Venue: Centre Broca
Baptiste Lacoste
University of Ottawa
https://med.uottawa.ca/cellular-molecular/people/lacoste-baptiste
Invited by Jean-Luc Morel (INCIA)
Title
Non-neuronal underpinnings of altered brain development
Abstract
The Neurovascular Development Research Lab (NDRL) directed by Dr. Baptiste Lacoste (University of Ottawa, Ontario, Canada) focuses on the discovery of mechanisms underlying cerebrovascular health, with the goal of developping new treatments for neurological conditions involving vascular deficiencies. Using state-of-the art approaches, the NDRL investigates the vascular underpinnings of autism spectrum disorders and the role of glial cells in postnatal cerebrovascular development. The NDRL has recently extended its program to investigate abnormalities in brain metabolism in autism mouse models. Such projects involve mouse genetics, human-derived stem cells, primary brain cell cultures, electron microscopy, transcriptomic and metabolic profiling, as well as 3D imaging and advanced structural quantifications. During his seminar, Dr. Lacoste will summarize their recent work on the role of brain endothelial cells in autism, and on the control of neurovascular maturation by astrocyte-derived factors.
References
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