Valentin Nägerl
Team leader
University professor - Researcher / Université de Bordeaux/ Contact
+33 5 33 51 47 07
www.orcid.org/0000-0001-6831-9008
/ Address of work
IINS - UMR 5297 - CNRS - Université de Bordeaux - Centre Broca Nouvelle-Aquitaine - 146 rue Léo-Saignat - CS 61292 CASE 130 - 33076 Bordeaux cedex -France
Scientific articles
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Arkitekt: streaming analysis and real-time workflows for microscopy
Nat Methods. 2024-09-18.
10.1038/s41592-024-02404-5 -
Impact of a tilted coverslip on two-photon and STED microscopy
Biomed. Opt. Express. 2024-01-16. 15(2) : 743.
10.1364/BOE.510512 -
Shadow imaging for panoptical visualization of brain tissue in vivo
Nat Commun. 2023-10-12. 14(1)
10.1038/s41467-023-42055-2 -
Fluorescent sensors for imaging of interstitial calcium
Nat Commun. 2023-10-05. 14(1)
10.1038/s41467-023-41928-w -
The impact of chemical fixation on the microanatomy of mouse organotypic hippocampal slices
eNeuro. 2023-09-14. : ENEURO.0104-23.2023.
10.1523/ENEURO.0104-23.2023 -
Nanoscale and functional heterogeneity of the hippocampal extracellular space
Cell Reports. 2023-05-01. 42(5) : 112478.
10.1016/j.celrep.2023.112478 -
The impact of chemical fixation on the microanatomy of mouse brain tissue
prePrint bioRXiv. 2023-02-22.
10.1101/2023.02.21.528828 -
Imaging dendritic spines in the hippocampus of a living mouse by 3D-STED microscopy
PrePrint bioRxiv. 2023-02-01.
10.1101/2023.02.01.526326 -
Shadow imaging for panoptical visualization of living brain tissue
. 2022-11-03.
10.1101/2022.11.03.511028 -
Control of Ca 2+ signals by astrocyte nanoscale morphology at tripartite synapses
Glia. 2022-09-13.
10.1002/glia.24258 -
Getting sharper: the brain under the spotlight of super-resolution microscopy
Trends in Cell Biology. 2022-07-01.
10.1016/j.tcb.2022.06.011 -
Deciphering the functional nano‐anatomy of the tripartite synapse using s timulated emission depletion microscopy
Glia. 2021-10-19.
10.1002/glia.24103 -
Aberration correction in stimulated emission depletion microscopy to increase imaging depth in living brain tissue
Neurophoton.. 2021-06-14. 8(03)
10.1117/1.nph.8.3.035001 -
Nanoscale imaging of the functional anatomy of the brain
Neuroforum. 2021-03-18.
10.1515/nf-2021-0004 -
Super‐resolution shadow imaging reveals local remodeling of astrocytic microstructures and brain extracellular space after osmotic challenge
Glia. 2021-03-12.
10.1002/glia.23995 -
Il faut être trois pour danser le tango
Med Sci (Paris). 2021-02-01. 37(2) : 127-129.
10.1051/medsci/2020275 -
Aberration correction in STED microscopy to increase imaging depth in living brain tissue
Preprint bioRxiv. 2021-01-06.
10.1101/2021.01.05.425408 -
Super-resolution shadow imaging reveals local remodeling of astrocytic microstructures and brain extracellular space after osmotic challenge
Preprint bioRxiv. 2021-01-05.
10.1101/2021.01.05.425369 -
Turning up the Green Light
Trends in Cell Biology. 2020-12-01.
10.1016/j.tcb.2020.12.007 -
Ultrastructural Imaging of Activity-Dependent Synaptic Membrane-Trafficking Events in Cultured Brain Slices
Neuron. 2020-09-28. 108 : 1-18.
10.1016/j.neuron.2020.09.004 -
LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia
Neuron. 2020-09-01.
