56 (5) : 367-381.
  DOI: 10.1016/j.phrs.2007.09.006
• Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice.
  Krisztina Monory, Heike Blaudzun, Federico Massa, Nadine Kaiser, Thomas Lemberger, Günther Schütz, Carsten T Wotjak, Beat Lutz, Giovanni Marsicano.
  PLoS Biol. 2007-10-09. 5 (10) : e269.
  DOI: 10.1371/journal.pbio.0050269
• Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon.
  Angelo A. Izzo, , Gabriella Aviello, Stefania Petrosino, Pierangelo Orlando, Giovanni Marsicano, Beat Lutz, Francesca Borrelli, Raffaele Capasso, Santosh Nigam, Francesco Capasso, Vincenzo Di Marzo.
  J Mol Med. 2007-09-06. 86 (1) : 89-98.
  DOI: 10.1007/s00109-007-0248-4
• Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex.
  b. yuece, a. sibaev, u. c. broedl, g. marsicano, b. göke, b. lutz, h. d. allescher, m. storr.
  Neurogastroenterol Motil. 2007-09-01. 19 (9) : 744-753.
  DOI: 10.1111/j.1365-2982.2007.00975.x
• Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice.
  M A Steiner, K Wanisch, K Monory, G Marsicano, E Borroni, H Bächli, F Holsboer, B Lutz, C T Wotjak.
  Pharmacogenomics J. 2007-08-07. 8 (3) : 196-208.
  DOI: 10.1038/sj.tpj.6500466
• Role of cannabinoid type 1 receptors in locomotor activity and striatal signaling in response to psychostimulants.
  A.-G. Corbille, E. Valjent, G. Marsicano, C. Ledent, B. Lutz, D. Herve, J.-A. Girault.
  Journal of Neuroscience. 2007-06-27. 27 (26) : 6937-6947.
  DOI: 10.1523/jneurosci.3936-06.2007
• Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.
  Nitin Agarwal, Pal Pacher, Irmgard Tegeder, Fumimasa Amaya, Cristina E Constantin, Gary J Brenner, Tiziana Rubino, Christoph W Michalski, Giovanni Marsicano, Krisztina Monory, Ken Mackie, Claudiu Marian, Sandor Batkai, Daniela Parolaro, Michael J Fischer, Peter Reeh, George Kunos, Michaela Kress, Beat Lutz, Clifford J Woolf, Rohini Kuner.
  Nat Neurosci. 2007-06-10. 10 (7) : 870-879.
  DOI: 10.1038/nn1916
• The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis.
  Tania Aguado, Eva Romero, Krisztina Monory, Javier Palazuelos, Michael Sendtner, Giovanni Marsicano, Beat Lutz, Manuel Guzmán, Ismael Galve-Roperh.
  J. Biol. Chem.. 2007-06-07. 282 (33) : 23892-23898.
  DOI: 10.1074/jbc.m700678200
• Hardwiring the brain: endocannabinoids shape neuronal connectivity.
  P. Berghuis, A. M. Rajnicek, Y. M. Morozov, R. A. Ross, J. Mulder, G. M. Urban, K. Monory, G. Marsicano, M. Matteoli, A. Canty, A. J. Irving, I. Katona, Y. Yanagawa, P. Rakic, B. Lutz, K. Mackie, T. Harkany.
  Science. 2007-05-25. 316 (5828) : 1212-1216.
  DOI: 10.1126/science.1137406
• Identification of the cannabinoid receptor type 1 in serotonergic cells of raphe nuclei in mice.
  M. Häring, G. Marsicano, B. Lutz, K. Monory.
  Neuroscience. 2007-05-01. 146 (3) : 1212-1219.
  DOI: 10.1016/j.neuroscience.2007.02.021
• Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells.
  Katarzyna Maresz, Gareth Pryce, Eugene D Ponomarev, Giovanni Marsicano, J Ludovic Croxford, Leah P Shriver, Catherine Ledent, Xiaodong Cheng, Erica J Carrier, Monica K Mann, Gavin Giovannoni, Roger G Pertwee, Takashi Yamamura, Nancy E Buckley, Cecilia J Hillard, Beat Lutz, David Baker, Bonnie N Dittel.
  Nat Med. 2007-04-01. 13 (4) : 492-497.
  DOI: 10.1038/nm1561
• Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis function.
  Daniela Cota, Michel-Alexander Steiner, Giovanni Marsicano, Cristina Cervino, James P. Herman, Yvonne Grübler, Johanna Stalla, Renato Pasquali, Beat Lutz, Günter K. Stalla, Uberto Pagotto.
