Lieu : Centre Broca Nouvelle-Aquitaine
Guillaume Montagnac
Directeur de recherche – INSERM
Equipe « Endocytose, cytosquelette et migration cellulaire »
Gustave Roussy
Invité par David Perrais
Abstract
Clathrin-mediated endocytosis is a fundamental process allowing the cell to internalize surface exposed receptors and their ligands. It relies on the formation of clathrin-coated structures (CCSs) that typically recruit receptors and concomitantly progressively bend the plasma membrane to form endocytic vesicles that bud in the cytosol. However, this process can be mechanically impaired when receptors to be internalized are engaged with the substrate. Our work highlights the role of the cell microenvironment in regulating endocytosis, potentially turning it into frustrated endocytosis with important consequences for cell migration, signaling and proliferation. »