Xavier Fioramonti

Scientific articles

• Blockage of ATGL-mediated breakdown of lipid droplets in microglia alleviates neuroinflammatory and behavioural responses to lipopolysaccharides.
  Josephine Louise Robb, Frédérick Boisjoly, Arturo Israel Machuca-Parra, Adeline Coursan, Romane Manceau, Danie Majeur, Demetra Rodaros, Khalil Bouyakdan, Karine Greffard, Jean-François Bilodeau, Anik Forest, Caroline Daneault, Matthieu Ruiz, Cyril Laurent, Nathalie Arbour, Sophie Layé, Xavier Fioramonti, Charlotte Madore, Stephanie Fulton, Thierry Alquier.
  Brain, Behavior, and Immunity. 2025-01-01. 123 : 315-333.
  10.1016/j.bbi.2024.09.027
• A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion
  Mireia Montaner, Jessica Denom, Vincent Simon, Wanqing Jiang, Marie K. Holt, Daniel I. Brierley, Claude Rouch, Ewout Foppen, Nadim Kassis, David Jarriault, Dawood Khan, Louise Eygret, Francois Mifsud, David J. Hodson, Johannes Broichhagen, Lukas Van Oudenhove, Xavier Fioramonti, Victor Gault, Daniela Cota, Frank Reimann, Fiona M. Gribble, Stephanie Migrenne-Li, Stefan Trapp, Hirac Gurden, Christophe Magnan.
  Nat Commun. 2024-08-13. 15(1)
  10.1038/s41467-024-51076-4
• Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity
  Stéphane Leon, Vincent Simon, Thomas H. Lee, Lukas Steuernagel, Samantha Clark, Nasim Biglari, Thierry Lesté-Lasserre, Nathalie Dupuy, Astrid Cannich, Luigi Bellocchio, Philippe Zizzari, Camille Allard, Delphine Gonzales, Yves Le Feuvre, Emeline Lhuillier, Alexandre Brochard, Jean Charles Nicolas, Jérémie Teillon, Macha Nikolski, Giovanni Marsicano, Xavier Fioramonti, Jens C. Brüning, Daniela Cota, Carmelo Quarta.
  Nat Commun. 2024-04-24. 15(1)
  10.1038/s41467-024-47877-2
• Serotonergic neurons are involved in the counter-regulatory response to hypoglycemia.
  Hugo Martin, Adeline Coursan, Justine Lallement, Mathieu Di Miceli, Janany Kandiah, Ilyès Raho, Jasmine Buttler, Jean‐Philippe Guilloux, Philippe De Deurwaerdere, Sophie Layé, Vanessa H. Routh, Bruno P. Guiard, Christophe Magnan, Céline Cruciani‐Guglielmacci, Xavier Fioramonti.
  J Neuroendocrinology. 2023-10-19.
  10.1111/jne.13344
• Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11β-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency
  Julie Brossaud, Clémentine Bosch-Bouju, Nathalie Marissal-Arvy, Marie-Neige Campas-Lebecque, Jean-Christophe Helbling, Scott P. Webster, Brian R. Walker, Xavier Fioramonti, Guillaume Ferreira, Pascal Barat, Jean-Benoît Corcuff, Marie-Pierre Moisan.
  Diabetologia. 2023-06-10.
  10.1007/s00125-023-05942-3
• Insulin modulates emotional behavior through a serotonin-dependent mechanism
  Hugo Martin, Sébastien Bullich, Maud Martinat, Mathilde Chataigner, Mathieu Di Miceli, Vincent Simon, Samantha Clark, Jasmine Butler, Mareike Schell, Simran Chopra, Francis Chaouloff, Andre Kleinridders, Daniela Cota, Philippe De Deurwaerdere, Luc Pénicaud, Sophie Layé, Bruno P. Guiard, Xavier Fioramonti.
  Mol Psychiatry. 2022-10-07.
  10.1038/S41380-022-01812-3
• Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain
  Franck Aby, Louis-Etienne Lorenzo, Zoé Grivet, Rabia Bouali-Benazzouz, Hugo Martin, Stéphane Valerio, Sara Whitestone, Dominique Isabel, Walid Idi, Otmane Bouchatta, Philippe De Deurwaerdere, Antoine G. Godin, Cyril Herry, Xavier Fioramonti, Marc Landry, Yves De Koninck, Pascal Fossat.
  Sci. Adv.. 2022-07-29. 8(30)
  10.1126/sciadv.abo0689
• Dietary Long-Chain n-3 Polyunsaturated Fatty Acid Supplementation Alters Electrophysiological Properties in the Nucleus Accumbens and Emotional Behavior in Naïve and Chronically Stressed Mice
  Mathieu Di Miceli, Maud Martinat, Moïra Rossitto, Agnès Aubert, Shoug Alashmali, Clémentine Bosch-Bouju, Xavier Fioramonti, Corinne Joffre, Richard P. Bazinet, Sophie Layé.
  IJMS. 2022-06-14. 23(12) : 6650.
  10.3390/ijms23126650
• Functional heterogeneity of POMC neurons relies on mTORC1 signaling
  Nicolas Saucisse, Wilfrid Mazier, Vincent Simon, Elke Binder, Caterina Catania, Luigi Bellocchio, Roman A. Romanov, Stéphane Léon, Isabelle Matias, Philippe Zizzari, Carmelo Quarta, Astrid Cannich, Kana Meece, Delphine Gonzales, Samantha Clark, Julia M. Becker, Giles S.H. Yeo, Xavier Fioramonti, Florian T. Merkle, Sharon L. Wardlaw, Tibor Harkany, Federico Massa, Giovanni Marsicano, Daniela Cota.
  Cell Reports. 2021-10-01. 37(2) : 109800.
  10.1016/j.celrep.2021.109800
• Tetracosahexaenoylethanolamide, a novel n-acylethanolamide, is elevated in ischemia and increases neuronal output
  Lin Lin, Adam H Metherel, Mathieu Di Miceli, Zhen Liu, Cigdem Sahin, Xavier Fioramonti, Carolyn L. Cummins, Sophie Layé, Richard P. Bazinet.
  J. Lipid Res.. 2020-08-21. : jlr.RA120001024.
  10.1194/jlr.ra120001024
• In silico Hierarchical Clustering of Neuronal Populations in the Rat Ventral Tegmental Area Based on Extracellular Electrophysiological Properties
  Mathieu Di Miceli, Zoé Husson, Philippe Ruel, Sophie Layé, Daniela Cota, Xavier Fioramonti, Clémentine Bosch-Bouju, Benjamin Gronier.
  Front. Neural Circuits. 2020-08-13. 14
  10.3389/fncir.2020.00051
• Causal Link between n-3 Polyunsaturated Fatty Acid Deficiency and Motivation Deficits.
  Fabien Ducrocq, Roman Walle, Andrea Contini, Asma Oummadi, Baptiste Caraballo, Suzanne van der Veldt, Marie-Lou Boyer, Frank Aby, Tarson Tolentino-Cortez, Jean-Christophe Helbling, Lucy Martine, Stéphane Grégoire, Stéphanie Cabaret, Sylvie Vancassel, Sophie Layé, Jing Xuan Kang, Xavier Fioramonti, Olivier Berdeaux, Gabriel Barreda-Gómez, Elodie Masson, Guillaume Ferreira, David W.L. Ma, Clementine Bosch-Bouju, Véronique De Smedt-Peyrusse, Pierre Trifilieff.
  Cell Metabolism. 2020-04-01. 31(4) : 755-772.e7.
  10.1016/j.cmet.2020.02.012
• Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons
  Chloé Berland, Enrica Montalban, Elodie Perrin, Mathieu Di Miceli, Yuko Nakamura, Maud Martinat, Mary Sullivan, Xue S. Davis, Mohammad Ali Shenasa, Claire Martin, Stefania Tolu, Fabio Marti, Stephanie Caille, Julien Castel, Sylvie Perez, Casper Gravesen Salinas, Chloé Morel, Jacob Hecksher-Sørensen, Martine Cador, Xavier Fioramonti, Matthias H. Tschöp, Sophie Layé, Laurent Venance, Philippe Faure, Thomas S. Hnasko, Dana M. Small, Giuseppe Gangarossa, Serge H. Luquet.
