Ignacio Fernandez Moncada

Publications

• A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes in male mice.
  Ignacio Fernández-Moncada, Gianluca Lavanco, Unai B. Fundazuri, Nasrin Bollmohr, Sarah Mountadem, Tommaso Dalla Tor, Pauline Hachaguer, Francisca Julio-Kalajzic, Doriane Gisquet, Roman Serrat, Luigi Bellocchio, Astrid Cannich, Bérénice Fortunato-Marsol, Yusuke Nasu, Robert E. Campbell, Filippo Drago, Carla Cannizzaro, Guillaume Ferreira, Anne-Karine Bouzier-Sore, Luc Pellerin, Juan P. Bolaños, Gilles Bonvento, L. Felipe Barros, Stephane H. R. Oliet, Aude Panatier, Giovanni Marsicano.
  Nat Commun. 2024-08-09. 15(1)
  10.1038/s41467-024-51008-2
• An enquiry to the role of CB1 receptors in neurodegeneration.
  Ignacio Fernández-Moncada, Abel Eraso-Pichot, Tommaso Dalla Tor, Bérénice Fortunato-Marsol, Giovanni Marsicano.
  Neurobiology of Disease. 2023-08-01. 184 : 106235.
  10.1016/j.nbd.2023.106235
• Type‐1 cannabinoid receptors and their ever‐expanding roles in brain energy processes
  Ignacio Fernández‐Moncada, Rui S. Rodrigues, Unai B. Fundazuri, Luigi Bellocchio, Giovanni Marsicano.
  Journal of Neurochemistry. 2023-07-28.
  10.1111/jnc.15922
• Metabolic Recruitment in Brain Tissue.
  L.F. Barros, I. Ruminot, T. Sotelo-Hitschfeld, R. Lerchundi, I. Fernández-Moncada.
  Annu. Rev. Physiol.. 2023-02-10. 85(1) : 115-135.
  10.1146/annurev-physiol-021422-091035
• Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?
  Ignacio Fernández-Moncada,Giovanni Marsicano.
  Essays in Biochemistry. 2023-01-16.
  10.1042/EBC20220089
• Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis.
  Joris Guyon, Ignacio Fernandez‐Moncada, Claire M Larrieu, Cyrielle L Bouchez, Antonio C Pagano Zottola, Johanna Galvis, Tiffanie Chouleur, Audrey Burban, Kevin Joseph, Vidhya M Ravi, Heidi Espedal, Gro Vatne Røsland, Boutaina Daher, Aurélien Barre, Benjamin Dartigues, Slim Karkar, Justine Rudewicz, Irati Romero‐Garmendia, Barbara Klink, Konrad Grützmann, Marie‐Alix Derieppe, Thibaut Molinié, Nina Obad, Céline Léon, Giorgio Seano, Hrvoje Miletic, Dieter Henrik Heiland, Giovanni Marsicano, Macha Nikolski, Rolf Bjerkvig, Andreas Bikfalvi, Thomas Daubon.
  EMBO Mol Med. 2022-10-24.
  10.15252/emmm.202115343
• Inhibition of the sodium-dependent HCO3- transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype.
  Vinciane Saint-Criq, Anita Guequén, Amber R Philp, Sandra Villanueva, Tábata Apablaza, Ignacio Fernández-Moncada, Agustín Mansilla, Livia Delpiano, Iván Ruminot, Cristian Carrasco, Michael A Gray, Carlos A Flores.
  eLife. 2022-05-30. 11
  10.7554/elife.75871
• CB1R-dependent regulation of astrocyte physiology and astrocyte-neuron interactions
  Ana Covelo, Abel Eraso-Pichot, Ignacio Fernández-Moncada, Román Serrat, Giovanni Marsicano.
  Neuropharmacology. 2021-06-01. : 108678.
  10.1016/j.neuropharm.2021.108678
• Subcellular specificity of cannabinoid effects in striatonigral circuits.
  Soria-Gomez E, Pagano Zottola AC, Mariani Y, Desprez T, Barresi M, Bonilla-Del Río I, Muguruza C, Le Bon-Jego M, Julio-Kalajzić F, Flynn R, Terral G, Fernández-Moncada I, Robin LM, Oliveira da Cruz JF, Corinti S, Amer YO, Goncalves J, Varilh M, Cannich A, Redon B, Zhao Z, Lesté-Lasserre T, Vincent P, Tolentino-Cortes T, Busquets-García A, Puente N, Bains JS, Hebert-Chatelain E, Barreda-Gómez G, Chaouloff F, Lohman AW, Callado LF, Grandes P, Baufreton J, Marsicano G, Bellocchio L..
  Neuron. 2021-03-01.
