Didier Dulon
Team leader
Director of Research - PhD (DR) / Inserm/ Team
Clinical and translational exploration of sensorineural hearing loss
INSERM U1120, Genetics and Physiology of Hearing, Institut Pasteur, Paris
/ Contact
+33 5 47 30 74 71
www.orcid.org/0000-0003-1541-6861
/ Address of work
Hôpital CHU Pellegrin Bat PQR3, 3eme étage33076 Bordeaux
Scientific articles
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A free intravesicular C-terminal of otoferlin is essential for synaptic vesicle docking and fusion at auditory inner hair cell ribbon synapses.
Progress in Neurobiology. 2024-09-01. 240 : 102658.
10.1016/j.pneurobio.2024.102658 -
Clarin-2 gene supplementation durably preserves hearing in a model of progressive hearing loss
Molecular Therapy. 2024-01-01.
10.1016/j.ymthe.2024.01.021 -
Proof of concept of intracochlear drug administration by laser-assisted bioprinting in mice.
Hearing Research. 2023-10-01. 438 : 108880.
10.1016/j.heares.2023.108880 -
Hyperacusis in the Adult Fmr1-KO Mouse Model of Fragile X Syndrome: The Therapeutic Relevance of Cochlear Alterations and BKCa Channels
IJMS. 2023-07-24. 24(14) : 11863.
10.3390/ijms241411863 -
Otoferlin as a multirole Ca2+ signaling protein: from inner ear synapses to cancer pathways
Front. Cell. Neurosci.. 2023-07-19. 17
10.3389/fncel.2023.1197611 -
The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses.
iScience. 2022-12-01. 25(12) : 105628.
10.1016/j.isci.2022.105628 -
Clarin‐2 is essential for hearing by maintaining stereocilia integrity and function
EMBO Mol Med. 2019-08-26. 11(9)
10.15252/emmm.201910288 -
Viral Transfer of Mini-Otoferlins Partially Restores the Fast Component of Exocytosis and Uncovers Ultrafast Endocytosis in Auditory Hair Cells of Otoferlin Knock-Out Mice.
J. Neurosci.. 2019-03-04. : 1550-18.
10.1523/jneurosci.1550-18.2018 -
Clustered Ca2+ Channels Are Blocked by Synaptic Vesicle Proton Release at Mammalian Auditory Ribbon Synapses
Cell Reports. 2018-12-01. 25(12) : 3451-3464.e3.
10.1016/j.celrep.2018.11.072 -
Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome
Journal of Clinical Investigation. 2018-07-09. 128(8) : 3382-3401.
10.1172/jci94351 -
Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses.
eLife. 2017-11-07. 6
10.7554/elife.31013 -
Local gene therapy durably restores vestibular function in a mouse model of Usher syndrome type 1G.
Proc Natl Acad Sci USA. 2017-08-23. 114(36) : 9695-9700.
10.1073/pnas.1708894114 -
Different CaV1.3 Channel Isoforms Control Distinct Components of the Synaptic Vesicle Cycle in Auditory Inner Hair Cells.
J. Neurosci.. 2017-02-13. 37(11) : 2960-2975.
10.1523/jneurosci.2374-16.2017 -
Increasing intracellular free calcium induces circumferential contractions in isolated cochlear outer hair cells.
J Neurosci.. 1990-04-15. (10) : 4.
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Actions of subtype-specific purinergic ligands on rat spiral ganglion neurons.
Acta Otolaryngol Suppl.. 2004-08. (553) : 23-7.
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Motility of cochlear outer hair cells.
Am J Otol.. 1992-03-01. 13(2) : 108-12.
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A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells.
eLife. 2015-11-14. 4
10.7554/elife.10988 -
Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes.
Cell. 2015-11-01. 163(4) : 894-906.
10.1016/j.cell.2015.10.023 -
Exocytotic machineries of vestibular type I and cochlear ribbon synapses display similar intrinsic otoferlin-dependent Ca2+ sensitivity but a different coupling to Ca2+ channels.
Journal of Neuroscience. 2014-08-13. 34(33) : 10853-10869.
