Giovanni Marsicano

Scientific articles

• Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice
  Paula Gómez-Sotres, Urszula Skupio, Tommaso Dalla Tor, Francisca Julio-Kalajzic, Astrid Cannich, Doriane Gisquet, Itziar Bonilla-Del Rio, Filippo Drago, Nagore Puente, Pedro Grandes, Luigi Bellocchio, Arnau Busquets-Garcia, Jaideep S. Bains, Giovanni Marsicano.
  Nat Commun. 2024-08-18. 15(1)
  10.1038/s41467-024-51416-4
• A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes in male mice.
  Ignacio Fernández-Moncada, Gianluca Lavanco, Unai B. Fundazuri, Nasrin Bollmohr, Sarah Mountadem, Tommaso Dalla Tor, Pauline Hachaguer, Francisca Julio-Kalajzic, Doriane Gisquet, Roman Serrat, Luigi Bellocchio, Astrid Cannich, Bérénice Fortunato-Marsol, Yusuke Nasu, Robert E. Campbell, Filippo Drago, Carla Cannizzaro, Guillaume Ferreira, Anne-Karine Bouzier-Sore, Luc Pellerin, Juan P. Bolaños, Gilles Bonvento, L. Felipe Barros, Stephane H. R. Oliet, Aude Panatier, Giovanni Marsicano.
  Nat Commun. 2024-08-09. 15(1)
  10.1038/s41467-024-51008-2
• Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity
  Stéphane Leon, Vincent Simon, Thomas H. Lee, Lukas Steuernagel, Samantha Clark, Nasim Biglari, Thierry Lesté-Lasserre, Nathalie Dupuy, Astrid Cannich, Luigi Bellocchio, Philippe Zizzari, Camille Allard, Delphine Gonzales, Yves Le Feuvre, Emeline Lhuillier, Alexandre Brochard, Jean Charles Nicolas, Jérémie Teillon, Macha Nikolski, Giovanni Marsicano, Xavier Fioramonti, Jens C. Brüning, Daniela Cota, Carmelo Quarta.
  Nat Commun. 2024-04-24. 15(1)
  10.1038/s41467-024-47877-2
• Endogenous cannabinoids in the piriform cortex tune olfactory perception
  Geoffrey Terral, Evan Harrell, Gabriel Lepousez, Yohan Wards, Dinghuang Huang, Tiphaine Dolique, Giulio Casali, Antoine Nissant, Pierre-Marie Lledo, Guillaume Ferreira, Giovanni Marsicano, Lisa Roux.
  Nat Commun. 2024-02-09. 15(1)
  10.1038/s41467-024-45161-x
• Striatopallidal cannabinoid type-1 receptors mediate amphetamine-induced sensitization
  Yamuna Mariani, Ana Covelo, Rui S. Rodrigues, Francisca Julio-Kalajzić, Antonio C. Pagano Zottola, Gianluca Lavanco, Michela Fabrizio, Doriane Gisquet, Filippo Drago, Astrid Cannich, Jerome Baufreton, Giovanni Marsicano, Luigi Bellocchio.
  Current Biology. 2023-11-01. 33(22) : 5011-5022.e6.
  10.1016/j.cub.2023.09.075
• An enquiry to the role of CB1 receptors in neurodegeneration.
  Ignacio Fernández-Moncada, Abel Eraso-Pichot, Tommaso Dalla Tor, Bérénice Fortunato-Marsol, Giovanni Marsicano.
  Neurobiology of Disease. 2023-08-01. 184 : 106235.
  10.1016/j.nbd.2023.106235
• Type‐1 cannabinoid receptors and their ever‐expanding roles in brain energy processes
  Ignacio Fernández‐Moncada, Rui S. Rodrigues, Unai B. Fundazuri, Luigi Bellocchio, Giovanni Marsicano.
  Journal of Neurochemistry. 2023-07-28.
  10.1111/jnc.15922
• Signaling-specific inhibition of the CB₁ receptor for cannabis use disorder: phase 1 and phase 2a randomized trials.
  Margaret Haney, Monique Vallée, Sandy Fabre, Stephanie Collins Reed, Marion Zanese, Ghislaine Campistron, Caroline A. Arout, Richard W. Foltin, Ziva D. Cooper, Tonisha Kearney-Ramos, Mathilde Metna, Zuzana Justinova, Charles Schindler, Etienne Hebert-Chatelain, Luigi Bellocchio, Adeline Cathala, Andrea Bari, Roman Serrat, David B. Finlay, Filippo Caraci, Bastien Redon, Elena Martín-García, Arnau Busquets-Garcia, Isabelle Matias, Frances R. Levin, François-Xavier Felpin, Nicolas Simon, Daniela Cota, Umberto Spampinato, Rafael Maldonado, Yavin Shaham, Michelle Glass, Lars Lykke Thomsen, Helle Mengel, Giovanni Marsicano, Stéphanie Monlezun, Jean-Michel Revest, Pier Vincenzo Piazza.
  Nat Med. 2023-06-01. 29(6) : 1487-1499.
  10.1038/s41591-023-02381-w
• To deliberate, remember; to anticipate, forget: Cognitive deliberation profiles underpinning active forgetting-dependent everyday-like memory performance in young and aged mice
  Christopher Stevens, Shaam Al Abed, Azza Sellami, Eva Ducourneau, Cathy Lacroix, Mathilde Bouchet, Faustine Roudier, Giovanni Marsicano, Aline Marighetto.
  . 2023-04-30.
  10.1101/2023.04.29.538679
• Mitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition
  Urszula Skupio, Julia Welte, Roman Serrat, Abel Eraso-Pichot, Francisca Julio-Kalajzić, Doriane Gisquet, Astrid Cannich, Sebastien Delcasso, Isabelle Matias, Unai B. Fundazuri, Sandrine Pouvreau, Antonio C. Pagano Zottola, Gianluca Lavanco, Filippo Drago, Inigo Ruiz de Azua, Beat Lutz, Luigi Bellocchio, Arnau Busquets-Garcia, Francis Chaouloff, Giovanni Marsicano.
  Neuron. 2023-04-01.
  10.1016/j.neuron.2023.04.001
• Age-dependent effects of estradiol on temporal memory: A role for the type 1 cannabinoid receptor?
  Mylène Potier, Marlène Maitre, Thierry Leste-Lasserre, Giovanni Marsicano, Francis Chaouloff, Aline Marighetto.
  Psychoneuroendocrinology. 2023-02-01. 148 : 106002.
  10.1016/j.psyneuen.2022.106002
• Astroglial CB1 receptors, energy metabolism, and gliotransmission: an integrated signaling system?
  Ignacio Fernández-Moncada,Giovanni Marsicano.
  Essays in Biochemistry. 2023-01-16.
  10.1042/EBC20220089
• Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis.
  Joris Guyon, Ignacio Fernandez‐Moncada, Claire M Larrieu, Cyrielle L Bouchez, Antonio C Pagano Zottola, Johanna Galvis, Tiffanie Chouleur, Audrey Burban, Kevin Joseph, Vidhya M Ravi, Heidi Espedal, Gro Vatne Røsland, Boutaina Daher, Aurélien Barre, Benjamin Dartigues, Slim Karkar, Justine Rudewicz, Irati Romero‐Garmendia, Barbara Klink, Konrad Grützmann, Marie‐Alix Derieppe, Thibaut Molinié, Nina Obad, Céline Léon, Giorgio Seano, Hrvoje Miletic, Dieter Henrik Heiland, Giovanni Marsicano, Macha Nikolski, Rolf Bjerkvig, Andreas Bikfalvi, Thomas Daubon.
  EMBO Mol Med. 2022-10-24.
  10.15252/emmm.202115343
• Expression of Functional Cannabinoid Type-1 (CB1) Receptor in Mitochondria of White Adipocytes
  Antonio C. Pagano Zottola, Ilenia Severi, Astrid Cannich, Philippe Ciofi, Daniela Cota, Giovanni Marsicano, Antonio Giordano, Luigi Bellocchio.
  Cells. 2022-08-19. 11(16) : 2582.
  10.3390/cells11162582
• Endocannabinoid signaling in astrocytes
  Abel Eraso‐Pichot, Sandrine Pouvreau, Alexandre Olivera‐Pinto, Paula Gomez‐Sotres, Urszula Skupio, Giovanni Marsicano.
  Glia. 2022-07-13.
