Mario Carta
Team leader
Researcher - PhD (CR) / CNRS/ Contact
+33 5 33 51 47 59
www.orcid.org/0000-0003-1225-2742
Mario Carta (CRCN-CNRS, University of Bordeaux) is a neurobiologist with strong expertise in electrophysiology of synaptic transmission and plasticity and in cortical processing in vitro and in vivo. The general aim of his research is to understand how synapses and neuronal circuits function and how they are regulated in various physiological or pathological states. He was trained as a slice electrophysiologist in the Valenzuela lab (University of New Mexico, USA) where he studied how ethanol, neurosteroids and various pharmacological compounds modulate neuronal and synaptic plasticity and circuit functions in the hippocampus and cerebellum. He worked as a post-doc in the laboratory of Christophe Mulle (University of Bordeaux) to tackle molecular and cell biological aspects of synaptic physiology and plasticity. In 2013, he was recruited as a junior researcher at the CNRS. From 2017 until the end of 2021, he joined the laboratory of James Poulet (MDC, Berlin) where he investigated in vivo cortical circuits during sensory stimulation and behavior, focusing on the role of the mouse insular cortex in thermosensory perception. He learned how to use cutting-edge approaches such as wide field, 2-photon calcium imaging and electrophysiology in anesthetized and awake behaving animals. Mario Carta returned to Bordeaux in 2022, where he now investigates the synaptic mechanisms underlying gustatory processing in the mouse cortex.
Scientific articles
-
The cellular coding of temperature in the mammalian cortex
Nature. 2023-02-08. 614(7949) : 725-731.
10.1038/s41586-023-05705-5 -
Control of spike transfer at hippocampal mossy fiber synapses in vivo by GABAA and GABAB receptor-mediated inhibition
J. Neurosci.. 2017-01-18. 37(3) : 587-598.
10.1523/JNEUROSCI.2057-16.2017 -
Control of Spike Transfer at Hippocampal Mossy Fiber Synapses In Vivo by GABA A and GABA B Receptor-Mediated Inhibition
J. Neurosci.. 2016-12-02. 37(3) : 587-598.
10.1523/JNEUROSCI.2057-16.2016 -
Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex.
Nat Commun. 2015-12-01. 6(1)
10.1038/ncomms10181 -
Exclusive photorelease of signalling lipids at the plasma membrane
Nat Commun. 2015-12-01. 6(1)
10.1038/ncomms10056 -
Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex
Nat Commun. 2015-12-01. 6(1)
10.1038/ncomms10181 -
Scribble1/AP2 complex coordinates NMDA receptor endocytic recycling.
Cell Reports. 2014-10-01. 9(2) : 712-727.
10.1016/j.celrep.2014.09.017 -
Kainate receptors in the hippocampus.
Eur J Neurosci. 2014-04-17. 39(11) : 1835-1844.
10.1111/ejn.12590 -
Membrane lipids tune synaptic transmission by direct modulation of presynaptic potassium channels.
Neuron. 2014-02-01. 81(4) : 787-799.
10.1016/j.neuron.2013.12.028 -
Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway
Philosophical Transactions of the Royal Society B: Biological Sciences. 2013-12-02. 369(1633) : 20130160-20130160.
10.1098/rstb.2013.0160 -
CaMKII-dependent phosphorylation of GluK5 mediates plasticity of kainate receptors.
EMBO J. 2013-01-04. 32(4) : 496-510.
10.1038/emboj.2012.334 -
NMDA receptor-dependent metaplasticity at hippocampal mossy fiber synapses.
Nat Neurosci. 2011-05-01. 14(6) : 691-693.
10.1038/nn.2809 -
Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage
Journal of Neuroscience. 2010-12-01. 30(48) : 16343-16355.
10.1523/JNEUROSCI.1984-10.2010 -
Profilin II regulates the exocytosis of kainate glutamate receptors
J. Biol. Chem.. 2010-10-11. 285(51) : 40060-40071.
10.1074/jbc.M110.140442 -
Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses.
Nat Neurosci. 2010-01-17. 13(2) : 197-204.
10.1038/nn.2481 -
Spike-timing-dependent plasticity induces presynaptic changes at immature hippocampal mossy fiber synapses
Journal of Neuroscience. 2009-07-01. 29(26) : 8299-8301.
10.1523/JNEUROSCI.1997-09.2009 -
Changes in expression and function of extrasynaptic GABAA receptors in the rat hippocampus during pregnancy and after delivery
Journal of Neuroscience. 2009-02-11. 29(6) : 1755-1765.
10.1523/JNEUROSCI.3684-08.2009 -
Alcohol impairs long-term depression at the cerebellar parallel fiber-Purkinje cell synapse
Journal of Neurophysiology. 2008-12-01. 100(6) : 3167-3174.