  Cell Metabolism. 2020-03-01.
  10.1016/j.cmet.2020.02.010
• POMC Neurons Dysfunction in Diet-induced Metabolic Disease: Hallmark or Mechanism of Disease?
  Carmelo Quarta, Xavier Fioramonti, Daniela Cota.
  Neuroscience. 2019-11-01.
  10.1016/j.neuroscience.2019.09.031
• Metformin promotes anxiolytic and antidepressant-like responses in insulin-resistant mice by decreasing circulating branched-chain amino acids
  Juliane Zemdegs, Hugo Martin, Hiranya Pintana, Sebastien Bullich, Stella Manta, Marie A. Marqués, Cédric Moro, Sophie Layé, Fabien Ducrocq, Nipon Chattipakorn, Siriporn C. Chattipakorn, Claire Rampon, Luc Pénicaud, Xavier Fioramonti, Bruno P. Guiard.
  J. Neurosci.. 2019-06-03. 39(30) : 5935-5948.
  10.1523/jneurosci.2904-18.2019
• The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system
  Khalil Bouyakdan, Hugo Martin, Fabienne Liénard, Lionel Budry, Bouchra Taib, Demetra Rodaros, Chloé Chrétien, Éric Biron, Zoé Husson, Daniela Cota, Luc Pénicaud, Stephanie Fulton, Xavier Fioramonti, and Thierry Alquier.
  J Clin Invest. 2019-04-02.
  10.1172/JCI123454
• Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing.
  Lucie Desmoulins, Chloé Chrétien, Romain Paccoud, Stephan Collins, Céline Cruciani-Guglielmacci, Anne Galinier, Fabienne Liénard, Aurore Quinault, Sylvie Grall, Camille Allard, Claire Fenech, Lionel Carneiro, Thomas Mouillot, Audren Fournel, Claude Knauf, Christophe Magnan, Xavier Fioramonti, Luc Pénicaud, Corinne Leloup.
  Molecular Metabolism. 2019-02-01. 20 : 166-177.
  10.1016/j.molmet.2018.11.007
• Glucose and hypothalamic astrocytes: More than a fueling role?
  C. Leloup, C. Allard, L. Carneiro, X. Fioramonti, S. Collins, L. Pénicaud.
  Neuroscience. 2016-05-01. 323 : 110-120.
  10.1016/j.neuroscience.2015.06.007
• Hypothalamic astroglial connexins are required for brain glucose sensing-induced insulin secretion.
  Camille Allard, Lionel Carneiro, Sylvie Grall, Brandon H Cline, Xavier Fioramonti, Chloé Chrétien, Fawzia Baba-Aissa, Christian Giaume, Luc Pénicaud, Corinne Leloup.
  J Cereb Blood Flow Metab. 2013-12-04. 34(2) : 339-346.
  10.1038/jcbfm.2013.206
• Importance of mitochondrial dynamin-related protein 1 in hypothalamic glucose sensitivity in rats.
  Lionel Carneiro, Camille Allard, Christophe Guissard, Xavier Fioramonti, Cécile Tourrel-Cuzin, Danielle Bailbé, Corinne Barreau, Géraldine Offer, Emmanuelle Nédelec, Bénédicte Salin, Michel Rigoulet, Pascale Belenguer, Luc Pénicaud, Corinne Leloup.
  Antioxidants & Redox Signaling. 2012-08-01. 17(3) : 433-444.
  10.1089/ars.2011.4254
• A new ATP-sensitive K⁺ channel-independent mechanism is involved in glucose-excited neurons of mouse arcuate nucleus
  X. Fioramonti, A. Lorsignol, A. Taupignon, L. Penicaud.
  Diabetes. 2004-10-25. 53(11) : 2767-2775.
  10.2337/diabetes.53.11.2767