10.1016/j.neuron.2020.08.030 -
Visualiser l’espace extracellulaire du cerveau par imagerie super-résolutive en contraste inversé
Med Sci (Paris). 2020-06-01. 36(6-7) : 559-561.
10.1051/medsci/2020105 -
Author Correction: Structural basis of astrocytic Ca2+ signals at tripartite synapses
Nat Commun. 2020-05-18. 11(1)
10.1038/s41467-020-16453-9 -
Structural basis of astrocytic Ca2+ signals at tripartite synapses
Nat Commun. 2020-04-20. 11(1)
10.1038/s41467-020-15648-4 -
Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance
Sci. Immunol.. 2020-04-03. 5(46) : eaaz4371.
10.1126/sciimmunol.aaz4371 -
SpineJ: A software tool for quantitative analysis of nanoscale spine morphology
Methods. 2020-03-01. 174 : 49-55.
10.1016/j.ymeth.2020.01.020 -
A simple tissue clearing method for increasing the depth penetration of STED microscopy of fixed brain slices
J. Phys. D: Appl. Phys.. 2020-01-23.
10.1088/1361-6463/ab6f1b -
A super-resolution platform for correlative live single-molecule imaging and STED microscopy
Nat Methods. 2019-10-21.
10.1038/s41592-019-0611-8 -
SpineJ : A software tool for quantitative analysis of nanoscale spine morphology
. 2019-09-10.
10.1101/764548 -
Simulation of calcium signaling in fine astrocytic processes: Effect of spatial properties on spontaneous activity
PLoS Comput Biol. 2019-08-19. 15(8) : e1006795.
10.1371/journal.pcbi.1006795 -
Lattice light sheet microscopy and photo-stimulation in brain slices
Neural Imaging and Sensing 2019. 2019-03-01.
10.1117/12.2509467 -
Unveiling the Extracellular Space of the Brain: From Super-resolved Microstructure to In Vivo Function
J. Neurosci.. 2018-10-31. 38(44) : 9355-9363.
10.1523/JNEUROSCI.1664-18.2018 -
Chronic 2P-STED imaging reveals high turnover of dendritic spines in the hippocampus in vivo
eLife. 2018-06-22. 7
10.7554/eLife.34700 -
Astroglia withdraw from potentiated synapses boosting inter-synaptic cross-talk
. 2018-06-17.
10.1101/349233 -
Evidence for altered dendritic spine compartmentalization in Alzheimer’s disease and functional effects in a mouse model
Acta Neuropathol. 2018-04-25. 135(6) : 839-854.
10.1007/s00401-018-1847-6 -
Super-Resolution Imaging of the Extracellular Space in Living Brain Tissue
Cell. 2018-02-01. 172(5) : 1108-1121.e15.
10.1016/j.cell.2018.02.007 -
Super-resolution STED imaging reveals a new type of axonal plasticity,La plasticité axonale révélée par l’imagerie super-résolution STED
Med Sci (Paris). 2018-01-01. 34(1) : 17-20.
10.1051/medsci/20183401005 -
APC/CCdh1-Rock2 pathway controls dendritic integrity and memory
Proc Natl Acad Sci USA. 2017-04-10. 114(17) : 4513-4518.
10.1073/pnas.1616024114 -
Superresolution imaging reveals activity-dependent plasticity of axon morphology linked to changes in action potential conduction velocity
Proc Natl Acad Sci USA. 2017-01-23. 114(6) : 1401-1406.
10.1073/pnas.1607541114 -
Two-Photon STED Microscopy for Nanoscale Imaging of Neural Morphology In Vivo
Methods in Molecular Biology. 2017-01-01. : 45-64.
10.1007/978-1-4939-7265-4_5 -
Special Section Guest Editorial:Super-resolution microscopy of neural structure and function
Neurophoton. 2016-12-21. 3(4) : 041801.
10.1117/1.NPh.3.4.041801 -
Induction of hippocampal long-term potentiation increases the morphological dynamics of microglial processes and prolongs their contacts with dendritic spines
Sci Rep. 2016-09-08. 6(1)
10.1038/srep32422 -
Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors.
Nat Comms. 2016-06-17. 7 : 11915.
10.1038/ncomms11915 -
Dendritic Spines as Tunable Regulators of Synaptic Signals
Front. Psychiatry. 2016-06-09. 7
10.3389/fpsyt.2016.00101 -
Spines slow down dendritic chloride diffusion and affect short-term ionic plasticity of GABAergic inhibition.
Sci Rep. 2016-03-18. 6(1)
10.1038/srep23196 -
Biochemical compartmentalization in dendrites
Dendrites. 2016-03-01. : 285-324.
10.1093/acprof:oso/9780198745273.003.0010 -
Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice.
Journal of Neuroscience. 2015-11-11. 35(45) : 15073-15081.
10.1523/JNEUROSCI.1087-15.2015 -
Altered morphological dynamics of activated microglia after induction of status epilepticus.
J Neuroinflammation. 2015-11-04. 12(1)
10.1186/s12974-015-0421-6 -
STED microscopy for nanoscale imaging in living brain slices.
Methods. 2015-10-01. 88 : 57-66.
10.1016/j.ymeth.2015.06.006 -
Dissecting tripartite synapses with STED microscopy
Philosophical Transactions of the Royal Society B: Biological Sciences. 2014-09-15. 369(1654) : 20130597-20130597.
10.1098/rstb.2013.0597 -
Stimulated emission depletion (STED) microscopy reveals nanoscale defects in the developmental trajectory of dendritic spine morphogenesis in a mouse model of fragile X syndrome.
Journal of Neuroscience. 2014-04-30. 34(18) : 6405-6412.
10.1523/JNEUROSCI.5302-13.2014 -
Spine neck plasticity regulates compartmentalization of synapses
Nat Neurosci. 2014-03-23. 17(5) : 678-685.
10.1038/nn.3682 -
Nanoscale Imaging of Synapses
Neuromethods. 2014-01-01.
10.1007/978-1-4614-9179-8 -
Two-Photon Excitation STED Microscopy for Imaging Synapses and Glia in Acute Brain Slices
Neuromethods. 2014-01-01. : 205-220.
10.1007/978-1-4614-9179-8_11 -
Superresolution imaging for neuroscience
Experimental Neurology. 2013-04-01. 242 : 33-40.
10.1016/j.expneurol.2012.10.004 -
Two-photon excitation STED microscopy in two colors in acute brain slices.
Biophysical Journal. 2013-02-01. 104(4) : 778-785.
10.1016/j.bpj.2012.12.054 -
3SBA-04 STED imaging of synapses in living brain slices : from structure to function(3SBA Cutting-edge optical imaging approach to neuroscience-From single molecule to in vivo-,Symposium)
Biophysics. 2013-01-01. 53(supplement1-2) : S102.
10.2142/biophys.53.s102_2 -
Two-Color STED Imaging of Synapses in Living Brain Slices
Nanoimaging. 2012-09-18. : 65-80.
10.1007/978-1-62703-137-0_5 -
Stimulated Emission Depletion (STED) Imaging of Dendritic Spines in Living Hippocampal Slices
Cold Spring Harb Protoc. 2012-05-01. 2012(5) : pdb.prot069260.
10.1101/pdb.prot069260 -
Beyond Abbe’s Resolution Barrier
Cellular Imaging Techniques for Neuroscience and Beyond. 2012-01-01. : 35-54.
10.1016/b978-0-12-385872-6.00002-7 -
Two-Color STED Microscopy of Living Synapses Using A Single Laser-Beam Pair
Biophysical Journal. 2011-11-01. 101(10) : 2545-2552.
10.1016/j.bpj.2011.10.011 -
In vivo imaging of intersynaptic vesicle exchange using VGLUT1 Venus knock-in mice.
Journal of Neuroscience. 2011-10-26. 31(43) : 15544-15559.
10.1523/JNEUROSCI.2073-11.2011 -
STED Nanoscopy of Actin Dynamics in Synapses Deep Inside Living Brain Slices
Biophysical Journal. 2011-09-01. 101(5) : 1277-1284.
10.1016/j.bpj.2011.07.027 -
A Global Spatial Similarity Optimization Scheme to Track Large Numbers of Dendritic Spines in Time-Lapse Confocal Microscopy
IEEE Trans. Med. Imaging. 2011-03-01. 30(3) : 632-641.
10.1109/tmi.2010.2090354 -
Knowledge-Based Morphology Quantification of STED Dendritic Spine Images
IFMBE Proceedings. 2011-01-01. : 1210-1213.
10.1007/978-3-642-23508-5_313 -
Imaging living synapses at the nanoscale by STED microscopy.
Journal of Neuroscience. 2010-07-14. 30(28) : 9341-9346.
10.1523/JNEUROSCI.0990-10.2010 -
STED Nanoscopy in Living Cells using Live Cell Compatible Markers
Biophysical Journal. 2009-02-01. 96(3) : 17a.
10.1016/j.bpj.2008.12.988 -
Nanoscale imaging of living synapses by STED microscopy
Neuroscience Research. 2009-01-01. 65 : S26.
10.1016/j.neures.2009.09.1637 -
Live-cell imaging of dendritic spines by STED microscopy.
Proceedings of the National Academy of Sciences. 2008-11-21. 105(48) : 18982-18987.
10.1073/pnas.0810028105 -
LTD Induction Causes Morphological Changes of Presynaptic Boutons and Reduces Their Contacts with Spines
Neuron. 2008-11-01. 60(4) : 590-597.
10.1016/j.neuron.2008.09.018 -
Protracted synaptogenesis after activity-dependent spinogenesis in hippocampal neurons
Journal of Neuroscience. 2007-07-25. 27(30) : 8149-8156.
10.1523/JNEUROSCI.0511-07.2007 -
A Balance of Protein Synthesis and Proteasome-Dependent Degradation Determines the Maintenance of LTP
Neuron. 2006-10-01. 52(2) : 239-245.
10.1016/j.neuron.2006.08.015 -
Neuronal activity determines the protein synthesis dependence of long-term potentiation
Nat Neurosci. 2006-03-12. 9(4) : 478-480.
10.1038/nn1667 -
Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion.
J Exp Med. 2005-06-06. 201(11) : 1805-1814.
10.1084/jem.20050011 -
Competing for memory: hippocampal LTP under regimes of reduced protein synthesis.
Neuron. 2004-12-01. 44(6) : 1011-1020.
10.1016/j.neuron.2004.10.033 -
Bidirectional Activity-Dependent Morphological Plasticity in Hippocampal Neurons
Neuron. 2004-12-01. 44(5) : 759-767.
10.1016/j.neuron.2004.11.016 -
Spatial micromovements of uncemented femoral components after torsional loads.
J Biomech Eng. 2002-12-27. 124(6) : 706.
10.1115/1.1517565 -
Binding Kinetics of Calbindin-D28k Determined by Flash Photolysis of Caged Ca2+
Biophysical Journal. 2000-12-01. 79(6) : 3009-3018.
10.1016/s0006-3495(00)76537-4 -
Bending vibrations of the femur and the oscillatory behavior of a cemented femoral hip endoprosthesis.
J Biomech Eng. 2000-02-28. 122(4) : 416.
10.1115/1.1286317 -
Calcium-dependent inactivation of high-threshold calcium currents in human dentate gyrus granule cells
The Journal of Physiology. 1998-05-01. 509(1) : 39-45.
10.1111/j.1469-7793.1998.039bo.x