  10.1002/glia.24246
• Metabolic Messengers: endocannabinoids
  Arnau Busquets-García, Juan P. Bolaños, Giovanni Marsicano.
  Nat Metab. 2022-07-11.
  10.1038/s42255-022-00600-1
• Imaging mitochondrial calcium dynamics in the central nervous system
  Roman Serrat, Alexandre Oliveira-Pinto, Giovanni Marsicano, Sandrine Pouvreau.
  Journal of Neuroscience Methods. 2022-05-01. 373 : 109560.
  10.1016/j.jneumeth.2022.109560
• Differential expression of the neuronal CB1 cannabinoid receptor in the hippocampus of male Ts65Dn Down syndrome mouse model
  Nadia Di Franco, Guillaume Drutel, Valérie Roullot-Lacarrière, Francisca Julio-Kalajzic, Valérie Lalanne, Agnès Grel, Thierry Leste-Lasserre, Isabelle Matias, Astrid Cannich, Delphine Gonzales, Vincent Simon, Daniela Cota, Giovanni Marsicano, Pier Vincenzo Piazza, Monique Vallée, Jean-Michel Revest.
  Molecular and Cellular Neuroscience. 2022-03-01. 119 : 103705.
  10.1016/j.mcn.2022.103705
• Cannabinoid Signalling in the Brain: New Vistas
  A. Busquets‐Garcia, M. Melis, L. Bellocchio, G. Marsicano.
  Eur J of Neuroscience. 2022-02-03.
  10.1111/ejn.15618
• The role of the endocannabinoid system as a therapeutic target for autism spectrum disorder: Lessons from behavioral studies on mouse models
  Susanna Pietropaolo, Giovanni Marsicano.
  Neuroscience & Biobehavioral Reviews. 2022-01-01. 132 : 664-678.
  10.1016/j.neubiorev.2021.11.031
• Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner
  Julia De Meij, Zain Alfanek, Lydie Morel, Fanny Decoeur, Quentin Leyrolle, Katherine Picard, Micael Carrier, Agnes Aubert, Alexandra Séré, Céline Lucas, Gerald Laforest, Jean-Christophe Helbling, Marie-Eve Tremblay, Daniela Cota, Marie-Pierre Moisan, Giovanni Marsicano, Sophie Layé, Agnès Nadjar.
  Cannabis and Cannabinoid Research. 2021-12-01. 6(6) : 488-507.
  10.1089/can.2020.0170
• Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration
  Roman Serrat, Ana Covelo, Vladimir Kouskoff, Sebastien Delcasso, Andrea Ruiz-Calvo, Nicolas Chenouard, Carol Stella, Corinne Blancard, Benedicte Salin, Francisca Julio-Kalajzić, Astrid Cannich, Federico Massa, Marjorie Varilh, Severine Deforges, Laurie M. Robin, Diego De Stefani, Arnau Busquets-Garcia, Frederic Gambino, Anna Beyeler, Sandrine Pouvreau, Giovanni Marsicano.
  Cell Reports. 2021-12-01. 37(12) : 110133.
  10.1016/j.celrep.2021.110133
• Functional heterogeneity of POMC neurons relies on mTORC1 signaling
  Nicolas Saucisse, Wilfrid Mazier, Vincent Simon, Elke Binder, Caterina Catania, Luigi Bellocchio, Roman A. Romanov, Stéphane Léon, Isabelle Matias, Philippe Zizzari, Carmelo Quarta, Astrid Cannich, Kana Meece, Delphine Gonzales, Samantha Clark, Julia M. Becker, Giles S.H. Yeo, Xavier Fioramonti, Florian T. Merkle, Sharon L. Wardlaw, Tibor Harkany, Federico Massa, Giovanni Marsicano, Daniela Cota.
  Cell Reports. 2021-10-01. 37(2) : 109800.
  10.1016/j.celrep.2021.109800
• The temporal origin of dentate granule neurons dictates their role in spatial memory
  Nuria Masachs, Vanessa Charrier, Fanny Farrugia, Valerie Lemaire, Nicolas Blin, Wilfrid Mazier, Sophie Tronel, Marie-Françoise Montaron, Shaoyu Ge, Giovanni Marsicano, Daniela Cota, Véronique Deroche-Gamonet, Cyril Herry, Djoher Nora Abrous.
  Mol Psychiatry. 2021-09-15.
  10.1038/s41380-021-01276-x
• Neural Substrates of Incidental Associations and Mediated Learning: The Role of Cannabinoid Receptors.
  Christina Ioannidou, Arnau Busquets-Garcia, Guillaume Ferreira, Giovanni Marsicano.
  Front. Behav. Neurosci.. 2021-08-06. 15
  10.3389/fnbeh.2021.722796
• Communication and social interaction in the cannabinoid‐type 1 receptor null mouse: Implications for autism spectrum disorder
  William Fyke, Marika Premoli, Victor Echeverry Alzate, José A. López‐Moreno, Valerie Lemaire‐Mayo, Wim E. Crusio, Giovanni Marsicano, Markus Wöhr, Susanna Pietropaolo.
  Autism Research. 2021-06-26. 14(9) : 1854-1872.
  10.1002/aur.2562
• CB1R-dependent regulation of astrocyte physiology and astrocyte-neuron interactions
  Ana Covelo, Abel Eraso-Pichot, Ignacio Fernández-Moncada, Román Serrat, Giovanni Marsicano.
  Neuropharmacology. 2021-06-01. : 108678.
  10.1016/j.neuropharm.2021.108678
• Hypothalamic bile acid-TGR5 signaling protects from obesity.
  Ashley Castellanos-Jankiewicz, Omar Guzmán-Quevedo, Valérie S. Fénelon, Philippe Zizzari, Carmelo Quarta, Luigi Bellocchio, Anne Tailleux, Julie Charton, Daniela Fernandois, Marcus Henricsson, Catherine Piveteau, Vincent Simon, Camille Allard, Sandrine Quemener, Valentine Guinot, Nathalie Hennuyer, Alessia Perino, Alexia Duveau, Marlène Maitre, Thierry Leste-Lasserre, Samantha Clark, Nathalie Dupuy, Astrid Cannich, Delphine Gonzales, Benoit Deprez, Gilles Mithieux, David Dombrowicz, Fredrik Bäckhed, Vincent Prevot, Giovanni Marsicano, Bart Staels, Kristina Schoonjans, Daniela Cota.
  Cell Metabolism. 2021-04-01.
  10.1016/j.cmet.2021.04.009
• Long-lasting synaptic regulation of dopamine neurons by astrocytes in the Ventral Tegmental Area
  Linda Requie, Marta Gómez-Gonzalo, Francesca Managò, Mauro Congiu, Marcello Melone, Angela Chiavegato, Arianna Arianna, Giada Pacinelli, Marsicano Giovanni, Francesco Papaleo, Anna Muntoni, Fiorenzo Conti, Giorgio Carmignoto.
  . 2021-03-23.
  10.21203/rs.3.rs-301561/v1
• Spinal astroglial cannabinoid receptors control pathological tremor
  Eva Maria Meier Carlsen, Sarah Falk, Urszula Skupio, Laurie Robin, Antonio C. Pagano Zottola, Giovanni Marsicano, Jean-François Perrier.
  Nat Neurosci. 2021-03-18.
  10.1038/s41593-021-00818-4
• Cannabis and exercise: Effects of Δ⁹-tetrahydrocannabinol on preference and motivation for wheel-running in mice
  Imane Hurel, Carolina Muguruza, Bastien Redon, Giovanni Marsicano, Francis Chaouloff.
  Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2021-03-01. 105 : 110117.
  10.1016/j.pnpbp.2020.110117
• Astroglial calcium transfer from endoplasmic reticulum to mitochondria determines synaptic integration
  Roman Serrat, Ana Covelo, Vladimir Kouskoff, Sebastien Delcasso, Andrea Ruiz, Nicolas Chenouard, Carol Stella, Corinne Blancard, Benedicte Salin, Francisca Julio-Kalajzić, Astrid Cannich, Federico Massa, Marjorie Varilh, Severine Deforges, Laurie M. Robin, Diego De Stefani, Arnau Busquets-Garcia, Frederic Gambino, Anna Beyeler, Sandrine Pouvreau, Giovanni Marsicano.
  Preprint bioRxiv. 2020-12-08.
  10.1101/2020.12.08.415620
• A Novel Cortical Mechanism for Top-Down Control of Water Intake.
