Tracking defensive states with prefrontal dynorphin-expressing neurons
Neuron. 2024-06-01; 112(12): 1899-1901
DOI: 10.1016/j.neuron.2024.05.028
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1. Neuron. 2024 Jun 19;112(12):1899-1901. doi: 10.1016/j.neuron.2024.05.028.
Tracking defensive states with prefrontal dynorphin-expressing neurons.
Bienvenu T(1), Dejean C(2), Herry C(3).
Author information:
(1)University Bordeaux, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat, 33077
Bordeaux, France; INSERM, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat,
33077 Bordeaux, France; Centre de Référence Régional des Pathologies Anxieuses
et de la Dépression, Pôle de Psychiatrie Générale et Universitaire, Centre
Hospitalier Charles Perrens, Bordeaux, France. Electronic address:
.
(2)University Bordeaux, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat, 33077
Bordeaux, France; INSERM, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat,
33077 Bordeaux, France.
(3)University Bordeaux, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat, 33077
Bordeaux, France; INSERM, Neurocentre Magendie, U1215, 146 Rue Léo-Saignat,
33077 Bordeaux, France. Electronic address: .
The dynamic suppression of threat-related behavior as a function of
environmental constraint is critical for survival in mammals, yet the
neurobiological underpinnings remain largely unknown. In this issue of Neuron,
Wang et al.1 identified prefrontal dynorphin-expressing neurons as key elements
for tracking threat-related behavioral states and regulating fear suppression.
Copyright © 2024 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.neuron.2024.05.028
PMID: 38901400 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of interests The authors declare no
competing interests.