Venue : Centre Broca
Nathalie Dehorter
Queensland Brain Institute, The University of Queensland – Australia
https://qbi.uq.edu.au/profile/16195/nathalie-dehorter
Invited by Margaux Lebouc and Jérôme Baufreton (IMN)
Title
Monitoring the Monitors: Molecular Control of the Developing Interneurons in Health and Disease
Abstract
Interneurons display functional diversity with unique gene expression profiles and distinct electrophysiological signatures which are essential to maintain the excitation-inhibition balance in neuronal networks. Yet, there is a profound lack of insight into how specific subclasses of interneurons adjust their activity via activity-dependent transcriptional programs to ultimately shape circuit development and homeostasis in health and disease. For this talk, I will present published and unpublished work uncovering the role of key regulators of interneuron function and will show how targeting developing interneurons in autism spectrum disorder represents a viable target to treat the deleterious symptoms of this condition.
Biosketch
Dr Nathalie Dehorter is a group leader at the Queensland Brain Institute, University of Queensland and Visiting Fellow at the Australian National University. Her research interests aim to unravel the molecular command behind the function of the developing interneurons of the cortex and striatum to expand our understanding of brain development and pathogenesis of neuropsychiatric conditions such as autism spectrum disorder.
Publications
Parvalbumin Interneuron Activity Underlies Vulnerability to Post-Traumatic Stress Disorder in Autism. Al Abed AS, Allen TV, Ahmed NY, Sellami A, Sontani Y, Marighetto A, Desmedt A, Dehorter N. BioRxiv 2023 doi: https://doi.org/10.1101/2021.01.18.427217
Developmental deficits of MGE-derived interneurons in the Cntnap2 knockout mouse model of autism spectrum disorder. Ahmed NY, Knowles R, Liu L, Yan Y, Li X, Schumann U, Wang Y, Sontani Y, Reynolds N, Natoli R, Wen J, Del Pino I, Mi D, Dehorter N. Front Cell Dev Biol. 2023 Feb 1;11:1112062. doi: 10.3389/fcell.2023.1112062. eCollection 2023.
Er81 Transcription Factor Fine-Tunes Striatal Cholinergic Interneuron Activity and Drives Habit Formation. Ahmed NY, Ranjbar-Slamloo Y, Al Abed AS, Gao L, Sontani Y, RCom-H’cheo-Gauthier A, Arabzadeh E, Dehorter N. J Neurosci. 2021 May 19;41(20):4392-4409. doi: 10.1523/JNEUROSCI.0967-20.2021. Epub 2021 Apr 13
A Second Wave for the Neurokinin Tac2 Pathway in Brain Research. Al Abed AS, Reynolds NJ, Dehorter N. Biol Psychiatry. 2021 Aug 1;90(3):156-164. doi: 10.1016/j.biopsych.2021.02.016. Epub 2021 Feb 23.PMID: 33867115 Review.
From Progenitors to Progeny: Shaping Striatal Circuit Development and Function. Knowles R, Ellender T.J, Dehorter N. J Neurosci. 2021 Nov 17;41(46):9483-9502. doi: 10.1523/JNEUROSCI.0620-21.2021.PMID: 34789560 Free PMC article. Review.
Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch. Dehorter N, Ciceri G, Bartolini G, Lim L, del Pino I, Marín O. Science. 2015 Sep 11;349(6253):1216-20. doi: 10.1126/science.aab3415.