![#](https://www.bordeaux-neurocampus.fr/wp-content/uploads/2018/07/Ahmed-Serge-Portrait-30.jpg)
Serge Ahmed
Team leader
Researcher - PhD (DR) / CNRS/ Contact
+33 5 33 51 48 05
www.orcid.org/0000-0002-1225-9234
![](https://www.bordeaux-neurocampus.fr/wp-content/uploads/2018/07/Ahmed-Serge-Portrait-30.jpg)
Scientific articles
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The multiple faces of footshock punishment in animal research on addiction
Neurobiology of Learning and Memory. 2024-06-01. : 107955.
10.1016/j.nlm.2024.107955 -
Bidirectional relationship between attentional deficits and escalation of nicotine intake in male rats
Psychopharmacology. 2024-05-14.
10.1007/s00213-024-06604-x -
Knowledge by omission: the significance of omissions in the 5-choice serial reaction time task
Psychopharmacology. 2024-03-06.
10.1007/s00213-024-06564-2 -
The importance of choice and agency in animal models of addiction
J Neural Transm. 2023-10-31.
10.1007/s00702-023-02712-8 -
Large‐scale brain correlates of sweet versus cocaine reward in rats
Eur J of Neuroscience. 2022-12-01.
10.1111/ejn.15879 -
Cocaine falls into oblivion during volitional initiation of choice trials
Addiction Biology. 2022-10-04. 27(6)
10.1111/adb.13235 -
Altered neuronal activity in the ventromedial prefrontal cortex drives nicotine intake escalation
Neuropsychopharmacol.. 2022-08-30.
10.1038/s41386-022-01428-9 -
Large-scale brain correlates of sweet versus cocaine reward in rats
Preprint bioRxiv. 2022-06-02.
10.1101/2022.06.01.494287 -
Inhibition of striatal SEZ6 by miR-3594-5p is a drug-specific marker for late-stage heroin intake escalation
. 2021-07-26.
10.1101/2021.07.26.453355 -
Probing the decision-making mechanisms underlying choice between drug and nondrug rewards in rats
eLife. 2021-04-26. 10
10.7554/eLife.64993 -
Habit, choice and addiction
Neuropsychopharmacol.. 2020-11-09.
10.1038/s41386-020-00899-y -
Loss of resistance to punishment of cocaine use after prior experience
Preprint bioRxiv. 2020-07-26.
10.1101/2020.07.24.219170 -
Animal Models of the Behavioral Symptoms of Substance Use Disorders
Cold Spring Harb Perspect Med. 2020-06-08. : a040287.
10.1101/cshperspect.a040287 -
Reorganization of Theta Phase-Locking in the Orbitofrontal Cortex Drives Cocaine Choice Under the Influence
Sci Rep. 2020-05-15. 10(1) : 8041.
10.1038/s41598-020-64962-w -
Habitual Preference for the Nondrug Reward in a Drug Choice Setting
Front. Behav. Neurosci.. 2020-05-25. 14
10.3389/fnbeh.2020.00078 -
Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction
Neuropsychopharmacology. 2021-01. 46 : 288-296.
10.1038/s41386-020-0786-9 -
Sugar intake and craving during alcohol withdrawal in alcohol use disorder inpatients
Addiction Biology. 2020-04-19.
10.1111/adb.12907 -
Relapse to cocaine use persists following extinction of drug-primed craving
Neuropharmacology. 2019-06-01.
10.1016/j.neuropharm.2019.05.036 -
A neuronal population code for resemblance between drug and nondrug reward outcomes in the orbitofrontal cortex
Brain Struct Funct. 2018-12-11.
10.1007/s00429-018-1809-8 -
Trying to make sense of rodents’ drug choice behavior
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2018-12-01. 87 : 3-10.
10.1016/j.pnpbp.2017.09.027 -
A transdiagnostic dimensional approach towards a neuropsychological assessment for addiction: an international Delphi consensus study
Addiction. 2018-10-05.
10.1111/add.14424 -
Individual decision-making in the causal pathway to addiction: contributions and limitations of rodent models.
Pharmacology Biochemistry and Behavior. 2018-01-01. 164 : 22-31.