10.1523/jneurosci.0947-14.2014 -
The temporal characteristics of Ca2+ entry through L-type and T-type Ca2+ channels shape exocytosis efficiency in chick auditory hair cells during development.
Journal of Neurophysiology. 2012-12-01. 108(11) : 3116-3123.
10.1152/jn.00555.2012 -
Regulation of POU4F3 gene expression in hair cells by 5′ DNA in mice.
Neuroscience. 2011-12-01. 197 : 48-64.
10.1016/j.neuroscience.2011.09.033 -
Developmental acquisition of a rapid calcium-regulated vesicle supply allows sustained high rates of exocytosis in auditory hair cells.
PLoS ONE. 2011-10-06. 6(10) : e25714.
10.1371/journal.pone.0025714 -
Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells.
Journal of Neuroscience. 2010-10-06. 30(40) : 13281-13290.
10.1523/jneurosci.2528-10.2010 -
Purinergic signaling in cochleovestibular hair cells and afferent neurons.
Purinergic Signalling. 2010-05-20. 6(2) : 201-209.
10.1007/s11302-010-9183-x -
Otoferlin is critical for a highly sensitive and linear calcium-dependent exocytosis at vestibular hair cell ribbon synapses.
Journal of Neuroscience. 2009-08-26. 29(34) : 10474-10487.
10.1523/jneurosci.1009-09.2009 -
Is otospiralin inner ear specific? Evidence for its expression in mouse brain.
International Journal of Developmental Neuroscience. 2009-02-01. 27(1) : 87-96.
10.1016/j.ijdevneu.2008.09.001 -
Expression of Rho GTPases Rho-A and Rac1 in the adult and developing gerbil cerebellum.
International Journal of Developmental Neuroscience. 2008-11-01. 26(7) : 723-732.
10.1016/j.ijdevneu.2008.07.010 -
Calcium- and otoferlin-dependent exocytosis by immature outer hair cells.
Journal of Neuroscience. 2008-02-20. 28(8) : 1798-1803.
10.1523/jneurosci.4653-07.2008 -
Zinc protection against pneumolysin toxicity on rat cochlear hair cells.
Audiol Neurotol. 2007-09-21. 13(1) : 65-70.
10.1159/000108763 -
Multifrequency immittancemetry in experimentally induced stapes, round window and cochlear lesions.
Audiol Neurotol. 2007-01-01. 12(2) : 85-100.
10.1159/000097795 -
Neuromodulation in the spiral ganglion: shaping signals from the organ of corti to the CNS.
J Membrane Biol. 2006-01-01. 209(2-3) : 167-175.
10.1007/s00232-005-0841-9 -
The mechanism of pneumolysin-induced cochlear hair cell death in the rat.
The Journal of Physiology. 2005-09-28. 568(1) : 211-227.
10.1113/jphysiol.2005.092478 -
Expression analysis of neuroleukin, calmodulin, cortactin, and Rho7/Rnd2 in the intact and injured mouse brain.
Developmental Brain Research. 2005-09-01. 159(1) : 36-54.
10.1016/j.devbrainres.2005.06.013 -
Identification of differentially expressed genes in the developing mouse inferior colliculus.
Developmental Brain Research. 2005-09-01. 159(1) : 29-35.
10.1016/j.devbrainres.2005.06.010 -
Ryanodine receptors and BK channels act as a presynaptic depressor of neurotransmission in cochlear inner hair cells.
European Journal of Neuroscience. 2005-09-01. 22(5) : 1109-1119.
10.1111/j.1460-9568.2005.04310.x -
Localization and developmental expression of BK channels in mammalian cochlear hair cells.
Neuroscience. 2005-01-01. 130(2) : 475-484.
10.1016/j.neuroscience.2004.09.038 -
Intracochlear perfusion of pneumolysin, a pneumococcal protein, rapidly abolishes auditory potentials in the Guinea pig cochlea.
Acta Oto-Laryngologica. 2004-11-01. 124(9) : 1000-1007.
10.1080/00016480410017125 -
Developmental expression of Ca(v)1.3 (alpha1d) calcium channels in the mouse inner ear.
Developmental Brain Research. 2004-06-01. 150(2) : 167-175.
10.1016/j.devbrainres.2004.03.007 -
Effects of exposure of the ear to GSM microwaves: in vivo and in vitro experimental studies.
International Journal of Audiology. 2004-01-01. 43(9) : 545-554.
10.1080/14992020400050069 -
Effects of exposure of the ear to GSM microwaves: in vivo and in vitro experimental studies.
International Journal of Audiology. 2004-01-01. 43(9) : 545-554.
10.1080/14992020400050069 -
Contribution of BK Ca2+-activated K+ channels to auditory neurotransmission in the Guinea pig cochlea.
Journal of Neurophysiology. 2003-07-01. 90(1) : 320-332.
10.1152/jn.01155.2002 -
Substance P mobilizes intracellular calcium and activates a nonselective cation conductance in rat spiral ganglion neurons.
European Journal of Neuroscience. 2002-12-01. 16(11) : 2095-2102.
10.1046/j.1460-9568.2002.02292.x -
Comparative distribution of NK1, NK2, and NK3 receptors in the rat brainstem auditory nuclei.
Brain Research. 2002-08-01. 947(2) : 299-306.
10.1016/s0006-8993(02)03139-6 -
Comparative distribution of NK1, NK2, and NK3 receptors in the rat brainstem auditory nuclei.
Brain Research. 2002-08-01. 947(2) : 299-306.
10.1016/s0006-8993(02)03139-6 -
Nonselective cation conductance activated by muscarinic and purinergic receptors in rat spiral ganglion neurons.
American Journal of Physiology-Cell Physiology. 2002-05-01. 282(5) : C1121-C1135.
10.1152/ajpcell.00364.2001 -
The voltage-sensitive motor protein and the Ca2+-sensitive cytoskeleton in developing rat cochlear outer hair cells.
European Journal of Neuroscience. 2001-12-01. 14(12) : 1947-1952.
10.1046/j.0953-816x.2001.01826.x -
Tetraethylammonium ions block the nicotinic cholinergic receptors of cochlear outer hair cells.
Brain Research. 2001-10-01. 915(1) : 11-17.
10.1016/s0006-8993(01)02806-2 -
Gentamicin blocks ACh-evoked K+ current in guinea-pig outer hair cells by impairing Ca2+ entry at the cholinergic receptor.
The Journal of Physiology. 2000-06-01. 525(3) : 641-654.
10.1111/j.1469-7793.2000.t01-1-00641.x -
Acute and chronic effects of aminoglycosides on cochlear hair cells.
Annals of the New York Academy of Sciences. 1999-11-01. 884(1) : 60-68.
10.1111/j.1749-6632.1999.tb08636.x -
Muscarinic receptor-mediated calcium signaling in spiral ganglion neurons of the mammalian cochlea.
Brain Research. 1999-11-01. 846(2) : 196-203.
10.1016/s0006-8993(99)02034-x -
The bacterial Neo gene confers neomycin resistance to mammalian cochlear hair cells.
NeuroReport. 1999-04-01. 10(6) : 1189-1193.
10.1097/00001756-199904260-00006 -
Expression of small-conductance calcium-activated potassium channels (SK) in outer hair cells of the rat cochlea.
European Journal of Neuroscience. 1998-03-01. 10(3) : 907-915.
10.1046/j.1460-9568.1998.00098.x -
Cholinergic responses in developing outer hair cells of the rat cochlea.
European Journal of Neuroscience. 1996-09-01. 8(9) : 1945-1952.
10.1111/j.1460-9568.1996.tb01338.x -
ATP activates non-selective cation channels and calcium release in inner hair cells of the guinea-pig cochlea.
The Journal of Physiology. 1996-03-15. 491(3) : 707-718.
10.1113/jphysiol.1996.sp021251 -
Direct measurements of Ca(2+)-activated K+ currents in inner hair cells of the guinea-pig cochlea using photolabile Ca2+ chelators.
Pflügers Arch. 1995-07-01. 430(3) : 365-373.
10.1007/bf00373911 -
Organic material concentration in auditory outer hair cells measured by laser interferometry.
Cytometry. 1995-05-01. 20(1) : 1-6.
10.1002/cyto.990200102 -
Uptake of amikacin by hair cells of the guinea pig cochlea and vestibule and ototoxicity: comparison with gentamicin.
Hearing Research. 1995-02-01. 82(2) : 179-183.
10.1016/0378-5955(94)00175-p -
Photo-released intracellular Ca2+ evokes reversible mechanical responses in supporting cells of the guinea-pig organ of Corti.
Biochemical and Biophysical Research Communications. 1994-06-01. 201(3) : 1263-1269.
10.1006/bbrc.1994.1841 -
Mammalian cochlear outer hair cells density evaluated by means of an optical tweezer.
Biochemical and Biophysical Research Communications. 1993-10-01. 196(1) : 363-368.
10.1006/bbrc.1993.2257 -
Characterization of Ca2+ signals generated by extracellular nucleotides in supporting cells of the organ of Corti.
Cell Calcium. 1993-03-01. 14(3) : 245-254.
10.1016/0143-4160(93)90071-d -
Cellular and subcellular localization of tritiated gentamicin in the guinea pig cochlea following combined treatment with ethacrynic acid.
Hearing Research. 1992-01-01. 57(2) : 157-165.
10.1016/0378-5955(92)90148-g -
First appearance and development of motile properties in outer hair cells isolated from guinea-pig cochlea.
Hearing Research. 1991-12-01. 57(1) : 129-141.
10.1016/0378-5955(91)90082-k -
Cisplatin blocks depolarization-induced calcium entry in isolated cochlear outer hair cells.
Hearing Research. 1991-11-01. 56(1-2) : 143-147.
10.1016/0378-5955(91)90163-4 -
Differential motile response of isolated inner and outer hair cells to stimulation by potassium and calcium ions.
Hearing Research. 1991-03-01. 52(1) : 225-231.
10.1016/0378-5955(91)90202-k -
Aminoglycoside antibiotics impair calcium entry but not viability and motility in isolated cochlear outer hair cells.
J. Neurosci. Res.. 1989-10-01. 24(2) : 338-346.
10.1002/jnr.490240226 -
Vestibular hair cells isolated from guinea pig labyrinth.
Hearing Research. 1989-07-01. 40(3) : 255-260.
10.1016/0378-5955(89)90166-4 -
Dynamic changes following combined treatment with gentamicin and ethacrynic acid with and without acoustic stimulation. Cellular uptake and functional correlates.
Acta Oto-Laryngologica. 1989-01-01. 108(5-6) : 404-413.
10.3109/00016488909125546 -
Photo-induced irreversible shortening and swelling of isolated cochlear outer hair cells.
International Journal of Radiation Biology. 1989-01-01. 55(6) : 1007-1014.
10.1080/09553008914551031 -
Potassium-depolarization induces motility in isolated outer hair cells by an osmotic mechanism.
Hearing Research. 1988-02-01. 32(2-3) : 123-129.
10.1016/0378-5955(88)90084-6 -
Relationship between the nephrotoxicity and ototoxicity induced by gentamicin in the guinea pig.
Acta Oto-Laryngologica. 1988-01-01. 106(3-4) : 219-225.
10.3109/00016488809106429 -
Osmotically induced motility of outer hair cells: implications for Menière’s disease.
Arch Otorhinolaryngol. 1987-07-01. 244(2) : 104-107.
10.1007/bf00458558 -
Comparative uptake of gentamicin, netilmicin, and amikacin in the guinea pig cochlea and vestibule.
Antimicrobial Agents and Chemotherapy. 1986-07-01. 30(1) : 96-100.
10.1128/aac.30.1.96 -
Study of the electrokinetic properties of reconstituted sarcoplasmic reticulum vesicles.
Archives of Biochemistry and Biophysics. 1986-04-01. 246(1) : 355-365.
10.1016/0003-9861(86)90480-7