11Beta-Hydroxysteroid Dehydrogenase Messenger Ribonucleic Acid Expression, Bioactivity and Immunoreactivity in Rat Cerebellum.
J Neuroendocrinol. 1990-12-01; 2(6): 853-858
DOI: 10.1111/j.1365-2826.1990.tb00651.x
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1. J Neuroendocrinol. 1990 Dec 1;2(6):853-8. doi:
10.1111/j.1365-2826.1990.tb00651.x.
11Beta-Hydroxysteroid Dehydrogenase Messenger Ribonucleic Acid Expression,
Bioactivity and Immunoreactivity in Rat Cerebellum.
Moisan MP(1), Seckl JR, Brett LP, Monder C, Agarwal AK, White PC, Edwards CR.
Author information:
(1)Department of Medicine, Western General Hospital, Edinburgh EH4 2XU, UK.
Abstract 11beta-Hydroxysteroid dehydrogenase (11beta-OHSD) metabolizes
corticosterone to inactive 11-dehydrocorticosterone and thus protects
non-specific mineralocorticoid receptors from exposure to corticosterone in the
kidney in vivo. Clearly, 11beta-OHSD might also regulate corticosterone access to
glucocorticoid receptors. We have investigated cerebellum, a tissue with high
glucocorticoid receptor, but very low mineralocorticoid receptor levels and have
shown marked 11beta-OHSD bioactivity with similar co-substrate requirements and
inhibition kinetics to the renal enzyme. 11beta-OHSD messenger ribonucleic acid
was expressed in cerebellum and was localized in Purkinje and granule cells. This
distribution was confirmed immunohistochemically. Thus, we provide evidence for
11beta-OHSD in cerebellum and suggest that it may regulate the access of
corticosterone to glucocorticoid receptors in addition to mineralocorticoid
receptors.
DOI: 10.1111/j.1365-2826.1990.tb00651.x
PMID: 19215429