10.1016/j.pbb.2017.07.005 -
Misdeed of the need: towards computational accounts of transition to addiction.
Current Opinion in Neurobiology. 2017-10-01. 46 : 142-153.
10.1016/j.conb.2017.08.014 -
Incubation of Accumbal Neuronal Reactivity to Cocaine Cues During Abstinence Predicts Individual Vulnerability to Relapse.
Neuropsychopharmacology. 2017-09-18. 43(5) : 1059-1065.
10.1038/npp.2017.224 -
Neuronal representation of individual heroin choices in the orbitofrontal cortex
Addiction Biology. 2017-07-13. 23(3) : 880-888.
10.1111/adb.12536 -
Preference for Cocaine is Represented in the Orbitofrontal Cortex by an Increased Proportion of Cocaine Use-Coding Neurons.
Cereb. Cortex. 2017-01-04.
10.1093/cercor/bhw398 -
Cocaine addiction as a homeostatic reinforcement learning disorder.
Psychological Review. 2017-01-01. 124(2) : 130-153.
10.1037/rev0000046 -
Erratum to: Review of the nutritional benefits and risks related to intense sweeteners.
Arch Public Health. 2015-10-23. 73(1)
10.1186/s13690-015-0102-z -
Review of the nutritional benefits and risks related to intense sweeteners.
Arch Public Health. 2015-10-01. 73(1)
10.1186/s13690-015-0092-x -
Rats quit nicotine for a sweet reward following an extensive history of nicotine use.
Addiction Biology. 2015-09-16. 22(1) : 142-151.
10.1111/adb.12306 -
Choosing under the influence: A drug-specific mechanism by which the setting controls drug choices in rats
Neuropsychopharmacol. 2015-07-01. 41(2) : 646-657.
10.1038/npp.2015.195 -
Alternative models of addiction.
Front. Psychiatry. 2015-02-13. 6
10.3389/fpsyt.2015.00020 -
Escalation of cocaine intake and incubation of cocaine seeking are correlated with dissociable neuronal processes in different accumbens subregions.
Biological Psychiatry. 2014-07-01. 76(1) : 31-39.
10.1016/j.biopsych.2013.08.032 -
Coordinated Recruitment of Cortical-Subcortical Circuits and Ascending Dopamine and Serotonin Neurons During Inhibitory Control of Cocaine Seeking in Rats.
Cereb. Cortex. 2014-05-28. 25(9) : 3167-3181.
10.1093/cercor/bhu112 -
A redescription of data does not count as a general theory.
Psychopharmacology. 2014-05-27. 231(19) : 3909-3910.
10.1007/s00213-014-3622-2 -
Drug versus sweet reward: greater attraction to and preference for sweet versus drug cues.
Addiction Biology. 2014-03-07. 20(3) : 433-444.
10.1111/adb.12134 -
Neurobiology of addiction versus drug use driven by lack of choice.
Current Opinion in Neurobiology. 2013-08-01. 23(4) : 581-587.
10.1016/j.conb.2013.01.028 -
Sugar addiction: pushing the drug-sugar analogy to the limit.
Current Opinion in Clinical Nutrition and Metabolic Care. 2013-07-01. 16(4) : 434-439.
10.1097/mco.0b013e328361c8b8 -
A choice-based screening method for compulsive drug users in rats.
Current Protocols in Neuroscience. 2013-07-01. 64(1) : 9.44.1-9.44.17.
10.1002/0471142301.ns0944s64 -
Levodopa gains psychostimulant-like properties after nigral dopaminergic loss.
Ann Neurol.. 2013-07-01. 74(1) : 140-144.
10.1002/ana.23881 -
Discriminative inhibitory control of cocaine seeking involves the prelimbic prefrontal cortex.
Biological Psychiatry. 2013-02-01. 73(3) : 271-279.
10.1016/j.biopsych.2012.08.011 -
Extended heroin access increases heroin choices over a potent nondrug alternative
Neuropsychopharmacol. 2013-01-15. 38(7) : 1209-1220.
10.1038/npp.2013.17 -
Reinforcing properties of Pramipexole in normal and parkinsonian rats.
