Lieu : Centre Broca Nouvelle-Aquitaine
Vestibular reflex circuits: from molecules to function
Joel Glover
Institute of Basic Medical Science, University of Oslo
Webpage : https://www.med.uio.no/imb/english/people/aca/joel/index.html
Invité par Muriel Thoby-Brisson, INCIA
Abstract
Vestibular reflex circuits are known to provide rapid modulation of muscle activity to compensate for disturbances of position and balance. As such, they include relatively direct pathways that channel vestibular sensory information to motor output, with a connectional logic that is, at least in general terms, readily comprehensible. Because vestibular reflex circuits appeared early in vertebrate evolution, and many of their organizational features are highly conserved across the vertebrate radiation, it is likely that their developmental construction is governed to a large extent by deterministic molecular mechanisms. Using this as a working hypothesis, we are investigating patterns of gene expression in central vestibular projection neurons, in an attempt to identify molecular signatures that may be related to the specification of synaptic connectivity in vestibular circuits. In this talk, I will present our efforts to identify molecular signatures for identified vestibulospinal neuron groups, and to use these to 1) develop hypotheses about how vestibulospinal neuron identities are determined, and 2) generate genetic tools for the selective characterization and manipulation of vestibulospinal neurons and their functional connections. I will also touch on more recent efforts to expand this analysis to other classes of vestibular projection neurons, as well as experiments we have conducted over several years to provide more detailed and comprehensive knowledge about how vestibular projections are organized and what they do.
Last publications
- Kondratskaya, Elena; Ievglevskyi, Oleksandr; Züchner, Mark; Samara, Athina; Glover, Joel & Boulland, Jean-Luc (2019). Locomotor central pattern generator excitability states and serotonin sensitivity after spontaneous recovery from a neonatal lumbar spinal cord injury. Brain Research. ISSN 0006-8993. 1708, s 10- 19 . doi: 10.1016/j.brainres.2018.12.001
- Lunde, Anders; Okaty, Benjamin W; Dymecki, Susan M & Glover, Joel (2019). Molecular profiling defines evolutionarily conserved transcription factor signatures of major vestibulospinal neuron groups. eNeuro. ISSN 2373-2822. 6(1), s 1- 25 . doi: 10.1523/ENEURO.0475-18.2019
- Mikhaleva, Yana; Tolstenkov, Oleg & Glover, Joel (2019). Gap junction-dependent coordination of intercellular calcium signalling in the developing appendicularian tunicate Oikopleura dioica. Developmental Biology. ISSN 0012-1606. 450(1), s 9- 22 . doi: 10.1016/j.ydbio.2019.03.006
- Glover, Joel; Elliott, Karen L.; Erives, Albert; Chizhikov, Victor V. & Fritzsch, Bernd (2018). Wilhelm His’ lasting insights into hindbrain and cranial ganglia development and evolution. Developmental Biology. ISSN 0012-1606. Published ahead of print . doi: 10.1016/j.ydbio.2018.02.001
- Lynagh, Timothy; Mikhaleva, Yana; Colding, Janne M.; Glover, Joel & Pless, Stephan A. (2018). Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 115(33), s 8430- 8435 . doi: 10.1073/pnas.1806614115
- Mazzini, Letizia; Ferrari, Daniela; Andjus, Pavle R.; Buzanska, Leonora; Cantello, Roberto; De Marchi, Fabiola; Gelati, Maurizio; Giniatullin, Rashid; Glover, Joel; Grilli, Mariagrazia; Kozlova, Elena N.; Maioli, Margherita; Mitrečić, Dinko; Pivoriunas, Augustas; Sanchez-Pernaute, Rosario; Sarnowska, Anna & Vescovi, Angelo L. (2018). Advances in stem cell therapy for amyotrophic lateral sclerosis. Expert Opinion on Biological Therapy. ISSN 1471-2598. 18(8), s 865- 881 . doi: 10.1080/14712598.2018.1503248