  Endocrinology. 2007-04-01. 148 (4) : 1574-1581.
  DOI: 10.1210/en.2005-1649
• Protective activation of the endocannabinoid system during ischemia in dopamine neurons.
  Miriam Melis, Giuliano Pillolla, Tiziana Bisogno, Alberto Minassi, Stefania Petrosino, Simona Perra, Anna Lisa Muntoni, Beat Lutz, Gian Luigi Gessa, Giovanni Marsicano.
  Neurobiology of Disease. 2006-10-01. 24 (1) : 15-27.
  DOI: 10.1016/j.nbd.2006.04.010
• The endocannabinoid system controls key epileptogenic circuits in the hippocampus.
  Krisztina Monory, Federico Massa, Michaela Egertová, Matthias Eder, Heike Blaudzun, Ruth Westenbroek, Wolfgang Kelsch, Wolfgang Jacob, Rudolf Marsch, Marc Ekker, Jason Long, John L. Rubenstein, Sandra Goebbels, Klaus-Armin Nave, Matthew During, Matthias Klugmann, Barbara Wölfel, Hans-Ulrich Dodt, Walter Zieglgänsberger, Carsten T. Wotjak, Ken Mackie, Maurice R. Elphick, Giovanni Marsicano, Beat Lutz.
  Neuron. 2006-08-01. 51 (4) : 455-466.
  DOI: 10.1016/j.neuron.2006.07.006
• Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes.
  K. Kamprath, G. Marsicano, J. Tang, K. Monory, T. Bisogno, V. D. Marzo, B. Lutz, C. T. Wotjak.
  Journal of Neuroscience. 2006-06-21. 26 (25) : 6677-6686.
  DOI: 10.1523/jneurosci.0153-06.2006
• Cannabinoid receptor type 1 located on presynaptic terminals of principal neurons in the forebrain controls glutamatergic synaptic transmission.
  M. R. Domenici.
  Journal of Neuroscience. 2006-05-24. 26 (21) : 5794-5799.
  DOI: 10.1523/jneurosci.0372-06.2006
• How many sites of action for endocannabinoids to control energy metabolism?
  U Pagotto, C Cervino, V Vicennati, G Marsicano, B Lutz, R Pasquali.
  Int J Obes. 2006-03-29. 30 (S1) : S39-S43.
  DOI: 10.1038/sj.ijo.0803277
• CB1 and TRPV1 receptors mediate protective effects on colonic electrophysiological properties in mice.
  A. Sibaev, F. Massa, B. Yüce, G. Marsicano, H. A. Lehr, B. Lutz, B. Göke, H. D. Allescher, M. Storr.
  J Mol Med. 2006-02-25. 84 (6) : 513-520.
  DOI: 10.1007/s00109-006-0040-x
• The emerging role of the endocannabinoid system in endocrine regulation and energy balance.
  Uberto Pagotto, Giovanni Marsicano, Daniela Cota, Beat Lutz, Renato Pasquali.
  Endocrine Reviews. 2006-02-01. 27 (1) : 73-100.
  DOI: 10.1210/er.2005-0009
• The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells.
  T. Aguado.
  Journal of Neuroscience. 2006-02-01. 26 (5) : 1551-1561.
  DOI: 10.1523/jneurosci.3101-05.2006
• Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene sulfonic acid induced colitis.
  F. Massa, A. Sibaev, G. Marsicano, H. Blaudzun, M. Storr, B. Lutz.
  J Mol Med. 2005-12-31. 84 (2) : 142-146.
  DOI: 10.1007/s00109-005-0016-2
• The endocannabinoid system drives neural progenitor proliferation.
  Tania Aguado, Krisztina Monory, Javier Palazuelos, Nephi Stella, Benjamin Cravatt, Beat Lutz, Giovanni Marsicano, Zaal Kokaia, Manuel Guzmán, Ismael Galve-Roperh.
  The FASEB Journal. 2005-10-01. 19 (12) : 1704-1706.
  DOI: 10.1096/fj.05-3995fje
• Fatty acid amide hydrolase controls mouse intestinal motility in vivo.
  Raffaele Capasso, Isabel Matias, Beat Lutz, Francesca Borrelli, Francesco Capasso, Giovanni Marsicano, Nicola Mascolo, Stefania Petrosino, Krisztina Monory, Marta Valenti, Vincenzo Di Marzo, Angelo A. Izzo.
  Gastroenterology. 2005-09-01. 129 (3) : 941-951.
  DOI: 10.1053/j.gastro.2005.06.018
• Cannabinoid CB1 receptor is dispensable for memory extinction in an appetitively-motivated learning task.
