Gregory Giannone

Publications

• Actin-driven nanotopography promotes stable integrin adhesion formation in developing tissue
  Tianchi Chen, Cecilia H. Fernández-Espartero, Abigail Illand, Ching-Ting Tsai, Yang Yang, Benjamin Klapholz, Pierre Jouchet, Mélanie Fabre, Olivier Rossier, Bianxiao Cui, Sandrine Lévêque-Fort, Nicholas H. Brown, Grégory Giannone.
  Nat Commun. 2024-10-07. 15(1)
  10.1038/s41467-024-52899-x
• Integrin-based adhesion compartmentalizes ALK3 of the BMPRII to control cell adhesion and migration
  Amaris Guevara-Garcia, Laure Fourel, Ingrid Bourrin-Reynard, Adria Sales, Christiane Oddou, Mylène Pezet, Olivier Rossier, Paul Machillot, Line Chaar, Anne-Pascale Bouin, Gregory Giannone, Olivier Destaing, Catherine Picart, Corinne Albiges-Rizo.
  Journal of Cell Biology. 2022-10-07. 221(12)
  10.1083/jcb.202107110
• Talin and kindlin cooperate to control the density of integrin clusters
  Julien Pernier, Marcelina Cardoso Dos Santos, Mariem Souissi, Adrien Joly, Hemalatha Narassimprakash, Olivier Rossier, Grégory Giannone, Emmanuèle Helfer, Kheya Sengupta, Christophe Le Clainche.
  . 2022-10-07.
  10.1101/2022.10.07.511266
• Novel imaging methods and force probes for molecular mechanobiology of cytoskeleton and adhesion
  Filipe Nunes Vicente, Tianchi Chen, Olivier Rossier, Grégory Giannone.
  Trends in Cell Biology. 2022-08-01.
  10.1016/j.tcb.2022.07.008
• Une fenêtre sur la mécano-biologie à l’échelle moléculaire grâce à la microscopie de super-résolution
  Filipe Nunes Vicente, Olivier Rossier, Grégory Giannone.
  Med Sci (Paris). 2022-01-01. 38(1) : 15-17.
  10.1051/medsci/2021233
• Forces generated by lamellipodial actin filament elongation regulate the WAVE complex during cell migration
  Amine Mehidi, Frieda Kage, Zeynep Karatas, Maureen Cercy, Matthias Schaks, Anna Polesskaya, Matthieu Sainlos, Alexis M. Gautreau, Olivier Rossier, Klemens Rottner, Grégory Giannone.
  Nat Cell Biol. 2021-11-01. 23(11) : 1148-1162.
  10.1038/s41556-021-00786-8
• Integrin-Functionalised Giant Unilamellar Vesicles via Gel-Assisted Formation: Good Practices and Pitfalls
  Mariem Souissi, Julien Pernier, Olivier Rossier, Gregory Giannone, Christophe Le Clainche, Emmanuèle Helfer, Kheya Sengupta.
  IJMS. 2021-06-13. 22(12) : 6335.
  10.3390/ijms22126335
• Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions.
  Thomas Orré, Adrien Joly, Zeynep Karatas, Birgit Kastberger, Clément Cabriel, Ralph T. Böttcher, Sandrine Lévêque-Fort, Jean-Baptiste Sibarita, Reinhard Fässler, Bernhard Wehrle-Haller, Olivier Rossier, Grégory Giannone.
  Nat Commun. 2021-05-25. 12(1)
  10.1038/s41467-021-23372-w
• Engineering paralog-specific PSD-95 synthetic binders as potent and minimally invasive imaging probes
  Charlotte Rimbault, Christelle Breillat, Benjamin Compans, Estelle Toulmé, Filipe Nunes Vicente, Monica Fernandez-Monreal, Patrice Mascalchi, Camille Genuer, Virginia Puente-Muñoz, Isabel Gauthereau, Eric Hosy, Gregory Giannone, Ingrid Chamma, Cameron D. Mackereth, Christel Poujol, Daniel Choquet, Matthieu Sainlos.
  . 2021-04-08.
  10.1101/2021.04.07.438431
• Single-Protein Tracking to Study Protein Interactions During Integrin-Based Migration.
  A. V. Radhakrishnan, Tianchi Chen, Jose Filipe Nunes Vicente, Thomas Orré, Amine Mehidi, Olivier Rossier, Grégory Giannone.