  10.1016/j.neuron.2021.03.007
• Bidirectional astrocytic GLUT1 activation by elevated extracellular K+
  Ignacio Fernández‐Moncada, Daniel Robles‐Maldonado, Pablo Castro, Karin Alegría, Robert Epp, Iván Ruminot, Luis Felipe Barros.
  Glia. 2020-12-05. 69(4) : 1012-1021.
  10.1002/glia.23944
• Aerobic Glycolysis in the Brain: Warburg and Crabtree Contra Pasteur
  L. Felipe Barros, Iván Ruminot, Alejandro San Martín, Rodrigo Lerchundi, Ignacio Fernández-Moncada, Felipe Baeza-Lehnert.
  Neurochem Res. 2020-01-24.
  10.1007/s11064-020-02964-w
• Neuronal control of astrocytic respiration through a variant of the Crabtree effect
  Ignacio Fernández-Moncada, Iván Ruminot, Daniel Robles-Maldonado, Karin Alegría, Joachim W. Deitmer, L. Felipe Barros.
  Proc Natl Acad Sci USA. 2018-01-29. 115(7) : 1623-1628.
  10.1073/pnas.1716469115
• Near-critical GLUT1 and Neurodegeneration
  L. Felipe Barros, Alejandro San Martín, Ivan Ruminot, Pamela Y. Sandoval, Ignacio Fernández-Moncada, Felipe Baeza-Lehnert, Robinson Arce-Molina, Yasna Contreras-Baeza, Francisca Cortés-Molina, Alex Galaz, Karin Alegría.
  Journal of Neuroscience Research. 2017-02-02. 95(11) : 2267-2274.
  10.1002/jnr.23998
• Targeting of astrocytic glucose metabolism by beta-hydroxybutyrate
  Rocío Valdebenito, Iván Ruminot, Pamela Garrido-Gerter, Ignacio Fernández-Moncada, Linda Forero-Quintero, Karin Alegría, Holger M Becker, Joachim W Deitmer, L Felipe Barros.
  J Cereb Blood Flow Metab. 2016-07-22. 36(10) : 1813-1822.
  10.1177/0271678X15613955
• NH4+ triggers the release of astrocytic lactate via mitochondrial pyruvate shunting
  Rodrigo Lerchundi, Ignacio Fernández-Moncada, Yasna Contreras-Baeza, Tamara Sotelo-Hitschfeld, Philipp Mächler, Matthias T. Wyss, Jillian Stobart, Felipe Baeza-Lehnert, Karin Alegría, Bruno Weber, L. Felipe Barros.
  Proc Natl Acad Sci USA. 2015-08-18. 112(35) : 11090-11095.
  10.1073/pnas.1508259112
• Channel-mediated lactate release by K+ stimulated astrocytes
  T. Sotelo-Hitschfeld, M. I. Niemeyer, P. Machler, I. Ruminot, R. Lerchundi, M. T. Wyss, J. Stobart, I. Fernandez-Moncada, R. Valdebenito, P. Garrido-Gerter, Y. Contreras-Baeza, B. L. Schneider, P. Aebischer, S. Lengacher, A. San Martin, J. Le Douce, G. Bonvento, P. J. Magistretti, F. V. Sepulveda, B. Weber, L. F. Barros.
  Journal of Neuroscience. 2015-03-11. 35(10) : 4168-4178.
  10.1523/JNEUROSCI.5036-14.2015
• Single-cell imaging tools for brain energy metabolism: a review
  Alejandro San Martín, Tamara Sotelo-Hitschfeld, Rodrigo Lerchundi, Ignacio Fernández-Moncada, Sebastian Ceballo, Rocío Valdebenito, Felipe Baeza-Lehnert, Karin Alegría, Yasna Contreras-Baeza, Pamela Garrido-Gerter, Ignacio Romero-Gómez, L. Felipe Barros.
  Neurophoton. 2014-06-12. 1(1) : 011004.
  10.1117/1.nph.1.1.011004
• Non-preferential fuelling of the Na+/K+-ATPase pump
  Ignacio Fernández-Moncada, L. Felipe Barros.
  Biochemical Journal. 2014-05-29. 460(3) : 353-361.
  10.1042/bj20140003
• Small is fast: Astrocytic glucose and lactate metabolism at cellular resolution
  L. F. Barros, A. San Martín, T. Sotelo-Hitschfeld, R. Lerchundi, I. Fernández-Moncada, I. Ruminot, R. Gutiérrez, R. Valdebenito, S. Ceballo, K. Alegría, F. Baeza-Lehnert, D. Espinoza.
  Front. Cell. Neurosci.. 2013-01-01. 7
  10.3389/fncel.2013.00027
• Acute feedback control of astrocytic glycolysis by lactate
  T. Sotelo-Hitschfeld, I. FernáNdez-Moncada, L. F. Barros.
  Glia. 2012-01-30. 60(4) : 674-680.
  10.1002/glia.22304