Association between anhedonia and suicidal events in patients with mood disorders: A 3-year prospective study.
Depression and Anxiety. 2020-07-11; 38(1): 17-27
DOI: 10.1002/da.23072
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1. Depress Anxiety. 2021 Jan;38(1):17-27. doi: 10.1002/da.23072. Epub 2020 Jul
11.
Association between anhedonia and suicidal events in patients with mood
disorders: A 3-year prospective study.
Ducasse D(1)(2)(3), Dubois J(2), Jaussent I(2), Azorin JM(3)(4), Etain B(3)(5),
Gard S(3)(6), Henry C(3)(5), Bougerol T(3)(7), Kahn JP(3)(8), Aubin V(3)(9),
Bellivier F(3)(10), Belzeaux R(3)(4), Dubertret C(3)(11)(12), Dubreucq J(3)(7),
Llorca PM(13), Loftus J(3)(9), Passerieux C(3)(14), Polosan M(3)(7), Samalin
L(13), Leboyer M(3)(5), Yrondi A(3)(15), Bennabi D(3)(16), Haffen E(3)(17),
Maruani J(3)(18), Allauze E(3)(13), Camus V(19), D’Amato T(20), Doumy O(6),
Holtzmann J(7), Lançon C(21), Moliere F(1), Moirand R(20), Richieri RM(21), Horn
M(22), Schmitt L(15), Stephan F(23), Genty JB(13), Vaiva G(22), Walter M(23),
El-Hage W(19), Aouizerate B(6), Olié E(1)(2)(3), Courtet P(1)(2)(3).
Author information:
(1)CHU Montpellier, Hôpital Lapeyronie, Department of Emergency Psychiatry and
Post Acute Care, CHRU, Montpellier, France.
(2)Inserm, U1061 Montpellier, University of Montpellier, Neuropsychiatry:
Epidemiological and Clinical Research, Montpellier, France.
(3)Fondation FondaMental, Créteil, France.
(4)AP HM, Psychiatric Pole, Marseille, France.
(5)Université Paris-Est, Hopital Henri Mondor, DHU PePSY and AP-HP, Créteil,
France.
(6)Charles Perrens Hospital, Bordeaux, France.
(7)Service de Psychiatrie de l’adulte, CS 10217, Centre Expert Dépression
Résistante FondaMental, CHU de Grenoble, Hôpital Nord, Grenoble, France.
(8)Brabois Hospital, Academic Hospital of Nancy, Vandoeuvre Les Nancy, France.
(9)Department of Psychiatry, Princesse-Grace Hospital, La Colle, Monaco.
(10)Hospital Saint-Louis-Lariboisière-Fernand Widal, AP-HP, Paris, France.
(11)Department of Psychiatry, Louis Mourier Hospital, AP-HP, INSERM U894, School
of Medicine, Paris Diderot University, Sorbonne Paris Cité, France.
(12)Department of Psychiatry and Clinical Psychology, Psychotherapy Center of
Nancy and School of Medicine, Lorraine University, Lorraine, France.
(13)Service de Psychiatrie de l’adulte B, Centre Expert Dépression Résistante
FondaMental, CHU de Clermont-Ferrand, Clermont-Ferrand, France.
(14)Academic Hospital of Versailles, Le Chesnay, France.
(15)Service de Psychiatrie et de Psychologie Médicale de l’adulte, Centre Expert
Dépression Résistante FondaMental, CHRU de Toulouse, Hôpital Purpan, Toulouse,
France.
(16)Service de Psychiatrie clinique, Centre Expert Dépression Résistante
FondaMental, EA 481 Neurosciences, Université de Bourgogne Franche Comté,
Besançon, France.
(17)Service de Psychiatrie clinique, Centre Expert Dépression Résistante
FondaMental, Centre Investigation Clinique 1431-INSERM, EA 481 Neurosciences,
Université de Bourgogne Franche Comté, Besançon, France.
(18)Service de Psychiatrie adulte, Centre Expert Dépression Résistante
FondaMental, Hôpital Fernand-Widal, Paris, France.
(19)Clinique Psychiatrique Universitaire, Centre Expert Dépression Résistante
FondaMental, Inserm U1253 Imaging and Brain, CHRU de Tours, Tours, France.
(20)Service Universitaire de Psychiatrie adulte, Centre Expert Dépression
Résistante FondaMental, Centre Hospitalier Le Vinatier, Bron cedex, France.
(21)Pôle Psychiatrie, Centre Expert Dépression Résistante FondaMental, CHU La
Conception, Marseille, France.
(22)Service de Psychiatrie adulte, Centre Expert Dépression Résistante
FondaMental, CHRU de Lille, Hôpital Fontan 1, Lille, France.
(23)Service de Psychiatrie de l’adulte, Centre Expert Dépression Résistante
FondaMental, CHU de Brest, Hôpital de Bohars, Bohars, France.
BACKGROUND: As almost all mental disorders are associated with increased
suicidal-related behavior, anhedonia might be a trans-diagnostic dimension to
target for suicide prevention.
METHODS: For this 3-year-long prospective study, 2,839 outpatients with mood
disorders were recruited. They were divided in: (a) two groups according to the
occurrence or not of suicidal ideation during the follow-up, and (b) two groups
according to the occurrence or not of suicide attempts during the follow-up.
Anhedonia was assessed using a composite score (the French version of the
14-item Snaith-Hamilton Pleasure Scale and item 13 of the Quick Inventory of
Depressive Symptomatology scale) at inclusion and at 6, 12, 24, and 36 months
after inclusion.
RESULTS: Patients with mood disorders and anhedonia at least at one follow-up
visit had a 1.4-fold higher risk of suicidal ideation (adjusted odds
ratio = 1.35; 95% confidence interval [1.07, 1.70]), even after adjustment for
confounding factors of suicide risk (i.e., bipolar or unipolar disorder, sex,
age, marital status, education level, antidepressant intake, personal history of
suicide attempt, at least one childhood trauma, and mean of the maximum
depression score during the follow-up). Conversely, association between
anhedonia and suicide attempt did not remain significant after adjustment.
CONCLUSIONS: The significant association between anhedonia and suicide ideation
in patients with mood disorders stresses the need of targeting hedonia in mood
disorders, and of research focusing on the position to pleasure in life through
eudaimonia.
© 2020 Wiley Periodicals LLC.
DOI: 10.1002/da.23072
PMID: 32652874 [Indexed for MEDLINE]