  The Integrin Interactome. 2020-11-20. : 85-113.
  10.1007/978-1-0716-0962-0_8
• Cell stretching is amplified by active actin remodelling to deform and recruit proteins in mechanosensitive structures
  Sophie Massou, Filipe Nunes Vicente, Franziska Wetzel, Amine Mehidi, Dan Strehle, Cecile Leduc, Raphaël Voituriez, Olivier Rossier, Pierre Nassoy, Grégory Giannone.
  Nat Cell Biol. 2020-07-27.
  10.1038/s41556-020-0548-2
• A micromechanical cell stretching device compatible with super-resolution microscopy and single protein tracking
  Filipe Nunes Vicente, Sophie Massou, Franziska Wetzel, Amine Mehidi, Dan Strehle, Cecile Leduc, Raphaël Voituriez, Olivier Rossier, Nassoy Pierre, Grégory Giannone.
  . 2020-07-27.
  10.21203/rs.3.pex-961/v1
• Actin dynamics in cell migration.
  Matthias Schaks, Grégory Giannone, Klemens Rottner.
  Essays in Biochemistry. 2019-09-24. 63(5) : 483-495.
  10.1042/ebc20190015
• Transient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion.
  Amine Mehidi, Olivier Rossier, Matthias Schaks, Anaël Chazeau, Fabien Binamé, Amanda Remorino, Mathieu Coppey, Zeynep Karatas, Jean-Baptiste Sibarita, Klemens Rottner, Violaine Moreau, Grégory Giannone.
  Current Biology. 2019-09-01. 29(17) : 2852-2866.e5.
  10.1016/j.cub.2019.07.035
• The inner life of integrin adhesion sites: From single molecules to functional macromolecular complexes.
  Thomas Orré, Olivier Rossier, Grégory Giannone.
  Experimental Cell Research. 2019-06-01. 379(2) : 235-244.
  10.1016/j.yexcr.2019.03.036
• A tessellation-based colocalization analysis approach for single-molecule localization microscopy
  Florian Levet, Guillaume Julien, Rémi Galland, Corey Butler, Anne Beghin, Anaël Chazeau, Philipp Hoess, Jonas Ries, Grégory Giannone, Jean-Baptiste Sibarita.
  Nat Commun. 2019-05-30. 10(1)
  10.1038/s41467-019-10007-4
• Self-Interference (SELFI) Microscopy for Live Super-Resolution Imaging and Single Particle Tracking in 3D
  Jeanne Linarès-Loyez, Joana S. Ferreira, Olivier Rossier, Brahim Lounis, Gregory Giannone, Laurent Groc, Laurent Cognet, Pierre Bon.
  Front. Phys.. 2019-05-08. 7
  10.3389/fphy.2019.00068
• Using Single-Protein Tracking to Study Cell Migration.
  Thomas Orré, Amine Mehidi, Sophie Massou, Olivier Rossier, Grégory Giannone.
  Methods in Molecular Biology. 2018-01-01. : 291-311.
  10.1007/978-1-4939-7701-7_21
• Optimized labeling of membrane proteins for applications to super-resolution imaging in confined cellular environments using monomeric streptavidin
  Ingrid Chamma, Olivier Rossier, Grégory Giannone, Olivier Thoumine, Matthieu Sainlos.
  Nat Protoc. 2017-03-09. 12(4) : 748-763.
  10.1038/nprot.2017.010
• Organization and dynamics of the actin cytoskeleton during dendritic spine morphological remodeling.
  Anaël Chazeau, Grégory Giannone.
  Cell. Mol. Life Sci.. 2016-04-22. 73(16) : 3053-3073.
  10.1007/s00018-016-2214-1
• Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing.
  Roshni Basu, Benjamin M. Whitlock, Julien Husson, Audrey Le Floc’h, Weiyang Jin, Alon Oyler-Yaniv, Farokh Dotiwala, Gregory Giannone, Claire Hivroz, Nicolas Biais, Judy Lieberman, Lance C. Kam, Morgan Huse.
  Cell. 2016-03-01. 165(1) : 100-110.
  10.1016/j.cell.2016.01.021
• Super-resolution links vinculin localization to function in focal adhesions.
  Grégory Giannone.
  Nat Cell Biol. 2015-06-30. 17(7) : 845-847.
  10.1038/ncb3196
• Single-molecule imaging in live cell using gold nanoparticles.
