Decision and adaptation (DECAD)
The main scope of our research is to understand the cognitive and neural bases of adaptive decision-making. Successful adaptation to complex and dynamic environments requires flexible use of our current knowledge about the world, including our ability to predict and control events under changing circumstances. These processes can be readily modelled and studied in rodents using approaches founded in experimental psychology and behavioural neuroscience. By employing both descriptive and functional neuroanatomical techniques (viral vectors, chemogenetics), we aim to understand the interplay between cortical and subcortical brain regions in such adaptive cognition. Ultimately, our research will elucidate the foundations of decision-making in the mammalian brain, both in normal and pathological conditions.
Mots clés
Analyses des données, Apprentissage, Assemblées neuronales, Attention, Codage et intégration du signal, Cognition, Comportement, Comportement alimentaire, Connectivité, Dépression, Déséquilibre alimentaire et vulnérabilité psychiatrique, Emotion, Fonctions exécutives, Formation et fonctionnement des circuits neuronaux, Motivation, Mémoire, Optogénétique, Optogénétique et chemogénétique, Schizophrénie, Troubles anxieux, Troubles des comportements alimentaires, Troubles du comportement, decision-makingSelected publications
-
Adaptive Responding to Stimulus–Outcome Associations Requires Noradrenergic Transmission in the Medial Prefrontal Cortex
Alessandro Piccin, Hadrien Plat, Mathieu Wolff, Etienne Coutureau.
J. Neurosci.. 2024-04-29. 44 (22) : e0078242024.
DOI: 10.1523/JNEUROSCI.0078-24.2024 -
A hippocampo-cortical pathway detects changes in the validity of an action as a predictor of reward.
Robin Piquet, Angélique Faugère, Shauna L. Parkes.
Current Biology. 2024-01-01. 34 (1) : 24-35.e4.
DOI: 10.1016/j.cub.2023.11.036 -
Inhibition of noradrenergic signaling in rodent orbitofrontal cortex impairs the updating of goal-directed actions
Juan Carlos Cerpa, Alessandro Piccin, Margot Dehove, Marina Lavigne, Eric J Kremer, Mathieu Wolff, Shauna L Parkes, Etienne Coutureau.
eLife. 2023-02-20. 12
DOI: 10.7554/eLife.81623 -
Dopamine and noradrenaline modulation of goal-directed behavior in orbital and medial prefrontal cortex: Toward a division of labor?
Juan-Carlos Cerpa, Etienne Coutureau, Shauna L. Parkes.
Behavioral Neuroscience. 2021-04-01. 135 (2) : 138-153.
DOI: 10.1037/bne0000426 -
Dopamine blockade impairs the exploration-exploitation trade-off in rats
François Cinotti, Virginie Fresno, Nassim Aklil, Etienne Coutureau, Benoît Girard, Alain R. Marchand & Mehdi Khamassi.
Scientific Reports. 2019-05-01. 9 (6770)
DOI: 10.1038/s41598-019-43245-z. -
A thalamocortical circuit for updating action-outcome associations
Virginie Fresno, Shauna L Parkes, Angélique Faugère, Etienne Coutureau, Mathieu Wolff.
Elife. 2019-04-23. 8
DOI: 10.7554/eLife.46187 -
The Cognitive Thalamus as a Gateway to Mental Representations
Mathieu Wolff, Seralynne D. Vann.
J. Neurosci.. 2018-11-02. 39 (1) : 3-14.
DOI: 10.1523/JNEUROSCI.0479-18.2018 -
Thalamocortical and corticothalamic pathways differentially contribute to goal-directed behaviors in the rat
Fabien Alcaraz, Virginie Fresno, Alain R Marchand, Eric J Kremer, Etienne Coutureau, Mathieu Wolff.
eLife. 2018-02-06. 7
DOI: 10.7554/eLife.32517 -
Insular and Ventrolateral Orbitofrontal Cortices Differentially Contribute to Goal-Directed Behavior in Rodents.
Shauna L Parkes, Pascal M Ravassard, Juan-Carlos Cerpa, Mathieu Wolff, Guillaume Ferreira, Etienne Coutureau.
Cerebral Cortex. 2017-05-25. 28 (7) : 2313-2325.
DOI: 10.1093/cercor/bhx132 -
Flexible Use of Predictive Cues beyond the Orbitofrontal Cortex: Role of the Submedius Thalamic Nucleus
F. Alcaraz, A. R. Marchand, E. Vidal, A. Guillou, A. Faugere, E. Coutureau, M. Wolff.
Journal of Neuroscience. 2015-09-23. 35 (38) : 13183-13193.
DOI: 10.1523/jneurosci.1237-15.2015 -
Functional heterogeneity of the limbic thalamus: From hippocampal to cortical functions
Mathieu Wolff, Fabien Alcaraz, Alain R. Marchand, Etienne Coutureau.
Neuroscience & Biobehavioral Reviews. 2015-07-01. 54 : 120-130.
DOI: 10.1016/j.neubiorev.2014.11.011 -
Parallel Maturation of Goal-Directed Behavior and Dopaminergic Systems during Adolescence
F. Naneix, A. R. Marchand, G. Di Scala, J.-R. Pape, E. Coutureau.
Journal of Neuroscience. 2012-11-14. 32 (46) : 16223-16232.
DOI: 10.1523/jneurosci.3080-12.2012 -
Pavlovian to instrumental transfer: A neurobehavioural perspective
Nathan M. Holmes, Alain R. Marchand, Etienne Coutureau.
Neuroscience & Biobehavioral Reviews. 2010-07-01. 34 (8) : 1277-1295.
DOI: 10.1016/j.neubiorev.2010.03.007
Team member(s)
Chercheurs, Praticiens hospitaliers...
Etienne Coutureau Coutureau (Researcher)
Shauna Parkes Parkes (Researcher)
Nicole Mons Mons (Researcher)
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Doctorant(s)
Sarah Morceau Morceau
Yacine Tensaouti Tensaouti
Hadrien Plat Plat
Florence Pontais Pontais
Juan Manuel Dafauce Garcia Dafauce Garcia
Mélie Talaron Talaron
Emma Marillat Marillat
Louis Morel Morel
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC