Sandra Dovero

Scientific articles

• Nigral ATP13A2 depletion induces Parkinson’s disease-related neurodegeneration in a pilot study in non-human primates
  Joanna Sikora, Sandra Dovero, Rémi Kinet, Marie-Laure Arotcarena, Sylvain Bohic, Erwan Bezard, Pierre-Olivier Fernagut, Benjamin Dehay.
  npj Parkinsons Dis.. 2024-08-01. 10(1)
  10.1038/s41531-024-00757-4
• Reconsidering α-Synuclein inclusion pathology in neurons, mice, and humans with an antibody sensing NAC engagement during α-Synuclein amyloid conversion
  Francesca De Giorgi, Ænora Letourneur, Marianna Kashyrina, Federica Zinghirino, Sandra Dovero, Nathalie Dutheil, Leslie-Ann Largitte, Marie-Laure Arotçarena, Erwan Bezard, Marie-Hélène Canron, Wassilios Meissner, Francesco De Nuccio, Dario Domenico Lofrumento, Florent Laferrière, François Ichas.
  Preprint - Research Square. 2024-02-07.
  10.21203/rs.3.rs-3921168/v1
• Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain
  Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Morgane Darricau, Gregory Porras, Marie-Laure Thiolat, Inés Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, María Trinidad Herrero, Miquel Vila, José A. Obeso, Erwan Bezard, Benjamin Dehay.
  npj Parkinsons Dis.. 2023-09-19. 9(1)
  10.1038/s41531-023-00579-w
• Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates
  Fayard Audrey, Fenyi Alexis, Lavisse Sonia, Dovero Sandra, Bousset Luc, Tracy Bellande, Lecourtois Sophie, Jouy Christophe, Guillermier Martine, Jan Caroline, Gipchtein Pauline, Dehay Benjamin, Bezard Erwan, Melki Ronald, Hantraye Philippe, Aron Badin Romina.
  Neurobiology of Disease. 2023-03-01. : 106086.
  10.1016/j.nbd.2023.106086
• Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology
  Margaux Teil, Sandra Dovero, Mathieu Bourdenx, Marie-Laure Arotcarena, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Ines Trigo-Damas, Celine Perier, Cristina Estrada, Nuria Garcia-Carrillo, Michele Morari, Wassilios G Meissner, María Trinidad Herrero, Miquel Vila, Jose A Obeso, Erwan Bezard, Benjamin Dehay.
  Brain. 2022-03-14. 145(3) : 1001-1017.
  10.1093/brain/awab374
• In vivo susceptibility to energy failure parkinsonism and LRRK2 kinase activity
  Salvatore Novello, Daniela Mercatelli, Federica Albanese, Chiara Domenicale, Alberto Brugnoli, Elisabetta D'Aversa, Silvia Vantaggiato, Sandra Dovero, Valentina Murtaj, Luca Presotto, Monica Borgatti, Derya R. Shimshek, Erwan Bezard, Rosa Maria Moresco, Sara Belloli, Michele Morari.
  Neurobiology of Disease. 2022-01-01. 162 : 105579.
  10.1016/j.nbd.2021.105579
• Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus Macaques
  Marie-Laure Arotcarena, Sandra Dovero, Nathalie Biendon, Nathalie Dutheil, Vincent Planche, Erwan Bezard, Benjamin Dehay.
  Front. Bioeng. Biotechnol.. 2021-11-15. 9
  10.3389/fbioe.2021.762209
• Comparison of the expression and toxicity of AAV2/9 carrying the human A53T α-synuclein gene in presence or absence of WPRE
  Xiuping Sun, Xuan Yu, Ling Zhang, Wenjie Zhao, Manshi Wang, Yu Zhang, Xianglei Li, Ran Gao, Ludivine S. Breger, Sandra Dovero, Gregory Porras, Pierre-Olivier Fernagut, Benjamin Dehay, Erwan Bezard, Chuan Qin.
  Heliyon. 2021-02-01. 7(2) : e06302.
  10.1016/j.heliyon.2021.e06302
• Evaluation of blood flow as a route for propagation in experimental synucleinopathy
  Xuan Yu, Marine Persillet, Ling Zhang, Yu Zhang, Sun Xiuping, Xianglei Li, Gao Ran, Ludivine S. Breger, Sandra Dovero, Gregory Porras, Benjamin Dehay, Erwan Bezard, Chuan Qin.
  Neurobiology of Disease. 2021-01-01. : 105255.
  10.1016/j.nbd.2021.105255
• Acute Striato-Cortical Synchronization Induces Focal Motor Seizures in Primates
  Jerome Aupy, Bastien Ribot, Sandra Dovero, Nathalie Biendon, Tho-Hai Nguyen, Gregory Porras, Marc Deffains, Dominique Guehl, Pierre Burbaud.
  Cerebral Cortex. 2020-08-08.
  10.1093/cercor/bhaa212
• Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates
  Marie-Laure Arotcarena, Sandra Dovero, Alice Prigent, Mathieu Bourdenx, Sandrine Camus, Gregory Porras, Marie-Laure Thiolat, Maddalena Tasselli, Philippe Aubert, Niels Kruse, Brit Mollenhauer, Ines Trigo Damas, Cristina Estrada, Nuria Garcia-Carrillo, Nishant N Vaikath, Omar M A El-Agnaf, Maria Trinidad Herrero, Miquel Vila, Jose A Obeso, Pascal Derkinderen, Benjamin Dehay, Erwan Bezard.
  Brain. 2020-05-01. 143(5) : 1462-1475.
  10.1093/brain/awaa096
• Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates
  M. Bourdenx, A. Nioche, S. Dovero, M.-L. Arotcarena, S. Camus, G. Porras, M.-L. Thiolat, N. P. Rougier, A. Prigent, P. Aubert, S. Bohic, C. Sandt, F. Laferrière, E. Doudnikoff, N. Kruse, B. Mollenhauer, S. Novello, M. Morari, T. Leste-Lasserre, I. Trigo Damas, M. Goillandeau, C. Perier, C. Estrada, N. Garcia-Carrillo, A. Recasens, N. N. Vaikath, O. M. A. El-Agnaf, M. T. Herrero, P. Derkinderen, M. Vila, J. A. Obeso, B. Dehay, E. Bezard.
  Sci. Adv.. 2020-05-01. 6(20) : eaaz9165.
  10.1126/sciadv.aaz9165
• Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates
  M. Bourdenx, A. Nioche, S. Dovero, M.-L. Arotcarena, S. Camus, G. Porras, M.-L. Thiolat, N. P. Rougier, A. Prigent, P. Aubert, S. Bohic, C. Sandt, F. Laferrière, E. Doudnikoff, N. Kruse, B. Mollenhauer, S. Novello, M. Morari, T. Leste-Lasserre, I. Trigo Damas, M. Goillandeau, C. Perier, C. Estrada, N. Garcia-Carrillo, A. Recasens, N. N. Vaikath, O. M. A. El-Agnaf, M. Trinidad Herrero, P. Derkinderen, M. Vila, J. A. Obeso, B. Dehay, E. Bezard.
  . 2019-10-31.
  10.1101/825216
• Transcription factor EB overexpression prevents neurodegeneration in experimental synucleinopathies
  Marie-Laure Arotcarena, Mathieu Bourdenx, Nathalie Dutheil, Marie-Laure Thiolat, Evelyne Doudnikoff, Sandra Dovero, Andrea Ballabio, Pierre-Olivier Fernagut, Wassilios G. Meissner, Erwan Bezard, Benjamin Dehay.
  JCI Insight. 2019-08-22. 4(16)
  10.1172/jci.insight.129719
• Early prenatal exposure to MPTP does not affect nigrostrial neurons in macaque monkey.
  Mathieu Bourdenx, Sandra Dovero, Philippe De DeurwAerdère, Qin Li, Erwan Bezard.
  Synapse. 2015-12-04. 70(2) : 52-56.
  10.1002/syn.21876
• Unexpected toxicity of very low dose MPTP in mice: A clue to the etiology of Parkinson’s disease?
  Sandra Dovero, Christian Gross, Erwan Bezard.
  Synapse. 2015-12-01. 70(2) : 49-51.
  10.1002/syn.21875
• Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.
  Ariadna Recasens, Benjamin Dehay, Jordi Bové, Iria Carballo-Carbajal, Sandra Dovero, Ana Pérez-Villalba, Pierre-Olivier Fernagut, Javier Blesa, Annabelle Parent, Celine Perier, Isabel Fariñas, José A. Obeso, Erwan Bezard, Miquel Vila.
  Ann Neurol.. 2014-02-18. 75(3) : 351-362.
  10.1002/ana.24066
• Immediate-early gene expression in structures outside the basal ganglia is associated to l-DOPA-induced dyskinesia.
  Matthieu F. Bastide, Sandra Dovero, Giselle Charron, Gregory Porras, Christian E. Gross, Pierre-Olivier Fernagut, Erwan Bézard.
  Neurobiology of Disease. 2014-02-01. 62 : 179-192.
