Mechanisms of neural circuit sensitivity to altered nutritional status (FoodCircus)
The general objective of FoodCircus is to unravel the mechanisms by which environmental and genetic factors affect behavioral phenotypes/dimensions with symptomatic relevance for neurological and psychiatric disorders. A main interest concerns the developmental influence of nutritional status – such as diet-induced obesity, unsaturated fatty acids and vitamin A deficiencies – which has been consistently linked with the etiology of several brain disorders.
We also develop a line of research aiming at dissecting the mechanisms linking genetic polymorphisms associated with several neurodevelopmental disorders, with discrete behavioral alterations relevant for the symptomatology of psychiatric diseases.
Furthermore, FoodCircus is involved in transdisciplinary projects aiming at developing new tools to observe and manipulate discrete neurobiological processes.
The investigators of FoodCircus aim at identifying the underlying cellular/molecular mechanisms within discrete neuronal circuits of two main vulnerable brain systems: the hippocampal and fronto-striatal circuits which control cognitive processes such as mnemonic and executive functions.
Our specific aims are:
i) To elucidate the neuronal mechanisms by which obesogenic diet impairs hippocampal-dependent memory, with an emphasis on sex differences.
ii) To identify the mechanisms by which genetic and nutritional (polyunsaturated fatty acids and vitamin A biostatus) factors impact the development of mesocorticolimbic dopamine circuits and the consequences on executive functions.
iii) To develop innovative neurotechnologies for the dynamic detection of neurotransmitters, as well as intracerebral drug delivery.
The perspectives of projects are to identify targetable factors for the alleviation or prevention of specific symptomatic dimensions of brain disorders.
Mots clés
Apprentissage, Déséquilibre alimentaire et vulnérabilité psychiatrique, Mémoire, Neuroimagerie chez l’humainSelected publications
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Feeding the hippocampus … with specific nutrients
Pierre Trifilieff, Guillaume Ferreira.
Nat Metab. 2025-01-15.
DOI: 10.1038/s42255-024-01180-y -
Impact of dietary vitamin A on striatal function in adult rats.
Anaïs Marie, Rémi Kinet, Jean‐Christophe Helbling, Morgane Darricau, Serge Alfos, Mathieu Di Miceli, Maria‐Florencia Angelo, Aline Foury, Emmanuel Richard, Pierre Trifilieff, Nicolas P. Mallet, Clementine Bosch‐Bouju.
The FASEB Journal. 2023-07-01. 37 (8)
DOI: 10.1096/fj.202300133r -
The Addiction-Susceptibility TaqIA/Ankk1 Controls Reward and Metabolism Through D2 Receptor-Expressing Neurons
Enrica Montalban, Roman Walle, Julien Castel, Anthony Ansoult, Rim Hassouna, Ewout Foppen, Xi Fang, Zach Hutelin, Sophie Mickus, Emily Perszyk, Anna Petitbon, Jérémy Berthelet, Fernando Rodrigues-Lima, Alberto Cebrian-Serrano, Giuseppe Gangarossa, Claire Martin, Pierre Trifilieff, Clémentine Bosch-Bouju, Dana. M. Small, Serge Luquet.
Biological Psychiatry. 2023-02-01.
DOI: 10.1016/j.biopsych.2023.02.010 -
Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling.
Marie-Lise Jobin, Véronique De Smedt-Peyrusse, Fabien Ducrocq, Rim Baccouch, Asma Oummadi, Maria Hauge Pedersen, Brian Medel-Lacruz, Maria-Florencia Angelo, Sandrine Villette, Pierre Van Delft, Laetitia Fouillen, Sébastien Mongrand, Jana Selent, Tarson Tolentino-Cortez, Gabriel Barreda-Gómez, Stéphane Grégoire, Elodie Masson, Thierry Durroux, Jonathan A. Javitch, Ramon Guixà-González, Isabel D. Alves, Pierre Trifilieff.
Mol Psychiatry. 2023-01-06.
DOI: 10.1038/s41380-022-01928-6 -
Hippocampal oxytocin is involved in spatial memory and synaptic plasticity deficits following acute high-fat diet intake in juvenile rats.
Tala Khazen, Nisha Rajan Narattil, Guillaume Ferreira, Mouna Maroun.
Cerebral Cortex. 2022-08-20.
