Nutrition and Neuropsychiatric Symptom Dimensions (NutriPsy)

The overarching scientific objective of the Nutripsy team is to understand how nutrition can contribute to mental health, and to identify the mechanisms by which nutritional imbalances promote the development of neuropsychiatric symptoms, focusing on inflammatory processes. For this purpose, we propose a translational and integrative research program with the following complementary specific aims:

to elucidate the mechanisms by which inflammation, in relation to dietary habits, leads to neuropsychiatric symptom dimensions and antidepressant resistance
to determine the influence of environmental factors and genetic variants related to inflammation on depressive symptoms and antidepressant response in clinical and preclinical models of nutritional imbalances,
to propose innovative personalized treatment strategies through targeted nutritional approaches guided by the clinical, biological/inflammatory, and nutritional profiles of patients.

This research program represents a critical step toward a precision medicine applied to mental health, in a context where the efficacy of standard treatments remains mitigated.

Mots clés

Bioénergétique du cerveau et physiologie, Cognition, Comportement alimentaire, Contaminants alimentaires, Dépression, Déséquilibre alimentaire et vulnérabilité psychiatrique, Développement du système nerveux, Effet signal des nutriments dans le cerveau, Emotion, Interactions nutriments et traitement neuropharmacologique, Maladies Neuro-développementales, Metabolism, Motivation, Mémoire, Neuroimagerie chez l’humain, Nutrition protectrice et vieillissement cognitif, Relations microbiote-intestin-cerveau, Troubles du comportement, Troubles métaboliques et obésité

Selected publications

Saffron extract interferes with lipopolysaccharide-induced brain activation of the kynurenine pathway and impairment of monoamine neurotransmission in mice
Camille Monchaux de Oliveira, Jennifer Morael, Alexandrine Guille, Camille Amadieu, Sylvie Vancassel, David Gaudout, Lucile Capuron, Line Pourtau, Nathalie Castanon.
Front. Nutr.. 2023-10-05. 10
DOI: 10.3389/fnut.2023.1267839

Strain-specific changes in nucleus accumbens transcriptome and motivation for palatable food reward in mice exposed to maternal separation.
Simon Benoit, Mathilde Henry, Sara Fneich, Alexia Mathou, Lin Xia, Aline Foury, Mélanie Jouin, Claudine Junien, Lucile Capuron, Luc Jouneau, Marie-Pierre Moisan, Cyrille Delpierre, Anne Gabory, Muriel Darnaudéry.
Front. Nutr.. 2023-07-26. 10
DOI: 10.3389/fnut.2023.1190392

Structural basis of glucocorticoid receptor signaling bias
Freddy Jeanneteau, Onno C. Meijer, Marie‐Pierre Moisan.
J Neuroendocrinology. 2022-10-11.
DOI: 10.1111/jne.13203

Team leader

Lucile Capuron
INRAE

Marie-Pierre Moisan
INRAE

Team member(s)

Chercheurs, Praticiens hospitaliers...

Bruno Aouizerate (University teacher - researcher - Hospital practitioner)
Jean-Benoît Corcuff (University teacher - researcher - Hospital practitioner)
Julie Brossaud (University teacher - researcher - Hospital practitioner)
Muriel Darnaudéry (University Teacher - Researcher)
Nathalie Castanon (Researcher)
Pascal Barat (University teacher - researcher - Hospital practitioner)
Sylvie Vancassel (Researcher)
Quentin Leyrolle (Enseignant-chercheur)

Ingénieur(e)s, technicien(ne)s

Aline Foury
Sandra Dexpert
Jean-Christophe Helbling
Eva Bruchet

Post-doctorant(s)

Enrica Montalban
Rachel Ginieis
Camille Amadieu
Cassandra Gheorghe

Doctorant(s)

Juliette Montet
Ana Raner

Neuropsychologist(s) and speech therapist(s)

Ingénieur(s) hospitalier(s) et ARC