Sharp wave ripples during learning stabilize the hippocampal spatial map.
Nat Neurosci. 2017-04-10; 20(6): 845-853
DOI: 10.1038/nn.4543
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1. Nat Neurosci. 2017 Jun;20(6):845-853. doi: 10.1038/nn.4543. Epub 2017 Apr 10.
Sharp wave ripples during learning stabilize the hippocampal spatial map.
Roux L(1), Hu B(1), Eichler R(1), Stark E(1)(2), Buzsáki G(1)(3)(4).
Author information:
(1)New York University Neuroscience Institute, New York University, New York, New
York, USA.
(2)Tel Aviv University, Sackler Faculty of Medicine and Sagol School of
Neuroscience, Department of Physiology and Pharmacology, Tel Aviv, Israel.
(3)Department of Neurology, Medical Center, New York University, New York, New
York, USA.
(4)Center for Neural Science, New York University, New York, New York, USA.
Cognitive representation of the environment requires a stable hippocampal map,
but the mechanisms maintaining a given map are unknown. Because sharp
wave-ripples (SPW-R) orchestrate both retrospective and prospective spatial
information, we hypothesized that disrupting neuronal activity during SPW-Rs
affects spatial representation. Mice learned new sets of three goal locations
daily in a multiwell maze. We used closed-loop SPW-R detection at goal locations
to trigger optogenetic silencing of a subset of CA1 pyramidal neurons. Control
place cells (nonsilenced or silenced outside SPW-Rs) largely maintained the
location of their place fields after learning and showed increased spatial
information content. In contrast, the place fields of SPW-R-silenced place cells
remapped, and their spatial information remained unaltered. SPW-R silencing did
not impact the firing rates or proportions of place cells. These results suggest
that interference with SPW-R-associated activity during learning prevents
stabilization and refinement of hippocampal maps.
DOI: 10.1038/nn.4543
PMCID: PMC5446786
PMID: 28394323 [Indexed for MEDLINE]