Misfolding of alpha-synuclein and tau protein: from basic mechanisms to therapeutic development
Course Directors
Erwan Bezard, PhD, Wassilios Meissner, MD, PhD
Faculty
Laura Parkkinen, PhD
Thiago Outeiro, PhD
Maria Grazia Spillantini, FMedSci, FRS
Morvane Colin, PhD
Günter Höglinger, MD, PhD
Course Description
The overall aim of the course is to teach the fundamental mechanisms underlying aggregation and propagation of a-synuclein and tau protein in neurodegenerative movement disorders. Ongoing efforts for the development of therapeutic strategies targeting these two proteins will also be discussed. The course consists of seven virtual lectures given by international experts in the field, followed by an interactive Q&A session to answer the questions of the participants. The course will close with an interactive panel discussion including all experts to address the critical next steps to move the field forward.
The course is part of a broader effort of the International Parkinson and Movement Disorder Society to engage young neurologists and neuroscientists into research on movement disorders and promote translational research involving multidisciplinary approaches.
Interactive Components
Real Time Question and Answer Session (30 minutes) and Real Time Discussion on Critical Next Steps to Move the Field Forward
Target Audience
Young Neurologists and Young Scientists
Learning Objectives
- Describe the prototypical neuropathological lesions observed in synucleinopathies and tauopathies
- Recognize the complex mechanisms underlying pathological aggregation of a-synuclein and tau protein
- Debate the putative role of distinct a-synuclein and tau species/strains for disease phenotypes and progression
- Discuss ongoing efforts towards the development of therapies targeting a-synuclein or tau protein
Program
Lectures and discussion begin September 30 at 14:00 CEST
| Welcome and Course Introduction Erwan Bezard and Wassilios Meissner |
| Neuropathology in Synucleinopathies and Tauopathies Laura Parkkinen |
| Mechanisms Underlying Protein Aggregation in Synucleinopathies Tiago Outeiro |
| Mechanisms Underlying Protein Aggregation in Tauopathies Maria Grazia Spillantini |
| Propagation of α-synucleinopathy Erwan Bezard |
| Spreading of Tauopathies Morvane Colin |
| Therapeutic Strategies Targeting α-synuclein: From Bench to Bed Wassilios Meissner |
| Therapeutic Strategies Targeting Tau Protein: From Bench to Bed Günther Höglinger |
| Interactive Question and Answer Session All Faculty |
| Critical Next Steps to Move the Field Forward Discussion between faculty and participants |
| Concluding Remarks Erwan Bezard and Wassilios Meissner |
Register
https://mds.execinc.com/edibo/BASIC20VIR?_ga=2.12052733.81843017.1600070485-1980107551.1598961072