Neurobiology of Disease. 2013-01-01. 49 : 79-86.
10.1016/j.nbd.2012.08.005 -
Animal studies of addictive behavior.
Cold Spring Harbor Perspectives in Medicine. 2012-12-18. 3(4) : a011932-a011932.
10.1101/cshperspect.a011932 -
The science of making drug-addicted animals.
Neuroscience. 2012-06-01. 211 : 107-125.
10.1016/j.neuroscience.2011.08.014 -
Sugars, addiction and obesity
Obes. 2012-02-03. 7(1) : 3-9.
10.1007/s11690-012-0307-z -
Toward an evolutionary basis for resilience to drug addiction.
Behav Brain Sci. 2011-11-10. 34(06) : 310-311.
10.1017/s0140525x11000677 -
Drug specificity in extended access cocaine and heroin self-administration.
Addiction Biology. 2011-10-13. 17(6) : 964-976.
10.1111/j.1369-1600.2011.00385.x -
Diazepam promotes choice of abstinence in cocaine self-administering rats.
Addiction Biology. 2011-09-28. 17(2) : 378-391.
10.1111/j.1369-1600.2011.00368.x -
Preclinical validation of a novel cocaine exposure therapy for relapse prevention.
Biological Psychiatry. 2011-09-01. 70(6) : 593-598.
10.1016/j.biopsych.2011.03.036 -
Cracking the molecular code of cocaine addiction.
ILAR Journal. 2011-01-01. 52(3) : 309-320.
10.1093/ilar.52.3.309 -
Validation crisis in animal models of drug addiction: beyond non-disordered drug use toward drug addiction.
Neuroscience & Biobehavioral Reviews. 2010-11-01. 35(2) : 172-184.
10.1016/j.neubiorev.2010.04.005 -
Cocaine is low on the value ladder of rats: Possible evidence for resilience to addiction
PLoS ONE. 2010-07-28. 5(7) : e11592.
10.1371/journal.pone.0011592 -
Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats.
PLoS ONE. 2010-02-19. 5(2) : e9296.
10.1371/journal.pone.0009296 -
Risk-prone individuals prefer the wrong options on a rat version of the Iowa Gambling Task.
Biological Psychiatry. 2009-10-01. 66(8) : 743-749.
10.1016/j.biopsych.2009.04.008 -
Computational approaches to the neurobiology of drug addiction.
Pharmacopsychiatry. 2009-05-01. 42(S 01) : S144-S152.
10.1055/s-0029-1216345 -
Supply of a nondrug substitute reduces escalated heroin consumption.
Neuropsychopharmacol. 2007-10-31. 33(9) : 2272-2282.
10.1038/sj.npp.1301602 -
The simulation of addiction: pharmacological and neurocomputational models of drug self-administration.
Drug and Alcohol Dependence. 2007-10-01. 90(2-3) : 304-311.
10.1016/j.drugalcdep.2007.01.008 -
Intense sweetness surpasses cocaine reward
PLoS ONE. 2007-08-01. 2(8) : e698.
10.1371/journal.pone.0000698 -
A critical transition in cocaine self-administration: behavioral and neurobiological implications.
Psychopharmacology. 2007-02-21. 192(3) : 337-346.
10.1007/s00213-007-0724-0 -
Explaining the escalation of drug use in substance dependence: models and appropriate animal laboratory tests.
Pharmacology. 2007-01-01. 80(2-3) : 65-119.
10.1159/000103923 -
Heroin-induced reinstatement is specific to compulsive heroin use and dissociable from heroin reward and sensitization.
Neuropsychopharmacol. 2006-04-26. 32(3) : 616-624.
10.1038/sj.npp.1301083 -
Imbalance between drug and non-drug reward availability: a major risk factor for addiction.
European Journal of Pharmacology. 2005-12-01. 526(1-3) : 9-20.
10.1016/j.ejphar.2005.09.036 -
Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction.
Proceedings of the National Academy of Sciences. 2005-08-02. 102(32) : 11533-11538.
10.1073/pnas.0504438102 -
Dissociation of psychomotor sensitization from compulsive cocaine consumption.
Neuropsychopharmacol. 2005-07-20. 31(3) : 563-571.
10.1038/sj.npp.1300834 -
Mesolimbic dopamine drives the diurnal variation in opiate-induced feeding.
Pharmacology Biochemistry and Behavior. 2005-07-01. 81(3) : 569-574.
10.1016/j.pbb.2005.04.009 -
Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function.
Psychopharmacology. 2005-02-25. 180(3) : 473-490.
10.1007/s00213-005-2180-z -
Neuroscience. Addiction as compulsive reward prediction.
Science. 2004-12-10. 306(5703) : 1901-1902.
10.1126/science.1107071 -
Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens.
Journal of Pharmacology and Experimental Therapeutics. 2004-05-26. 311(1) : 265-273.
10.1124/jpet.104.067504 -
A non-invasive gating device for continuous drug delivery that allows control over the timing and duration of spontaneous opiate withdrawal.
Journal of Neuroscience Methods. 2004-05-01. 135(1-2) : 129-135.
10.1016/j.jneumeth.2003.12.008 -
Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake.
Psychopharmacology. 2004-04-01. 172(4) : 450-454.
10.1007/s00213-003-1682-9 -
Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels.
Journal of Neurochemistry. 2004-02-04. 86(1) : 102-113.
10.1046/j.1471-4159.2003.01833.x -
Neurobiological mechanisms in the transition from drug use to drug dependence.
Neuroscience & Biobehavioral Reviews. 2004-01-01. 27(8) : 739-749.
10.1016/j.neubiorev.2003.11.007 -
The transition from controlled to compulsive drug use is associated with a loss of sensitization.
Brain Research. 2004-01-01. 995(1) : 46-54.
10.1016/j.brainres.2003.09.053 -
Conditioning and opiate withdrawal.
Nature. 2000-06-01. 405(6790) : 1013-1014.
10.1038/35016630 -
Persistent increase in the motivation to take heroin in rats with a history of drug escalation.
Neuropsychopharmacology. 2000-04-01. 22(4) : 413-421.
10.1016/s0893-133x(99)00133-5 -
Microinjections of an opiate receptor antagonist into the bed nucleus of the stria terminalis suppress heroin self-administration in dependent rats.
Brain Research. 2000-01-01. 854(1-2) : 85-92.
10.1016/s0006-8993(99)02288-x -
Long-lasting increase in the set point for cocaine self-administration after escalation in rats.
Psychopharmacology. 1999-10-04. 146(3) : 303-312.
10.1007/s002130051121 -
Transition from moderate to excessive drug intake: change in hedonic set point.
Science. 1998-10-09. 282(5387) : 298-300.
10.1126/science.282.5387.298 -
Corticotropin-releasing factor receptor blockade enhances conditioned aversive properties of cocaine in rats.
Psychopharmacology. 1998-03-23. 136(3) : 247-255.
10.1007/s002130050563 -
Amphetamine-induced conditioned activity is insensitive to perturbations known to affect pavlovian conditioned responses in rats.
Behavioral Neuroscience. 1998-01-01. 112(5) : 1167-1176.
10.1037//0735-7044.112.5.1167 -
Cocaine- but not food-seeking behavior is reinstated by stress after extinction.
Psychopharmacology. 1997-08-05. 132(3) : 289-295.
10.1007/s002130050347 -
Amphetamine-induced conditioned activity does not result from a failure of rats to habituate to novelty.
Psychopharmacology. 1996-02-01. 123(4) : 325-332.
10.1007/bf02246642 -
Amphetamine-induced conditioned activity in rats: comparison with novelty-induced activity and role of the basolateral amygdala.
Behavioral Neuroscience. 1995-01-01. 109(4) : 723-733.
10.1037//0735-7044.109.4.723 -
Social deprivation enhances the vulnerability of male Wistar rats to stressor- and amphetamine-induced behavioral sensitization.
Psychopharmacology. 1995-01-01. 117(1) : 116-124.
10.1007/bf02245106 -
Corticotropin-releasing factor induces a place aversion independent of its neuroendocrine role.
Brain Research. 1992-12-01. 597(2) : 304-309.
10.1016/0006-8993(92)91487-y