Choice, Addiction and Neurodysfunctions (Candy)
Our research aims at studying the environmental, psychological and neurobiological determinants of the hallmark stages and behavioral features of addiction, including transition to addiction, individual drug preferences, loss of control, craving and vulnerability to relapse. To pursue our research goals, we resort to a wide array of relevant methods, procedures and techniques ranging from innovative behavioral procedures, specially designed to probe addiction-related behavioral processes (e.g., decision-making, choice and attention), state-of-the-art methods for in vivo recording and manipulation of neuronal activity in discrete brain circuits in behaving rats, to transcriptomic approaches. We also participate to clinically-oriented research projects, mainly by offering consulting to study design and/or data interpretation.
Mots clés
Assemblées neuronales, Attention, Comportement, Craving, Neurophysiologie, Optogénétique, Rechute, addiction, choix, circuits neuronaux, decision-making, preference, transcriptomiqueSelected publications
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The multiple faces of footshock punishment in animal research on addiction
Michel Engeln, Serge H. Ahmed.
Neurobiology of Learning and Memory. 2024-06-01. : 107955.
DOI: 10.1016/j.nlm.2024.107955 -
Bidirectional relationship between attentional deficits and escalation of nicotine intake in male rats
Caroline Vouillac-Mendoza, Serge H. Ahmed, Karine Guillem.
Psychopharmacology. 2024-05-14.
DOI: 10.1007/s00213-024-06604-x -
Knowledge by omission: the significance of omissions in the 5-choice serial reaction time task
Caroline Vouillac-Mendoza, Audrey Durand, Serge H. Ahmed, Karine Guillem.
Psychopharmacology. 2024-03-06.
DOI: 10.1007/s00213-024-06564-2 -
The importance of choice and agency in animal models of addiction
Serge H. Ahmed.
J Neural Transm. 2023-10-31.
DOI: 10.1007/s00702-023-02712-8 -
Large‐scale brain correlates of sweet versus cocaine reward in rats
Magalie Lenoir, Sylvia Navailles, Youna Vandaele, Caroline Vouillac‐Mendoza, Karine Guillem, Serge H. Ahmed.
Eur J of Neuroscience. 2022-12-01.
DOI: 10.1111/ejn.15879 -
Cocaine falls into oblivion during volitional initiation of choice trials
Youna Vandaele, Eric Augier, Caroline Vouillac‐Mendoza, Serge H. Ahmed.
Addiction Biology. 2022-10-04. 27 (6)
DOI: 10.1111/adb.13235 -
Probing the decision-making mechanisms underlying choice between drug and nondrug rewards in rats
Youna Vandaele, Magalie Lenoir, Caroline Vouillac-Mendoza, Karine Guillem, Serge H Ahmed.
eLife. 2021-04-26. 10
DOI: 10.7554/eLife.64993 -
Habit, choice and addiction
Y. Vandaele, S. H. Ahmed.
Neuropsychopharmacol.. 2020-11-09.
DOI: 10.1038/s41386-020-00899-y -
Sex-Specific Role for Egr3 in Nucleus Accumbens D2-Medium Spiny Neurons Following Long-Term Abstinence From Cocaine Self-administration
Michel Engeln, Swarup Mitra, Ramesh Chandra, Utsav Gyawali, Megan E. Fox, David M. Dietz, Mary Kay Lobo.
Biological Psychiatry. 2020-06-01. 87 (11) : 992-1000.
DOI: 10.1016/j.biopsych.2019.10.019
Team member(s)
Chercheurs, Praticiens hospitaliers...
Magalie Lenoir Lenoir (Researcher)
Michel Engeln Englen (Researcher)
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC