Venue: Centre Broca nouvelle-Aquitaine
Coffee, caffeine and brain function
Rodrigo Cunha
Center for Neuroscience and Cell Biology (CNC) – Coimbra – Portugal
http://www.cnbc.pt/research/department_group_show.asp?iddep=1107&idgrp=1109
Invited by Eric Boué-Grabot – IMN
Selection of publications:
– Gonçalves F.Q., Lopes JP, Silva HB, Lemos C, Silva AC, Gonçalves N, Tomé AR, Ferreira SG, Canas PM, Rial D, Agostinho P, Cunha RA (2019) Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer’s disease depends on increased formation of ATP-derived extracellular adenosine. Neurobiology of Disease 132: 104570.
– Canas PM, Porciúncula LO, Simões AP, Augusto E, Silva HB, Machado NJ, Gonçalves N, Alfaro TM, Gonçalves FQ, Araújo IM, Real JI, Coelho JE, Andrade GM, Almeida RD, Chen JF, Kofalvi A, Agostinho P, Cunha RA (2018) Neuronal adenosine A2A receptors are critical mediators of neurodegeneration triggered by convulsions. eNeuro 5: e0385-18.
– Simões AP, Machado NJ, Gonçalves N, Kaster MP, Simões AT, Nunes A, Pereira de Almeida L, Goosens KA, Rial D, Cunha RA (2016) Adenosine A2A receptors in the amygdala control synaptic plasticity and contextual fear memory. Neuropsychopharmacology 41, 2862-2871.
– Kaster MP, Machado NJ, Silva HB, Ardais AP, Santana M, Baqi Y, Müller CE, Rodrigues ALS, Porciúncula LO, Chen JF, Tomé AR, Agostinho P, Canas PM, Cunha RA (2015) Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress. Proc Natl Acad Sci USA 112: 7833-7838.
– Li P, Rial R, Canas PM, Yoo JH, Li W, Zhou X, Wang Y, van Westen GJP, Payen MP, Augusto E, Gonçalves N, Tomé AR, Li Z, Wu Z, Hou X, Zhou Y, IJzerman AP, Boyden ES, Cunha RA, Qu J, Chen JF (2015) Optogenetic activation of intracellular adenosine A2A receptor signaling in hippocampus is sufficient to trigger CREB phosphorylation and impair memory. Mol Psychiatry 20: 1339-1349.
Organised by Bordeaux Neurocampus