Precision-medicine findings from the FACE-SZ cohort to develop motivation-enhancing programs in real-world schizophrenia.
The World Journal of Biological Psychiatry. 2022-02-01; 23(9): 703-714
DOI: 10.1080/15622975.2022.2031286
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1. World J Biol Psychiatry. 2022 Nov;23(9):703-714. doi:
10.1080/15622975.2022.2031286. Epub 2022 Feb 1.
Precision-medicine findings from the FACE-SZ cohort to develop
motivation-enhancing programs in real-world schizophrenia.
Korchia T(1)(2), Tastevin M(1)(2), Sunhary de Verville PL(2), Joober R(3),
Andrieu-Haller C(1)(2), Faugere M(1)(2), Godin O(1), Etchecopar-Etchart D(1)(2),
Berna F(1)(4), Aouizerate B(1)(5)(6), Capdevielle D(1)(7), Chereau I(1)(8),
Clauss-Kobayashi J(1)(4), Coulon N(1)(9), Dorey JM(1)(10), Dubertret C(1)(11),
Dubreucq J(1)(9), Mallet J(1)(11), Misdrahi D(1)(5)(12), Passerieux
C(1)(13)(14), Rey R(1)(10), Schürhoff F(1)(15), Szoke A(1)(15), Urbach
M(1)(13)(14), Leboyer M(1)(15), Llorca PM(1)(8), Lançon C(1)(2), Richieri
R(1)(2), Boyer L(1)(2), Fond G(1)(2).
Author information:
(1)Fondation FondaMental, Créteil, France.
(2)Secteur Timone, EA 327, Faculté de Médecine, CEReSS-Centre d’Etude et de
Recherche sur les Services de Santé et la Qualité de vie, AP-HM, Aix-Marseille
Université, Marseille, France.
(3)Prevention and Early Intervention Program for Psychosis (PEPP-Montréal),
Department of Psychiatry, Douglas Mental Health University Institute, McGill
University, Montréal, Canada.
(4)INSERM U1114, Fédération de Médecine Translationnelle de Strasbourg, Hôpitaux
Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France.
(5)Centre Hospitalier Charles Perrens, F-33076 Université de Bordeaux, CNRS UMR
5287-INCIA, Pôle de psychiatrie Générale et Universitaire, Bordeaux, France.
(6)INRA, NutriNeuro, University of Bordeaux, Bordeaux, France.
(7)Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHRU
Montpellier, IGF, CNRS, INSERM, Université Montpellier, Montpellier, France.
(8)CMP-B, CHU, CNRS, Clermont Auvergne INP, Université Clermont Auvergne,
Clermont-Ferrand, France.
(9)Centre Référent de Réhabilitation Psychosociale, CH Alpes Isère, Grenoble,
France.
(10)INSERM U1028, CNRS UMR5292, Centre de Recherche en Neurosciences de Lyon,
Université Claude Bernard Lyon 1, Bron Cedex, France.
(11)Department of Psychiatry, Louis Mourier Hospital, Université de Paris,
AP-HP, Colombes, Paris, France.
(12)CNRS UMR 5287-INCIA, Université de Bordeaux, Bordeaux, France.
(13)Centre Hospitalier de Versailles, Service Universitaire de Psychiatrie
d’Adultes et d’Addictologie, Le Chesnay, France.
(14)DisAP-DevPsy-CESP, INSERM UMR1018, Université Paris-Saclay, Villejuif,
France.
(15)Hôpitaux Universitaires « H. Mondor », DMU IMPACT, INSERM, IMRB,
translational Neuropsychiatry, Fondation FondaMental, Université Paris Est
Creteil (UPEC), AP-HP, Creteil, France.
BACKGROUND: In people with schizophrenia, major areas of everyday life are
impaired, including independent living, productive activities, social
relationships and overall quality of life. Enhanced understanding of factors
that hinder real-life functioning is vital for treatments to translate into more
positive outcomes.
AIM: The goal of the present study was to identify factors associated with
motivation deficits in real-life schizophrenia, and to assess its contribution
to impaired functioning and quality of life.
METHODS: Based on previous literature and clinical experience, several factors
were selected and grouped into factors potentially explaining motivation
deficits. Some of these variables were never investigated before in relationship
with motivation deficits.
RESULTS: In 561 patients with schizophrenia of the national FACE-SZ cohort
living in the community, 235 (41.9%) reported severe motivation deficits. These
deficits were found to be significantly associated with impaired socially useful
activities, psychological and physical quality of life (in almost all domains),
alcohol use disorder (aOR = 2.141, p = 0.021), severe nicotine dependence (aOR =
2.906, p