  Sabine M. Hölter, Magdalena Kallnik, Wolfgang Wurst, Giovanni Marsicano, Beat Lutz, Carsten T. Wotjak.
  European Journal of Pharmacology. 2005-03-01. 510 (1-2) : 69-74.
  DOI: 10.1016/j.ejphar.2005.01.008
• Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons.
  M. Melis.
  Journal of Neuroscience. 2004-11-24. 24 (47) : 10707-10715.
  DOI: 10.1523/jneurosci.3502-04.2004
• Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling.
  S. C. Azad.
  Journal of Neuroscience. 2004-11-03. 24 (44) : 9953-9961.
  DOI: 10.1523/jneurosci.2134-04.2004
• CB1 cannabinoid receptors modulate kinase and phosphatase activity during extinction of conditioned fear in mice.
  A. Cannich.
  Learning & Memory. 2004-09-01. 11 (5) : 625-632.
  DOI: 10.1101/lm.77904
• The endogenous cannabinoid system protects against colonic inflammation.
  Federico Massa, Giovanni Marsicano, Heike Hermann, Astrid Cannich, Krisztina Monory, Benjamin F. Cravatt, Gian-Luca Ferri, Andrei Sibaev, Martin Storr, Beat Lutz.
  J. Clin. Invest.. 2004-04-15. 113 (8) : 1202-1209.
  DOI: 10.1172/jci200419465
• The endogenous cannabinoid system protects against colonic inflammation.
  Federico Massa, Giovanni Marsicano, Heike Hermann, Astrid Cannich, Krisztina Monory, Benjamin F. Cravatt, Gian-Luca Ferri, Andrei Sibaev, Martin Storr, Beat Lutz.
  J. Clin. Invest.. 2004-04-15. 113 (8) : 1202-1209.
  DOI: 10.1172/jci200419465
• Reduced sensitivity to reward in CB1 knockout mice.
  Carles Sanchis-Segura, Brandon H. Cline, Giovanni Marsicano, Beat Lutz, Rainer Spanagel.
  Psychopharmacology. 2004-04-09. 176 (2) : 223-232.
  DOI: 10.1007/s00213-004-1877-8
• Involvement of brain-derived neurotrophic factor in cannabinoid receptor-dependent protection against excitotoxicity.
  Leonid G. Khaspekov, Maria S. Brenz Verca, Lidia E. Frumkina, Heike Hermann, Giovanni Marsicano, Beat Lutz.
  Eur J Neurosci. 2004-04-01. 19 (7) : 1691-1698.
  DOI: 10.1111/j.1460-9568.2004.03285.x
• Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon.
  M. Storr, A. Sibaev, G. Marsicano, B. Lutz, V. Schusdziarra, J.-P. Timmermans, H. D. Allescher.
  American Journal of Physiology-Gastrointestinal and Liver Physiology. 2004-01-01. 286 (1) : G110-G117.
  DOI: 10.1152/ajpgi.00148.2003
• CB1 cannabinoid receptors and on-demand defense against excitotoxicity.
  G. Marsicano.
  Science. 2003-10-03. 302 (5642) : 84-88.
  DOI: 10.1126/science.1088208
• An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice.
  Angelo A. Izzo, Francesco Capasso, Anna Costagliola, Tiziana Bisogno, Giovanni Marsicano, Alessia Ligresti, Isabel Matias, Raffaele Capasso, Luisa Pinto, Francesca Borrelli, Aldo Cecio, Beat Lutz, Nicola Mascolo, Vincenzo Di Marzo.
  Gastroenterology. 2003-09-01. 125 (3) : 765-774.
  DOI: 10.1016/s0016-5085(03)00892-8
• The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.
  Daniela Cota, Giovanni Marsicano, Matthias Tschöp, Yvonne Grübler, Cornelia Flachskamm, Mirjam Schubert, Dorothee Auer, Alexander Yassouridis, Christa Thöne-Reineke, Sylvia Ortmann, Federica Tomassoni, Cristina Cervino, Enzo Nisoli, Astrid C.E. Linthorst, Renato Pasquali, Beat Lutz, Günter K. Stalla, Uberto Pagotto.
  J. Clin. Invest.. 2003-08-01. 112 (3) : 423-431.
  DOI: 10.1172/jci17725
• Endogenous cannabinoid system as a modulator of food intake.
  D Cota, G Marsicano, B Lutz, V Vicennati, G K Stalla, R Pasquali, U Pagotto.
  Int J Obes. 2003-03-01. 27 (3) : 289-301.
  DOI: 10.1038/sj.ijo.0802250
• Activation of the cannabinoid receptor type 1 decreases glutamatergic and GABAergic synaptic transmission in the lateral amygdala of the mouse.