  Zhe Zhao, Edgar Soria-Gómez, Marjorie Varilh, Ana Covelo, Francisca Julio-Kalajzić, Astrid Cannich, Adriana Castiglione, Léonie Vanhoutte, Alexia Duveau, Philippe Zizzari, Anna Beyeler, Daniela Cota, Luigi Bellocchio, Arnau Busquets-Garcia, Giovanni Marsicano.
  Current Biology. 2020-12-01. 30(23) : 4789-4798.e4.
  10.1016/j.cub.2020.09.011
• Cannabinoid-induced motor dysfunction via autophagy inhibition
  Cristina Blázquez, Andrea Ruiz-Calvo, Raquel Bajo-Grañeras, Jerome M. Baufreton, Eva Resel, Marjorie Varilh, Antonio C. Pagano Zottola, Yamuna Mariani, Astrid Cannich, José A. Rodríguez-Navarro, Giovanni Marsicano, Ismael Galve-Roperh, Luigi Bellocchio, Manuel Guzmán.
  Autophagy. 2020-10-20. 16(12) : 2289-2291.
  10.1080/15548627.2020.1827560
• Exercise craving potentiates excitatory inputs to ventral tegmental area dopaminergic neurons
  Maria‐Carmen Medrano, Imane Hurel, Emma Mesguich, Bastien Redon, Christopher Stevens, François Georges, Miriam Melis, Giovanni Marsicano, Francis Chaouloff.
  Addiction Biology. 2020-10-05.
  10.1111/adb.12967
• Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination
  Cristina Blázquez, Andrea Ruiz-Calvo, Raquel Bajo-Grañeras, Jérôme M Baufreton, Eva Resel, Marjorie Varilh, Antonio C Pagano Zottola, Yamuna Mariani, Astrid Cannich, José A Rodríguez-Navarro, Giovanni Marsicano, Ismael Galve-Roperh, Luigi Bellocchio, Manuel Guzmán.
  eLife. 2020-08-10. 9
  10.7554/eLife.56811
• Sex‐dependent pharmacological profiles of the synthetic cannabinoid MMB‐Fubinaca
  José F. Oliveira da Cruz, Christina Ioannidou, Antonio C. Pagano Zottola, Carolina Muguruza, Paula Gomez‐Sotres, Monica Fernandez, Luis F. Callado, Giovanni Marsicano, Arnau Busquets‐Garcia.
  Addiction Biology. 2020-08-03.
  10.1111/adb.12940
• Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory
  Jose F. Oliveira da Cruz, Arnau Busquets-Garcia, Zhe Zhao, Marjorie Varilh, Gianluca Lavanco, Luigi Bellocchio, Laurie Robin, Astrid Cannich, Francisca Julio-Kalajzić, Thierry Lesté-Lasserre, Marlène Maître, Filippo Drago, Giovanni Marsicano, Edgar Soria-Gómez.
  Cell Reports. 2020-08-01. 32(7) : 108046.
  10.1016/j.celrep.2020.108046
• Glucose metabolism links astroglial mitochondria to cannabinoid effects
  Daniel Jimenez-Blasco, Arnau Busquets-Garcia, Etienne Hebert-Chatelain, Roman Serrat, Carlos Vicente-Gutierrez, Christina Ioannidou, Paula Gómez-Sotres, Irene Lopez-Fabuel, Monica Resch-Beusher, Eva Resel, Dorian Arnouil, Dave Saraswat, Marjorie Varilh, Astrid Cannich, Francisca Julio-Kalajzic, Itziar Bonilla-Del Río, Angeles Almeida, Nagore Puente, Svein Achicallende, Maria-Luz Lopez-Rodriguez, Charlotte Jollé, Nicole Déglon, Luc Pellerin, Charlène Josephine, Gilles Bonvento, Aude Panatier, Beat Lutz, Pier-Vincenzo Piazza, Manuel Guzmán, Luigi Bellocchio, Anne-Karine Bouzier-Sore, Pedro Grandes, Juan P. Bolaños, Giovanni Marsicano.
  Nature. 2020-07-08.
  10.1038/s41586-020-2470-y
• Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum
  Emma Puighermanal, Laia Castell, Anna Esteve-Codina, Su Melser, Konstantin Kaganovsky, Charleine Zussy, Jihane Boubaker-Vitre, Marta Gut, Stephanie Rialle, Christoph Kellendonk, Elisenda Sanz, Albert Quintana, Giovanni Marsicano, Miquel Martin, Marcelo Rubinstein, Jean-Antoine Girault, Jun B. Ding, Emmanuel Valjent.
  Nat Commun. 2020-04-23. 11(1)
  10.1038/s41467-020-15716-9
• Structural basis of astrocytic Ca2+ signals at tripartite synapses
  Misa Arizono, V. V. G. Krishna Inavalli, Aude Panatier, Thomas Pfeiffer, Julie Angibaud, Florian Levet, Mirelle J. T. Ter Veer, Jillian Stobart, Luigi Bellocchio, Katsuhiko Mikoshiba, Giovanni Marsicano, Bruno Weber, Stéphane H. R. Oliet, U. Valentin Nägerl.
  Nat Commun. 2020-04-20. 11(1)
  10.1038/s41467-020-15648-4
• Cannabinoid control of olfactory processes: The where matters
  Geoffrey Terral, Giovanni Marsicano, Pedro Grandes, Edgar Soria-Gómez.
  Genes. 2020-04-16. 11(4) : 431.
  10.3390/genes11040431
• A new mutant mouse model lacking mitochondrial-associated CB1 receptor
  Antonio C. Pagano Zottola, Edgar Soria-Gomez, Itziar Bonilla-del-Río, Carolina Muguruza, Geoffrey Terral, Laurie M. Robin, José F. Oliveira da Cruz, Bastien Redon, Thierry Lesté-Lasserre, Tarson Tolentino-Cortes, Nagore Puente, Gabriel Barreda-Gómez, Francis Chaouloff, Luis F. Callado, Pedro Grandes, Giovanni Marsicano, Luigi Bellocchio.
  Preprint bioRxiv. 2020-03-31.
  10.1101/2020.03.30.009472
• POMC neurons functional heterogeneity relies on mTORC1 signaling.
  Nicolas Saucisse, Wilfrid Mazier, Vincent Simon, Elke Binder, Caterina Catania, Luigi Bellocchio, Roman A. Romanov, Isabelle Matias, Philippe Zizzari, Stephane Leon, Carmelo Quarta, Astrid Cannich, Kana Meece, Delphine Gonzales, Samantha Clark, Julia M. Becker, Giles S.H. Yeo, Florian T. Merkle, Sharon L. Wardlaw, Tibor Harkany, Federico Massa, Giovanni Marsicano, Daniela Cota.
  . 2020-03-26.
  10.1101/2020.03.25.007765
• Synaptic Functions of Type-1 Cannabinoid Receptors in Inhibitory Circuits of the Anterior Piriform Cortex
  Geoffrey Terral, Marjorie Varilh, Astrid Cannich, Federico Massa, Guillaume Ferreira, Giovanni Marsicano.
  Neuroscience. 2020-03-01.
  10.1016/j.neuroscience.2020.03.002
• Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity
  Michelle Corkrum, Ana Covelo, Justin Lines, Luigi Bellocchio, Marc Pisansky, Kelvin Loke, Ruth Quintana, Patrick E. Rothwell, Rafael Lujan, Giovanni Marsicano, Eduardo D. Martin, Mark J. Thomas, Paulo Kofuji, Alfonso Araque.
  Neuron. 2020-03-01. 105(6) : 1036-1047.e5.
  10.1016/j.neuron.2019.12.026
• Alpha technology: A powerful tool to detect mouse brain intracellular signaling events
  Marion Zanese, Giovanni Tomaselli, Valérie Roullot-Lacarrière, Maïté Moreau, Luigi Bellocchio, Agnès Grel, Giovanni Marsicano, Nathalie Sans, Monique Vallée, Jean-Michel Revest.
  Journal of Neuroscience Methods. 2020-02-01. 332 : 108543.
  10.1016/j.jneumeth.2019.108543
• An Alternative Maze to Assess Novel Object Recognition in Mice
  José Fernando Oliveira da Cruz, Maria Gomis-Gonzalez, Rafael Maldonado, Giovanni Marsicano, Andrés Ozaita, Arnau Busquets-Garcia.
  BIO-PROTOCOL. 2020-01-01. 10(12)
  10.21769/bioprotoc.3651
• The ergogenic impact of the glucocorticoid prednisolone does not translate into increased running motivation in mice
  Bastien Redon, Claire Violleau, François Georges, Giovanni Marsicano, Francis Chaouloff.
  Psychoneuroendocrinology. 2020-01-01. 111 : 104489.
  10.1016/j.psyneuen.2019.104489
• mTORC1 and CB1 receptor signaling regulate excitatory glutamatergic inputs onto the hypothalamic paraventricular nucleus in response to energy availability
  Wilfrid Mazier, Nicolas Saucisse, Vincent Simon, Astrid Cannich, Giovanni Marsicano, Federico Massa, Daniela Cota.
  Molecular Metabolism. 2019-10-01. 28 : 151-159.
  10.1016/j.molmet.2019.08.005
• Top-down control of water intake by the endocannabinoid system
  Zhe Zhao, Edgar Soria-Gómez, Marjorie Varilh, Francisca Julio-Kalajzić, Astrid Cannich, Adriana Castiglione, Léonie Vanhoutte, Alexia Duveau, Philippe Zizzari, Anna Beyeler, Daniela Cota, Luigi Bellocchio, Arnau Busquets-Garcia, Giovanni Marsicano.
  Preprint bioRxiv. 2019-08-09.
  10.1101/729970
• CB1 Receptors in the Anterior Piriform Cortex Control Odor Preference Memory
  Geoffrey Terral, Arnau Busquets-Garcia, Marjorie Varilh, Svein Achicallende, Astrid Cannich, Luigi Bellocchio, Itziar Bonilla-Del Río, Federico Massa, Nagore Puente, Edgar Soria-Gomez, Pedro Grandes, Guillaume Ferreira, Giovanni Marsicano.
  Current Biology. 2019-08-01. 29(15) : 2455-2464.e5.
  10.1016/j.cub.2019.06.041
• Beyond the activity-based anorexia model: Reinforcing values of exercise and feeding examined in stressed adolescent Male and female mice
  Imane Hurel, Bastien Redon, Amandine Scocard, Meryl Malezieux, Giovanni Marsicano, Francis Chaouloff.
  Front. Pharmacol.. 2019-05-17. 10
  10.3389/fphar.2019.00587
• The motivation for exercise over palatable food is dictated by cannabinoid type-1 receptors.
  Carolina Muguruza, Bastien Redon, Giulia R. Fois, Imane Hurel, Amandine Scocard, Claire Nguyen, Christopher Stevens, Edgar Soria-Gomez, Marjorie Varilh, Astrid Cannich, Justine Daniault, Arnau Busquets-Garcia, Teresa Pelliccia, Stéphanie Caillé, François Georges, Giovanni Marsicano, Francis Chaouloff.
  JCI Insight. 2019-03-07. 4(5)
  10.1172/jci.insight.126190
• An Operant Conditioning Task to Assess the Choice between Wheel Running and Palatable Food in Mice.
  Bastien Redon, Imane Hurel, Giovanni Marsicano, Francis Chaouloff.
  BIO-PROTOCOL. 2019-01-01. 9(19)
  10.21769/bioprotoc.3381
• Localization of the cannabinoid type-1 receptor in subcellular astrocyte compartments of mutant mouse hippocampus.
  Ana Gutiérrez-Rodríguez, Itziar Bonilla-Del Río, Nagore Puente, Sonia M. Gómez-Urquijo, Christine J. Fontaine, Jon Egaña-Huguet, Izaskun Elezgarai, Sabine Ruehle, Beat Lutz, Laurie M. Robin, Edgar Soria-Gómez, Luigi Bellocchio, Jalindar D. Padwal, Mario van der Stelt, Juan Mendizabal-Zubiaga, Leire Reguero, Almudena Ramos, Inmaculada Gerrikagoitia, Giovanni Marsicano, Pedro Grandes.
  Glia. 2018-02-26. 66(7) : 1417-1431.
  10.1002/glia.23314
• Ribosomal Protein S6 Phosphorylation Is Involved in Novelty-Induced Locomotion, Synaptic Plasticity and mRNA Translation.
  Emma Puighermanal, Anne Biever, Vincent Pascoli, Su Melser, Marine Pratlong, Laura Cutando, Stephanie Rialle, Dany Severac, Jihane Boubaker-Vitre, Oded Meyuhas, Giovanni Marsicano, Christian Lüscher, Emmanuel Valjent.
  Front. Mol. Neurosci.. 2017-12-21. 10
  10.3389/fnmol.2017.00419
• Pathway-Specific Control of Striatal Neuron Vulnerability by Corticostriatal Cannabinoid CB1 Receptors.
  Andrea Ruiz-Calvo, Irene B Maroto, Raquel Bajo-Grañeras, Anna Chiarlone, Ángel Gaudioso, José J Ferrero, Eva Resel, José Sánchez-Prieto, José A Rodríguez-Navarro, Giovanni Marsicano, Ismael Galve-Roperh, Luigi Bellocchio, Manuel Guzmán.
  Cerebral Cortex. 2017-10-31. 28(1) : 307-322.
  10.1093/cercor/bhx285
• Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages.
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• Synapse-specific astrocyte gating of amygdala-related behavior.
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• CB1 Receptor Signaling in the Brain: Extracting Specificity from Ubiquity.
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• CB1 Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal.
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  Biological Psychiatry. 2017-04-01. 81(7) : 625-634.
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• The CB1 Receptor as the Cornerstone of Exostasis.
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  Neuron. 2017-03-01. 93(6) : 1252-1274.
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• Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice.
  A Busquets-Garcia, E Soria-Gómez, B Redon, Y Mackenbach, M Vallée, F Chaouloff, M Varilh, G Ferreira, P-V Piazza, G Marsicano.
  Mol Psychiatry. 2017-02-21. 22(11) : 1594-1603.
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• Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases.
  Marc P. Baggelaar, Annelot C. M. van Esbroeck, Eva J. van Rooden, Bogdan I. Florea, Herman S. Overkleeft, Giovanni Marsicano, Francis Chaouloff, Mario van der Stelt.
  ACS Chem. Biol.. 2017-02-13. 12(3) : 852-861.
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• Cannabinoids and mitochondria
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  Endocannabinoids and Lipid Mediators in Brain Functions. 2017-01-01. : 211-235.
  10.1007/978-3-319-57371-7_8
• Role of endocannabinoids in synaptic plasticity and memory
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  Reference Module in Neuroscience and Biobehavioral Psychology. 2017-01-01.
  10.1016/B978-0-12-809324-5.02289-6
• Functional Analysis of Mitochondrial CB1 Cannabinoid Receptors (mtCB1) in the Brain.
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  Methods in Enzymology. 2017-01-01. : 143-174.
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• Representation-mediated Aversion as a Model to Study Psychotic-like States in Mice.
  Arnau Busquets-Garcia, Edgar Soria-Gómez, Guillaume Ferreira, Giovanni Marsicano.
  BIO-PROTOCOL. 2017-01-01. 7(12)
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• Interacting Cannabinoid and Opioid Receptors in the Nucleus Accumbens Core Control Adolescent Social Play.
  Antonia Manduca, Olivier Lassalle, Marja Sepers, Patrizia Campolongo, Vincenzo Cuomo, Giovanni Marsicano, Brigitte Kieffer, Louk J. M. J Vanderschuren, Viviana Trezza, Olivier J. J. Manzoni.
  Front. Behav. Neurosci.. 2016-11-16. 10
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• A cannabinoid link between mitochondria and memory.
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  Nature. 2016-11-01. 539(7630) : 555-559.
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• Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration.
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• Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation.
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  Proc Natl Acad Sci USA. 2016-08-15. 113(35) : 9904-9909.
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• Anatomical characterization of the cannabinoid CB1 receptor in cell-type-specific mutant mouse rescue models.
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• Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus.
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  Sci Rep. 2016-06-27. 6(1)
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• MitoBrain, Putting energy into the brain.
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  Neurobiology of Disease. 2016-06-01. 90 : 1-2.
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• Cannabinoid receptor type-1: breaking the dogmas.
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• Astroglial type-1 cannabinoid receptor (CB1): A new player in the tripartite synapse.
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• Running per se stimulates the dendritic arbor of newborn dentate granule cells in mouse hippocampus in a duration-dependent manner.
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  Hippocampus. 2015-12-08. 26(3) : 282-288.
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• Stimulation of in vivo dopamine transmission and intravenous self-administration in rats and mice by JWH-018, a Spice cannabinoid.
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• The endocannabinoid system in guarding against fear, anxiety and stress.
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• Differential Control of Cocaine Self-Administration by GABAergic and Glutamatergic CB1 Cannabinoid Receptors.
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• The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice.
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• Habenular CB1 Receptors Control the Expression of Aversive Memories.
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• Dissecting the cannabinergic control of behavior: The where matters.
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• Duration- and environment-dependent effects of repeated voluntary exercise on anxiety and cued fear in mice.
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• Opposite control of frontocortical 2-arachidonoylglycerol turnover rate by cannabinoid type-1 receptors located on glutamatergic neurons and on astrocytes.
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• Cannabinoid type 1 (CB1) receptors on Sim1-expressing neurons regulate energy expenditure in male mice.
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• Cannabinoid control of fear responses
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• Rising stars: modulation of brain functions by astroglial type-1 cannabinoid receptors.
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• New insights on food intake control by olfactory processes: the emerging role of the endocannabinoid system.
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• CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin.
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• Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats.
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• Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor.
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• Studying mitochondrial CB1 receptors: Yes we can.
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• Cannabinoid type-1 receptors in the paraventricular nucleus of the hypothalamus inhibit stimulated food intake.
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• Pregnenolone can protect the brain from cannabis intoxication (Science (94))
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• The endocannabinoid system controls food intake via olfactory processes.
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  Nat Neurosci. 2014-02-09. 17(3) : 407-415.
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• Pregnenolone can protect the brain from cannabis intoxication.
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• Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists.
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  The FASEB Journal. 2014-01-01. 28(1) : 117-130.
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• Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis.
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• Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis
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• Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes.
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  Molecular Metabolism. 2013-11-01. 2(4) : 393-404.
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• Activation of STAT3 is involved in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptors in rats.
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  Brain Research. 2013-09-01. 1529 : 154-164.
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• Glycogen synthase kinase-3β is involved in electroacupuncture pretreatment via the cannabinoid CB1 receptor in ischemic stroke.
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• Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions.
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• Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance.
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  Biological Psychiatry. 2013-05-01. 73(9) : 895-903.
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• Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB₁ receptor blockade.
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  Proceedings of the National Academy of Sciences. 2013-03-04. 110(12) : 4786-4791.
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• Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus.
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• Two-photon excitation STED microscopy in two colors in acute brain slices.
  Philipp Bethge, Ronan Chéreau, Elena Avignone, Giovanni Marsicano, U. Valentin Nägerl.
  Biophysical Journal. 2013-02-01. 104(4) : 778-785.
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• Dissociation of the pharmacological effects of THC by mTOR blockade.
  Emma Puighermanal, Arnau Busquets-Garcia, Maria Gomis-González, Giovanni Marsicano, Rafael Maldonado, Andrés Ozaita.
  Neuropsychopharmacol. 2013-01-28. 38(7) : 1334-1343.
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• Striatal GABAergic and cortical glutamatergic neurons mediate contrasting effects of cannabinoids on cortical network synchrony.
  C. Sales-Carbonell, P. E. Rueda-Orozco, E. Soria-Gomez, G. Buzsaki, G. Marsicano, D. Robbe.
  Proceedings of the National Academy of Sciences. 2012-12-26. 110(2) : 719-724.
  10.1073/pnas.1217144110
• Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor.
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  Proceedings of the National Academy of Sciences. 2012-11-12. 109(51) : 21134-21139.
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• Hypothalamic CB1 cannabinoid receptors regulate energy balance in mice.
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  Endocrinology. 2012-09-01. 153(9) : 4136-4143.
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• Un nouveau biomarqueur de l’obésité humaine : les endocannabinoïdes salivaires
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• Endocannabinoids measurement in human saliva as potential biomarker of obesity.
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  PLoS ONE. 2012-07-31. 7(7) : e42399.
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• Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo.
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• Bimodal control of fear-coping strategies by CB₁ cannabinoid receptors.
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• Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice.
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  Neuropsychopharmacol. 2012-03-21. 37(8) : 1885-1900.
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• Mitochondrial CB₁ receptors regulate neuronal energy metabolism.
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• Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD.
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  Cell. 2012-03-01. 148(5) : 1039-1050.
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• Cannabinoid type 1 receptors located on single-minded 1-expressing neurons control emotional behaviors.
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• Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses
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• Moving bliss: a new anandamide transporter.
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• State-dependent, bidirectional modulation of neural network activity by endocannabinoids.
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  Journal of Neuroscience. 2011-11-16. 31(46) : 16591-16596.
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• GABAergic and cortical and subcortical glutamatergic axon terminals contain CB1 cannabinoid receptors in the ventromedial nucleus of the hypothalamus.
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• Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity.
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• Synergistic post-prandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity
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  Appetite. 2011-07-01. 57 : S17.
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• New fat and new neurons: endocannabinoids control neurogenesis in obesity (Commentary on Rivera et al.).
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• Endocannabinoids and motor behavior: CB1 receptors also control running activity.
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  Physiology. 2011-04-01. 26(2) : 76-77.
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• Emotional consequences of wheel running in mice: which is the appropriate control?
  Sarah Dubreucq, Giovanni Marsicano, Francis Chaouloff.
  Hippocampus. 2011-02-24. 21(3) : 239-242.
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• Presynaptic CB1 receptors regulate synaptic plasticity at cerebellar parallel fiber synapses.
  Megan R. Carey, Michael H. Myoga, Kimberly R. McDaniels, Giovanni Marsicano, Beat Lutz, Ken Mackie, Wade G. Regehr.
  Journal of Neurophysiology. 2011-02-01. 105(2) : 958-963.
  10.1152/jn.00980.2010
• Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease.
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  Brain. 2010-10-07. 134(1) : 119-136.
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• CB1 receptor deficiency decreases wheel-running activity: consequences on emotional behaviours and hippocampal neurogenesis.
  Sarah Dubreucq, Muriel Koehl, Djoher N. Abrous, Giovanni Marsicano, Francis Chaouloff.
  Experimental Neurology. 2010-07-01. 224(1) : 106-113.
  10.1016/j.expneurol.2010.01.017
• CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance.
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  Cell Metabolism. 2010-04-01. 11(4) : 273-285.
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• Bimodal control of stimulated food intake by the endocannabinoid system.
  Luigi Bellocchio, Pauline Lafenêtre, Astrid Cannich, Daniela Cota, Nagore Puente, Pedro Grandes, Francis Chaouloff, Pier Vincenzo Piazza, Giovanni Marsicano.
  Nat Neurosci. 2010-02-07. 13(3) : 281-283.
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• Localization and function of the cannabinoid CB1 receptor in the anterolateral bed nucleus of the stria terminalis.
  Nagore Puente, Izaskun Elezgarai, Mathieu Lafourcade, Leire Reguero, Giovanni Marsicano, François Georges, Olivier J. Manzoni, Pedro Grandes.
  PLoS ONE. 2010-01-25. 5(1) : e8869.
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• Synaptic activation of kainate receptors gates presynaptic CB(1) signaling at GABAergic synapses.
  Joana Lourenço, Astrid Cannich, Mario Carta, Françoise Coussen, Christophe Mulle, Giovanni Marsicano.
  Nat Neurosci. 2010-01-17. 13(2) : 197-204.
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• Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system.
  Pauline Lafenêtre, Francis Chaouloff, Giovanni Marsicano.
  Neuropharmacology. 2009-12-01. 57(7-8) : 715-721.
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• Self-modulation of neocortical pyramidal neurons by endocannabinoids.
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  Nat Neurosci. 2009-11-15. 12(12) : 1488-1490.
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• Endocannabinoids render exploratory behaviour largely independent of the test aversiveness: role of glutamatergic transmission.
  W. Jacob, A. Yassouridis, G. Marsicano, K. Monory, B. Lutz, C. T. Wotjak.
  Genes, Brain and Behavior. 2009-10-01. 8(7) : 685-698.
  10.1111/j.1601-183x.2009.00512.x
• Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization.
  A. J. Pernia-Andrade, A. Kato, R. Witschi, R. Nyilas, I. Katona, T. F. Freund, M. Watanabe, J. Filitz, W. Koppert, J. Schuttler, G. Ji, V. Neugebauer, G. Marsicano, B. Lutz, H. Vanegas, H. U. Zeilhofer.
  Science. 2009-08-06. 325(5941) : 760-764.
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• Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling.
  Emma Puighermanal, Giovanni Marsicano, Arnau Busquets-Garcia, Beat Lutz, Rafael Maldonado, Andrés Ozaita.
  Nat Neurosci. 2009-08-02. 12(9) : 1152-1158.
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• WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease.
  David A. Price, Alex A. Martinez, Alexandre Seillier, Wouter Koek, Yolanda Acosta, Elizabeth Fernandez, Randy Strong, Beat Lutz, Giovanni Marsicano, James L. Roberts, Andrea Giuffrida.
  European Journal of Neuroscience. 2009-06-01. 29(11) : 2177-2186.
  10.1111/j.1460-9568.2009.06764.x
• Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling.
  K. Kamprath, W. Plendl, G. Marsicano, J. M. Deussing, W. Wurst, B. Lutz, C. T. Wotjak.
  Genes, Brain and Behavior. 2009-03-01. 8(2) : 203-211.
  10.1111/j.1601-183x.2008.00463.x
• Roles of the endocannabinoid system in learning and memory.
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  Behavioral Neurobiology of the Endocannabinoid System. 2009-01-01. : 201-230.
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• Endocannabinoid role in synaptic plasticity and learning
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  Encyclopedia of Neuroscience. 2009-01-01. : 963-975.
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• Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice.
  Douglas Osei-Hyiaman, Jie Liu, Liang Zhou, Grzegorz Godlewski, Judith Harvey-White, Won-il Jeong, Sándor Bátkai, Giovanni Marsicano, Beat Lutz, Christoph Buettner, George Kunos.
  J. Clin. Invest.. 2008-09-02. 118(9) : 3160-3169.
  10.1172/jci34827
• Conditional cannabinoid receptor type 1 mutants reveal neuron subpopulation-specific effects on behavioral and neuroendocrine stress responses.
  Michel A. Steiner, Giovanni Marsicano, Carsten T. Wotjak, Beat Lutz.
  Psychoneuroendocrinology. 2008-09-01. 33(8) : 1165-1170.
  10.1016/j.psyneuen.2008.06.004
• Cannabinoids enhance susceptibility of immature brain to ethanol neurotoxicity.
  Henrik H. Hansen, Birte Krutz, Marco Sifringer, Vanya Stefovska, Petra Bittigau, Fritz Pragst, Giovanni Marsicano, Beat Lutz, Chrysanthy Ikonomidou.
  Ann Neurol.. 2008-07-01. 64(1) : 42-52.
  10.1002/ana.21287
• Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning.
  J. Mulder, T. Aguado, E. Keimpema, K. Barabas, C. J. Ballester Rosado, L. Nguyen, K. Monory, G. Marsicano, V. Di Marzo, Y. L. Hurd, F. Guillemot, K. Mackie, B. Lutz, M. Guzman, H.-C. Lu, I. Galve-Roperh, T. Harkany.
  Proceedings of the National Academy of Sciences. 2008-06-18. 105(25) : 8760-8765.
  10.1073/pnas.0803545105
• Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes.
  L. Tedesco, A. Valerio, C. Cervino, A. Cardile, C. Pagano, R. Vettor, R. Pasquali, M. O. Carruba, G. Marsicano, B. Lutz, U. Pagotto, E. Nisoli.
  Diabetes. 2008-05-13. 57(8) : 2028-2036.
  10.2337/db07-1623
• Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver.
  Won-il Jeong, Douglas Osei-Hyiaman, Ogyi Park, Jie Liu, Sándor Bátkai, Partha Mukhopadhyay, Norio Horiguchi, Judith Harvey-White, Giovanni Marsicano, Beat Lutz, Bin Gao, George Kunos.
  Cell Metabolism. 2008-03-01. 7(3) : 227-235.
  10.1016/j.cmet.2007.12.007
• Activation of CB1 specifically located on GABAergic interneurons inhibits LTD in the lateral amygdala.
  S. C. Azad, J. Kurz, G. Marsicano, B. Lutz, W. Zieglgansberger, G. Rammes.
  Learning & Memory. 2008-02-22. 15(3) : 143-152.
  10.1101/lm.741908
• Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice.
  Michel A. Steiner, Giovanni Marsicano, Eric J. Nestler, Florian Holsboer, Beat Lutz, Carsten T. Wotjak.
  Psychoneuroendocrinology. 2008-01-01. 33(1) : 54-67.
  10.1016/j.psyneuen.2007.09.008
• Anatomical distribution of receptors, ligands and enzymes in the brain and in the spinal cord: Circuitries and neurochemistry
  Giovanni Marsicano, Rohini Kuner.
  Cannabinoids and the Brain. 2008-01-01. : 161-201.
  10.1007/978-0-387-74349-3_10
• The endocannabinoid system in the processing of anxiety and fear and how CB1 receptors may modulate fear extinction.
  Pauline Lafenêtre, Francis Chaouloff, Giovanni Marsicano.
  Pharmacological Research. 2007-11-01. 56(5) : 367-381.
  10.1016/j.phrs.2007.09.006
• The endocannabinoid system in the processing of anxiety and fear and how CB1 receptors may modulate fear extinction
  Pauline Lafenêtre, Francis Chaouloff, Giovanni Marsicano.
  Pharmacological Research. 2007-11-01. 56(5) : 367-381.
  10.1016/j.phrs.2007.09.006
• Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice.
  Krisztina Monory, Heike Blaudzun, Federico Massa, Nadine Kaiser, Thomas Lemberger, Günther Schütz, Carsten T Wotjak, Beat Lutz, Giovanni Marsicano.
  PLoS Biol. 2007-10-09. 5(10) : e269.
  10.1371/journal.pbio.0050269
• Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon.
  Angelo A. Izzo, , Gabriella Aviello, Stefania Petrosino, Pierangelo Orlando, Giovanni Marsicano, Beat Lutz, Francesca Borrelli, Raffaele Capasso, Santosh Nigam, Francesco Capasso, Vincenzo Di Marzo.
  J Mol Med. 2007-09-06. 86(1) : 89-98.
  10.1007/s00109-007-0248-4
• Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex.
  b. yuece, a. sibaev, u. c. broedl, g. marsicano, b. göke, b. lutz, h. d. allescher, m. storr.
  Neurogastroenterol Motil. 2007-09-01. 19(9) : 744-753.
  10.1111/j.1365-2982.2007.00975.x
• Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice.
  M A Steiner, K Wanisch, K Monory, G Marsicano, E Borroni, H Bächli, F Holsboer, B Lutz, C T Wotjak.
  Pharmacogenomics J. 2007-08-07. 8(3) : 196-208.
  10.1038/sj.tpj.6500466
• Role of cannabinoid type 1 receptors in locomotor activity and striatal signaling in response to psychostimulants.
  A.-G. Corbille, E. Valjent, G. Marsicano, C. Ledent, B. Lutz, D. Herve, J.-A. Girault.
  Journal of Neuroscience. 2007-06-27. 27(26) : 6937-6947.
  10.1523/jneurosci.3936-06.2007
• Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.
  Nitin Agarwal, Pal Pacher, Irmgard Tegeder, Fumimasa Amaya, Cristina E Constantin, Gary J Brenner, Tiziana Rubino, Christoph W Michalski, Giovanni Marsicano, Krisztina Monory, Ken Mackie, Claudiu Marian, Sandor Batkai, Daniela Parolaro, Michael J Fischer, Peter Reeh, George Kunos, Michaela Kress, Beat Lutz, Clifford J Woolf, Rohini Kuner.
  Nat Neurosci. 2007-06-10. 10(7) : 870-879.
  10.1038/nn1916
• The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis.
  Tania Aguado, Eva Romero, Krisztina Monory, Javier Palazuelos, Michael Sendtner, Giovanni Marsicano, Beat Lutz, Manuel Guzmán, Ismael Galve-Roperh.
  J. Biol. Chem.. 2007-06-07. 282(33) : 23892-23898.
  10.1074/jbc.m700678200
• Hardwiring the brain: endocannabinoids shape neuronal connectivity.
  P. Berghuis, A. M. Rajnicek, Y. M. Morozov, R. A. Ross, J. Mulder, G. M. Urban, K. Monory, G. Marsicano, M. Matteoli, A. Canty, A. J. Irving, I. Katona, Y. Yanagawa, P. Rakic, B. Lutz, K. Mackie, T. Harkany.
  Science. 2007-05-25. 316(5828) : 1212-1216.
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• Identification of the cannabinoid receptor type 1 in serotonergic cells of raphe nuclei in mice.
  M. Häring, G. Marsicano, B. Lutz, K. Monory.
  Neuroscience. 2007-05-01. 146(3) : 1212-1219.
  10.1016/j.neuroscience.2007.02.021
• Identification of the cannabinoid receptor type 1 in serotonergic cells of raphe nuclei in mice
  M. Häring, G. Marsicano, B. Lutz, K. Monory.
  Neuroscience. 2007-05-01. 146(3) : 1212-1219.
  10.1016/j.neuroscience.2007.02.021
• Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells.
  Katarzyna Maresz, Gareth Pryce, Eugene D Ponomarev, Giovanni Marsicano, J Ludovic Croxford, Leah P Shriver, Catherine Ledent, Xiaodong Cheng, Erica J Carrier, Monica K Mann, Gavin Giovannoni, Roger G Pertwee, Takashi Yamamura, Nancy E Buckley, Cecilia J Hillard, Beat Lutz, David Baker, Bonnie N Dittel.
  Nat Med. 2007-04-01. 13(4) : 492-497.
  10.1038/nm1561
• Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis function.
  Daniela Cota, Michel-Alexander Steiner, Giovanni Marsicano, Cristina Cervino, James P. Herman, Yvonne Grübler, Johanna Stalla, Renato Pasquali, Beat Lutz, Günter K. Stalla, Uberto Pagotto.
  Endocrinology. 2007-04-01. 148(4) : 1574-1581.
  10.1210/en.2005-1649
• Protective activation of the endocannabinoid system during ischemia in dopamine neurons.
  Miriam Melis, Giuliano Pillolla, Tiziana Bisogno, Alberto Minassi, Stefania Petrosino, Simona Perra, Anna Lisa Muntoni, Beat Lutz, Gian Luigi Gessa, Giovanni Marsicano.
  Neurobiology of Disease. 2006-10-01. 24(1) : 15-27.
  10.1016/j.nbd.2006.04.010
• The endocannabinoid system controls key epileptogenic circuits in the hippocampus.
  Krisztina Monory, Federico Massa, Michaela Egertová, Matthias Eder, Heike Blaudzun, Ruth Westenbroek, Wolfgang Kelsch, Wolfgang Jacob, Rudolf Marsch, Marc Ekker, Jason Long, John L. Rubenstein, Sandra Goebbels, Klaus-Armin Nave, Matthew During, Matthias Klugmann, Barbara Wölfel, Hans-Ulrich Dodt, Walter Zieglgänsberger, Carsten T. Wotjak, Ken Mackie, Maurice R. Elphick, Giovanni Marsicano, Beat Lutz.
  Neuron. 2006-08-01. 51(4) : 455-466.
  10.1016/j.neuron.2006.07.006
• Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes.
  K. Kamprath, G. Marsicano, J. Tang, K. Monory, T. Bisogno, V. D. Marzo, B. Lutz, C. T. Wotjak.
  Journal of Neuroscience. 2006-06-21. 26(25) : 6677-6686.
  10.1523/jneurosci.0153-06.2006
• Cannabinoid receptor type 1 located on presynaptic terminals of principal neurons in the forebrain controls glutamatergic synaptic transmission.
  M. R. Domenici.
  Journal of Neuroscience. 2006-05-24. 26(21) : 5794-5799.
  10.1523/jneurosci.0372-06.2006
• How many sites of action for endocannabinoids to control energy metabolism?
  U Pagotto, C Cervino, V Vicennati, G Marsicano, B Lutz, R Pasquali.
  Int J Obes. 2006-03-29. 30(S1) : S39-S43.
  10.1038/sj.ijo.0803277
• CB1 and TRPV1 receptors mediate protective effects on colonic electrophysiological properties in mice.
  A. Sibaev, F. Massa, B. Yüce, G. Marsicano, H. A. Lehr, B. Lutz, B. Göke, H. D. Allescher, M. Storr.
  J Mol Med. 2006-02-25. 84(6) : 513-520.
  10.1007/s00109-006-0040-x
• The emerging role of the endocannabinoid system in endocrine regulation and energy balance.
  Uberto Pagotto, Giovanni Marsicano, Daniela Cota, Beat Lutz, Renato Pasquali.
  Endocrine Reviews. 2006-02-01. 27(1) : 73-100.
  10.1210/er.2005-0009
• The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells.
  T. Aguado.
  Journal of Neuroscience. 2006-02-01. 26(5) : 1551-1561.
  10.1523/jneurosci.3101-05.2006
• Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene sulfonic acid induced colitis.
  F. Massa, A. Sibaev, G. Marsicano, H. Blaudzun, M. Storr, B. Lutz.
  J Mol Med. 2005-12-31. 84(2) : 142-146.
  10.1007/s00109-005-0016-2
• The endocannabinoid system drives neural progenitor proliferation.
  Tania Aguado, Krisztina Monory, Javier Palazuelos, Nephi Stella, Benjamin Cravatt, Beat Lutz, Giovanni Marsicano, Zaal Kokaia, Manuel Guzmán, Ismael Galve-Roperh.
  The FASEB Journal. 2005-10-01. 19(12) : 1704-1706.
  10.1096/fj.05-3995fje
• Fatty acid amide hydrolase controls mouse intestinal motility in vivo.
  Raffaele Capasso, Isabel Matias, Beat Lutz, Francesca Borrelli, Francesco Capasso, Giovanni Marsicano, Nicola Mascolo, Stefania Petrosino, Krisztina Monory, Marta Valenti, Vincenzo Di Marzo, Angelo A. Izzo.
  Gastroenterology. 2005-09-01. 129(3) : 941-951.
  10.1053/j.gastro.2005.06.018
• Cannabinoid CB1 receptor is dispensable for memory extinction in an appetitively-motivated learning task.
  Sabine M. Hölter, Magdalena Kallnik, Wolfgang Wurst, Giovanni Marsicano, Beat Lutz, Carsten T. Wotjak.
  European Journal of Pharmacology. 2005-03-01. 510(1-2) : 69-74.
  10.1016/j.ejphar.2005.01.008
• Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons.
  M. Melis.
  Journal of Neuroscience. 2004-11-24. 24(47) : 10707-10715.
  10.1523/jneurosci.3502-04.2004
• Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons
  M. Melis.
  Journal of Neuroscience. 2004-11-24. 24(47) : 10707-10715.
  10.1523/JNEUROSCI.3502-04.2004
• Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling.
  S. C. Azad.
  Journal of Neuroscience. 2004-11-03. 24(44) : 9953-9961.
  10.1523/jneurosci.2134-04.2004
• CB1 cannabinoid receptors modulate kinase and phosphatase activity during extinction of conditioned fear in mice.
  A. Cannich.
  Learning & Memory. 2004-09-01. 11(5) : 625-632.
  10.1101/lm.77904
• The endogenous cannabinoid system protects against colonic inflammation.
  Federico Massa, Giovanni Marsicano, Heike Hermann, Astrid Cannich, Krisztina Monory, Benjamin F. Cravatt, Gian-Luca Ferri, Andrei Sibaev, Martin Storr, Beat Lutz.
  J. Clin. Invest.. 2004-04-15. 113(8) : 1202-1209.
  10.1172/jci200419465
• The endogenous cannabinoid system protects against colonic inflammation.
  Federico Massa, Giovanni Marsicano, Heike Hermann, Astrid Cannich, Krisztina Monory, Benjamin F. Cravatt, Gian-Luca Ferri, Andrei Sibaev, Martin Storr, Beat Lutz.
  J. Clin. Invest.. 2004-04-15. 113(8) : 1202-1209.
  10.1172/jci200419465
• Reduced sensitivity to reward in CB1 knockout mice.
  Carles Sanchis-Segura, Brandon H. Cline, Giovanni Marsicano, Beat Lutz, Rainer Spanagel.
  Psychopharmacology. 2004-04-09. 176(2) : 223-232.
  10.1007/s00213-004-1877-8
• Involvement of brain-derived neurotrophic factor in cannabinoid receptor-dependent protection against excitotoxicity.
  Leonid G. Khaspekov, Maria S. Brenz Verca, Lidia E. Frumkina, Heike Hermann, Giovanni Marsicano, Beat Lutz.
  Eur J Neurosci. 2004-04-01. 19(7) : 1691-1698.