  Cécile Leduc, Satyabrata Si, Jérémie J. Gautier, Zhenghong Gao, Edakkattuparambil S. Shibu, Alexis Gautreau, Grégory Giannone, Laurent Cognet, Brahim Lounis.
  Methods in Cell Biology. 2015-01-01. : 13-27.
  10.1016/bs.mcb.2014.10.002
• Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion.
  Anaël Chazeau, Amine Mehidi, Deepak Nair, Jérémie J Gautier, Cécile Leduc, Ingrid Chamma, Frieda Kage, Adel Kechkar, Olivier Thoumine, Klemens Rottner, Daniel Choquet, Alexis Gautreau, Jean‐Baptiste Sibarita, Grégory Giannone.
  EMBO J.. 2014-10-07. 33(23) : 2745-2764.
  10.15252/embj.201488837
• The cancer glycocalyx mechanically primes integrin-mediated growth and survival.
  Matthew J. Paszek, Christopher C. DuFort, Olivier Rossier, Russell Bainer, Janna K. Mouw, Kamil Godula, Jason E. Hudak, Jonathon N. Lakins, Amanda C. Wijekoon, Luke Cassereau, Matthew G. Rubashkin, Mark J. Magbanua, Kurt S. Thorn, Michael W. Davidson, Hope S. Rugo, John W. Park, Daniel A. Hammer, Grégory Giannone, Carolyn R. Bertozzi, Valerie M. Weaver.
  Nature. 2014-06-25. 511(7509) : 319-325.
  10.1038/nature13535
• Glutamate involvement in calcium-dependent migration of astrocytoma cells.
  Abdelkader Hamadi, Grégory Giannone, Kenneth Takeda, Philippe Rondé.
  Cancer Cell International. 2014-01-01. 14(1) : 42.
  10.1186/1475-2867-14-42
• A highly specific gold nanoprobe for live-cell single-molecule imaging.
  Cécile Leduc, Satyabrata Si, Jérémie Gautier, Martinho Soto-Ribeiro, Bernhard Wehrle-Haller, Alexis Gautreau, Grégory Giannone, Laurent Cognet, Brahim Lounis.
  Nano Lett.. 2013-03-06. 13(4) : 1489-1494.
  10.1021/nl304561g
• Quantum-yield-optimized fluorophores for site-specific labeling and super-resolution imaging.
  Christian Grunwald, Katrin Schulze, Gregory Giannone, Laurent Cognet, Brahim Lounis, Daniel Choquet, Robert Tampé.
  J. Am. Chem. Soc.. 2011-06-01. 133(21) : 8090-8093.
  10.1021/ja200967z
• Multi-level molecular clutches in motile cell processes.
  Grégory Giannone, René-Marc Mège, Olivier Thoumine.
  Trends in Cell Biology. 2009-09-01. 19(9) : 475-486.
  10.1016/j.tcb.2009.07.001
• Neurexin/neuroligin interaction kinetics characterized by counting single cell-surface attached quantum dots.
  Edouard Saint-Michel, Grégory Giannone, Daniel Choquet, Olivier Thoumine.
  Biophysical Journal. 2009-07-01. 97(2) : 480-489.
  10.1016/j.bpj.2009.04.044
• Activity-independent and subunit-specific recruitment of functional AMPA receptors at neurexin/neuroligin contacts.
  M. Heine, O. Thoumine, M. Mondin, B. Tessier, G. Giannone, D. Choquet.
  Proceedings of the National Academy of Sciences. 2008-12-19. 105(52) : 20947-20952.
  10.1073/pnas.0804007106
• Sensitive liposomes encoded with oligonucleotide amphiphiles: a biocompatible switch.
  Arnaud Gissot, Carmelo Di Primo, Isabelle Bestel, Gregory Giannone, Hubert Chapuis, Philippe Barthélémy.
  Chem. Commun.. 2008-01-01. (43) : 5550.
  10.1039/b812398e
• Nonmuscle myosin IIA-dependent force inhibits cell spreading and drives F-actin flow.
  Yunfei Cai, Nicolas Biais, Gregory Giannone, Monica Tanase, Guoying Jiang, Jake M. Hofman, Chris H. Wiggins, Pascal Silberzan, Axel Buguin, Benoit Ladoux, Michael P. Sheetz.
  Biophysical Journal. 2006-11-01. 91(10) : 3907-3920.