DOI: 10.1093/cercor/bhac317 -
A synaptomic analysis reveals dopamine hub synapses in the mouse striatum
Vincent Paget-Blanc, Marlene E. Pfeffer, Marie Pronot, Paul Lapios, Maria-Florencia Angelo, Roman Walle, Fabrice P. Cordelières, Florian Levet, Stéphane Claverol, Sabrina Lacomme, Mélina Petrel, Christelle Martin, Vincent Pitard, Véronique De Smedt Peyrusse, Thomas Biederer, David Perrais, Pierre Trifilieff, Etienne Herzog.
Nat Commun. 2022-06-03. 13 (1)
DOI: 10.1038/s41467-022-30776-9 -
Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine’s rewarding effects but preserves natural reward processing.
Andry Andrianarivelo, Estefani Saint-Jour, Paula Pousinha, Sebastian P. Fernandez, Anna Petitbon, Veronique De Smedt-Peyrusse, Nicolas Heck, Vanesa Ortiz, Marie-Charlotte Allichon, Vincent Kappès, Sandrine Betuing, Roman Walle, Ying Zhu, Charlène Joséphine, Alexis-Pierre Bemelmans, Gustavo Turecki, Naguib Mechawar, Jonathan A. Javitch, Jocelyne Caboche, Pierre Trifilieff, Jacques Barik, Peter Vanhoutte.
Sci. Adv.. 2021-10-22. 7 (43)
DOI: 10.1126/sciadv.abg5970 -
Chemogenetic silencing of hippocampus and amygdala reveals a double dissociation in periadolescent obesogenic diet-induced memory alterations
Fabien Naneix, Ioannis Bakoyiannis, Marianela Santoyo-Zedillo, Clémentine Bosch-Bouju, Gustavo Pacheco-Lopez, Etienne Coutureau, Guillaume Ferreira.
Neurobiology of Learning and Memory. 2021-02-01. 178 : 107354.
DOI: 10.1016/j.nlm.2020.107354 -
Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits.
Fabien Ducrocq, Roman Walle, Andrea Contini, Asma Oummadi, Baptiste Caraballo, Suzanne van der Veldt, Marie-Lou Boyer, Frank Aby, Tarson Tolentino-Cortez, Jean-Christophe Helbling, Lucy Martine, Stéphane Grégoire, Stéphanie Cabaret, Sylvie Vancassel, Sophie Layé, Jing Xuan Kang, Xavier Fioramonti, Olivier Berdeaux, Gabriel Barreda-Gómez, Elodie Masson, Guillaume Ferreira, David W.L. Ma, Clementine Bosch-Bouju, Véronique De Smedt-Peyrusse, Pierre Trifilieff.
Cell Metabolism. 2020-04-01. 31 (4) : 755-772.e7.
DOI: 10.1016/j.cmet.2020.02.012 -
Vitamin A deficiency impairs contextual fear memory in rats: Abnormalities in the glucocorticoid pathway
Damien Bonhomme, Serge Alfos, Scott P. Webster, Mathieu Wolff, Véronique Pallet, Katia Touyarot.
J Neuroendocrinol. 2019-11-01. 31 (11)
DOI: 10.1111/jne.12802 -
CB1 Receptors in the Anterior Piriform Cortex Control Odor Preference Memory
Geoffrey Terral, Arnau Busquets-Garcia, Marjorie Varilh, Svein Achicallende, Astrid Cannich, Luigi Bellocchio, Itziar Bonilla-Del Río, Federico Massa, Nagore Puente, Edgar Soria-Gomez, Pedro Grandes, Guillaume Ferreira, Giovanni Marsicano.
Current Biology. 2019-08-01. 29 (15) : 2455-2464.e5.
DOI: 10.1016/j.cub.2019.06.041
Team member(s)
Chercheurs, Praticiens hospitaliers...
Katia Touyarot Touyarot (University Teacher- Researcher)
Pauline Lafenêtre Lafenêtre (University Teacher- Researcher)
Ingénieur(e)s, technicien(ne)s
Jean-Christophe Helbling Helbling
Serge Alfos Alfos
Maria Florencia Angelo Angelo
Mylène Potier Potier
Post-doctorant(s)
Zoé Mazurie Mazurie
Fabien Ducrocq Ducrocq
Asma Oummadi Oummadi
Sébastien Moreno Moreno
Ignacio Fernandez Fernandez
Ignacio Fernandez Moncada Fernandez Moncada
Doctorant(s)
Camille Ruffier Ruffier
Clément Laffont Laffont
Arielle Rakotonandrasana Rakotonandrasana
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC