NeuroDTx: Neuromodulation and Digital Therapeutics
Over the past few years, our team has initiated a multifaceted research program that aims at developing new neuromodulation strategies and neuroprosthetic systems for improving motor and cognitive functions in neurological disorders. We believe that this field requires a synergistic approach between neuromodulation / neuroprosthetics and computational neuroscience, two aspects led collaboratively by Dr. Fabien Wagner (CNRS) and Dr. Amélie Aussel (Inria). We are currently conducting the following projects:
- Biophysical models of the neural circuits that produce cognition, especially memory and attention, and how they are affected by neurostimulation.
- Personalized physical models of the head and brain based on neuroimaging (CT, anatomical and diffusion MRI) to determine the distribution of the electric field induced by various neurostimulation methods and the affected brain structures.
- Invasive neurostimulation in non-human primates for improving memory using novel intracranial brain implants that target large-scale brain networks identified by submillimeter MRI protocols. The MEMOPROSTHETICS project is funded by an ERC starting grant led by Dr. Fabien Wagner (2022-2027).
- Non-invasive brain and spinal cord stimulation for improving motor and cognitive functions after spinal cord injury and stroke. This project is funded by a fellowship from the “Fondation pour la Recherche Médicale” (FRM) attributed to Dr. Nabila Brihmat (2024-2027), and is performed in collaboration with Dr. Hélène Cassoudesalle from the Physical Medicine and Rehabilitation department at the CHU-BDX.
- Multimodal digital therapeutics for improving cognition in neurovascular disorders using EEG biomarker identification, high-definition transcranial alternating current stimulation (tACS), and cognitive training. This effort is part of the new Vascular Brain Health Institute (https://ihu-vbhi.fr/) and involves a collaboration with Pr. Stéphanie Debette (CHU-BDX), Dr. Fabien Lotte (Inria) and Dr. Hélène Sauzéon (Inria).
Mots clés
Apprentissage, Cognition, Démences, Interfaces humain-machine et Santé connectée, Mémoire, Neurophysiologie, Plasticité des réseaux, brain stimulation, brain-machine interfaces, neuroengineering, neuromodulation, neuroprostheticsSelected publications
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A dynamical computational model of theta generation in hippocampal circuits to study theta-gamma oscillations during neurostimulation
Nikolaos Vardalakis, Amélie Aussel, Nicolas P. Rougier, Fabien B. Wagner.
eLife. 2023-02-14.
DOI: 10.7554/eLife.87356.3 -
Neuroprosthetics: from sensorimotor to cognitive disorders
Ankur Gupta, Nikolaos Vardalakis, Fabien B. Wagner.
Comm Biol. 2023-01-06.
DOI: 10.1038/s42003-022-04390-w -
Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis
Andreas Rowald, Salif Komi, Robin Demesmaeker, Edeny Baaklini, Sergio Daniel Hernandez-Charpak, Edoardo Paoles, Hazael Montanaro, Antonino Cassara, Fabio Becce, Bryn Lloyd, Taylor Newton, Jimmy Ravier, Nawal Kinany, Marina D’Ercole, Aurélie Paley, Nicolas Hankov, Camille Varescon, Laura McCracken, Molywan Vat, Miroslav Caban, Anne Watrin, Charlotte Jacquet, Léa Bole-Feysot, Cathal Harte, Henri Lorach, Andrea Galvez, Manon Tschopp, Natacha Herrmann, Moïra Wacker, Lionel Geernaert, Isabelle Fodor, Valentin Radevich, Katrien Van Den Keybus, Grégoire Eberle, Etienne Pralong, Maxime Roulet, Jean-Baptiste Ledoux, Eleonora Fornari, Stefano Mandija, Loan Mattera, Roberto Martuzzi, Bruno Nazarian, Stefan Benkler, Simone Callegari, Nathan Greiner, Benjamin Fuhrer, Martijn Froeling, Nik Buse, Tim Denison, Rik Buschman, Christian Wende, Damien Ganty, Jurriaan Bakker, Vincent Delattre, Hendrik Lambert, Karen Minassian, Cornelis A. T. van den Berg, Anne Kavounoudias, Silvestro Micera, Dimitri Van De Ville, Quentin Barraud, Erkan Kurt, Niels Kuster, Esra Neufeld, Marco Capogrosso, Leonie Asboth, Fabien B. Wagner, Jocelyne Bloch, Grégoire Courtine.
Nat Med. 2022-02-07.
DOI: 10.1038/s41591-021-01663-5 -
Spinal Cord Stimulation to Enable Leg Motor Control and Walking in People with Spinal Cord Injury
Ismael Seáñez, Marco Capogrosso, Karen Minassian, Fabien B. Wagner.
Neurorehabilitation Technology. 2022-01-01. : 369-399.
DOI: 10.1007/978-3-031-08995-4_18
Team leader
Team member(s)
Chercheurs, Praticiens hospitaliers...
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Nabila Brihmat
Brihmat
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC