Nathalie Dutheil
Facility leader
Research Engineer (IR) - / CNRS/ Contact
+33 5 33 51 47 23
www.orcid.org/0000-0001-9121-217X
/ Address of work
IMN - UMR 5293 - CNRS/Université de Bordeaux - Centre Broca Nouvelle-Aquitaine – 3e étage - 146 rue Léo-Saignat
- CS 61292 – Case 28 - 33076 Bordeaux cedex - France
Scientific articles
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Reconsidering α-Synuclein inclusion pathology in neurons, mice, and humans with an antibody sensing NAC engagement during α-Synuclein amyloid conversion
Preprint - Research Square. 2024-02-07.
10.21203/rs.3.rs-3921168/v1 -
GRK2‐ Targeted Knockdown as Therapy for Multiple System Atrophy
Movement Disorders. 2023-04-24.
10.1002/mds.29422 -
Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques
Front. Bioeng. Biotechnol.. 2021-11-15. 9
10.3389/fbioe.2021.762209 -
Impaired brain insulin signalling in Parkinson’s disease
Neuropathol Appl Neurobiol. 2021-08-17.
10.1111/nan.12760 -
Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons
Sci. Adv.. 2020-10-01. 6(40) : eabc4364.
10.1126/sciadv.abc4364 -
Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neurons
. 2020-02-12.
10.1101/2020.02.11.943670 -
Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
JCI Insight. 2019-08-22. 4(16)
10.1172/jci.insight.129719 -
In utero delivery of rAAV2/9 induces neuronal expression of the transgene in the brain: towards new models of Parkinson’s disease.
Gene Ther. 2017-11-16. 24(12) : 801-809.
10.1038/gt.2017.84 -
Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy.
Mov Disord.. 2017-05-29. 32(8) : 1230-1239.
10.1002/mds.27041 -
Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression.
acta neuropathol commun. 2015-07-25. 3(1)
10.1186/s40478-015-0222-2 -
Systemic gene delivery to the central nervous system using Adeno-associated virus.
Front. Mol. Neurosci.. 2014-06-02. 7
10.3389/fnmol.2014.00050 -
Adeno-associated virus Rep represses the human integration site promoter by two pathways that are similar to those required for the regulation of the viral p5 promoter.
Journal of Virology. 2014-05-14. 88(15) : 8227-8241.
10.1128/jvi.00412-14 -
Transcriptional analysis of the adeno-associated virus integration site.
Journal of Virology. 2009-09-16. 83(23) : 12512-12525.
10.1128/jvi.01754-09 -
Site-specific integration of adeno-associated virus involves partial duplication of the target locus.
Proceedings of the National Academy of Sciences. 2009-04-16. 106(18) : 7571-7576.
10.1073/pnas.0806821106 -
Characterization of the mouse adeno-associated virus AAVS1 ortholog.
Journal of Virology. 2004-07-27. 78(16) : 8917-8921.
10.1128/jvi.78.16.8917-8921.2004 -
Adeno-associated virus site-specifically integrates into a muscle-specific DNA region.
Proceedings of the National Academy of Sciences. 2000-04-11. 97(9) : 4862-4866.
10.1073/pnas.080079397