Developmental Brain Physiology and Pathology
A great challenge for our comprehension of the brain development is to identify how different biological signals converge and drive the maturation of excitatory synapses in the healthy and diseased brain. The goal of our lab is to use a multi-scale approach to decrypt the molecular mechanisms underpinning the maturation of the glutamatergic NMDA receptor-mediated signaling. How is this signaling regulated by scaffold proteins, transmembrane partners (e.g. dopamine receptors), molecules from the extracellular space, and the immune system? In addition, we investigate the instrumental role(s) of these molecular complexes in models of psychosis, in order to propose innovative therapeutical strategies.
Mots clés
Dépression, Développement du système nerveux, Imagerie cellulaire in vitro ou in vivo, Maladies Neuro-développementales, Microscopie super-résolutive, Physiologie synaptique, Schizophrénie, Signalisation, Synapse molecular complexesSelected publications
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Regulation of membrane NMDA receptors by dynamics and protein interactions
Mar Petit-Pedrol, Laurent Groc.
Journal of Cell Biology. 2020-12-18. 220 (1)
DOI: 10.1083/jcb.202006101 -
Synucleinopathy alters nanoscale organization and diffusion in the brain extracellular space through hyaluronan remodeling
Federico N. Soria, Chiara Paviolo, Evelyne Doudnikoff, Marie-Laure Arotcarena, Antony Lee, Noémie Danné, Amit Kumar Mandal, Philippe Gosset, Benjamin Dehay, Laurent Groc, Laurent Cognet, Erwan Bezard.
Nat Commun. 2020-07-10. 11 (1)
DOI: 10.1038/s41467-020-17328-9 -
Human endogenous retroviral protein triggers deficit in glutamate synapse maturation and behaviors associated with psychosis
E. M. Johansson, D. Bouchet, R. Tamouza, P. Ellul, AS. Morr, E. Avignone, R. Germi, M. Leboyer, H. Perron, L. Groc.
Sci. Adv.. 2020-07-01. 6 (29) : eabc0708.
DOI: 10.1126/sciadv.abc0708 -
Single nanoparticle tracking of N-methyl-D-aspartate receptors in cultured and intact brain tissue
Varela JA, Ferreira JS, Dupuis JP, Durand P, Bouchet D, Groc L..
Neurophotonics. 2016-07-12. 3 (4)
DOI: 10.1117/1.NPh.3.4.041808] -
Nanoscale exploration of the extracellular space in the live brain by combining single carbon nanotube tracking and super-resolution imaging analysis
Chiara Paviolo, Federico N. Soria, Joana S. Ferreira, Antony Lee, Laurent Groc, Erwan Bezard, Laurent Cognet.
Methods. 2019-03-09.
DOI: 10.1016/j.ymeth.2019.03.005 -
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses
Joana S Ferreira, Thomas Papouin, Laurent Ladépêche, Andrea Yao, Valentin C Langlais, Delphine Bouchet, Jérôme Dulong, Jean-Pierre Mothet, Silvia Sacchi, Loredano Pollegioni, Pierre Paoletti, Stéphane Henri Richard Oliet, Laurent Groc.
eLife. 2017-06-09. 6
DOI: 10.7554/eLife.25492 -
mGlu1 receptor canonical signaling pathway contributes to the opening of the orphan GluD2 receptor.
Selma Dadak, Nathalie Bouquier, Elise Goyet, Laurent Fagni, Carole Levenes, Julie Perroy.
Neuropharmacology. 2017-03-01. 115 : 92-99.
DOI: 10.1016/j.neuropharm.2016.06.001 -
Fluorescent-Based Strategies to Investigate G Protein-Coupled Receptors: Evolution of the Techniques to a Better Understanding
Orestis Faklaris, Joyce Heuninck, Amandine Falco, Elise Goyet, Jurriaan M. Zwier, Jean-Philippe Pin, Bernard Mouillac, Julie Perroy, Thierry Durroux.
Topics in Medicinal Chemistry. 2017-01-01.
DOI: 10.1007/7355_2017_2 -
Fast and high resolution single-cell BRET imaging.
Elise Goyet, Nathalie Bouquier, Vincent Ollendorff, Julie Perroy.
Sci Rep. 2016-06-15. 6 (1)
DOI: 10.1038/srep28231 -
Multiple domains in the C-terminus of NMDA receptor GluN2B subunit contribute to neuronal death following in vitro ischemia.
Marta M. Vieira, Jeannette Schmidt, Joana S. Ferreira, Kevin She, Shinichiro Oku, Miranda Mele, Armanda E. Santos, Carlos B. Duarte, Ann Marie Craig, Ana Luísa Carvalho.
Neurobiology of Disease. 2016-05-01. 89 : 223-234.
DOI: 10.1016/j.nbd.2015.11.007 -
GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome
J. S. Ferreira, J. Schmidt, P. Rio, R. Aguas, A. Rooyakkers, K. W. Li, A. B. Smit, A. M. Craig, A. L. Carvalho.
Journal of Neuroscience. 2015-06-03. 35 (22) : 8462-8479.
DOI: 10.1523/JNEUROSCI.3567-14.2015 -
Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.
Kevin She, Joana S. Ferreira, Ana Luisa Carvalho, Ann Marie Craig.
J. Biol. Chem.. 2012-06-27. 287 (33) : 27432-27445.
DOI: 10.1074/jbc.M112.345108 -
Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors
Sandra D. Santos, Olga Iuliano, Luís Ribeiro, Julien Veran, Joana S. Ferreira, Pedro Rio, Christophe Mulle, Carlos B. Duarte, Ana Luísa Carvalho.
J. Biol. Chem.. 2012-01-05. 287 (9) : 6868-6877.
DOI: 10.1074/jbc.M111.322909 -
Activity and protein kinase C regulate synaptic accumulation of N-methyl-D-aspartate (NMDA) receptors independently of GluN1 splice variant.
Joana S. Ferreira, Amanda Rooyakkers, Kevin She, Luis Ribeiro, Ana Luísa Carvalho, Ann Marie Craig.
J. Biol. Chem.. 2011-06-15. 286 (32) : 28331-28342.
DOI: 10.1074/jbc.M111.222539 -
Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors.
André R. Gomes, Joana S. Ferreira, Ana V. Paternain, Juan Lerma, Carlos B. Duarte, Ana Luísa Carvalho.
Molecular and Cellular Neuroscience. 2008-02-01. 37 (2) : 323-334.
DOI: 10.1016/j.mcn.2007.10.008
Team leader
Team member(s)
Chercheurs, Praticiens hospitaliers...
Hélène Grea
Grea
(University Teacher- Researcher)
Julien Dupuis Dupuis (Researcher)
Olivier Nicole Nicole (Researcher)
Frédéric Villega Villega (Researcher)
Julien Dupuis Dupuis (Researcher)
Olivier Nicole Nicole (Researcher)
Frédéric Villega Villega (Researcher)
Ingénieur(e)s, technicien(ne)s
Delphine Bouchet-Tessier
Bouchet-Tessier
Morgane Méras Méras
Romain Boularand Boularand
Thomas Lechanoine Lechanoine
Thomas Grard Grard
Madelyne Jego Jego
Morgane Méras Méras
Romain Boularand Boularand
Thomas Lechanoine Lechanoine
Thomas Grard Grard
Madelyne Jego Jego
Post-doctorant(s)
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC