Nathalie Castanon

Scientific articles

• Saffron extract interferes with lipopolysaccharide-induced brain activation of the kynurenine pathway and impairment of monoamine neurotransmission in mice
  Camille Monchaux de Oliveira, Jennifer Morael, Alexandrine Guille, Camille Amadieu, Sylvie Vancassel, David Gaudout, Lucile Capuron, Line Pourtau, Nathalie Castanon.
  Front. Nutr.. 2023-10-05. 10
  10.3389/fnut.2023.1267839
• Acute Effect of a Saffron Extract (Safr’Inside^TM) and Its Main Volatile Compound on the Stress Response in Healthy Young Men: A Randomized, Double Blind, Placebo-Controlled, Crossover Study
  Camille Pouchieu, Line Pourtau, Julie Brossaud, David Gaudout, Jean-Benoit Corcuff, Lucile Capuron, Nathalie Castanon, Pierre Philip.
  Nutrients. 2023-06-27. 15(13) : 2921.
  10.3390/nu15132921
• Tetrahydrobiopterin modulates the behavioral neuroinflammatory response to an LPS challenge in mice
  S. Vancassel, H. Fanet, N. Castanon, C. Monchaux De Oliveira, S. Cussotto, L. Capuron.
  Brain, Behavior, and Immunity. 2022-10-01. 105 : 139-148.
  10.1016/j.bbi.2022.06.016
• Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (SafrInsideTM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders
  Fabien Wauquier, Line Boutin-Wittrant, Line Pourtau, David Gaudout, Benjamin Moras, Adeline Vignault, Camille Monchaux De Oliveira, Julien Gabaston, Carole Vaysse, Karène Bertrand, Hélène Abrous, Lucile Capuron, Nathalie Castanon, David Vauzour, Véronique Roux, Nicolas Macian, Gisèle Pickering, Yohann Wittrant.
  Nutrients. 2022-04-05. 14(7) : 1511.
  10.3390/nu14071511
• Prevention of Stress-Induced Depressive-like Behavior by Saffron Extract Is Associated with Modulation of Kynurenine Pathway and Monoamine Neurotransmission
  Camille Monchaux De Oliveira, Véronique De Smedt-Peyrusse, Jennifer Morael, Sylvie Vancassel, Lucile Capuron, David Gaudout, Line Pourtau, Nathalie Castanon.
  Pharmaceutics. 2021-12-14. 13(12) : 2155.
  10.3390/pharmaceutics13122155
• A new experimental design to study inflammation-related versus non-inflammation-related depression in mice
  Pierre Cardinal, Camille Monchaux de Oliveira, Julie Sauvant, Aline Foury, Muriel Darnaudéry, Sylvie Vancassel, Nathalie Castanon, Lucile Capuron.
  J Neuroinflammation. 2021-12-01. 18(1)
  10.1186/s12974-021-02330-9
• Anthocyanin-rich bilberry extract exerts a complex nutrigenomic effect in hippocampus of ApoE-/- mice
  Irena Krga, Anne-Laure Dinel, Sophie Laye, Nathalie Castanon, Dragan Milenkovic.
  Free Radical Biology and Medicine. 2021-12-01. 177 : S89.
  10.1016/j.freeradbiomed.2021.08.117
• Nutrigenomic modification induced by anthocyanin-rich bilberry extract in the hippocampus of ApoE-/- mice
  Dragan Milenkovic, Irena Krga, Anne-Laure Dinel, Christine Morand, Sophie Laye, Nathalie Castanon.
  Journal of Functional Foods. 2021-10-01. 85 : 104609.
  10.1016/j.jff.2021.104609
• Tetrahydrobioterin (BH4) Pathway: From Metabolism to Neuropsychiatry
  H. Fanet, L. Capuron, N. Castanon, F. Calon, S. Vancassel.
  CN. 2021-04-29. 19(5) : 591-609.
  10.2174/1570159x18666200729103529
• Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission
  Camille Monchaux De Oliveira, Line Pourtau, Sylvie Vancassel, Camille Pouchieu, Lucile Capuron, David Gaudout, Nathalie Castanon.
  Nutrients. 2021-03-11. 13(3) : 904.
  10.3390/nu13030904
• Inflammatory Bases of Neuropsychiatric Symptom Domains: Mechanisms and Specificity.
  Bruno Aouizerate, Sylvie Vancassel, Nathalie Castanon, Lucile Capuron.
  Immuno-Psychiatry. 2021-01-01. : 335-353.
  10.1007/978-3-030-71229-7_20
• The gut microbiota metabolite indole increases emotional responses and adrenal medulla activity in chronically stressed male mice
  Hayatte-Dounia Mir, Alexandre Milman, Magali Monnoye, Véronique Douard, Catherine Philippe, Agnès Aubert, Nathalie Castanon, Sylvie Vancassel, Nathalie C. Guérineau, Laurent Naudon, Sylvie Rabot.
  Psychoneuroendocrinology. 2020-09-01. 119 : 104750.
  10.1016/j.psyneuen.2020.104750
• Rapeseed oil fortified with micronutrients improves cognitive alterations associated with metabolic syndrome
  Célia Fourrier, Camille Kropp, Agnès Aubert, Julie Sauvant, Carole Vaysse, Jean-Michel Chardigny, Sophie Layé, Corinne Joffre, Nathalie Castanon.
  Brain, Behavior, and Immunity. 2019-11-01.
  10.1016/j.bbi.2019.11.002
• Obesity and Depression: Shared Pathophysiology and Translational Implications
  Lison Huet, Ines Delgado, Bruno Aouizerate, Nathalie Castanon, Lucile Capuron.
  Neurobiology of Depression. 2019-01-01. : 169-183.
  10.1016/b978-0-12-813333-0.00016-0
• Brain tumor necrosis factor-α mediates anxiety-like behavior in a mouse model of severe obesity.
  Célia Fourrier, Clémentine Bosch-Bouju, Raphaël Boursereau, Julie Sauvant, Agnès Aubert, Lucile Capuron, Guillaume Ferreira, Sophie Layé, Nathalie Castanon.
  Brain, Behavior, and Immunity. 2018-11-01.
  10.1016/j.bbi.2018.11.316
• Role of Inflammation in Neuropsychiatric Comorbidity of Obesity: Experimental and Clinical Evidence
  Célia Fourrier, Lucile Capuron, Nathalie Castanon.
  Inflammation and Immunity in Depression. 2018-01-01. : 357-375.
  10.1016/b978-0-12-811073-7.00020-9
• Switching adolescent high-fat diet to adult control diet restores neurocognitive alterations
  Chloé Boitard, Shauna L. Parkes, Amandine Cavaroc, Frédéric Tantot, Nathalie Castanon, Sophie Layé, Sophie Tronel, Gustavo Pacheco-Lopez, Etienne Coutureau, Guillaume Ferreira.
  Front. Behav. Neurosci.. 2016-11-21. 10
  10.3389/fnbeh.2016.00225
• Obesity- and Neuroinflammation-Associated Mood and Cognitive Disorders
  Nathalie Castanon, Giamal Luheshi, Sophie Layé.
  Neuroinflammation. 2015-03-06. : 139-153.
  10.1002/9781118732748.ch9
• Animal Models to Study the Role of Kynurenine Pathway in Mood, Behavior, and Cognition
  Nathalie Castanon.
  Targeting the Broadly Pathogenic Kynurenine Pathway. 2015-01-01. : 323-337.
  10.1007/978-3-319-11870-3_25
• Cytokines and depression: experimental evidence and intermediate mechanisms
  Robert Dantzer, Jason C. O’Connor, Nathalie Castanon, Jacques Lestage, Keith W. Kelley.
  Understanding depression. 2009-07-01. : 123-138.
  10.1093/med/9780199533077.003.0010
• Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin
  J. C. O'Connor, C. Andre, Y. Wang, M. A. Lawson, S. S. Szegedi, J. Lestage, N. Castanon, K. W. Kelley, R. Dantzer.
  Journal of Neuroscience. 2009-04-01. 29(13) : 4200-4209.
  10.1523/JNEUROSCI.5032-08.2009
• Induction of IDO by bacille Calmette-Guérin is responsible for development of murine depressive-like behavior
  Jason C. O'Connor, Marcus A. Lawson, Caroline André, Eileen M. Briley, Sandra S. Szegedi, Jacques Lestage, Nathalie Castanon, Miles Herkenham, Robert Dantzer, Keith W. Kelley.
  J Immunol. 2009-02-20. 182(5) : 3202-3212.