10.1152/jn.90384.2008 -
Isoniazid-induced reduction in GABAergic neurotransmission alters the function of the cerebellar cortical circuit
Neuroscience. 2008-06-01. 154(2) : 710-719.
10.1016/j.neuroscience.2008.02.024 -
Modulation of GABAA receptors in cerebellar granule neurons by ethanol: a review of genetic and electrophysiological studies
Alcohol. 2007-05-01. 41(3) : 187-199.
10.1016/j.alcohol.2007.04.004 -
The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system
Neuropharmacology. 2006-09-01. 51(4) : 805-815.
10.1016/j.neuropharm.2006.05.023 -
Human astrocytes can be induced to differentiate into cells with neuronal phenotype
Experimental Cell Research. 2006-07-01. 312(12) : 2336-2346.
10.1016/j.yexcr.2006.03.031 -
Social isolation-induced increase in α4 and δ subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABAA receptor function
J Neurochem. 2006-07-01. 98(1) : 122-133.
10.1111/j.1471-4159.2006.03850.x -
Basis of the gabamimetic profile of ethanol
Alcoholism Clin Exp Res. 2006-04-01. 30(4) : 731-744.
10.1111/j.0145-6008.2006.00086.x -
Alcohol potently modulates climbing fiber→purkinje neuron synapses: Role of metabotropic glutamate receptors
Journal of Neuroscience. 2006-02-15. 26(7) : 1906-1912.
10.1523/JNEUROSCI.4430-05.2006 -
Developmentally regulated actions of alcohol on hippocampal glutamatergic transmission
Journal of Neuroscience. 2005-08-31. 25(35) : 8027-8036.
10.1523/JNEUROSCI.2434-05.2005 -
Letter to the editor (multiple letters)
Alcoholism: Clinical & Experimental Research. 2005-07-01. 29(7) : 1356-1357.
10.1097/01.ALC.0000171926.66397.94 -
Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors
Journal of Neuroscience. 2005-03-02. 25(9) : 2285-2294.
10.1523/JNEUROSCI.3877-04.2005 -
Neurosteroid paradoxical enhancement of paired-pulse inhibition through paired-pulse facilitation of inhibitory circuits in dentate granule cells
Neuropharmacology. 2005-03-01. 48(4) : 584-596.
10.1016/j.neuropharm.2004.11.014 -
Alcohol Enhances GABAergic Transmission to Cerebellar Granule Cells via an Increase in Golgi Cell Excitability
Journal of Neuroscience. 2004-04-14. 24(15) : 3746-3751.
10.1523/JNEUROSCI.0067-04.2004 -
Chronic Ethanol Consumption Reduces 8δ-and μ-Opioid Receptor-Stimulated G-Protein Coupling in Rat Brain
Alcoholism: Clinical & Experimental Research. 2004-01-01. 28(1) : 98-104.
10.1097/01.ALC.0000108658.00243.BF -
Neurosteroid modulation of glutamate release in hippocampal neurons: Lack of an effect of a chronic prenatal ethanol exposure paradigm
Alcoholism: Clinical & Experimental Research. 2003-07-01. 27(7) : 1194-1198.
10.1097/01.ALC.0000075828.50697.70 -
Alcohol potently inhibits the kainate receptor-dependent excitatory drive of hippocampal interneurons
Proceedings of the National Academy of Sciences. 2003-05-05. 100(11) : 6813-6818.
10.1073/pnas.1137276100 -
Cocaine inhibits 5-HT3 receptor function in neurons from transgenic mice overexpressing the receptor
European Journal of Pharmacology. 2003-01-17. 459(2-3) : 167-169.
10.1016/S0014-2999(02)02867-4 -
Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABAA receptor subtypes
European Journal of Pharmacology. 2002-09-01. 451(2) : 103-110.
10.1016/S0014-2999(02)02191-X -
Ethanol withdrawal upregulates kainate receptors in cultured rat hippocampal neurons
Neuroscience Letters. 2002-07-01. 327(2) : 128-132.
10.1016/S0304-3940(02)00399-3 -
Delta opioid receptor localization in the rat cerebellum
Brain Research. 2002-03-01. 931(1) : 100-105.
10.1016/S0006-8993(02)02248-5 -
Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis
Nat Neurosci. 2001-12-19. 5(1) : 19-26.
10.1038/nn783 -
Increase in expression of the GABAA receptor α4 subunit gene induced by withdrawal of, but not by long-term treatment with, benzodiazepine full or partial agonists
Molecular Brain Research. 2001-08-01. 92(1-2) : 138-148.
10.1016/S0169-328X(01)00164-4