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Schematics of the task. Left: Choices by the rat are rewarded with different probabilities in easy trials (7/8; 1/16; 1/16) and difficult trials (5/8; 3/16; 3/16). Learning measurement is the proportion of choices on the best lever during 24-trial blocks of learning where best lever and probabilities do not change. Exploration measurement is the proportion of choice shifts after a reward. Difficult trials as well as dopamine blockade decrease performance and increase exploration. Right: A simple Q-learning model with forgetting accurately reproduces the rat’s behavior. Random exploration parameters of the model significantly increase when dopamine is blocked. Learning parameters are not affected.

Virginie Fresno, Alain Marchand et al in Scientific Reports

Neurobiological control of exploration during learning

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© Pierrick Coupé, LABRI (CNRS/Bordeaux INP/Université de Bordeaux). Silhouettes : © rashadashurov/Stock.adobe.com

P. Coupé, E. Lanuza, J.V. Manjón, G. Catheline in Scientific Reports

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Mathieu Wolff & Seralynne Vann in JNeurosci

The Cognitive Thalamus as a gateway to mental representations. 

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The nanoscale topography of GluN2-NMDA receptor subtypes tunes plasticity at glutamatergic synapses.

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Dentate Granule Neurons Generated During Perinatal Life Display Distinct Morphological Features Compared With Later-Born Neurons in the Mouse Hippocampus. Thomas Kerloch, Solène Clavreul, Adeline Goron, Djoher Nora Abrous, Emilie Pacary. Cereb Cortex. 2018 Sep 12. doi: 10.1093/cercor/bhy224.

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Polyphenols from grape and blueberry improve episodic memory in healthy elderly with lower level of memory performance: a bicentric double-blind, randomized, placebo-controlled clinical study. 

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Neuronal Activity and Intracellular Calcium Levels Regulate Intracellular Transport of Newly Synthesized AMPAR. 

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nanoparticules - Didier Morin - INCIA - Bordeaux Neurocampus

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Eating memory?

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Thomas Pfeiffer, Valentin Nagerl et al. ineLife

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Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium.

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J. Baufreton, B. Bessière et al. inMovement Disorders

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GAT-3 Dysfunction Generates Tonic Inhibition in External Globus Pallidus Neurons in Parkinsonian Rodents.

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Emilie Pacary, Olivier Nicole et al. in Mol Psychiatry

A novel role for CAMKIIβ in the regulation of cortical neuron migration: implications for neurodevelopmental disorders.

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Adult Hippocampal Neurogenesis in Human: Myth or Reality?

Lucas Benoit, Ummi Ciptasari, Joséphine Gay, Marie Letournel, Lorraine Madur, Morgane Raynaud From Abrous’s Lab

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Cyril Dejean & Cyril Herry in Biol Psychiatry

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Mathieu Bourdenx & Benjamin Dehay dans Acta Neuro

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Temporal Memory and Its Enhancement by Estradiol Requires Surface Dynamics of Hippocampal CA1 N-Methyl-D-Aspartate Receptors.

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The Endocannabinoid System: Pivotal Orchestrator of Obesity and Metabolic Disease. Mazier W, Saucisse N, Gatta-Cherifi B, Cota D. Trends Endocrinol Metab. 2015 Oct;26(10):524-37. doi: 10.1016/j.tem.2015.07.007. Review. Daniela Cota: The first reports of increased appetite induced by cannabis (also known as marijuana) in humans were documented in 300 AD. Pharmacological studies carried out in different animal models between the late seventies and the early nineties had further shown that peripheral or central administration of Δ9-tetrahydrocannabinol (THC), the main psychoactive component of marijuana, or other synthetic cannabinoids increased food intake, especially for palatable food. However, understanding of the biological mechanisms underlying the “munchies”…

Mise en ligne : 4 April 2018