Luigi Bellocchio

Publications

• Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice
  Paula Gómez-Sotres, Urszula Skupio, Tommaso Dalla Tor, Francisca Julio-Kalajzic, Astrid Cannich, Doriane Gisquet, Itziar Bonilla-Del Rio, Filippo Drago, Nagore Puente, Pedro Grandes, Luigi Bellocchio, Arnau Busquets-Garcia, Jaideep S. Bains, Giovanni Marsicano.
  Nat Commun. 2024-08-18. 15(1)
  10.1038/s41467-024-51416-4
• A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes in male mice.
  Ignacio Fernández-Moncada, Gianluca Lavanco, Unai B. Fundazuri, Nasrin Bollmohr, Sarah Mountadem, Tommaso Dalla Tor, Pauline Hachaguer, Francisca Julio-Kalajzic, Doriane Gisquet, Roman Serrat, Luigi Bellocchio, Astrid Cannich, Bérénice Fortunato-Marsol, Yusuke Nasu, Robert E. Campbell, Filippo Drago, Carla Cannizzaro, Guillaume Ferreira, Anne-Karine Bouzier-Sore, Luc Pellerin, Juan P. Bolaños, Gilles Bonvento, L. Felipe Barros, Stephane H. R. Oliet, Aude Panatier, Giovanni Marsicano.
  Nat Commun. 2024-08-09. 15(1)
  10.1038/s41467-024-51008-2
• Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity
  Stéphane Leon, Vincent Simon, Thomas H. Lee, Lukas Steuernagel, Samantha Clark, Nasim Biglari, Thierry Lesté-Lasserre, Nathalie Dupuy, Astrid Cannich, Luigi Bellocchio, Philippe Zizzari, Camille Allard, Delphine Gonzales, Yves Le Feuvre, Emeline Lhuillier, Alexandre Brochard, Jean Charles Nicolas, Jérémie Teillon, Macha Nikolski, Giovanni Marsicano, Xavier Fioramonti, Jens C. Brüning, Daniela Cota, Carmelo Quarta.
  Nat Commun. 2024-04-24. 15(1)
  10.1038/s41467-024-47877-2
• Striatopallidal cannabinoid type-1 receptors mediate amphetamine-induced sensitization
  Yamuna Mariani, Ana Covelo, Rui S. Rodrigues, Francisca Julio-Kalajzić, Antonio C. Pagano Zottola, Gianluca Lavanco, Michela Fabrizio, Doriane Gisquet, Filippo Drago, Astrid Cannich, Jerome Baufreton, Giovanni Marsicano, Luigi Bellocchio.
  Current Biology. 2023-11-01. 33(22) : 5011-5022.e6.
  10.1016/j.cub.2023.09.075
• Type‐1 cannabinoid receptors and their ever‐expanding roles in brain energy processes
  Ignacio Fernández‐Moncada, Rui S. Rodrigues, Unai B. Fundazuri, Luigi Bellocchio, Giovanni Marsicano.
  Journal of Neurochemistry. 2023-07-28.
  10.1111/jnc.15922
• Early Administration of the Phytocannabinoid Cannabidivarin Prevents the Neurobehavioral Abnormalities Associated with the Fmr1-KO Mouse Model of Fragile X Syndrome
  Marika Premoli, William Fyke, Luigi Bellocchio, Valerie Lemaire, Marie Wolley-Roberts, Bruno Bontempi, Susanna Pietropaolo.
  Cells. 2023-07-25. 12(15) : 1927.
  10.3390/cells12151927
• Signaling-specific inhibition of the CB₁ receptor for cannabis use disorder: phase 1 and phase 2a randomized trials.
  Margaret Haney, Monique Vallée, Sandy Fabre, Stephanie Collins Reed, Marion Zanese, Ghislaine Campistron, Caroline A. Arout, Richard W. Foltin, Ziva D. Cooper, Tonisha Kearney-Ramos, Mathilde Metna, Zuzana Justinova, Charles Schindler, Etienne Hebert-Chatelain, Luigi Bellocchio, Adeline Cathala, Andrea Bari, Roman Serrat, David B. Finlay, Filippo Caraci, Bastien Redon, Elena Martín-García, Arnau Busquets-Garcia, Isabelle Matias, Frances R. Levin, François-Xavier Felpin, Nicolas Simon, Daniela Cota, Umberto Spampinato, Rafael Maldonado, Yavin Shaham, Michelle Glass, Lars Lykke Thomsen, Helle Mengel, Giovanni Marsicano, Stéphanie Monlezun, Jean-Michel Revest, Pier Vincenzo Piazza.
