Nutrition and Neuropsychiatric Symptom Dimensions (NutriPsy)
The overarching scientific objective of the Nutripsy team is to understand how nutrition can contribute to mental health, and to identify the mechanisms by which nutritional imbalances promote the development of neuropsychiatric symptoms, focusing on inflammatory processes. For this purpose, we propose a translational and integrative research program with the following complementary specific aims:
- to elucidate the mechanisms by which inflammation, in relation to dietary habits, leads to neuropsychiatric symptom dimensions and antidepressant resistance
- to determine the influence of environmental factors and genetic variants related to inflammation on depressive symptoms and antidepressant response in clinical and preclinical models of nutritional imbalances,
- to propose innovative personalized treatment strategies through targeted nutritional approaches guided by the clinical, biological/inflammatory, and nutritional profiles of patients.
This research program represents a critical step toward a precision medicine applied to mental health, in a context where the efficacy of standard treatments remains mitigated.
Mots clés
Bioénergétique du cerveau et physiologie, Cognition, Comportement alimentaire, Contaminants alimentaires, Dépression, Déséquilibre alimentaire et vulnérabilité psychiatrique, Développement du système nerveux, Effet signal des nutriments dans le cerveau, Emotion, Interactions nutriments et traitement neuropharmacologique, Maladies Neuro-développementales, Metabolism, Motivation, Mémoire, Neuroimagerie chez l’humain, Nutrition protectrice et vieillissement cognitif, Relations microbiote-intestin-cerveau, Troubles du comportement, Troubles métaboliques et obésitéSelected publications
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Saffron extract interferes with lipopolysaccharide-induced brain activation of the kynurenine pathway and impairment of monoamine neurotransmission in mice
Camille Monchaux de Oliveira, Jennifer Morael, Alexandrine Guille, Camille Amadieu, Sylvie Vancassel, David Gaudout, Lucile Capuron, Line Pourtau, Nathalie Castanon.
Front. Nutr.. 2023-10-05. 10
DOI: 10.3389/fnut.2023.1267839 -
Strain-specific changes in nucleus accumbens transcriptome and motivation for palatable food reward in mice exposed to maternal separation.
Simon Benoit, Mathilde Henry, Sara Fneich, Alexia Mathou, Lin Xia, Aline Foury, Mélanie Jouin, Claudine Junien, Lucile Capuron, Luc Jouneau, Marie-Pierre Moisan, Cyrille Delpierre, Anne Gabory, Muriel Darnaudéry.
Front. Nutr.. 2023-07-26. 10
DOI: 10.3389/fnut.2023.1190392 -
Acute Effect of a Saffron Extract (Safr’InsideTM) and Its Main Volatile Compound on the Stress Response in Healthy Young Men: A Randomized, Double Blind, Placebo-Controlled, Crossover Study
Camille Pouchieu, Line Pourtau, Julie Brossaud, David Gaudout, Jean-Benoit Corcuff, Lucile Capuron, Nathalie Castanon, Pierre Philip.
Nutrients. 2023-06-27. 15 (13) : 2921.
DOI: 10.3390/nu15132921 -
Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11β-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency
Julie Brossaud, Clémentine Bosch-Bouju, Nathalie Marissal-Arvy, Marie-Neige Campas-Lebecque, Jean-Christophe Helbling, Scott P. Webster, Brian R. Walker, Xavier Fioramonti, Guillaume Ferreira, Pascal Barat, Jean-Benoît Corcuff, Marie-Pierre Moisan.
Diabetologia. 2023-06-10.
DOI: 10.1007/s00125-023-05942-3 -
Structural basis of glucocorticoid receptor signaling bias
Freddy Jeanneteau, Onno C. Meijer, Marie‐Pierre Moisan.
J Neuroendocrinology. 2022-10-11.
DOI: 10.1111/jne.13203
Team leader
Chercheurs, Praticiens hospitaliers...
Bruno Aouizerate
Aouizerate
(University teacher - researcher - Hospital practitioner)
Pascal Barat Barat (University teacher - researcher - Hospital practitioner)
Julie Brossaud Brossaud (University teacher - researcher - Hospital practitioner)
Nathalie Castanon Castanon (Researcher)
Muriel Darnaudéry Darnaudéry (University Teacher - Researcher)
Amandine Ferrière Ferrière (Associate professor / hospital practitioner)
Quentin Leyrolle Leyrolle (Enseignant-chercheur)
Sylvie Vancassel Vancassel (Researcher)
Pascal Barat Barat (University teacher - researcher - Hospital practitioner)
Julie Brossaud Brossaud (University teacher - researcher - Hospital practitioner)
Nathalie Castanon Castanon (Researcher)
Muriel Darnaudéry Darnaudéry (University Teacher - Researcher)
Amandine Ferrière Ferrière (Associate professor / hospital practitioner)
Quentin Leyrolle Leyrolle (Enseignant-chercheur)
Sylvie Vancassel Vancassel (Researcher)
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Camille Amadieu
Amadieu
Cassandra Gheorghe Gheorghe
Rachel Ginieis Ginieis
Enrica Montalban Montalban
Cassandra Gheorghe Gheorghe
Rachel Ginieis Ginieis
Enrica Montalban Montalban
Doctorant(s)