Via zoom: https://u-bordeaux-fr.zoom.us/j/86237726350
Defense in english
Peptidergic control of pain: modulation of descending pathways by the relaxin systems
Abstract
Chronic pain, often accompanied by anxiety and depression, is a global scourge. The modulation of pain by neuropeptides (NP) is well known at the level of primary afferents and the spinal cord. However, little data is available on their role in pain in the brain. The relaxin family includes relaxin, which is present in the central nervous system (CNS) and has antifibrotic properties, and relaxin-3, which is strictly expressed in the CNS and has anxiolytic and antidepressant effects. Our objective is to study the modulation of pain by the neuropeptides relaxin and relaxin-3 in a mouse model of persistent inflammatory pain.
Our results show that not only the relaxin-3 / RXFP3 system, but also the relaxin / RXFP1 system, which is still poorly explored in the CNS, have analgesic effects in conditions of inflammatory pain. The sites of action of these peptide systems include cortical (cingulate cortex, claustrum) and subcortical (amygdala) regions that regulate descending pathways and sensory integration in the spinal cord. Our data highlight the therapeutic potential of this peptide family, whose role in pain has never been tested before.
Keywords: Chronic pain, amygdala, anterior cingulate cortex, relaxin, relaxin-3.
Publications
Animal models of pain: Diversity and benefits.
Abboud C., Duveau, A., Bouali-Benazzouz, R., Massé, K., Mattar, J., Brochoire, L., Fossat, P., Boué-Grabot, E., Hleihel, W., and Landry, M. J Neurosci Methods (2020) 108997
Analgesic effect of relaxin receptor (RXFP-1) activation on persistent inflammatory pain in mice: behavioral and neurochemical data.
Abboud C., Brochoire L., Drouet A., Akhter Hossain M., Hleihel W. and Landry M.
En soumission
Jury
Mme BERTRAND Sandrine, Professeure, Université de Bordeaux-France (Présidente)
Mme SANCHEZ PEREZ Ana Maria, Professeure, Université Jaume I de Castellon-Espagne (Rapportrice)
Mme ZAKY Amira, Professeure, Université d’Alexandrie-Egypte (Rapportrice)
Mme ABI FADEL Marianne, Professeure, Université Saint Joseph-Liban (Examinatrice)
M. FARES Nassim, Professeur, Université Saint Joseph-Liban (Examinateur)
M. MATTAR Hanna, Docteur, Université de Saint Esprit Kaslik-Liban (Examinateur)
M. LANDRY Marc, Professeur, Université de Bordeaux-France (Directeur de thèse)
M. HLEIHEL Walid, Professeur, Université du Saint Esprit Kaslik-Liban (Co-directeur de thèse)
Cynthia Alkhoury Abboud
Team Purinergic mediated neuroinflammation and brain disorders
IMN
Thesis supervisors: Marc Landry and Walid Hleihel (Université Saint-Esprit – Kaslik – Liban)