  Nat Med. 2023-06-01. 29(6) : 1487-1499.
  10.1038/s41591-023-02381-w
• Mitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition
  Urszula Skupio, Julia Welte, Roman Serrat, Abel Eraso-Pichot, Francisca Julio-Kalajzić, Doriane Gisquet, Astrid Cannich, Sebastien Delcasso, Isabelle Matias, Unai B. Fundazuri, Sandrine Pouvreau, Antonio C. Pagano Zottola, Gianluca Lavanco, Filippo Drago, Inigo Ruiz de Azua, Beat Lutz, Luigi Bellocchio, Arnau Busquets-Garcia, Francis Chaouloff, Giovanni Marsicano.
  Neuron. 2023-04-01.
  10.1016/j.neuron.2023.04.001
• Expression of Functional Cannabinoid Type-1 (CB1) Receptor in Mitochondria of White Adipocytes
  Antonio C. Pagano Zottola, Ilenia Severi, Astrid Cannich, Philippe Ciofi, Daniela Cota, Giovanni Marsicano, Antonio Giordano, Luigi Bellocchio.
  Cells. 2022-08-19. 11(16) : 2582.
  10.3390/cells11162582
• Cannabinoid Signalling in the Brain: New Vistas
  A. Busquets‐Garcia, M. Melis, L. Bellocchio, G. Marsicano.
  Eur J of Neuroscience. 2022-02-03.
  10.1111/ejn.15618
• Functional heterogeneity of POMC neurons relies on mTORC1 signaling
  Nicolas Saucisse, Wilfrid Mazier, Vincent Simon, Elke Binder, Caterina Catania, Luigi Bellocchio, Roman A. Romanov, Stéphane Léon, Isabelle Matias, Philippe Zizzari, Carmelo Quarta, Astrid Cannich, Kana Meece, Delphine Gonzales, Samantha Clark, Julia M. Becker, Giles S.H. Yeo, Xavier Fioramonti, Florian T. Merkle, Sharon L. Wardlaw, Tibor Harkany, Federico Massa, Giovanni Marsicano, Daniela Cota.
  Cell Reports. 2021-10-01. 37(2) : 109800.
  10.1016/j.celrep.2021.109800
• Subcellular specificity of cannabinoid effects in striatonigral circuits.
  Soria-Gomez E, Pagano Zottola AC, Mariani Y, Desprez T, Barresi M, Bonilla-Del Río I, Muguruza C, Le Bon-Jego M, Julio-Kalajzić F, Flynn R, Terral G, Fernández-Moncada I, Robin LM, Oliveira da Cruz JF, Corinti S, Amer YO, Goncalves J, Varilh M, Cannich A, Redon B, Zhao Z, Lesté-Lasserre T, Vincent P, Tolentino-Cortes T, Busquets-García A, Puente N, Bains JS, Hebert-Chatelain E, Barreda-Gómez G, Chaouloff F, Lohman AW, Callado LF, Grandes P, Baufreton J, Marsicano G, Bellocchio L..
  Neuron. 2021-03-01.
  10.1016/j.neuron.2021.03.007
• A Novel Cortical Mechanism for Top-Down Control of Water Intake.
  Zhe Zhao, Edgar Soria-Gómez, Marjorie Varilh, Ana Covelo, Francisca Julio-Kalajzić, Astrid Cannich, Adriana Castiglione, Léonie Vanhoutte, Alexia Duveau, Philippe Zizzari, Anna Beyeler, Daniela Cota, Luigi Bellocchio, Arnau Busquets-Garcia, Giovanni Marsicano.
  Current Biology. 2020-12-01. 30(23) : 4789-4798.e4.
  10.1016/j.cub.2020.09.011
• CB1 and GLP-1 Receptors Cross-Talk Provides New Therapies for Obesity
  Philippe Zizzari, Rongjun He , Sarah Falk, Luigi Bellocchio, Camille Allard, Samantha Clark, Thierry Lesté-Lasserre, Giovanni Marsicano, Christoffer Clemmensen, Diego Perez-Tilve , Brian Finan, Daniela Cota, Carmelo Quarta..