  S. C. Azad.
  Learning & Memory. 2003-03-01. 10 (2) : 116-128.
  DOI: 10.1101/lm.53303
• The endogenous cannabinoid system controls extinction of aversive memories.
  Giovanni Marsicano, Carsten T. Wotjak, Shahnaz C. Azad, Tiziana Bisogno, Gerhard Rammes, Maria Grazia Cascio, Heike Hermann, Jianrong Tang, Clementine Hofmann, Walter Zieglgänsberger, Vincenzo Di Marzo, Beat Lutz.
  Nature. 2002-08-01. 418 (6897) : 530-534.
  DOI: 10.1038/nature00839
• Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1.
  Giovanni Marsicano, Bernd Moosmann, Heike Hermann, Beat Lutz, Christian Behl.
  J Neurochem. 2002-02-01. 80 (3) : 448-456.
  DOI: 10.1046/j.0022-3042.2001.00716.x
• Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1.
  Giovanni Marsicano, Bernd Moosmann, Heike Hermann, Beat Lutz, Christian Behl.
  J Neurochem. 2002-02-01. 80 (3) : 448-456.
  DOI: 10.1046/j.0022-3042.2001.00716.x
• Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endogenous cannabinoids: first evidence for a direct role of cannabinoids on hormone modulation at the human pituitary level.
  U. Pagotto, G. Marsicano, F. Fezza, M. Theodoropoulou, Y. Grübler, J. Stalla, T. Arzberger, A. Milone, M. Losa, V. Di Marzo, B. Lutz, G. K. Stalla.
  The Journal of Clinical Endocrinology & Metabolism. 2001-06-01. 86 (6) : 2687-2696.
  DOI: 10.1210/jcem.86.6.7565
• Differential role of the nitric oxide pathway on delta(9)-THC-induced central nervous system effects in the mouse.
  Shahnaz Christina Azad, Giovanni Marsicano, Irina Eberlein, Jörg Putzke, Walter Zieglgänsberger, Rainer Spanagel, Beat Lutz.
  European Journal of Neuroscience. 2001-02-01. 13 (3) : 561-568.
  DOI: 10.1046/j.1460-9568.2001.01431.x
• Differential role of the nitric oxide pathway on delta(9)-THC-induced central nervous system effects in the mouse.
  Shahnaz Christina Azad, Giovanni Marsicano, Irina Eberlein, Jörg Putzke, Walter Zieglgänsberger, Rainer Spanagel, Beat Lutz.
  European Journal of Neuroscience. 2001-02-01. 13 (3) : 561-568.
  DOI: 10.1046/j.1460-9568.2001.01431.x
• An in vivo model of hyperacute rejection: characterization and evaluation of the effect of transgenic human complement inhibitors.
  Marirosa Mora, Massimo Lazzeri, Giovanni Marsicano, Lubbertus C.F. Mulder, Laura Carraresi, Alessandro Pieri, Alessio Benanchi, Daniela Grifoni, Sandra Nuti, Paolo Bruzzone, Mario Comporti, Raffaello Cortesini, Mara Rossini.
  Transgenic Research. 2000-01-01. 9 (3) : 205-213.
  DOI: 10.1023/a:1008928713058
• Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain.
  Giovanni Marsicano, Beat Lutz.
  European Journal of Neuroscience. 1999-12-01. 11 (12) : 4213-4225.
  DOI: 10.1046/j.1460-9568.1999.00847.x
• Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain.
  Giovanni Marsicano, Beat Lutz.
  European Journal of Neuroscience. 1999-12-01. 11 (12) : 4213-4225.
  DOI: 10.1046/j.1460-9568.1999.00847.x
• Kidneys derived from mice transgenic for human complement blockers are protected in an in vivo model of hyperacute rejection.
  MASSIMO LAZZERI, MARIROSA MORA, LUBBERTUS C.F. MULDER, GIOVANNI MARSICANO, GIOVANNI MARINUCCI, MANUELA BOSCHI, PAOLO BRUZZONE, DARIO ALFANI, RAFFAELLO CORTESINI, MARA ROSSINI.
  The Journal of Urology. 1998-04-01. 159 (4) : 1364-1369.
  DOI: 10.1016/s0022-5347(01)63617-6
• Factors controlling haemopoiesis in ovine long-term bone marrow cultures.
  Giovanni Marsicano, Donika Shehu, Cesare Galli.
  Veterinary Immunology and Immunopathology. 1997-03-01. 55 (4) : 291-301.
  DOI: 10.1016/s0165-2427(96)05599-7