Muriel Thoby-Brisson
Team Leader
Researcher / INSERM/ Contact
+33 5 57 57 47 73
www.orcid.org/0000-0003-3214-1724
/ Address of work
INCIA - UMR 5287 - CNRS/Université de Bordeaux - Zone nord Bat 2 - 2e étage, 146, rue Léo-Saignat - 33076 Bordeaux cedex
Scientific articles
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Central respiratory command and microglia: An early-life partnership
Current Opinion in Neurobiology. 2023-10-01. 82 : 102756.
10.1016/j.conb.2023.102756 -
Microglia shape the embryonic development of mammalian respiratory networks
eLife. 2022-11-02. 11
10.7554/eLife.80352 -
Perinatal development of central vestibular neurons in mice.
Front. Neurosci.. 2022-09-01. 16
10.3389/fnins.2022.935166 -
Chronic maternal exposure to titanium dioxide nanoparticles alters breathing in newborn offspring
Part Fibre Toxicol. 2022-08-18. 19(1)
10.1186/s12989-022-00497-4 -
Neurogenic mechanisms for locomotor-respiratory coordination in mammals
Front. Neuroanat.. 2022-07-28. 16
10.3389/fnana.2022.953746 -
Obstructive Apneas in a Mouse Model of Congenital Central Hypoventilation Syndrome
Am J Respir Crit Care Med. 2021-11-15. 204(10) : 1200-1210.
10.1164/rccm.202104-0887oc -
Synergistic interaction between sensory inputs and propriospinal signaling underlying quadrupedal locomotion
J Physiol. 2021-08-19.
10.1113/JP281861 -
A Rodent Model of Mild Neonatal Hypoxic Ischemic Encephalopathy
Front. Neurol.. 2021-05-05. 12
10.3389/fneur.2021.637947 -
Modulation of respiratory network activity by forelimb and hindlimb locomotor generators
Eur J Neurosci. 2020-03-09.
10.1111/ejn.14717 -
Neural mechanisms for sigh generation during prenatal development
Journal of Neurophysiology. 2018-09-01. 120(3) : 1162-1172.
10.1152/jn.00314.2018 -
Functional limb muscle innervation prior to cholinergic transmitter specification during early metamorphosis in Xenopus
eLife. 2018-05-30. 7
10.7554/eLife.30693 -
Acute exposure to zinc oxide nanoparticles critically disrupts operation of the respiratory neural network in neonatal rat.
NeuroToxicology. 2018-07. 67(150-160)
10.1016/j.neuro.2018.05.006 -
Role of the K+-Cl– Cotransporter KCC2a Isoform in Mammalian Respiration at Birth
eNeuro. 2018-01-01. 5(5) : ENEURO.0264-18.2018.
10.1523/ENEURO.0264-18.2018 -
The embryonic development of hindbrain respiratory networks is unaffected by mutation of the planar polarity protein Scribble.
Neuroscience. 2017-08-01. 357 : 160-171.
10.1016/j.neuroscience.2017.05.046 -
Development of pacemaker properties and rhythmogenic mechanisms in the mouse embryonic respiratory network
eLife. 2016-07-19. 5
10.7554/eLife.16125 -
Mechanisms Underlying Adaptation of Respiratory Network Activity to Modulatory Stimuli in the Mouse Embryo
Neural Plasticity. 2016-01-01. 2016 : 1-10.
10.1155/2016/3905257 -
Sigh and Eupnea Rhythmogenesis Involve Distinct Interconnected Subpopulations: A Combined Computational and Experimental Study
eneuro. 2015-03-01. 2(2) : ENEURO.0074-14.2015.
10.1523/eneuro.0074-14.2015 -
Generation of BAC transgenic tadpoles enabling live imaging of motoneurons by using the urotensin II-related peptide (ust2b) gene as a driver.
PLoS ONE. 2015-02-06. 10(2) : e0117370.
10.1371/journal.pone.0117370 -
Emergence of sigh rhythmogenesis in the embryonic mouse
J Physiol. 2014-03-21. 592(10) : 2169-2181.
10.1113/jphysiol.2013.268730 -
Remote Control of Respiratory Neural Network by Spinal Locomotor Generators
PLoS ONE. 2014-02-20. 9(2) : e89670.
10.1371/journal.pone.0089670 -
Respiratory circuits: development, function and models
Current Opinion in Neurobiology. 2012-08-01. 22(4) : 676-685.
