Emotion, Motivation and Cognition (EMOTIV)
Emotions refer to rewarding or aversive states induced by various stimuli (food, social interactions, drugs of abuse), which are related to brain circuits (reward and stress systems) and guide adaptive responses to the environment. While organizing behavior and promoting resilience in some subjects, emotional states can evolve into pathological states such as anxiety, depression or addiction. Our project relies on “mirrored” approaches aiming first at understanding neural dynamics of valence (either rewarding or aversive) and value of emotions, the “shift” which occurs with chronicity, internal (bodily) vs external context changes, and level (or loss) of control. The adaptative function of emotions also relies on attentional and cognitive processes such as learning strategies which vary individually. We thus investigate the influence of individual cognitive traits (“personality”) on behavioral and neural responses to emotional stimuli and stress.
Mots clés
Alcool, Anxiété, Attention Chemogenetique, Cognition, Corticosteroids, Dopamine, Dépression, Motivation, Mémoire, Nicotine, Optogénétique, Récompense, Réseaux neuronaux, Stress, Troubles addictifs, Troubles affectifs, Vieillissement, addiction, comportements sociaux, système cholinergique, émotionsSelected publications
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Poor inhibitory control predicts sex-specific vulnerability to nicotine rewarding properties in mice
Maria-Carmen Medrano, Florence Darlot, Martine Cador, Stephanie Caille.
Psychopharmacology. 2023-07-13.
DOI: 10.1007/s00213-023-06418-3 -
Impact of acute and chronic nicotine administration on midbrain dopaminergic neuron activity and related behaviours in TRPV1 knock‐out juvenile mice
Anne‐Emilie Allain, Oceane Aribo, Maria‐Carmen Medrano, Marie‐Line Fournier, Sandrine S. Bertrand, Stephanie Caille.
Eur J of Neuroscience. 2022-01-13.
DOI: 10.1111/ejn.15577 -
Flavor additives facilitate oral self-administration of nicotine solution in mice
Salma Tannous, Florence Darlot, Martine Cador, Stéphanie Caillé-Garnier.
Psychopharmacology. 2021-04-22.
DOI: 10.1007/s00213-021-05848-1 -
Bidirectional modulation of hippocampal and amygdala synaptic plasticity by post‐weaning obesogenic diet intake in male rats: Influence of the duration of diet exposure
Rose‐Marie Vouimba, Ioannis Bakoyiannis, Eva‐Gunnel Ducourneau, Mouna Maroun, Guillaume Ferreira.
Hippocampus. 2020-11-04.
DOI: 10.1002/hipo.23278 -
β4-Nicotinic Receptors Are Critically Involved in Reward-Related Behaviors and Self-Regulation of Nicotine Reinforcement
Marianne Husson, Lauriane Harrington, Léa Tochon, Yoon Cho, Inés Ibañez-Tallon, Uwe Maskos, Vincent David.
J. Neurosci.. 2020-03-17. 40 (17) : 3465-3477.
DOI: 10.1523/JNEUROSCI.0356-19.2020 -
Targeting the Glucocorticoid Receptors During Alcohol Withdrawal to Reduce Protracted Neurocognitive Disorders.
Daniel Béracochéa, Nicole Mons and Vincent David.
Front Psychiatry. 2019-09-18. 10 (580)
DOI: 10.3389/fpsyt.2019.00580 -
sst-receptor gene deletion exacerbates chronic stress-induced deficits: Consequences for emotional and cognitive ageing
Thomas Damien Prévôt, Cécile Viollet, Jacques Epelbaum, Gaëlle Dominguez, Daniel Béracochéa, Jean-Louis Guillou.
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2018-08-01. 86 : 390-400.
DOI: 10.1016/j.pnpbp.2018.01.022 -
Attentional capacities prior to drug exposure predict motivation to self-administer nicotine.
Youna Vandaele, Emilie Noe, Martine Cador, Françoise Dellu-Hagedorn, Stephanie Caille.
Psychopharmacology. 2018-04-27. 235 (7) : 2041-2050.
DOI: 10.1007/s00213-018-4901-0 -
Unlimited sucrose consumption during adolescence generates a depressive-like phenotype in adulthood
Aliou B. Gueye, Leandro F. Vendruscolo, Camila de Ávila, Catherine Le Moine, Muriel Darnaudéry, Martine Cador.
Neuropsychopharmacol. 2018-12-27. 43 (13) : 2627-2635.
DOI: 10.1038/s41386-018-0025-9 -
Morphine Reward Promotes Cue-Sensitive Learning: Implication of Dorsal Striatal CREB Activity.
Mathieu Baudonnat, Jean-Louis Guillou, Marianne Husson, Veronique D. Bohbot, Lars Schwabe, Vincent David.
Front. Psychiatry. 2017-05-30. 8
DOI: 10.3389/fpsyt.2017.00087 -
Alcohol withdrawal induces long-lasting spatial working memory impairments: relationship with changes in corticosterone response in the prefrontal cortex.
Gaelle Dominguez, Catherine Belzung, Christophe Pierard, Vincent David, Nadia Henkous, Laurence Decorte, Nicole Mons, Daniel Beracochea.
Addiction Biology. 2016-02-10. 22 (4) : 898-910.
DOI: 10.1111/adb.12371 -
Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement
S Tolu, R Eddine, F Marti, V David, M Graupner, S Pons, M Baudonnat, M Husson, M Besson, C Reperant, J Zemdegs, C Pagès, Y A H Hay, B Lambolez, J Caboche, B Gutkin, A M Gardier, J-P Changeux, P Faure, U Maskos.
Mol Psychiatry. 2012-07-03. 18 (3) : 382-393.
DOI: 10.1038/mp.2012.83 -
Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine.
R. Exley, N. Maubourguet, V. David, R. Eddine, A. Evrard, S. Pons, F. Marti, S. Threlfell, P. Cazala, J. M. McIntosh, J.-P. Changeux, U. Maskos, S. J. Cragg, P. Faure.
Proceedings of the National Academy of Sciences. 2011-04-18. 108 (18) : 7577-7582.
DOI: 10.1073/pnas.1103000108
Team member(s)
Chercheurs, Praticiens hospitaliers...
Marc Corio Corio (University Teacher- Researcher)
Martine Cador Cador (Researcher)
Rose-Marie Vouimba Vouimba (University Teacher- Researcher)
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC