Jonathan Elegheert
Career
After studying medicine (BSc) and biochemistry (MSc), I obtained my PhD in 2012 from Ghent University (Belgium), where I studied the structural biology of Colony-Stimulating Factor 1 (CSF-1) cytokine signalling in the lab of Prof. Savvas N. Savvides as a Research Foundation – Flanders (FWO)-funded doctoral fellow. In 2012, I joined the Division of Structural Biology (STRUBI) at the University of Oxford (UK) as an EMBO- and Marie Curie Actions-funded postdoctoral fellow. There, I transitioned into molecular neuroscience and investigated the structural biology of synaptic protein complexes, in the lab of Prof. A. Radu Aricescu. In 2018, I joined the IINS as a team leader enabled by an Initiative of Excellence (IdEx) Junior Chair (University of Bordeaux) and a Neurocampus starting package (Conseil Régional de la Nouvelle Aquitaine). In 2019, I was recruited to the CNRS, was a laureate of the CNRS-Inserm ATIP-Avenir program and obtained an ERC Starting Grant.
Publications
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GRID1/GluD1 homozygous variants linked to intellectual disability and spastic paraplegia impair mGlu1/5 receptor signaling and excitatory synapses
Mol Psychiatry. 2024-02-28.
10.1038/s41380-024-02469-w -
Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling
Cell. 2021-04-01. 184(8) : 2103-2120.e31.
10.1016/j.cell.2021.02.045 -
High-Level Production of Recombinant Eukaryotic Proteins from Mammalian Cells Using Lentivirus.
Methods in Molecular Biology. 2021-01-01. : 83-104.
10.1007/978-1-0716-1406-8_4 -
A synthetic synaptic organizer protein restores glutamatergic neuronal circuits.
Science. . 369(6507) : 1052-1053.
10.1126/science.abb4853 -
A synthetic synaptic organizer protein restores glutamatergic neuronal circuits
. 2020-02-27.
10.1101/2020.02.27.967836 -
Pumping the brakes: suppression of synapse development by MDGA-neuroligin interactions.
Current Opinion in Neurobiology. 2019-08-01. 57 : 71-80.
10.1016/j.conb.2019.01.002 -
Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins
Nat Protoc. 2018-11-19. 13(12) : 2991-3017.
10.1038/s41596-018-0075-9 -
Calibration-free in vitro quantification of protein homo-oligomerization using commercial instrumentation and free, open source brightness analysis software
JoVE. 2018-07-17. (137)
10.3791/58157 -
Structural dissection of Shewanella oneidensis old yellow enzyme 4 bound to a Meisenheimer complex and (nitro)phenolic ligands
FEBS Lett. 2017-09-15. 591(20) : 3391-3401.
10.1002/1873-3468.12833 -
Erratum: Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins (Journal Article (2017) 95(4) (896–913.e10) (S0896627317306888)(10.1016/j.neuron.2017.07.040))
Neuron. 2017-09-01. 96(1) : 242-244.
10.1016/j.neuron.2017.09.011 -
Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins.
Neuron. 2017-09-01. 96(1) : 242-244.
10.1016/j.neuron.2017.07.040 -
Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins
Neuron. 2017-08-01. 95(4) : 896-913.e10.
10.1016/j.neuron.2017.07.040 -
nandb-number and brightness in R with a novel automatic detrending algorithm.
Bioinformatics. 2017-07-11. 33(21) : 3508-3510.
10.1093/bioinformatics/btx434 -
Structural basis for integration of GluD receptors within synaptic organizer complexes.
Science. 2016-07-14. 353(6296) : 295-299.
10.1126/science.aae0104 -
Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1.
Structure. 2015-09-01. 23(9) : 1621-1631.
10.1016/j.str.2015.06.019 -
Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.
eLife. 2015-07-09. 4
10.7554/eLife.06554 -
Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein.
Nat Struct Mol Biol. 2015-05-04. 22(6) : 458-465.
10.1038/nsmb.3016 -
Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis
Nat Commun. 2014-11-11. 5(1)
10.1038/ncomms6209 -
The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Nucleic Acids Research. 2014-07-23. 42(15) : 10134-10147.
10.1093/nar/gku665 -
Human IL-34 and CSF-1 establish structurally similar extracellular assemblies with their common hematopoietic receptor.
Structure. 2013-04-01. 21(4) : 528-539.
10.1016/j.str.2013.01.018 -
Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1.
Nat Struct Mol Biol. 2012-08-19. 19(9) : 938-947.
10.1038/nsmb.2367 -
Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles.
Structure. 2011-12-01. 19(12) : 1762-1772.
10.1016/j.str.2011.10.012 -
Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex.
Blood. 2011-03-09. 118(1) : 60-68.
10.1182/blood-2011-01-329532 -
Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes
Acta Crystallogr F Struct Biol Cryst Commun. 2011-02-23. 67(3) : 325-331.
10.1107/S1744309111003319 -
Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes.
Acta Cryst Sect F. 2011-02-23. 67(3) : 325-331.
10.1107/S1744309111003319 -
Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA.
Proceedings of the National Academy of Sciences. 2010-07-13. 107(30) : 13270-13275.
10.1073/pnas.1005198107 -
Towards structural studies of the old yellow enzyme homologue SYE4 from Shewanella oneidensis and its complexes at atomic resolution
Acta Crystallogr F Struct Biol Cryst Commun. 2009-12-25. 66(1) : 85-90.
10.1107/S1744309109050386 -
Towards structural studies of the old yellow enzyme homologue SYE4 from Shewanella oneidensis and its complexes at atomic resolution.
Acta Cryst Sect F. 2009-12-25. 66(1) : 85-90.
10.1107/S1744309109050386