  Diabetes. 2020-10.
  10.2337/db20-0162
• Cannabinoid-induced motor dysfunction via autophagy inhibition
  Cristina Blázquez, Andrea Ruiz-Calvo, Raquel Bajo-Grañeras, Jerome M. Baufreton, Eva Resel, Marjorie Varilh, Antonio C. Pagano Zottola, Yamuna Mariani, Astrid Cannich, José A. Rodríguez-Navarro, Giovanni Marsicano, Ismael Galve-Roperh, Luigi Bellocchio, Manuel Guzmán.
  Autophagy. 2020-10-20. 16(12) : 2289-2291.
  10.1080/15548627.2020.1827560
• Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination
  Cristina Blázquez, Andrea Ruiz-Calvo, Raquel Bajo-Grañeras, Jérôme M Baufreton, Eva Resel, Marjorie Varilh, Antonio C Pagano Zottola, Yamuna Mariani, Astrid Cannich, José A Rodríguez-Navarro, Giovanni Marsicano, Ismael Galve-Roperh, Luigi Bellocchio, Manuel Guzmán.
  eLife. 2020-08-10. 9
  10.7554/eLife.56811
• Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory
  Jose F. Oliveira da Cruz, Arnau Busquets-Garcia, Zhe Zhao, Marjorie Varilh, Gianluca Lavanco, Luigi Bellocchio, Laurie Robin, Astrid Cannich, Francisca Julio-Kalajzić, Thierry Lesté-Lasserre, Marlène Maître, Filippo Drago, Giovanni Marsicano, Edgar Soria-Gómez.
  Cell Reports. 2020-08-01. 32(7) : 108046.
  10.1016/j.celrep.2020.108046
• Glucose metabolism links astroglial mitochondria to cannabinoid effects
  Daniel Jimenez-Blasco, Arnau Busquets-Garcia, Etienne Hebert-Chatelain, Roman Serrat, Carlos Vicente-Gutierrez, Christina Ioannidou, Paula Gómez-Sotres, Irene Lopez-Fabuel, Monica Resch-Beusher, Eva Resel, Dorian Arnouil, Dave Saraswat, Marjorie Varilh, Astrid Cannich, Francisca Julio-Kalajzic, Itziar Bonilla-Del Río, Angeles Almeida, Nagore Puente, Svein Achicallende, Maria-Luz Lopez-Rodriguez, Charlotte Jollé, Nicole Déglon, Luc Pellerin, Charlène Josephine, Gilles Bonvento, Aude Panatier, Beat Lutz, Pier-Vincenzo Piazza, Manuel Guzmán, Luigi Bellocchio, Anne-Karine Bouzier-Sore, Pedro Grandes, Juan P. Bolaños, Giovanni Marsicano.
  Nature. 2020-07-08.
  10.1038/s41586-020-2470-y
• Structural basis of astrocytic Ca2+ signals at tripartite synapses
  Misa Arizono, V. V. G. Krishna Inavalli, Aude Panatier, Thomas Pfeiffer, Julie Angibaud, Florian Levet, Mirelle J. T. Ter Veer, Jillian Stobart, Luigi Bellocchio, Katsuhiko Mikoshiba, Giovanni Marsicano, Bruno Weber, Stéphane H. R. Oliet, U. Valentin Nägerl.
  Nat Commun. 2020-04-20. 11(1)
  10.1038/s41467-020-15648-4
• Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity
  Michelle Corkrum, Ana Covelo, Justin Lines, Luigi Bellocchio, Marc Pisansky, Kelvin Loke, Ruth Quintana, Patrick E. Rothwell, Rafael Lujan, Giovanni Marsicano, Eduardo D. Martin, Mark J. Thomas, Paulo Kofuji, Alfonso Araque.
  Neuron. 2020-03-01. 105(6) : 1036-1047.e5.
  10.1016/j.neuron.2019.12.026
• Alpha technology: A powerful tool to detect mouse brain intracellular signaling events
  Marion Zanese, Giovanni Tomaselli, Valérie Roullot-Lacarrière, Maïté Moreau, Luigi Bellocchio, Agnès Grel, Giovanni Marsicano, Nathalie Sans, Monique Vallée, Jean-Michel Revest.
  Journal of Neuroscience Methods. 2020-02-01. 332 : 108543.
  10.1016/j.jneumeth.2019.108543
• The role of the endocannabinoid system in autism spectrum disorders: Evidence from mouse studies.
