Aging, sex, metabolic and life experience factors: contributions to neuro-inflammaging in Alzheimer’s disease research.
Neuroscience & Biobehavioral Reviews. 2024-07-01; 162: 105724
DOI: 10.1016/j.neubiorev.2024.105724
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Singhaarachchi PH(1), Antal P(2), Calon F(3), Culmsee C(4), Delpech JC(5), Feldotto M(6), Geertsema J(7), Hoeksema EE(7), Korosi A(7), Layé S(5), McQualter J(1), de Rooij SR(8), Rummel C(9), Slayo M(10), Sominsky L(11), Spencer SJ(12).
Author information:
(1)School of Health and Biomedical Sciences, RMIT University, Bundoora,
Melbourne, Victoria, Australia, 3083.
(2)Department of Measurement and Information Systems, Budapest University of
Technology and Economics, Hungary, 1111.
(3)Faculty of Pharmacy, Centre de Recherche du CHU de Québec-Laval University,
Quebec, Canada, G1V 0A6; International Associated Laboratory
OptiNutriBrain-NutriNeuro, Bordeaux, France, F-33000 and INAF, Quebec, Canada,
G1V 0A6.
(4)Institute of Pharmacology and Clinical Pharmacy, Philipps University of
Marburg, Marburg, Germany, D-35032; Center for Mind, Brain and Behavior-CMBB,
Giessen, D-35394, and Marburg, D-35032, Germany.
(5)International Associated Laboratory OptiNutriBrain-NutriNeuro, Bordeaux,
France, F-33000 and INAF, Quebec, Canada, G1V 0A6; Université de Bordeaux,
INRAE, Bordeaux INP, NutriNeurO, UMR 1286, Bordeaux, France, F-33000.
(6)Institute of Veterinary Physiology and Biochemistry, Justus Liebig University
Giessen, Giessen, Germany, D-35394.
(7)Center for Neuroscience, Swammerdam Institute for Life Sciences, University
of Amsterdam, Amsterdam, the Netherlands, 1018.
(8)Department of Epidemiology and Data Science, Amsterdam University Medical
Centers, University of Amsterdam, 1018.
(9)Center for Mind, Brain and Behavior-CMBB, Giessen, D-35394, and Marburg,
D-35032, Germany; Institute of Veterinary Physiology and Biochemistry, Justus
Liebig University Giessen, Giessen, Germany, D-35394.
(10)School of Health and Biomedical Sciences, RMIT University, Bundoora,
Melbourne, Victoria, Australia, 3083; Center for Mind, Brain and Behavior-CMBB,
Giessen, D-35394, and Marburg, D-35032, Germany; Institute of Veterinary
Physiology and Biochemistry, Justus Liebig University Giessen, Giessen, Germany,
D-35394.
(11)Barwon Health, Geelong, Victoria, Australia, 3220; IMPACT – the Institute
for Mental and Physical Health and Clinical Translation, School of Medicine,
Deakin University, Geelong, Victoria, Australia, 3217.
(12)School of Health and Biomedical Sciences, RMIT University, Bundoora,
Melbourne, Victoria, Australia, 3083. Electronic address:
.
Alzheimer’s disease (AD) is prevalent around the world, yet our understanding of
the disease is still very limited. Recent work suggests that the cornerstone of
AD may include the inflammation that accompanies it. Failure of a normal
pro-inflammatory immune response to resolve may lead to persistent central
inflammation that contributes to unsuccessful clearance of amyloid-beta plaques
as they form, neuronal death, and ultimately cognitive decline. Individual
metabolic, and dietary (lipid) profiles can differentially regulate this
inflammatory process with aging, obesity, poor diet, early life stress and other
inflammatory factors contributing to a greater risk of developing AD. Here, we
integrate evidence for the interface between these factors, and how they
contribute to a pro-inflammatory brain milieu. In particular, we discuss the
importance of appropriate polyunsaturated fatty acids (PUFA) in the diet for the
metabolism of specialised pro-resolving mediators (SPMs); raising the
possibility for dietary strategies to improve AD outlook.
Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.neubiorev.2024.105724
PMID: 38762130