  10.1016/j.nbd.2013.09.020
• Coordinated reset has sustained aftereffects in Parkinsonian monkeys.
  Peter A. Tass, Li Qin, Christian Hauptmann, Sandra Dovero, Erwan Bezard, Thomas Boraud, Wassilios G. Meissner.
  Ann Neurol.. 2012-11-01. 72(5) : 816-820.
  10.1002/ana.23663
• PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking
  Gregory Porras, Amandine Berthet, Benjamin Dehay, Qin Li, Laurent Ladepeche, Elisabeth Normand, Sandra Dovero, Audrey Martinez, Evelyne Doudnikoff, Marie-Laure Martin-Négrier, Qin Chuan, Bertrand Bloch, Daniel Choquet, Eric Boué-Grabot, Laurent Groc, Erwan Bezard.
  J. Clin. Invest.. 2012-10-08. 122(11) : 3977-3989.
  10.1172/JCI59426
• The associative and limbic thalamus in the pathophysiology of obsessive-compulsive disorder: An experimental study in the monkey
  J Y Rotge, B Aouizerate, V Amestoy, V Lambrecq, N Langbour, T H Nguyen, S Dovero, L Cardoit, J Tignol, B Bioulac, P Burbaud, D Guehl.
  Transl Psychiatry. 2012-09-01. 2(9) : e161-e161.
  10.1038/tp.2012.88
• Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques.
  Benjamin Dehay, Deniz Dalkara, Sandra Dovero, Qin Li, Erwan Bezard.
  Sci Rep. 2012-02-09. 2(1)
  10.1038/srep00253
• The translational value of the MPTP non-human primate model of Parkinsonism for deep brain stimulation research
  Peter A. Tass, Li Qin, Christian Hauptmann, Sandra Dovero, Erwan Bezard, Thomas Boraud, Wassilios G. Meissner.
  2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 2011-08-01.
  10.1109/IEMBS.2011.6090148
• Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia.
  S. Fasano, E. Bezard, A. D'Antoni, V. Francardo, M. Indrigo, L. Qin, S. Dovero, M. Cerovic, M. A. Cenci, R. Brambilla.
  Proceedings of the National Academy of Sciences. 2010-11-29. 107(50) : 21824-21829.
  10.1073/pnas.1012071107
• Dopamine transporter binding is unaffected by L-DOPA administration in normal and MPTP-treated monkeys.
  Pierre-Olivier Fernagut, Qin Li, Sandra Dovero, Piu Chan, Tao Wu, Paula Ravenscroft, Michael Hill, Zhenwen Chen, Erwan Bezard.
  PLoS ONE. 2010-11-22. 5(11) : e14053.
  10.1371/journal.pone.0014053
• Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia.
  Daniella Rylander, Martin Parent, Sean S. O'Sullivan, Sandra Dovero, Andrew J. Lees, Erwan Bezard, Laurent Descarries, M. Angela Cenci.
  Ann Neurol.. 2010-09-29. 68(5) : 619-628.
  10.1002/ana.22097
• Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesia.
  Emanuela Santini, Veronique Sgambato-Faure, Qin Li, Marc Savasta, Sandra Dovero, Gilberto Fisone, Erwan Bezard.
  PLoS ONE. 2010-08-23. 5(8) : e12322.
  10.1371/journal.pone.0012322
• Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson’s disease.
  M. R. Ahmed, A. Berthet, E. Bychkov, G. Porras, Q. Li, B. H. Bioulac, Y. T. Carl, B. Bloch, S. Kook, I. Aubert, S. Dovero, E. Doudnikoff, V. V. Gurevich, E. V. Gurevich, E. Bezard.
  Science Translational Medicine. 2010-04-21. 2(28) : 28ra28-28ra28.
  10.1126/scitranslmed.3000664
• Lentiviral overexpression of GRK6 alleviates L-Dopa-induced dyskinesia in experimental parkinson’s disease
  M. R. Ahmed, A. Berthet, E. Bychkov, G. Porras, Q. Li, B. H. Bioulac, Y. T. Carl, B. Bloch, S. Kook, I. Aubert, S. Dovero, E. Doudnikoff, V. V. Gurevich, E. V. Gurevich, E. Bezard.
  Science Translational Medicine. 2010-04-21. 2(28) : 28ra28-28ra28.
  10.1126/scitranslmed.3000664
• IGF-1 signaling reduces neuro-inflammatory response and sensitivity of neurons to MPTP.
  Agnès Nadjar, Olivier Berton, Shuhong Guo, Patricia Leneuve, Sandra Dovero, Elsa Diguet, François Tison, Baolu Zhao, Martin Holzenberger, Erwan Bezard.
  Neurobiology of Aging. 2009-12-01. 30(12) : 2021-2030.
  10.1016/j.neurobiolaging.2008.02.009
• Enhanced preproenkephalin-B-derived opioid transmission in striatum and subthalamic nucleus converges upon globus pallidus internalis in L-3,4-dihydroxyphenylalanine-induced dyskinesia.
  Incarnation Aubert, Céline Guigoni, Qin Li, Sandra Dovero, Bernard H. Bioulac, Christian E. Gross, Alan R. Crossman, Bertrand Bloch, Erwan Bezard.
  Biological Psychiatry. 2007-04-01. 61(7) : 836-844.
  10.1016/j.biopsych.2006.06.038
• Levodopa-induced dyskinesia in MPTP-treated macaques is not dependent on the extent and pattern of nigrostrial lesioning.
  Céline Guigoni, Sandra Dovero, Incarnation Aubert, Qin Li, Bernard H. Bioulac, Bertrand Bloch, Eugenia V. Gurevich, Christian E. Gross, Erwan Bezard.
  European Journal of Neuroscience. 2005-07-01. 22(1) : 283-287.
  10.1111/j.1460-9568.2005.04196.x
• Involvement of sensorimotor, limbic, and associative basal ganglia domains in L-3,4-dihydroxyphenylalanine-induced dyskinesia
  C. Guigoni.
  Journal of Neuroscience. 2005-02-23. 25(8) : 2102-2107.
  10.1523/JNEUROSCI.5059-04.2005
• Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia.
  Incarnation Aubert, Céline Guigoni, Kerstin Håkansson, Qin Li, Sandra Dovero, Nicole Barthe, Bernard H. Bioulac, Christian E. Gross, Gilberto Fisone, Bertrand Bloch, Erwan Bezard.
  Ann Neurol.. 2004-10-27. 57(1) : 17-26.
  10.1002/ana.20296
• Asymmetrically lesioned mesencephalon in healthy rodents: call for caution.
  Elsa Y. Pioli, Sandra Dovero, Bernard H. Bioulac, Christian E. Gross, Erwan Bezard.
  Brain Research. 2004-10-01. 1022(1-2) : 251-253.
  10.1016/j.brainres.2004.07.014
• Compensatory regulation of striatal neuropeptide gene expression occurs before changes in metabolic activity of basal ganglia nuclei
  Wassilios Meissner, Sandra Dovero, Bernard Bioulac, Christian E. Gross, Erwan Bezard.
  Neurobiology of Disease. 2003-06-01. 13(1) : 46-54.
  10.1016/S0969-9961(03)00011-1
• Pattern of levodopa-induced striatal changes is different in normal and MPTP-lesioned mice.
  Christian E. Gross, Paula Ravenscroft, Sandra Dovero, Mohamed Jaber, Bernard Bioulac, Erwan Bezard.
  Journal of Neurochemistry. 2003-03-01. 84(6) : 1246-1255.
  10.1046/j.1471-4159.2003.01600.x
• Pattern of levodopa-induced striatal changes is different in normal and MPTP-lesioned mice.
  Christian E. Gross, Paula Ravenscroft, Sandra Dovero, Mohamed Jaber, Bernard Bioulac, Erwan Bezard.
  Journal of Neurochemistry. 2003-03-01. 84(6) : 1246-1255.
  10.1046/j.1471-4159.2003.01600.x
• Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice
  Erwan Bezard, Sra Dovero, Christelle Imbert, Thomas Boraud, Christian E. Gross.
  Synapse. 2000-01-01. 38(3) : 363-368.
  10.1002/1098-2396(20001201)38:3<363::AID-SYN16>3.0.CO;2-A
• Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter.
  Erwan Bezard, Christian E. Gross, Marie-Christine Fournier, Sandra Dovero, Bertrand Bloch, Mohamed Jaber.
  Experimental Neurology. 1999-02-01. 155(2) : 268-273.
  10.1006/exnr.1998.6995
• Towards a dynamic approach of experimental parkinsonism
  Erwan Bezard, Thomas Boraud, Christelle Imbert, Sandra Dovero Bernard Bioulac, Christian E. Gross.
  Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1998-11-01. 22(8) : 1317-1329.
  10.1016/S0278-5846(98)00072-4
• Kinetics of nigral degeneration in a chronic model of MPTP-treated mice
  Erwan Bezard, Sandra Dovero, Bernard Bioulac, Christian E Gross.
  Neuroscience Letters. 1997-09-01. 234(1) : 47-50.
  10.1016/S0304-3940(97)00663-0