Yann Humeau

Team leader

Researcher - PhD (CR) / CNRS

/ Team

/ Contact

+33 5 33 51 47 03

www.orcid.org/0000-0003-0471-3414

/ Address of work
IINS - UMR 5297 - CNRS - Université de Bordeaux - Centre Broca Nouvelle-Aquitaine - 146 rue Léo-Saignat - CS 61292 CASE 130 - 33076 Bordeaux cedex -France

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Scientific articles

CA3 hippocampal synaptic plasticity supports ripple physiology during memory consolidation
Hajer El Oussini, Chun-Lei Zhang, Urielle François, Cecilia Castelli, Aurélie Lampin-Saint-Amaux, Marilyn Lepleux, Pablo Molle, Legeolas Velez, Cyril Dejean, Frederic Lanore, Cyril Herry, Daniel Choquet, Yann Humeau.
Nat Commun. 2023-12-14. 14(1)
10.1038/s41467-023-42969-x
Axo-axonic cells in neuropsychiatric disorders: a systematic review
Juliette Vivien, Anass El Azraoui, Cloé Lheraux, Frederic Lanore, Bruno Aouizerate, Cyril Herry, Yann Humeau, Thomas C. M. Bienvenu.
Front. Cell. Neurosci.. 2023-06-26. 17
10.3389/fncel.2023.1212202
Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice
Marta Prieto, Alessandra Folci, Gwénola Poupon, Sara Schiavi, Valeria Buzzelli, Marie Pronot, Urielle François, Paula Pousinha, Norma Lattuada, Sophie Abelanet, Sara Castagnola, Magda Chafai, Anouar Khayachi, Carole Gwizdek, Frédéric Brau, Emmanuel Deval, Maura Francolini, Barbara Bardoni, Yann Humeau, Viviana Trezza, Stéphane Martin.
Nat Commun. 2021-03-10. 12(1)
10.1038/s41467-021-21820-1
The integration of Gaussian noise by long-range amygdala inputs in frontal circuit promotes fear learning in mice
Mattia Aime, Elisabete Augusto, Vladimir Kouskoff, Tiago Campelo, Christelle Martin, Yann Humeau, Nicolas Chenouard, Frederic Gambino.
eLife. 2020-11-30. 9
10.7554/elife.62594
A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency
Xiao Min Zhang, Urielle François, Kätlin Silm, Maria Florencia Angelo, Maria Victoria Fernandez-Busch, Mona Maged, Christelle Martin, Véronique Bernard, Fabrice P Cordelières, Melissa Deshors, Stéphanie Pons, Uwe Maskos, Alexis Pierre Bemelmans, Sonja M Wojcik, Salah El Mestikawy, Yann Humeau, Etienne Herzog.
eLife. 2019-10-30. 8
10.7554/eLife.50401
The next generation of approaches to investigate the link between synaptic plasticity and learning
Yann Humeau, Daniel Choquet.
Nat Neurosci. 2019-09-02. 22(10) : 1536-1543.
10.1038/s41593-019-0480-6
Non-linear dendritic integration in frontal circuits shapes sensory discrimination in rodents
Mattia Aime, Elisabete Augusto, Vladimir Kouskoff, Christelle Martin, Yann Humeau, Nicolas Chenouard, Frédéric Gambino.
. 2019-03-06.
10.1101/569137
Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models
Hongyu Zhang, Chunlei Zhang, Jean Vincent, Diana Zala, Caroline Benstaali, Matthieu Sainlos, Dolors Grillo-Bosch, Sophie Daburon, Françoise Coussen, Yoon Cho, Denis J. David, Frederic Saudou, Yann Humeau, Daniel Choquet.
Nat Commun. 2018-10-15. 9(1)
10.1038/s41467-018-06675-3
Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors.
A. C. Penn, C. L. Zhang, F. Georges, L. Royer, C. Breillat, E. Hosy, J. D. Petersen, Y. Humeau, D. Choquet.
Nature. 2017-09-13. 549(7672) : 384-388.
10.1038/nature23658
Profiling olfactory stem cells from living patients identifies miRNAs relevant for autism pathophysiology.
Nguyen LS, Lepleux M, Makhlouf M, Martin C, Fregeac J, Siquier-Pernet K, Philippe A, Feron F, Gepner B, Rougeulle C, Humeau Y, Colleaux L.
Mol Autism.. 2016-01-08. 7(1)
10.1186/s13229-015-0064-6
The hippocampo-amygdala control of contextual fear expression is affected in a model of intellectual disability
Chun-Lei Zhang, Xander Houbaert, Marilyn Lepleux, Melissa Deshors, Elisabeth Normand, Frédéric Gambino, Etienne Herzog, Yann Humeau.
Brain Struct Funct. 2014-08-27. 220(6) : 3673-3682.
10.1007/s00429-014-0882-x
Coronin 1 Regulates Cognition and Behavior through Modulation of cAMP/Protein Kinase A Signaling
Rajesh Jayachandran, Xiaolong Liu, Somdeb BoseDasgupta, Philipp Müller, Chun-Lei Zhang, Despina Moshous, Vera Studer, Jacques Schneider, Christel Genoud, Catherine Fossoud, Frédéric Gambino, Malik Khelfaoui, Christian Müller, Deborah Bartholdi, Helene Rossez, Michael Stiess, Xander Houbaert, Rolf Jaussi, Daniel Frey, Richard A. Kammerer, Xavier Deupi, Jean-Pierre de Villartay, Andreas Lüthi, Yann Humeau, Jean Pieters.
PLoS Biol. 2014-03-25. 12(3) : e1001820.
10.1371/journal.pbio.1001820
Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway
M. Khelfaoui, F. Gambino, X. Houbaert, B. Ragazzon, C. Muller, M. Carta, F. Lanore, B. N. Srikumar, P. Gastrein, M. Lepleux, C.-L. Zhang, M. Kneib, B. Poulain, S. Reibel-Foisset, N. Vitale, J. Chelly, P. Billuart, A. Luthi, Y. Humeau.
Philosophical Transactions of the Royal Society B: Biological Sciences. 2013-12-02. 369(1633) : 20130160-20130160.
10.1098/rstb.2013.0160
In vivo evidence that TRAF4 is required for central nervous system myelin homeostasis
Sébastien Blaise, Marie Kneib, Adrien Rousseau, Frederic Gambino, Marie-Pierre Chenard, Nadia Messadeq, Martine Muckenstrum, Fabien Alpy, Catherine Tomasetto, Yann Humeau, Marie-Christine Rio.
PLoS ONE. 2012-02-17. 7(2) : e30917.
10.1371/journal.pone.0030917
Forebrain deletion of αGDI in adult mice worsens the pre-synaptic deficit at cortico-lateral amygdala synaptic connections
Veronica Bianchi, Frédéric Gambino, Luca Muzio, Daniela Toniolo, Yann Humeau, Patrizia D'Adamo.
PLoS ONE. 2012-01-23. 7(1) : e29763.
10.1371/journal.pone.0029763
The coffin-lowry syndrome-associated protein RSK2 and neurosecretion
M. Zeniou-Meyer, F. Gambino, Mohamed-Raafet Ammar, Y. Humeau, N. Vitale.
Cell Mol Neurobiol. 2010-11-01. 30(8) : 1401-1406.
10.1007/s10571-010-9578-9
Synaptic maturation at cortical projections to the lateral amygdala in a mouse model of rett syndrome
Frédéric Gambino, Malik Khelfaoui, Bernard Poulain, Thierry Bienvenu, Jamel Chelly, Yann Humeau.
PLoS ONE. 2010-07-02. 5(7) : e11399.
10.1371/journal.pone.0011399
IL1RAPL1 controls inhibitory networks during cerebellar development in mice
Frédéric Gambino, Marie Kneib, Alice Pavlowsky, Henriette Skala, Stéphane Heitz, Nicolas Vitale, Bernard Poulain, Malik Khelfaoui, Jamel Chelly, Pierre Billuart, Yann Humeau.
European Journal of Neuroscience. 2009-10-01. 30(8) : 1476-1486.
10.1111/j.1460-9568.2009.06975.x
L-type voltage-dependent Ca2+ channels mediate expression of presynaptic LTP in amygdala
Elodie Fourcaudot, Frederic Gambino, Guillaume Casassus, Bernard Poulain, Yann Humeau, Andreas Lüthi.
Nat Neurosci. 2009-08-02. 12(9) : 1093-1095.
10.1038/nn.2378
Amygdala Inhibitory Circuits and the Control of Fear Memory
Ingrid Ehrlich, Yann Humeau, François Grenier, Stephane Ciocchi, Cyril Herry, Andreas Lüthi.
Neuron. 2009-06-01. 62(6) : 757-771.
10.1016/j.neuron.2009.05.026
X-linked mental retardation: focus on synaptic function and plasticity
Yann Humeau, Frédéric Gambino, Jamel Chelly, Nicolas Vitale.
Journal of Neurochemistry. 2009-04-01. 109(1) : 1-14.
10.1111/j.1471-4159.2009.05881.x
cAMP/PKA signaling and RIM1α mediate presynaptic LTP in the lateral amygdala
E. Fourcaudot, F. Gambino, Y. Humeau, G. Casassus, H. Shaban, B. Poulain, A. Luthi.
Proceedings of the National Academy of Sciences. 2008-09-24. 105(39) : 15130-15135.
10.1073/pnas.0806938105
IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation
F. Gambino, A. Pavlowsky, A. Begle, J.-L. Dupont, N. Bahi, R. Courjaret, R. Gardette, H. Hadjkacem, H. Skala, B. Poulain, J. Chelly, N. Vitale, Y. Humeau.
Proceedings of the National Academy of Sciences. 2007-05-14. 104(21) : 9063-9068.
10.1073/pnas.0701133104
Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition
Hamdy Shaban, Yann Humeau, Cyril Herry, Guillaume Cassasus, Ryuichi Shigemoto, Stephane Ciocchi, Samuel Barbieri, Herman van der Putten, Klemens Kaupmann, Bernhard Bettler, Andreas Lüthi.
Nat Neurosci. 2006-07-02. 9(8) : 1028-1035.
10.1038/nn1732
Dendritic Spine Heterogeneity Determines Afferent-Specific Hebbian Plasticity in the Amygdala
Yann Humeau, Cyril Herry, Nicola Kemp, Hamdy Shaban, Elodie Fourcaudot, Stephanie Bissière, Andreas Lüthi.
Neuron. 2005-01-01. 45(1) : 119-131.
10.1016/j.neuron.2004.12.019