Major depression, sleep, hostility and body mass index are associated with impaired quality of life in schizophrenia. Results from the FACE-SZ cohort.
Journal of Affective Disorders. 2020-09-01; 274: 617-623
DOI: 10.1016/j.jad.2020.05.003
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1. J Affect Disord. 2020 Sep 1;274:617-623. doi: 10.1016/j.jad.2020.05.003. Epub
2020 May 19.
Major depression, sleep, hostility and body mass index are associated with
impaired quality of life in schizophrenia. Results from the FACE-SZ cohort.
Fond G(1), Korchia T(2), Sunhary de Verville PL(3), Godin O(3), Schürhoff F(4),
Berna F(5), André M(6), Aouizerate B(7), Capdevielle D(6), Chereau I(8), D’Amato
T(9), Dubertret C(10), Dubreucq J(11), Leignier S(11), Mallet J(10), Misdrahi
D(12), Passerieux C(13), Pignon B(4), Rey R(9), Szoke A(4), Urbach M(13),
Vidailhet P(14), Leboyer M(4), Llorca PM(8), Lançon C(2), Boyer L(2); FACE-SZ
(FondaMental Academic Centers of Expertise for Schizophrenia) group*.
Author information:
(1)Fondation FondaMental, Créteil, France; Aix-Marseille Univ, Faculté de
Médecine – Secteur Timone, EA 3279: CEReSS -Centre d’Etude et de Recherche sur
les Services de Santé et la Qualité de vie, 27 Boulevard Jean Moulin, 13005
Marseille, France. Electronic address: .
(2)Fondation FondaMental, Créteil, France; Aix-Marseille Univ, Faculté de
Médecine – Secteur Timone, EA 3279: CEReSS -Centre d’Etude et de Recherche sur
les Services de Santé et la Qualité de vie, 27 Boulevard Jean Moulin, 13005
Marseille, France.
(3)Fondation FondaMental, Créteil, France.
(4)Fondation FondaMental, Créteil, France; INSERM U955, équipe de psychiatrie
translationnelle, Créteil, France, Université Paris-Est Créteil, DHU Pe-PSY,
Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil, France.
(5)Fondation FondaMental, Créteil, France; Hôpitaux Universitaires de
Strasbourg, Université de Strasbourg, INSERM U1114, Fédération de Médecine
Translationnelle de Strasbourg, Strasbourg, France.
(6)Fondation FondaMental, Créteil, France; Service Universitaire de Psychiatrie
Adulte, Hôpital la Colombière, CHRU Montpellier, Université Montpellier 1,
Inserm 1061, Montpellier, France.
(7)Fondation FondaMental, Créteil, France; Centre Hospitalier Charles Perrens,
F-33076 Bordeaux, France, Université de Bordeaux; INRA, NutriNeuro, University
of Bordeaux, U1286 F-33076 Bordeaux, France.
(8)Fondation FondaMental, Créteil, France; CMP B, CHU, EA 7280 Faculté de
Médecine, Université d’Auvergne, BP 69 63003 Clermont-Ferrand Cedex 1, France.
(9)Fondation FondaMental, Créteil, France; INSERM U1028, CNRS UMR5292, Centre de
Recherche en Neurosciences de Lyon, Université Claude Bernard Lyon 1, Equipe
PSYR2, Centre Hospitalier Le Vinatier, Pole Est, 95 bd Pinel, BP 30039, 69678
Bron Cedex, France.
(10)Fondation FondaMental, Créteil, France; AP-HP, Department of Psychiatry,
Louis Mourier Hospital, Colombes, Inserm U894, Université Paris Diderot,
Sorbonne Paris Cité, Faculté de médecine, France.
(11)Fondation FondaMental, Créteil, France; Centre Référent de Réhabilitation
Psychosociale, CH Alpes Isère, Grenoble, France.
(12)Fondation FondaMental, Créteil, France; Centre Hospitalier Charles Perrens,
F-33076 Bordeaux, France, Université de Bordeaux; CNRS UMR 5287-INCIA, France.
(13)Fondation FondaMental, Créteil, France; Centre Hospitalier de Versailles,
Service de psychiatrie et d’addictologie adulte, Le Chesnay, EA 4047 HANDIReSP,
UFR des Sciences de la Santé Simone Veil, Université Versailles
Saint-Quentin-en-Yvelines, Versailles, France.
(14)Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, INSERM
U1114, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg,
France.
BACKGROUND: Impaired Quality of life (QoL) in schizophrenia has been mostly
associated with psychotic and mood symptomatology, insight and functioning so
far.
AIMS: QoL levels remain unsatisfactory due to other factors we aim to explore.
METHOD: We have explored sleep quality with the Pittsburgh Sleep Quality Index,
hostility with the Buss&Perry questionnaire, major depression with the Positive
and Negative Syndrome Scale depressive factor, functioning with the Global
Assessment of Functioning scale and weight gain with body mass index in addition
to other classical QoL-associated factors.
RESULTS: 559 patients (mean age=31 (SD 9) years, 74% male sex) were included in
the national FACE-SZ cohort. Impaired QoL has been significantly associated with
respectively major depression, impaired sleep quality, increased hostility,
impaired functioning and impaired insight independently of age, sex, treatments,
tobacco smoking and body mass index. Major depression was associated with
impaired psychological and physical well-being, and impaired self-esteem.
Impaired sleep quality has been associated with impaired psychological and
physical well-being and sentimental life. Hostility has been associated with
impaired psychological well-being and self-esteem, impaired friends’
relationships and impaired autonomy. Weight was associated with impaired
physical well-being. Tobacco smoking was associated with higher level of
friends’ relationships.
CONCLUSIONS: Major depression, sleep, hostility, and weight gain have been
identified as potential targets to improve QoL in schizophrenia and should be
implemented in the recommendations for good practice to optimize schizophrenia
care.
Copyright © 2020 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.jad.2020.05.003
PMID: 32663995 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of Competing Interest None.