  10.1529/biophysj.106.084806
• Lateral membrane waves constitute a universal dynamic pattern of motile cells.
  Hans-Günther Döbereiner, Benjamin J. Dubin-Thaler, Jake M. Hofman, Harry S. Xenias, Tasha N. Sims, Grégory Giannone, Michael L. Dustin, Chris H. Wiggins, Michael P. Sheetz.
  Phys. Rev. Lett.. 2006-07-20. 97(3)
  10.1103/physrevlett.97.038102
• Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways.
  Grégory Giannone, Michael P. Sheetz.
  Trends in Cell Biology. 2006-04-01. 16(4) : 213-223.
  10.1016/j.tcb.2006.02.005
• Force sensing and generation in cell phases: analyses of complex functions.
  Hans-Günther Döbereiner, Benjamin J. Dubin-Thaler, Gregory Giannone, Michael P. Sheetz.
  Journal of Applied Physiology. 2005-04-01. 98(4) : 1542-1546.
  10.1152/japplphysiol.01181.2004
• Dynamic phase transitions in cell spreading.
  Hans-Günther Döbereiner, Benjamin Dubin-Thaler, Grégory Giannone, Harry S. Xenias, Michael P. Sheetz.
  Phys. Rev. Lett.. 2004-09-02. 93(10)
  10.1103/physrevlett.93.108105
• Calcium rises locally trigger focal adhesion disassembly and enhance residency of focal adhesion kinase at focal adhesions.
  Grégory Giannone, Philippe Rondé, Mireille Gaire, Joël Beaudouin, Jacques Haiech, Jan Ellenberg, Kenneth Takeda.
  J. Biol. Chem.. 2004-04-21. 279(27) : 28715-28723.
  10.1074/jbc.m404054200
• Nanometer analysis of cell spreading on matrix-coated surfaces reveals two distinct cell states and STEPs.
  Benjamin J. Dubin-Thaler, Gregory Giannone, Hans-Günther Döbereiner, Michael P. Sheetz.
  Biophysical Journal. 2004-03-01. 86(3) : 1794-1806.
  10.1016/s0006-3495(04)74246-0
• Periodic lamellipodial contractions correlate with rearward actin waves.
  Grégory Giannone, Benjamin J Dubin-Thaler, Hans-Günther Döbereiner, Nelly Kieffer, Anne R Bresnick, Michael P Sheetz.
  Cell. 2004-02-01. 116(3) : 431-443.
  10.1016/s0092-8674(04)00058-3
• Talin1 is critical for force-dependent reinforcement of initial integrin-cytoskeleton bonds but not tyrosine kinase activation.
  Grégory Giannone, Guoying Jiang, Deborah H. Sutton, David R. Critchley, Michael P. Sheetz.
  J Cell Biol. 2003-10-27. 163(2) : 409-419.
  10.1083/jcb.200302001
• Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis.
  Sophie Martin, Grégory Giannone, Ramaroson Andriantsitohaina, M Carmen Martinez.
  British Journal of Pharmacology. 2003-07-01. 139(6) : 1095-1102.
  10.1038/sj.bjp.0705347
• Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin.
  Guoying Jiang, Grégory Giannone, David R. Critchley, Emiko Fukumoto, Michael P. Sheetz.
  Nature. 2003-07-01. 424(6946) : 334-337.
  10.1038/nature01805
• Calcium oscillations trigger focal adhesion disassembly in human U87 astrocytoma cells.
  Gregory Giannone, Philippe Rondé, Mireille Gaire, Jacques Haiech, Kenneth Takeda.
  J. Biol. Chem.. 2002-05-14. 277(29) : 26364-26371.
  10.1074/jbc.m203952200
• Mechanism of calcium oscillations in migrating human astrocytoma cells.
  Philippe Rondé, Gregory Giannone, Inna Gerasymova, Herrade Stoeckel, Kenneth Takeda, Jacques Haiech.
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2000-12-01. 1498(2-3) : 273-280.
  10.1016/s0167-4889(00)00102-6
• Novel activation of non-selective cationic channels by dinitrosyl iron-thiosulfate in PC12 cells.
  Grégory Giannone, Kenneth Takeda, Andrei L. Kleschyov.
  The Journal of Physiology. 2000-12-01. 529(3) : 735-745.
  10.1111/j.1469-7793.2000.00735.x