Venue: Centre Broca Nouvelle Aquitaine
Defense in english
Closed doors defense : confidentiality declaration to sign when entering the auditorium
Jeremy Lesas
Team: Herry (Magendie)
Title
Controlling fear in mice with clinically relevant stimulation of the prefrontal cortex
Abstract
Neuropsychiatric disorders affect an important part of the population. Several types of therapeutic strategies exist for the care of these disorders, such as drugs, functional therapy and neurostimulation. This latter has already proven effective for disorders such as Parkinson’s disease, major depression or obsessive-compulsive disorders, but is still ineffective for anxiety disorders : yet they represent an important part of resistant psychiatric conditions. This project aims at developing optogenetics, a recent technique which already revolutionized neuroscientific research, to open doors for its clinical translation, and to combine it with advanced knowledge on the physiology of fear and anxiety disorders using closed-loop stimulation of the prefrontal cortex.
Publication
in revision in Advanced Healthcare Materials :
Dye-based Fluorescent Organic Nanoparticles, New Promising Tools for Optogenetics
Jeremy Lesas, Thomas Bienvenu, Eleonore Kurek, Jean-Baptiste Verlhac, Delphine Girard, Frédéric Lanore, Mireille Blanchard-Desce, Cyril Herry, Jonathan Daniel* and Cyril Dejean*
Jury
Thesis superviosr: Dr. DEJEAN Cyril
Jury members:
Dr. HUMEAU Yann, Directeur de recherche, CNRS
Pr. VETERE Gisella, Professeur, ESPCI
Pr. BOUZIGUES Cédric, Professeur assistant, École Polytechnique
Pr. GUEHL Dominique, PU-PH, Université de Bordeaux
Dr. FERY-FORGUES Suzanne, Directrice de recherche, Université Toulouse III
Dr. BUI Ngoc Anh Thy, Chargée de recherche, Université de Bordeaux
Guests:
Dr. DANIEL Jonathan, Ingénieur de recherche, Université de Bordeaux
Dr. BIENVENU Thomas, Maître de conférences, Université de Bordeaux