10.1016/j.conb.2012.01.001 -
Brainstem Respiratory Oscillators Develop Independently of Neuronal Migration Defects in the Wnt/PCP Mouse Mutant looptail
PLoS ONE. 2012-02-17. 7(2) : e31140.
10.1371/journal.pone.0031140 -
Breathing without CO2 Chemosensitivity in Conditional Phox2b Mutants
Journal of Neuroscience. 2011-09-07. 31(36) : 12880-12888.
10.1523/jneurosci.1721-11.2011 -
Prenatal development of central rhythm generation
Respiratory Physiology & Neurobiology. 2011-08-01. 178(1) : 146-155.
10.1016/j.resp.2011.04.013 -
Phox2b, congenital central hypoventilation syndrome and the control of respiration.
Seminars in Cell & Developmental Biology. 2010-10-01. 21(8) : 814-822.
10.1016/j.semcdb.2010.07.006 -
Hindbrain interneurons and axon guidance signaling critical for breathing.
Nat Neurosci. 2010-08-02. 13(9) : 1066-1074.
10.1038/nn.2622 -
Teashirt 3 Regulates Development of Neurons Involved in Both Respiratory Rhythm and Airflow Control
Journal of Neuroscience. 2010-07-14. 30(28) : 9465-9476.
10.1523/jneurosci.1765-10.2010 -
Genetic factors determining the functional organization of neural circuits controlling rhythmic movements
Breathe, Walk and Chew: The Neural Challenge: Part I. 2010-01-01. : 39-46.
10.1016/b978-0-444-53613-6.00003-4 -
Defective Respiratory Rhythmogenesis and Loss of Central Chemosensitivity in Phox2b Mutants Targeting Retrotrapezoid Nucleus Neurons
Journal of Neuroscience. 2009-11-25. 29(47) : 14836-14846.
10.1523/jneurosci.2623-09.2009 -
Developmental basis of the rostro-caudal organization of the brainstem respiratory rhythm generator
Phil. Trans. R. Soc. B. 2009-09-12. 364(1529) : 2469-2476.
10.1098/rstb.2009.0090 -
Embryonic emergence of the respiratory rhythm generator
Respiratory Physiology & Neurobiology. 2009-08-01. 168(1-2) : 86-91.
10.1016/j.resp.2009.06.013 -
Genetic identification of an embryonic parafacial oscillator coupling to the preBötzinger complex
Nat Neurosci. 2009-07-05. 12(8) : 1028-1035.
10.1038/nn.2354 -
Brain-derived neurotrophic factor enhances fetal respiratory rhythm frequency in the mouse preBötzinger complexin vitro
European Journal of Neuroscience. 2008-08-01. 28(3) : 510-520.
10.1111/j.1460-9568.2008.06345.x -
Differential Modulation of Neural Network and Pacemaker Activity Underlying Eupnea and Sigh-Breathing Activities
Journal of Neurophysiology. 2008-05-01. 99(5) : 2114-2125.
10.1152/jn.01192.2007 -
Anatomical and functional development of the pre-Bötzinger complex in prenatal rodents
Journal of Applied Physiology. 2008-04-01. 104(4) : 1213-1219.
10.1152/japplphysiol.01061.2007 -
Abnormal inspiratory depth in Phox2a haploinsufficient mice
Neuroscience. 2007-03-01. 145(1) : 384-392.
10.1016/j.neuroscience.2006.11.055 -
Vesicular Glutamate Transporter 2 Is Required for Central Respiratory Rhythm Generation But Not for Locomotor Central Pattern Generation
Journal of Neuroscience. 2006-11-22. 26(47) : 12294-12307.
10.1523/jneurosci.3855-06.2006 -
Acute role of the brain-derived neurotrophic factor (BDNF) on the respiratory neural network activity in mice in vitro
Journal of Physiology-Paris. 2006-11-01. 100(5-6) : 290-296.
10.1016/j.jphysparis.2007.05.008 -
Ontogeny of central rhythm generation in chicks and rodents
Respiratory Physiology & Neurobiology. 2006-11-01. 154(1-2) : 37-46.
10.1016/j.resp.2006.02.004 -
The pre-Bötzinger oscillator in the mouse embryo
Journal of Physiology-Paris. 2006-11-01. 100(5-6) : 284-289.