  10.1111/j.1460-9568.2004.03285.x
• Cannabinoid receptor type 1 modulates excitatory and inhibitory neurotransmission in mouse colon.
  M. Storr, A. Sibaev, G. Marsicano, B. Lutz, V. Schusdziarra, J.-P. Timmermans, H. D. Allescher.
  American Journal of Physiology-Gastrointestinal and Liver Physiology. 2004-01-01. 286(1) : G110-G117.
  10.1152/ajpgi.00148.2003
• CB1 cannabinoid receptors and on-demand defense against excitotoxicity.
  G. Marsicano.
  Science. 2003-10-03. 302(5642) : 84-88.
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• An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice.
  Angelo A. Izzo, Francesco Capasso, Anna Costagliola, Tiziana Bisogno, Giovanni Marsicano, Alessia Ligresti, Isabel Matias, Raffaele Capasso, Luisa Pinto, Francesca Borrelli, Aldo Cecio, Beat Lutz, Nicola Mascolo, Vincenzo Di Marzo.
  Gastroenterology. 2003-09-01. 125(3) : 765-774.
  10.1016/s0016-5085(03)00892-8
• An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice
  Angelo A. Izzo, Francesco Capasso, Anna Costagliola, Tiziana Bisogno, Giovanni Marsicano, Alessia Ligresti, Isabel Matias, Raffaele Capasso, Luisa Pinto, Francesca Borrelli, Aldo Cecio, Beat Lutz, Nicola Mascolo, Vincenzo Di Marzo.
  Gastroenterology. 2003-09-01. 125(3) : 765-774.
  10.1016/S0016-5085(03)00892-8
• The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis.
  Daniela Cota, Giovanni Marsicano, Matthias Tschöp, Yvonne Grübler, Cornelia Flachskamm, Mirjam Schubert, Dorothee Auer, Alexander Yassouridis, Christa Thöne-Reineke, Sylvia Ortmann, Federica Tomassoni, Cristina Cervino, Enzo Nisoli, Astrid C.E. Linthorst, Renato Pasquali, Beat Lutz, Günter K. Stalla, Uberto Pagotto.
  J. Clin. Invest.. 2003-08-01. 112(3) : 423-431.
  10.1172/jci17725
• Cannabinoids in energy balance and prospectives in the therapy of obesity
  G. Marsicano, D. Cota, G. Stalla, R. Pasquali, U. Pagotto, B. Lutz.
  CMCCNSA. 2003-06-01. 3(2) : 81-87.
  10.2174/1568015033477839
• Endogenous cannabinoid system as a modulator of food intake.
  D Cota, G Marsicano, B Lutz, V Vicennati, G K Stalla, R Pasquali, U Pagotto.
  Int J Obes. 2003-03-01. 27(3) : 289-301.
  10.1038/sj.ijo.0802250
• Activation of the cannabinoid receptor type 1 decreases glutamatergic and GABAergic synaptic transmission in the lateral amygdala of the mouse.
  S. C. Azad.
  Learning & Memory. 2003-03-01. 10(2) : 116-128.
  10.1101/lm.53303
• The endogenous cannabinoid system controls extinction of aversive memories.
  Giovanni Marsicano, Carsten T. Wotjak, Shahnaz C. Azad, Tiziana Bisogno, Gerhard Rammes, Maria Grazia Cascio, Heike Hermann, Jianrong Tang, Clementine Hofmann, Walter Zieglgänsberger, Vincenzo Di Marzo, Beat Lutz.
  Nature. 2002-08-01. 418(6897) : 530-534.
  10.1038/nature00839
• Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1.
  Giovanni Marsicano, Bernd Moosmann, Heike Hermann, Beat Lutz, Christian Behl.
  J Neurochem. 2002-02-01. 80(3) : 448-456.
  10.1046/j.0022-3042.2001.00716.x
• Coexpression of the cannabinoid receptor type 1 with dopamine and serotonin receptors in distinct neuronal subpopulations of the adult mouse forebrain.
  H Hermann, G Marsicano, B Lutz.
  Neuroscience. 2002-02-01. 109(3) : 451-460.
  10.1016/s0306-4522(01)00509-7
• Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1.
  Giovanni Marsicano, Bernd Moosmann, Heike Hermann, Beat Lutz, Christian Behl.
  J Neurochem. 2002-02-01. 80(3) : 448-456.
  10.1046/j.0022-3042.2001.00716.x
• Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endogenous cannabinoids: first evidence for a direct role of cannabinoids on hormone modulation at the human pituitary level.
  U. Pagotto, G. Marsicano, F. Fezza, M. Theodoropoulou, Y. Grübler, J. Stalla, T. Arzberger, A. Milone, M. Losa, V. Di Marzo, B. Lutz, G. K. Stalla.
  The Journal of Clinical Endocrinology & Metabolism. 2001-06-01. 86(6) : 2687-2696.
  10.1210/jcem.86.6.7565
• Differential role of the nitric oxide pathway on delta(9)-THC-induced central nervous system effects in the mouse.
  Shahnaz Christina Azad, Giovanni Marsicano, Irina Eberlein, Jörg Putzke, Walter Zieglgänsberger, Rainer Spanagel, Beat Lutz.
  European Journal of Neuroscience. 2001-02-01. 13(3) : 561-568.
  10.1046/j.1460-9568.2001.01431.x
• Differential role of the nitric oxide pathway on delta(9)-THC-induced central nervous system effects in the mouse.
  Shahnaz Christina Azad, Giovanni Marsicano, Irina Eberlein, Jörg Putzke, Walter Zieglgänsberger, Rainer Spanagel, Beat Lutz.
  European Journal of Neuroscience. 2001-02-01. 13(3) : 561-568.
  10.1046/j.1460-9568.2001.01431.x
• An in vivo model of hyperacute rejection: characterization and evaluation of the effect of transgenic human complement inhibitors.
  Marirosa Mora, Massimo Lazzeri, Giovanni Marsicano, Lubbertus C.F. Mulder, Laura Carraresi, Alessandro Pieri, Alessio Benanchi, Daniela Grifoni, Sandra Nuti, Paolo Bruzzone, Mario Comporti, Raffaello Cortesini, Mara Rossini.
  Transgenic Research. 2000-01-01. 9(3) : 205-213.
  10.1023/a:1008928713058
• Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain.
  Giovanni Marsicano, Beat Lutz.
  European Journal of Neuroscience. 1999-12-01. 11(12) : 4213-4225.
  10.1046/j.1460-9568.1999.00847.x
• Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain.
  Giovanni Marsicano, Beat Lutz.
  European Journal of Neuroscience. 1999-12-01. 11(12) : 4213-4225.
  10.1046/j.1460-9568.1999.00847.x
• Kidneys derived from mice transgenic for human complement blockers are protected in an in vivo model of hyperacute rejection.
  MASSIMO LAZZERI, MARIROSA MORA, LUBBERTUS C.F. MULDER, GIOVANNI MARSICANO, GIOVANNI MARINUCCI, MANUELA BOSCHI, PAOLO BRUZZONE, DARIO ALFANI, RAFFAELLO CORTESINI, MARA ROSSINI.
  The Journal of Urology. 1998-04-01. 159(4) : 1364-1369.
  10.1016/s0022-5347(01)63617-6
• Kidneys derived from mice transgenic for human complement blockers are protected in an in vivo model of hyperacute rejection
  MASSIMO LAZZERI, MARIROSA MORA, LUBBERTUS C.F. MULDER, GIOVANNI MARSICANO, GIOVANNI MARINUCCI, MANUELA BOSCHI, PAOLO BRUZZONE, DARIO ALFANI, RAFFAELLO CORTESINI, MARA ROSSINI.
  Journal of Urology. 1998-04-01. 159(4) : 1364-1369.
  10.1016/S0022-5347(01)63617-6
• Factors controlling haemopoiesis in ovine long-term bone marrow cultures.
  Giovanni Marsicano, Donika Shehu, Cesare Galli.
  Veterinary Immunology and Immunopathology. 1997-03-01. 55(4) : 291-301.
  10.1016/s0165-2427(96)05599-7
• Factors controlling haemopoiesis in ovine long term bone marrow cultures
  Giovanni Marsicano, Donika Shehu, Cesare Galli.
  Veterinary Immunology and Immunopathology. 1997-03-01. 55(4) : 291-301.
  10.1016/S0165-2427(96)05599-7