Violent suicide attempt history in elderly patients with bipolar disorder: The role of sex, abdominal obesity, and verbal memory: Results from the FACE-BD cohort (FondaMental Advanced center of Expertise for Bipolar Disorders).
Journal of Affective Disorders. 2022-01-01; 296: 265-276
DOI: 10.1016/j.jad.2021.09.097
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1. J Affect Disord. 2022 Jan 1;296:265-276. doi: 10.1016/j.jad.2021.09.097. Epub
2021 Oct 1.
Violent suicide attempt history in elderly patients with bipolar disorder: The
role of sex, abdominal obesity, and verbal memory: Results from the FACE-BD
cohort (FondaMental Advanced center of Expertise for Bipolar Disorders).
Lengvenyte A(1), Aouizerate B(2), Aubin V(3), Loftus J(4), Marlinge E(5),
Belzeaux R(6), Dubertret C(7), Gard S(8), Haffen E(9), Schwan R(10), Llorca
PM(11), Passerieux C(12), Roux P(13), Polosan M(12), Etain B(5), Leboyer M(13);
FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD)
Collaborators; Courtet P(14), Olié E(14).
Author information:
(1)Department of Emergency Psychiatry and Post-Acute Care, CHU Montpellier, IGF,
University of Montpellier, CNRS, INSERM, 371 Av. du Doyen Gaston Giraud,
Montpellier 34090, France; Fondation FondaMental, Créteil, France; Faculty of
Medicine, Institute of Clinical Medicine, Psychiatric Clinic, Vilnius
University, Vilnius, Lithuania. Electronic address:
.
(2)Fondation FondaMental, Créteil, France; Department of Clinical and Academic
Psychiatry, Charles-Perrens Hospital, Bordeaux, France; France/NutriNeuro,
University of Bordeaux, UMR INRAE 1286, Bordeaux, France.
(3)Psychiatric Center, Hospital Princess Grace, Monaco, France.
(4)Fondation FondaMental, Créteil, France; Psychiatric Center, Hospital Princess
Grace, Monaco, France.
(5)Fondation FondaMental, Créteil, France; GHU Paris Nord, DMU Neurosciences,
Hôpital Fernand Widal AP-HP, Université de Paris, INSERM UMRS 1144, Paris,
France.
(6)Fondation FondaMental, Créteil, France; Pôle de Psychiatrie, Assistance
Publique Hôpitaux de Marseille, Marseille, France; CNRS Aix-Marseille
Université, INT-UMR7289, Marseille, France.
(7)Fondation FondaMental, Créteil, France; Groupe Hospitalo-Universitaire AP-HP
Nord, DMU ESPRIT, service de Psychiatrie et Addictologie, Faculté de médecine,
Hopital Louis Mourier, Inserm, AP-HP, Université de Paris, U1266, Colombes,
France.
(8)Fondation FondaMental, Créteil, France; Department of Clinical and Academic
Psychiatry, Charles-Perrens Hospital, Bordeaux, France.
(9)Fondation FondaMental, Créteil, France; Service de Psychiatrie de l’Adulte,
CHU de Besançon, Laboratoire de Neurosciences, Université de Franche-Comté,
UBFC, CIC-1431 INSERM, France.
(10)Fondation FondaMental, Créteil, France; Center Psychothérapique de Nancy,
Pôle Hospitalo-Universitaire de Psychiatrie d’Adultes du Grand Nancy, Université
de Lorraine, INSERM U1114, Nancy, France.
(11)Fondation FondaMental, Créteil, France; Department of Psychiatry, CHU
Clermont-Ferrand, University of Clermont Auvergne, EA 7280, Clermont-Ferrand,
France.
(12)Fondation FondaMental, Créteil, France; Service Universitaire de psychiatrie
d’adulte et d’addictologie, Le Chesnay, Université Paris-Saclay,
DisAP-DevPsy-CESP, Université Versailles Saint-Quentin-En-Yvelines, Center
Hospitalier de Versailles, INSERM UMR1018, Villejuif 94807, France.
(13)Fondation FondaMental, Créteil, France; INSERM, IMRB, Translational
Neuropsychiatry, AP-HP, DMU IMPACT, FHU ADAPT, Fondation FondaMental, Universite
Paris Est Créteil, Créteil F-94010, France.
(14)Department of Emergency Psychiatry and Post-Acute Care, CHU Montpellier,
IGF, University of Montpellier, CNRS, INSERM, 371 Av. du Doyen Gaston Giraud,
Montpellier 34090, France; Fondation FondaMental, Créteil, France.
BACKGROUND: Bipolar disorder (BD) is a chronic, lifelong condition, associated
with increased risk of obesity, cognitive impairment, and suicidal behaviors.
Abdominal obesity and a higher risk of violent suicide attempt (SA) seem to be
shared correlates with older age, BD, and male sex until middle age when
menopause-related female body changes occur. This study aimed at assessing the
role of abdominal obesity and cognition in the violent SA burden of individuals
with BD.
METHODS: From the well-defined nationwide cohort FACE-BD (FondaMental Advanced
center of Expertise for Bipolar Disorders), we extracted data on 619 euthymic BD
patients that were 50 years or older at inclusion. Cross-sectional clinical,
cognitive, and metabolic assessments were performed. SA history was based on
self-report.
RESULTS: Violent SA, in contrast to non-violent and no SA, was associated with
higher waist circumference, abdominal obesity and poorer California Verbal
Learning Test short-delay free recall (CVLT-SDFR) (ANOVA, p