10.1016/j.jphysparis.2007.05.007 -
Mice Lacking Brain/Kidney Phosphate-Activated Glutaminase Have Impaired Glutamatergic Synaptic Transmission, Altered Breathing, Disorganized Goal-Directed Behavior and Die Shortly after Birth
Journal of Neuroscience. 2006-04-26. 26(17) : 4660-4671.
10.1523/jneurosci.4241-05.2006 -
Neural tube patterning by Krox20 and emergence of a respiratory control
Respiratory Physiology & Neurobiology. 2005-11-01. 149(1-3) : 63-72.
10.1016/j.resp.2005.02.014 -
Emergence of the Pre-Botzinger Respiratory Rhythm Generator in the Mouse Embryo
Journal of Neuroscience. 2005-04-27. 25(17) : 4307-4318.
10.1523/jneurosci.0551-05.2005 -
Developmental gene control of brainstem function: views from the embryo
Progress in Biophysics and Molecular Biology. 2004-02-01. 84(2-3) : 89-106.
10.1016/j.pbiomolbio.2003.11.002 -
BDNF Preferentially Targets Membrane Properties of Rhythmically Active Neurons in the pre-Bötzinger Complex in Neonatal Mice
Advances in Experimental Medicine and Biology. 2004-01-01. : 115-120.
10.1007/0-387-27023-x_18 -
Expression of Functional Tyrosine Kinase B Receptors by Rhythmically Active Respiratory Neurons in the Pre-Bötzinger Complex of Neonatal Mice
J. Neurosci.. 2003-08-20. 23(20) : 7685-7689.
10.1523/jneurosci.23-20-07685.2003 -
Developmental molecular switches regulating breathing patterns in CNS
Respiratory Physiology & Neurobiology. 2003-05-01. 135(2-3) : 121-132.
10.1016/s1569-9048(03)00031-4 -
Emergence of neural net function during brain development
Journal of Physiology-Paris. 2003-01-01. 97(1) : 1-3.
10.1016/j.jphysparis.2003.10.001 -
From Hindbrain Segmentation to Breathing After Birth: Developmental Patterning in Rhombomeres 3 and 4
MN. 2003-01-01. 28(3) : 277-294.
10.1385/mn:28:3:277 -
Long-Term Neuromodulatory Regulation of a Motor Pattern–Generating Network: Maintenance of Synaptic Efficacy and Oscillatory Properties
Journal of Neurophysiology. 2002-12-01. 88(6) : 2942-2953.
10.1152/jn.00482.2001 -
Early development of respiratory rhythm generation in mouse and chick
Respiratory Physiology & Neurobiology. 2002-07-01. 131(1-2) : 5-13.
10.1016/s1569-9048(02)00033-2 -
Identification of Two Types of Inspiratory Pacemaker Neurons in the Isolated Respiratory Neural Network of Mice
Journal of Neurophysiology. 2001-07-01. 86(1) : 104-112.
10.1152/jn.2001.86.1.104 -
Reconfiguration of the Central Respiratory Network Under Normoxic and Hypdxic Conditions
Advances in Experimental Medicine and Biology. 2001-01-01. : 171-178.
10.1007/978-1-4615-1375-9_27 -
Role of Inspiratory Pacemaker Neurons in Mediating the Hypoxic Response of the Respiratory NetworkIn Vitro
J. Neurosci.. 2000-08-01. 20(15) : 5858-5866.
10.1523/jneurosci.20-15-05858.2000 -
Transition to Endogenous Bursting After Long-Term Decentralization Requires De Novo Transcription in a Critical Time Window
Journal of Neurophysiology. 2000-07-01. 84(1) : 596-599.
10.1152/jn.2000.84.1.596 -
Reconfiguration of the neural network controlling multiple breathing patterns: eupnea, sighs and gasps
Nat Neurosci. 2000-06-01. 3(6) : 600-607.
10.1038/75776 -
The Role of the Hyperpolarization-Activated Current in Modulating Rhythmic Activity in the Isolated Respiratory Network of Mice
J. Neurosci.. 2000-04-15. 20(8) : 2994-3005.
10.1523/jneurosci.20-08-02994.2000 -
Neuromodulatory Inputs Maintain Expression of a Lobster Motor Pattern-Generating Network in a Modulation-Dependent State: Evidence from Long-Term DecentralizationIn Vitro
J. Neurosci.. 1998-03-15. 18(6) : 2212-2225.
10.1523/jneurosci.18-06-02212.1998