  10.4049/jimmunol.0802722
• Inflammation, sickness behaviour and depression
  Robert Dantzer, Nathalie Castanon, Jacques Lestage, Maite Moreau, Lucile Capuron.
  Depression and Physical Illness. . : 265-279.
  10.1017/cbo9780511544293.013
• Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior
  Maïté Moreau, Caroline André, Jason C. O’Connor, Sara A. Dumich, Jeffrey A. Woods, Keith W. Kelley, Robert Dantzer, Jacques Lestage, Nathalie Castanon.
  Brain, Behavior, and Immunity. 2008-10-01. 22(7) : 1087-1095.
  10.1016/j.bbi.2008.04.001
• Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration
  Caroline André, Jason C. O'Connor, Keith W. Kelley, Jacques Lestage, Robert Dantzer, Nathalie Castanon.
  Journal of Neuroimmunology. 2008-08-01. 200(1-2) : 90-99.
  10.1016/j.jneuroim.2008.06.011
• Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice
  J C O'Connor, M A Lawson, C André, M Moreau, J Lestage, N Castanon, K W Kelley, R Dantzer.
  Mol Psychiatry. 2008-01-15. 14(5) : 511-522.
  10.1038/sj.mp.4002148
• Aging exacerbates depressive-like behavior in mice in response to activation of the peripheral innate immune system
  Jonathan P Godbout, Maïté Moreau, Jacques Lestage, Jing Chen, Nathan L Sparkman, Jason O' Connor, Nathalie Castanon, Keith W Kelley, Robert Dantzer, Rodney W Johnson.
  Neuropsychopharmacol. 2007-12-12. 33(10) : 2341-2351.
  10.1038/sj.npp.1301649
• Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior
  François Frenois, Maïté Moreau, Jason O’Connor, Marc Lawson, Charlotte Micon, Jacques Lestage, Keith W. Kelley, Robert Dantzer, Nathalie Castanon.
  Psychoneuroendocrinology. 2007-06-01. 32(5) : 516-531.
  10.1016/j.psyneuen.2007.03.005
• Bacille Calmette-Guérin inoculation induces chronic activation of peripheral and brain indoleamine 2,3-dioxygenase in mice
  Maïté Moreau, Jacques Lestage, Danièle Verrier, Cécile Mormède, Keith W. Kelley, Robert Dantzer, Nathalie Castanon.
  J INFECT DIS. 2005-08-01. 192(3) : 537-544.
  10.1086/431603
• Chronic administration of tianeptine balances lipopolysaccharide-induced expression of cytokines in the spleen and hypothalamus of rats
  Nathalie Castanon, Chantal Médina, Cécile Mormède, Robert Dantzer.
  Psychoneuroendocrinology. 2004-07-01. 29(6) : 778-790.
  10.1016/s0306-4530(03)00142-2
• Conditioned taste aversion with lipopolysaccharide and peptidoglycan does not activate cytokine gene expression in the spleen and hypothalamus of mice
  Cécile Mormède, Karine Palin, Keith W Kelley, Nathalie Castanon, Robert Dantzer.
  Brain, Behavior, and Immunity. 2004-03-01. 18(2) : 186-200.
  10.1016/s0889-1591(03)00133-8
• Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice
  Alena Lira, Mingming Zhou, Nathalie Castanon, Mark S Ansorge, Joshua A Gordon, Jasmine H Francis, Maria Bradley-Moore, Josko Lira, Mark D Underwood, Victoria Arango, Hank F Kung, Myron A Hofer, René Hen, Jay A Gingrich.
  Biological Psychiatry. 2003-11-01. 54(10) : 960-971.
  10.1016/s0006-3223(03)00696-6
• Conditioned place aversion with interleukin-1beta in mice is not associated with activation of the cytokine network
  Cécile Mormède, Nathalie Castanon, Chantal Médina, Robert Dantzer.
  Brain, Behavior, and Immunity. 2003-04-01. 17(2) : 110-120.
  10.1016/s0889-1591(02)00054-5
• Effects of antidepressants on cytokine production and actions
  N CASTANON, B LEONARD, P NEVEU, R YIRMIYA.
  Brain, Behavior, and Immunity. 2002-10-01. 16(5) : 569-574.
  10.1016/s0889-1591(02)00008-9
• Chronic mild stress in mice decreases peripheral cytokine and increases central cytokine expression independently of IL-10 regulation of the cytokine network
  Cécile Mormède, Nathalie Castanon, Chantal Médina, Elisabeth Moze, Jacques Lestage, Pierre J. Neveu, Robert Dantzer.
  Neuroimmunomodulation. 2002-01-01. 10(6) : 359-366.
  10.1159/000071477
• Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1beta in the rat
  Nathalie Castanon, Rose-Marie Bluthé, Robert Dantzer.
  Psychopharmacology. 2001-02-22. 154(1) : 50-60.
  10.1007/s002130000595
• Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists
  Nathalie Castanon, Kimberly Scearce-Levie, Jose J Lucas, Beatriz Rocha, René Hen.
  Pharmacology Biochemistry and Behavior. 2000-11-01. 67(3) : 559-566.
  10.1016/s0091-3057(00)00389-0
• Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats
  Rose-Marie Bluthé, Nathalie Castanon, Florence Pousset, Adrian Bristow, Chris Ball, Jacques Lestage, Bruno Michaud, Keith W Kelley, Robert Dantzer.
  Psychoneuroendocrinology. 1999-04-01. 24(3) : 301-311.
  10.1016/s0306-4530(98)00077-8
• Is there evidence for an effect of antidepressant drugs on immune function?
  Pierre J. Neveu, Nathalie Castanon.
  Advances in Experimental Medicine and Biology. 1999-01-01. : 267-281.
  10.1007/978-0-585-37970-8_15
• Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor
  Beatriz A. Rocha, Kimberly Scearce-Levie, José J. Lucas, Noboru Hiroi, Nathalie Castanon, John C. Crabbe, Eric J. Nestler, René Hen.
  Nature. 1998-05-01. 393(6681) : 175-178.
  10.1038/30259
• Genetic analysis of the relationships between behavioral and neuroendocrine traits in Roman High and Low Avoidance rat lines
  Nathalie Castanon, Fernando Perez-Diaz, Pierre Mormède.
  Behav Genet. 1995-07-01. 25(4) : 371-384.
  10.1007/bf02197288
• Cocaine sensitivity in Roman High and Low Avoidance rats is modulated by sex and gonadal hormone status
  Margaret Haney, Nathalie Castanon, Martine Cador, Michel Le Moal, Pierre Morme`de.
  Brain Research. 1994-05-01. 645(1-2) : 179-185.
  10.1016/0006-8993(94)91651-9
• Maturation of the behavioral and neuroendocrine differences between the Roman rat lines
  Nathalie Castanon, Josette Dulluc, Michel Le Moal, Pierre Mormède.
  Physiology & Behavior. 1994-04-01. 55(4) : 775-782.
  10.1016/0031-9384(94)90059-0
• Psychobiogenetics: adapted tools for the study of the coupling between behavioral and neuroendocrine traits of emotional reactivity
  N CASTANON, P MORMEDE.
  Psychoneuroendocrinology. 1994-01-01. 19(3) : 257-282.
  10.1016/0306-4530(94)90065-5
• Psychoneuroendocrine profile associated with hypertension or hyperactivity in spontaneously hypertensive rats
  N. Castanon, E. D. Hendley, X. M. Fan, P. Mormede.
  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 1993-12-01. 265(6) : R1304-R1310.
  10.1152/ajpregu.1993.265.6.r1304
• Prolactin as a link between behavioral and immune differences between the Roman rat lines
  Nathalie Castanon, Josette Dulluc, Michel Le Moal, Pierre Mormède.
  Physiology & Behavior. 1992-06-01. 51(6) : 1235-1241.
  10.1016/0031-9384(92)90314-r
• Different responsiveness of spleen lymphocytes from two lines of psychogenetically selected rats (Roman high and low avoidance)
  Carmen Sandi, Nathalie Castanon, Sergio Vitiello, Pierre J. Neveu, Pierre Morméde.
  Journal of Neuroimmunology. 1991-01-01. 31(1) : 27-33.
  10.1016/0165-5728(91)90083-j
• Multiple neuroendocrine responses to chronic social stress: interaction between individual characteristics and situational factors
  Pierre Mormède, Valérie Lemaire, Nathalie Castanon, Josette Dulluc, Martine Laval, Michel Le Moal.
  Physiology & Behavior. 1990-06-01. 47(6) : 1099-1105.
  10.1016/0031-9384(90)90358-b