Symposium – Glia, metabolism, synapses and behavior

Venue: Centre Broca

Organised by Giovanni Marsicano (Magendie)

About the symposium

Metabolic interactions between glial cells and neurons shape synaptic function and modulate behavior. In the brain, astrocytes and myelinating oligodendrocytes supply neurons with energy substrates, mainly lactate, to provide homeostatic metabolic support for axonal function and integrity. The metabolic features of neuron-glia interactions are complex and heterogeneous, and emerge nowadays as novel players in the pathogenesis of neurological disorders. This symposium will present recent evidence on the cellular mechanisms underlying metabolic cooperation between astrocytes, oligodendrocytes and neurons and their implications at the synaptic and behavioral levels and provide insights on the bioenergetic perturbations affecting glial cells during neuroinflammation.

Program

14:00 – Giovanni Marsicano – NeuroCentre Magendie
Opening remarks

14:05 – Juan P. Bolaños – University of Salamanca
Metabolic control of astrocytic mitochondrial supercomplexes in ROS signaling and behavior

14:45 – Aude Panatier – NeuroCentre Magendie
Glucose and lactate: when energy is required to calm down

15:25 – Ignacio Fernández-Moncada – NeuroCentre Magendie
Not only shuttle: CB1 integration of metabolic and signaling processes in behavior

16:00 – Coffee Break

16:30 – Anne-Karine Bouzier-Sore – CRMSB
The Astrocyte-Neuron Lactate Shuttle: Relevance for brain function & dysfunction

17:10 – Susana Mato – University of the Basque Country
Synaptic and metabolic implications of cortical astrocyte dysfunction in multiple sclerosis

17:40 – Aiman Saab – University of Zurich
Oligodendrocyte functions shape axonal energy metabolism

18:20 Giovanni Marsicano
Closing remarks