  Susanna Pietropaolo, Luigi Bellocchio, Inés Bouzón-Arnáiz, Benjamin K. Yee.
  Progress in Molecular Biology and Translational Science. 2020-01-01. : 183-208.
  10.1016/bs.pmbts.2020.04.016
• Top-down control of water intake by the endocannabinoid system
  Zhe Zhao, Edgar Soria-Gómez, Marjorie Varilh, Francisca Julio-Kalajzić, Astrid Cannich, Adriana Castiglione, Léonie Vanhoutte, Alexia Duveau, Philippe Zizzari, Anna Beyeler, Daniela Cota, Luigi Bellocchio, Arnau Busquets-Garcia, Giovanni Marsicano.
  Preprint bioRxiv. 2019-08-09.
  10.1101/729970
• CB1 Receptors in the Anterior Piriform Cortex Control Odor Preference Memory
  Geoffrey Terral, Arnau Busquets-Garcia, Marjorie Varilh, Svein Achicallende, Astrid Cannich, Luigi Bellocchio, Itziar Bonilla-Del Río, Federico Massa, Nagore Puente, Edgar Soria-Gomez, Pedro Grandes, Guillaume Ferreira, Giovanni Marsicano.
  Current Biology. 2019-08-01. 29(15) : 2455-2464.e5.
  10.1016/j.cub.2019.06.041
• Dissecting the cannabinergic control of behavior: The where matters.
  Arnau Busquets-Garcia, Tifany Desprez, Mathilde Metna-Laurent, Luigi Bellocchio, Giovanni Marsicano, Edgar Soria-Gomez.
  BioEssays. 2015-08-11. 37(11) : 1215-1225.
  10.1002/bies.201500046
• Chronic cannabinoid receptor stimulation selectively prevents motor impairments in a mouse model of Huntington’s disease.
  Susanna Pietropaolo, Luigi Bellocchio, Andrea Ruiz-Calvo, Magali Cabanas, Zhuowei Du, Manuel Guzmán, Maurice Garret, Yoon H. Cho.
  Neuropharmacology. 2015-02-01. 89 : 368-374.
  10.1016/j.neuropharm.2014.07.021
• CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin.
  Pierre Cardinal, Caroline André, Carmelo Quarta, Luigi Bellocchio, Samantha Clark, Melissa Elie, Thierry Leste-Lasserre, Marlene Maitre, Delphine Gonzales, Astrid Cannich, Uberto Pagotto, Giovanni Marsicano, Daniela Cota.
  Molecular Metabolism. 2014-10-01. 3(7) : 705-716.
  10.1016/j.molmet.2014.07.004
• Pregnenolone can protect the brain from cannabis intoxication.
  Monique Vallée, Sergio Vitiello, Luigi Bellocchio, Etienne Hébert-Chatelain, Stéphanie Monlezun, Elena Martin-Garcia, Fernando Kasanetz, Gemma L. Baillie, Francesca Panin, Adeline Cathala, Valérie Roullot-Lacarrière, Sandy Fabre, Dow P. Hurst, Diane L. Lynch, Derek M. Shore, Véronique Deroche-Gamonet, Umberto Spampinato, Jean-Michel Revest, Rafael Maldonado, Patricia H. Reggio, Ruth A. Ross, Giovanni Marsicano, Pier Vincenzo Piazza.
  Science. 2014-01-02. 343(6166) : 94-98.
  10.1126/science.1243985
• CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance.
  Carmelo Quarta, Luigi Bellocchio, Giacomo Mancini, Roberta Mazza, Cristina Cervino, Luzie J. Braulke, Csaba Fekete, Rocco Latorre, Cristina Nanni, Marco Bucci, Laura E. Clemens, Gerhard Heldmaier, Masahiko Watanabe, Thierry Leste-Lassere, Marlène Maitre, Laura Tedesco, Flaminia Fanelli, Stefan Reuss, Susanne Klaus, Raj Kamal Srivastava, Krisztina Monory, Alessandra Valerio, Annamaria Grandis, Roberto De Giorgio, Renato Pasquali, Enzo Nisoli, Daniela Cota, Beat Lutz, Giovanni Marsicano, Uberto Pagotto.
  Cell Metabolism. 2010-04-01. 11(4) : 273-285.
  10.1016/j.cmet.2010.02.015