Lieu : CGFB
Alexandra Calteau
LABGeM CEA / Institut de Biologie François Jacob / Genoscope
Organisé par le CBiB
MicroScope: an integrated platform for the annotation and exploration of microbial gene functions through genomic, pangenomic and metabolic comparative analysis
Abstract
Large-scale genome sequencing and the increasingly massive use of high-throughput approaches produce a vast amount of new information that completely transforms our understanding of thousands of microbial species. However, despite the development of powerful bioinformatics approaches, full interpretation of the content of these genomes remains a difficult task. Launched in 2005, the MicroScope platform (https://www.genoscope.cns.fr/agc/microscope) has been under continuous development and provides analysis for prokaryotic genome projects together with metabolic network reconstruction and post-genomic experiments allowing users to improve the understanding of gene functions. Recently new tools and pipeline have been developed to perform comparative analyses on hundreds of genomes based on pangenome graphs.
To date, MicroScope contains data for >12 300 microbial genomes, part of which are manually curated and maintained by microbiologists (>4700 personal accounts in January 2020). The platform enables collaborative work in a rich comparative genomic context and improves community-based curation efforts.
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